Education and Training

Medical School

MD - Tufts University School of Medicine, Boston, MA (Alpha Omega Alpha)

Residency

Pediatrics - Boston Children's Hospital, Boston, MA

Fellowship

Neonatal-Perinatal Medicine - Boston Children's Hospital, Boston, MA
Neonatal-Perinatal Medicine (Research) - The Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA

Board Certification

Neonatal/Perinatal Medicine
Pediatrics

Graduate Degree

PhD in Medicine and Cellular and Molecular Physiology - Tufts University School of Medicine, Boston, MA (Alpha Omega Alpha)

Titles and Academic Titles

Attending Physician in Neonatology

Chief, Section on Newborn Medicine, Pennsylvania Hospital

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2021

Mukhopadhyay S, Bryan M, Dhudasia MB, Quarshie W, Gerber JS, Grundmeier RW, Koebnick C, Sidell MA, Getahun D, Sharma AJ, Spiller MW, Schrag SJ, Puopolo KM. Intrapartum group B Streptococcal prophylaxis and childhood weight gain. Arch Dis Child Fetal Neonatal Ed. 2021 May 6:fetalneonatal-2020-320638. doi: 10.1136/archdischild-2020-320638. Epub ahead of print. PMID: 33958387.

Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Triebwasser JE, Gerber JS, Morris JS, Weirick ME, McAllister CM, Bolton MJ, Arevalo CP, Anderson EM, Goodwin EC, Hensley SE, Puopolo KM. Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios. JAMA Pediatr. 2021 Jan 29:e210038. doi: 10.1001/jamapediatrics.2021.0038. Epub ahead of print. PMID: 33512440; PMCID: PMC7846944.

Mukhopadhyay S, Puopolo KM, Hansen NI, Lorch SA, DeMauro SB, Greenberg RG, Cotten CM, Sanchez PJ, Bell EF, Eichenwald EC, Stoll BJ; NICHD Neonatal Research Network. Neurodevelopmental outcomes following neonatal late-onset sepsis and blood culture-negative conditions. Arch Dis Child Fetal Neonatal Ed. 2021 Jan 21:fetalneonatal-2020-320664. doi: 10.1136/archdischild-2020-320664. Epub ahead of print. PMID: 33478957.

Koebnick C, Sidell MA, Getahun D, Tartof SY, Rozema E, Taylor B, Xiang AH, Spiller MW, Sharma AJ, Mukhopadhyay S, Puopolo KM, Schrag SJ. Intrapartum Antibiotic Exposure and Body Mass Index in Children. Clin Infect Dis. 2021 Jan 25:ciab053. doi: 10.1093/cid/ciab053. Epub ahead of print. PMID: 33493270.

2020

Kuzniewicz MW, Puopolo KM. Antibiotic stewardship for early-onset sepsis. Semin Perinatol. 2020 Dec;44(8):151325. doi: 10.1016/j.semperi.2020.151325. Epub 2020 Oct 12.PMID: 33221072

Coffin SE, Abanyie F, Bryant K, Cantey J, Fiore A, Fritz S, Guzman-Cottrill J, Hersh AL, Huskins WC, Kociolek LK, Kronman M, Lautenbach E, Lee G, Linam M, Logan LK, Milstone A, Newland J, Nyquist AC, Palazzi DL, Patel S, Puopolo K, Reddy SC, Saiman L, Sandora T, Shane AL, Smith M, Tamma PD, Zaoutis T, Zerr D, Gerber JS; Pediatric research priorities in healthcare-associated infections and antimicrobial stewardship. CDC Prevention Epicenters Program.Infect Control Hosp Epidemiol. 2020 Nov 26:1-4. doi: 10.1017/ice.2020.1267. Online ahead of print.PMID: 33239122

Patrick SW, Barfield WD, Poindexter BB; Neonatal Opioid Withdrawal Syndrome. COMMITTEE ON FETUS AND NEWBORN, COMMITTEE ON SUBSTANCE USE AND PREVENTION.Pediatrics. 2020 Nov;146(5):e2020029074. doi: 10.1542/peds.2020-029074.PMID: 33106341 Review.

Hand IL, Shellhaas RA, Milla SS; Routine Neuroimaging of the Preterm Brain. COMMITTEE ON FETUS AND NEWBORN, SECTION ON NEUROLOGY, SECTION ON RADIOLOGY.Pediatrics. 2020 Nov;146(5):e2020029082. doi: 10.1542/peds.2020-029082.PMID: 33106343

Mukhopadhyay S, Wade KC, Dhudasia MB, Skerritt L, Chou JH, Dukhovny D, Puopolo KM. Clinical impact of neonatal hypoglycemia screening in the well-baby care. J Perinatol. 2020 Sep;40(9):1331-1338. doi: 10.1038/s41372-020-0641-1. Epub 2020 Mar 9.PMID: 32152490 Free PMC article.

Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Gerber JS, Arevalo CP, Bolton MJ, Weirick ME, Goodwin EC, Anderson EM, Greenplate AR, Kim J, Han N, Pattekar A, Dougherty J, Kuthuru O, Mathew D, Baxter AE, Vella LA, Weaver J, Verma A, Leite R, Morris JS, Rader DJ, Elovitz MA, Wherry EJ, Puopolo KM, Hensley SE. SARS-CoV-2 seroprevalence among parturient women in Philadelphia. Sci Immunol. 2020 Jul 29;5(49):eabd5709. doi: 10.1126/sciimmunol.abd5709.PMID: 32727884 Free PMC article.

Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Gerber JS, Arevalo CP, Bolton MJ, Weirick ME, Goodwin EC, Anderson EM, Greenplate AR, Kim J, Han N, Pattekar A, Dougherty J, Kuthuru O, Mathew D, Baxter AE, Vella LA, Weaver J, Verma A, Leite R, Morris JS, Rader DJ, Elovitz MA, Wherry EJ, Puopolo KM, Hensley SE. SARS-CoV-2 Seroprevalence Among Parturient Women. medRxiv. 2020 Jul 10:2020.07.08.20149179. doi: 10.1101/2020.07.08.20149179. Preprint.PMID: 32676623 Free PMC article. Updated.

Stoll BJ, Puopolo KM, Hansen NI, Sánchez PJ, Bell EF, Carlo WA, Cotten CM, D'Angio CT, Kazzi SNJ, Poindexter BB, Van Meurs KP, Hale EC, Collins MV, Das A, Baker CJ, Wyckoff MH, Yoder BA, Watterberg KL, Walsh MC, Devaskar U, Laptook AR, Sokol GM, Schrag SJ, Higgins RD; Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. JAMA Pediatr. 2020 Jul 1;174(7):e200593. doi: 10.1001/jamapediatrics.2020.0593. Epub 2020 Jul 6.PMID: 32364598

Kuzniewicz MW, Mukhopadhyay S, Li S, Walsh EM, Puopolo KM. Time to Positivity of Neonatal Blood Cultures for Early-onset Sepsis. Pediatr Infect Dis J. 2020 Jul;39(7):634-640. doi: 10.1097/INF.0000000000002632.PMID: 32379197

Fitzgerald MP, Massey SL, Fung FW, Puopolo KM, Posencheg M, Allen-Napoli L, Malcolm M, Abend NS. Expanding Access to Continuous EEG Monitoring in Neonatal Intensive Care Units. J Clin Neurophysiol. 2020 Jun 9. doi: 10.1097/WNP.0000000000000730. Online ahead of print.PMID: 32541608

Mukhopadhyay S, Puopolo KM, Hansen NI, Lorch SA, DeMauro SB, Greenberg RG, Cotten CM, Sánchez PJ, Bell EF, Eichenwald EC, Stoll BJ; Impact of Early-Onset Sepsis and Antibiotic Use on Death or Survival with Neurodevelopmental Impairment at 2 Years of Age among Extremely Preterm Infants.  Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 2020 Jun;221:39-46.e5. doi: 10.1016/j.jpeds.2020.02.038. PMID: 32446491 [PubMed - in process]

Wang KS, Cummings J, Stark A, Houck C, Oldham K, Grant C, Fallat M; Optimizing Resources in Children's Surgical Care: An Update on the American College of Surgeons' Verification Program. SECTION ON SURGERY, COMMITTEE ON FETUS AND NEWBORN, SECTION ON ANESTHESIOLOGY AND PAIN MEDICINE.Pediatrics. 2020 May;145(5):e20200708. doi: 10.1542/peds.2020-0708. Epub 2020 Apr 20.PMID: 32312909

Wang KS, Cummings J, Stark A, Houck C, Oldham K, Grant C, Fallat M; Optimizing Resources in Children's Surgical Care: An Update on the American College of Surgeons' Verification Program. SECTION ON SURGERY, COMMITTEE ON FETUS AND NEWBORN, SECTION ON ANESTHESIOLOGY AND PAIN MEDICINE.Pediatrics. 2020 May;145(5):e20200708. doi: 10.1542/peds.2020-0708. Epub 2020 Apr 20.PMID: 32312909

Watterberg K; Providing Care for Infants Born at Home. COMMITTEE ON FETUS AND NEWBORN.Pediatrics. 2020 May;145(5):e20200626. doi: 10.1542/peds.2020-0626. Epub 2020 Apr 20.PMID: 32312908 Review.

Flannery DD, Mukhopadhyay S, Jensen EA, Gerber JS, Passarella MR, Dysart K, Aghai ZH, Greenspan J, Puopolo KM. Influence of Patient Characteristics on Antibiotic Use Rates Among Preterm Infants. J Pediatric Infect Dis Soc. 2020 Mar 14. pii: piaa022. doi: 10.1093/jpids/piaa022. [Epub ahead of print]. PMID: 32170951

2019

Puopolo KM, Lynfield R, Cummings JJ; COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES. Management of Infants at Risk for Group B Streptococcal Disease. Pediatrics. 2019 Jul 8. pii: e20191881. doi: 10.1542/peds.2019-1881. [Epub ahead of print]

Shankaran S, Bell EF, Laptook AR, Saha S, Newman NS, Puopolo KM, Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network, et al. Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial. J Pediatr. 2019 Jan;204:96-102.e4. doi: 10.1016/j.jpeds.2018.08.079. PMID: 30337189.

Greenberg RG, Chowdhury D, Hansen NI, Smith PB, Stoll BJ, Puopolo KM, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, et al. Prolonged duration of early antibiotic therapy in extremely premature infants. Pediatr Res. 2019 Jan 22. doi: 10.1038/s41390-019-0300-4. [Epub ahead of print]. PMID: 30737489.

Mukhopadhyay S, Puopolo KM. Preventing Neonatal Group B Streptococcus Disease: The Limits of Success. JAMA Pediatr. 2019 Jan 14. doi: 10.1001/jamapediatrics.2018.4824. [Epub ahead of print]
PMID: 30640370

2018

Flannery DD, Ross RK, Mukhopadhyay S, Tribble AC, Puopolo KM, Gerber JS. Temporal Trends and Center Variation in Early Antibiotic Use Among Premature Infants. JAMA Network Open. 2018;1(1):e180164.

Flannery DD, Puopolo KM. Neonatal Antibiotic Use: How Much is Too Much? Pediatrics. 2018; 142(3):e20181942

Flannery DD, Puopolo KM. Neonatal Antibiotic Use: What Are We Doing and Where Shall We Go? Neoreviews, American Academy of Pediatrics. 2018;19(9):e516-525

Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018 Dec;142(6). pii: e20182894. doi: 10.1542/peds.2018-2894. PMID: 30455342

Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≤34 6/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018 Dec;142(6). pii: e20182896. doi: 10.1542/peds.2018-2896. PMID: 30455344

Mukhopadhyay S, Sengupta S, Puopolo KM. Challenges and opportunities for antibiotic stewardship among preterm infants. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 13. pii: fetalneonatal-2018-315412. doi: 10.1136/archdischild-2018-315412. [Epub ahead of print] Review. PMID: 30425110

2017

Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S, Newman TB, Kipnis P, Escobar GJ. A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis. JAMA Pediatr. 2017 Apr 1;171(4):365-371.

2014

Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, Newman TB, Zupancic J, Lieberman E, Draper D. Stratification of risk of early-onset sepsis in newborns >=34 weeks' gestation. Pediatrics. 2014 Jan;133(1):30-6.

Mukhopadhyay S, Dukhovny D, Mao W, Eichenwald EC, Puopolo KM. 2010 Perinatal GBS Prevention Guideline and Resource Utilization. Pediatrics. 2014 Jan 20. [Epub ahead of print].

Little SE, Robinson JN, Puopolo KM, Mukhopadhyay S, Wilkins-Haug LE, Acker DA, Zera CA. The effect of obstetric practice change to reduce early term delivery on perinatal outcome. J Perinatol. 2014 Jan 9.[Epub ahead of print]

Newman TB, Draper D, Puopolo KM, Wi,S, Escobar GJ. Combining Immature and Total Neutrophil Counts to Predict Early Onset Sepsis in Term and Late Preterm Newborns: Use of the I/T2. Pediatric Infectious Diseases Journal, accepted for publication, 2014.

Puopolo KM and Escobar GJ. Neonatal Sepsis. In Workbook in Practical Neonatology, 5th edition, 2014. Eds. Polin RA and Yoder MC.

2013

Mukhopadhyay S, Eichenwald EC, Puopolo KM. Neonatal early-onset sepsis evaluations among well-appearing infants: projected impact of changes in CDC GBS guidelines. J Perinatol. 2013 33(3):198-205.

Cape A, Tuomala RE, Taylor C, Puopolo KM. Peripartum Bacteremia in the Era of Group B Streptococcus Prophylaxis. Obstet Gynecol. 2013 121(4):812-818.

Klinzing DC, Ishmael N, Dunning Hotopp JC, Tettelin H, Shields KR, Madoff LC, Puopolo KM. The Two-Component Response Regulator LiaR Regulates Cell Wall Stress Responses, Pili Expression and Virulence in Group B Streptococcus. Microbiology. 2013 Jul;159(Pt 7):1521-34.

Puopolo KM and Escobar GJ. Early-Onset Sepsis: A Predictive Model Based on Maternal Risk Factors. Curr Opin Pediatr. 2013 25(2):161-166.
 

Posters and Presentations

2013

Neonatal Sepsis Club: Early-Onset Sepsis: What to do with the Asymptomatic Infant with Risk Factors for Sepsis and Can a Neonatal Sepsis Calculator Help Us? American Pediatric Society and the Society for Pediatric Research, Washington, D.C.

Early and Late-Onset Neonatal Sepsis. American Academy of Pediatrics NeoPREP course, San Diego, California.

Mukhopadhyay S., Dukhovny D, Eichenwald EC, Puopolo KM. “Neonatal Sepsis Risk Calculator: Projected Impact on a Retrospective Cohort.” American Pediatric Society and the Society for Pediatric Research, Washington, DC, May 6, 2013.

Cummings M, Patnode R, Puopolo KM. “Minimizing Central Venous Access Duration in Very−Low Birth Weight NICU Infants.” American Pediatric Society and the Society for Pediatric Research, Washington, DC, May 7, 2013.

2012

Neonatal Fluconazole Prophylaxis at a Low-Incidence Center / Platform Presentation (abstract) American Pediatric Society and the Society for Pediatric Research, Boston, Massachusetts

Minimizing Central Venous Access Duration in Very-Low Birth Weight Infants Massachusetts Neonatal Quality Improvement Collaborative, and March of Dimes Healthy Baby Symposium, Marlborough, Massachusetts

Mukhopadhyay S., Dukhovny D, Eichenwald EC, Puopolo KM. “Impact of Applying the 2010 CDC Prevention of Perinatal GBS Disease Guidelines.” American Pediatric Society and the Society for Pediatric Research, Boston, Massachusetts, April 29, 2012

Editorial and Academic Positions

Editorial positions

2020-present, Pediatrics, Editorial Board Member

Leadership and Memberships

Memberships in Professional Organizations

2014-present, American Academy of Pediatrics
 - 2014-present, Committee on Fetus and Newborn