Karen M. Puopolo, MD, PhD Karen Puopolo, MD, PhD, is an Attending Neonatologist and Chief, Section on Newborn Pediatrics at Pennsylvania Hospital. Locations: Main Campus; CHOP Newborn Care at Pennsylvania Hospital Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467) Education and Training Medical SchoolMD - Tufts University School of Medicine, Boston, MA (Alpha Omega Alpha) ResidencyPediatrics - Boston Children's Hospital, Boston, MA FellowshipNeonatal-Perinatal Medicine - Boston Children's Hospital, Boston, MA Neonatal-Perinatal Medicine (Research) - The Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA Board CertificationNeonatal/Perinatal MedicinePediatricsGraduate DegreePhD in Medicine and Cellular and Molecular Physiology - Tufts University School of Medicine, Boston, MA (Alpha Omega Alpha) Titles and Academic Titles Attending Physician in NeonatologyChief, Section on Newborn Pediatrics, Pennsylvania HospitalAssociate Professor of Clinical Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PAAssociate Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania Departments and Services Division of Neonatology Newborn/Infant Intensive Care Unit (N/IICU)Center for Pediatric Clinical Effectiveness (CPCE) Publications Papers2019 Shankaran S, Bell EF, Laptook AR, Saha S, Newman NS, Puopolo KM, Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network, et al. Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial. J Pediatr. 2019 Jan;204:96-102.e4. doi: 10.1016/j.jpeds.2018.08.079. PMID: 30337189. Greenberg RG, Chowdhury D, Hansen NI, Smith PB, Stoll BJ, Puopolo KM, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, et al. Prolonged duration of early antibiotic therapy in extremely premature infants. Pediatr Res. 2019 Jan 22. doi: 10.1038/s41390-019-0300-4. [Epub ahead of print]. PMID: 30737489. Mukhopadhyay S, Puopolo KM. Preventing Neonatal Group B Streptococcus Disease: The Limits of Success. JAMA Pediatr. 2019 Jan 14. doi: 10.1001/jamapediatrics.2018.4824. [Epub ahead of print] PMID: 30640370 2018 Flannery DD, Ross RK, Mukhopadhyay S, Tribble AC, Puopolo KM, Gerber JS. Temporal Trends and Center Variation in Early Antibiotic Use Among Premature Infants. JAMA Network Open. 2018;1(1):e180164. Flannery DD, Puopolo KM. Neonatal Antibiotic Use: How Much is Too Much? Pediatrics. 2018; 142(3):e20181942 Flannery DD, Puopolo KM. Neonatal Antibiotic Use: What Are We Doing and Where Shall We Go? Neoreviews, American Academy of Pediatrics. 2018;19(9):e516-525 Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018 Dec;142(6). pii: e20182894. doi: 10.1542/peds.2018-2894. PMID: 30455342 Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≤34 6/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018 Dec;142(6). pii: e20182896. doi: 10.1542/peds.2018-2896. PMID: 30455344 Mukhopadhyay S, Sengupta S, Puopolo KM. Challenges and opportunities for antibiotic stewardship among preterm infants. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 13. pii: fetalneonatal-2018-315412. doi: 10.1136/archdischild-2018-315412. [Epub ahead of print] Review. PMID: 30425110 2017 Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S, Newman TB, Kipnis P, Escobar GJ. A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis. JAMA Pediatr. 2017 Apr 1;171(4):365-371. 2014 Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, Newman TB, Zupancic J, Lieberman E, Draper D. Stratification of risk of early-onset sepsis in newborns >=34 weeks' gestation. Pediatrics. 2014 Jan;133(1):30-6. Mukhopadhyay S, Dukhovny D, Mao W, Eichenwald EC, Puopolo KM. 2010 Perinatal GBS Prevention Guideline and Resource Utilization. Pediatrics. 2014 Jan 20. [Epub ahead of print]. Little SE, Robinson JN, Puopolo KM, Mukhopadhyay S, Wilkins-Haug LE, Acker DA, Zera CA. The effect of obstetric practice change to reduce early term delivery on perinatal outcome. J Perinatol. 2014 Jan 9.[Epub ahead of print] Newman TB, Draper D, Puopolo KM, Wi,S, Escobar GJ. Combining Immature and Total Neutrophil Counts to Predict Early Onset Sepsis in Term and Late Preterm Newborns: Use of the I/T2. Pediatric Infectious Diseases Journal, accepted for publication, 2014. Puopolo KM and Escobar GJ. Neonatal Sepsis. In Workbook in Practical Neonatology, 5th edition, 2014. Eds. Polin RA and Yoder MC. 2013 Mukhopadhyay S, Eichenwald EC, Puopolo KM. Neonatal early-onset sepsis evaluations among well-appearing infants: projected impact of changes in CDC GBS guidelines. J Perinatol. 2013 33(3):198-205. Cape A, Tuomala RE, Taylor C, Puopolo KM. Peripartum Bacteremia in the Era of Group B Streptococcus Prophylaxis. Obstet Gynecol. 2013 121(4):812-818. Klinzing DC, Ishmael N, Dunning Hotopp JC, Tettelin H, Shields KR, Madoff LC, Puopolo KM. The Two-Component Response Regulator LiaR Regulates Cell Wall Stress Responses, Pili Expression and Virulence in Group B Streptococcus. Microbiology. 2013 Jul;159(Pt 7):1521-34. Puopolo KM and Escobar GJ. Early-Onset Sepsis: A Predictive Model Based on Maternal Risk Factors. Curr Opin Pediatr. 2013 25(2):161-166. Posters and Presentations2013 Neonatal Sepsis Club: Early-Onset Sepsis: What to do with the Asymptomatic Infant with Risk Factors for Sepsis and Can a Neonatal Sepsis Calculator Help Us? American Pediatric Society and the Society for Pediatric Research, Washington, D.C. Early and Late-Onset Neonatal Sepsis. American Academy of Pediatrics NeoPREP course, San Diego, California. Mukhopadhyay S., Dukhovny D, Eichenwald EC, Puopolo KM. “Neonatal Sepsis Risk Calculator: Projected Impact on a Retrospective Cohort.” American Pediatric Society and the Society for Pediatric Research, Washington, DC, May 6, 2013. Cummings M, Patnode R, Puopolo KM. “Minimizing Central Venous Access Duration in Very−Low Birth Weight NICU Infants.” American Pediatric Society and the Society for Pediatric Research, Washington, DC, May 7, 2013. 2012 Neonatal Fluconazole Prophylaxis at a Low-Incidence Center / Platform Presentation (abstract) American Pediatric Society and the Society for Pediatric Research, Boston, Massachusetts Minimizing Central Venous Access Duration in Very-Low Birth Weight Infants Massachusetts Neonatal Quality Improvement Collaborative, and March of Dimes Healthy Baby Symposium, Marlborough, Massachusetts Mukhopadhyay S., Dukhovny D, Eichenwald EC, Puopolo KM. “Impact of Applying the 2010 CDC Prevention of Perinatal GBS Disease Guidelines.” American Pediatric Society and the Society for Pediatric Research, Boston, Massachusetts, April 29, 2012 Editorial and Academic Positions Editorial positions 2013-2016, NeoReviews, Editorial Board Member 2012-2013, Pediatric Academic Society Annual Meeting Scientific Abstract reviewer, Invited reviewer Pediatrics, Ad hoc reviewer Archives of Disease in Childhood, Fetal and Neonatal Edition, Ad hoc reviewer Obstetrics and Gynecology, Ad hoc reviewer Pediatric Infectious Disease Journal, Ad hoc reviewer American Journal of Perinatology, Ad hoc reviewer Medical Science Monitor, Ad hoc reviewer Pediatric Research, Ad hoc reviewer Journal of Clinical Microbiology, Ad hoc reviewer Journal of Infectious Diseases, Ad hoc reviewer PLOS ONE, Ad hoc reviewer Patient Experience Ratings About the Patient Experience Rating System The Patient Experience Rating is an average of all responses to the care provider related questions shown above from our nationally-recognized Press Ganey Patient Satisfaction Survey. 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