Education and Training
MD - Tufts University School of Medicine, Boston, MA (Alpha Omega Alpha)
Pediatrics - Boston Children's Hospital, Boston, MA
Neonatal-Perinatal Medicine - Boston Children's Hospital, Boston, MA
Neonatal-Perinatal Medicine (Research) - The Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA
PhD in Medicine and Cellular and Molecular Physiology - Tufts University School of Medicine, Boston, MA (Alpha Omega Alpha)
Titles and Academic Titles
Attending Physician in Neonatology
Chief, Section on Newborn Pediatrics, Pennsylvania Hospital
Associate Professor of Clinical Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA
Associate Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Flannery DD, Mukhopadhyay S, Jensen EA, Gerber JS, Passarella MR, Dysart K, Aghai ZH, Greenspan J, Puopolo KM. Influence of Patient Characteristics on Antibiotic Use Rates Among Preterm Infants. J Pediatric Infect Dis Soc. 2020 Mar 14. pii: piaa022. doi: 10.1093/jpids/piaa022. [Epub ahead of print]. PMID: 32170951
Puopolo KM, Lynfield R, Cummings JJ; COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES. Management of Infants at Risk for Group B Streptococcal Disease. Pediatrics. 2019 Jul 8. pii: e20191881. doi: 10.1542/peds.2019-1881. [Epub ahead of print]
Shankaran S, Bell EF, Laptook AR, Saha S, Newman NS, Puopolo KM, Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network, et al. Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial. J Pediatr. 2019 Jan;204:96-102.e4. doi: 10.1016/j.jpeds.2018.08.079. PMID: 30337189.
Greenberg RG, Chowdhury D, Hansen NI, Smith PB, Stoll BJ, Puopolo KM, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, et al. Prolonged duration of early antibiotic therapy in extremely premature infants. Pediatr Res. 2019 Jan 22. doi: 10.1038/s41390-019-0300-4. [Epub ahead of print]. PMID: 30737489.
Mukhopadhyay S, Puopolo KM. Preventing Neonatal Group B Streptococcus Disease: The Limits of Success. JAMA Pediatr. 2019 Jan 14. doi: 10.1001/jamapediatrics.2018.4824. [Epub ahead of print]
Flannery DD, Ross RK, Mukhopadhyay S, Tribble AC, Puopolo KM, Gerber JS. Temporal Trends and Center Variation in Early Antibiotic Use Among Premature Infants. JAMA Network Open. 2018;1(1):e180164.
Flannery DD, Puopolo KM. Neonatal Antibiotic Use: How Much is Too Much? Pediatrics. 2018; 142(3):e20181942
Flannery DD, Puopolo KM. Neonatal Antibiotic Use: What Are We Doing and Where Shall We Go? Neoreviews, American Academy of Pediatrics. 2018;19(9):e516-525
Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018 Dec;142(6). pii: e20182894. doi: 10.1542/peds.2018-2894. PMID: 30455342
Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≤34 6/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018 Dec;142(6). pii: e20182896. doi: 10.1542/peds.2018-2896. PMID: 30455344
Mukhopadhyay S, Sengupta S, Puopolo KM. Challenges and opportunities for antibiotic stewardship among preterm infants. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 13. pii: fetalneonatal-2018-315412. doi: 10.1136/archdischild-2018-315412. [Epub ahead of print] Review. PMID: 30425110
Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S, Newman TB, Kipnis P, Escobar GJ. A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis. JAMA Pediatr. 2017 Apr 1;171(4):365-371.
Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, Newman TB, Zupancic J, Lieberman E, Draper D. Stratification of risk of early-onset sepsis in newborns >=34 weeks' gestation. Pediatrics. 2014 Jan;133(1):30-6.
Mukhopadhyay S, Dukhovny D, Mao W, Eichenwald EC, Puopolo KM. 2010 Perinatal GBS Prevention Guideline and Resource Utilization. Pediatrics. 2014 Jan 20. [Epub ahead of print].
Little SE, Robinson JN, Puopolo KM, Mukhopadhyay S, Wilkins-Haug LE, Acker DA, Zera CA. The effect of obstetric practice change to reduce early term delivery on perinatal outcome. J Perinatol. 2014 Jan 9.[Epub ahead of print]
Newman TB, Draper D, Puopolo KM, Wi,S, Escobar GJ. Combining Immature and Total Neutrophil Counts to Predict Early Onset Sepsis in Term and Late Preterm Newborns: Use of the I/T2. Pediatric Infectious Diseases Journal, accepted for publication, 2014.
Puopolo KM and Escobar GJ. Neonatal Sepsis. In Workbook in Practical Neonatology, 5th edition, 2014. Eds. Polin RA and Yoder MC.
Mukhopadhyay S, Eichenwald EC, Puopolo KM. Neonatal early-onset sepsis evaluations among well-appearing infants: projected impact of changes in CDC GBS guidelines. J Perinatol. 2013 33(3):198-205.
Cape A, Tuomala RE, Taylor C, Puopolo KM. Peripartum Bacteremia in the Era of Group B Streptococcus Prophylaxis. Obstet Gynecol. 2013 121(4):812-818.
Klinzing DC, Ishmael N, Dunning Hotopp JC, Tettelin H, Shields KR, Madoff LC, Puopolo KM. The Two-Component Response Regulator LiaR Regulates Cell Wall Stress Responses, Pili Expression and Virulence in Group B Streptococcus. Microbiology. 2013 Jul;159(Pt 7):1521-34.
Puopolo KM and Escobar GJ. Early-Onset Sepsis: A Predictive Model Based on Maternal Risk Factors. Curr Opin Pediatr. 2013 25(2):161-166.
Posters and Presentations
Neonatal Sepsis Club: Early-Onset Sepsis: What to do with the Asymptomatic Infant with Risk Factors for Sepsis and Can a Neonatal Sepsis Calculator Help Us? American Pediatric Society and the Society for Pediatric Research, Washington, D.C.
Early and Late-Onset Neonatal Sepsis. American Academy of Pediatrics NeoPREP course, San Diego, California.
Mukhopadhyay S., Dukhovny D, Eichenwald EC, Puopolo KM. “Neonatal Sepsis Risk Calculator: Projected Impact on a Retrospective Cohort.” American Pediatric Society and the Society for Pediatric Research, Washington, DC, May 6, 2013.
Cummings M, Patnode R, Puopolo KM. “Minimizing Central Venous Access Duration in Very−Low Birth Weight NICU Infants.” American Pediatric Society and the Society for Pediatric Research, Washington, DC, May 7, 2013.
Neonatal Fluconazole Prophylaxis at a Low-Incidence Center / Platform Presentation (abstract) American Pediatric Society and the Society for Pediatric Research, Boston, Massachusetts
Minimizing Central Venous Access Duration in Very-Low Birth Weight Infants Massachusetts Neonatal Quality Improvement Collaborative, and March of Dimes Healthy Baby Symposium, Marlborough, Massachusetts
Mukhopadhyay S., Dukhovny D, Eichenwald EC, Puopolo KM. “Impact of Applying the 2010 CDC Prevention of Perinatal GBS Disease Guidelines.” American Pediatric Society and the Society for Pediatric Research, Boston, Massachusetts, April 29, 2012
Editorial and Academic Positions
2013-2016, NeoReviews, Editorial Board Member
2012-2013, Pediatric Academic Society Annual Meeting Scientific Abstract reviewer, Invited reviewer
Pediatrics, Ad hoc reviewer
Archives of Disease in Childhood, Fetal and Neonatal Edition, Ad hoc reviewer
Obstetrics and Gynecology, Ad hoc reviewer
Pediatric Infectious Disease Journal, Ad hoc reviewer
American Journal of Perinatology, Ad hoc reviewer
Medical Science Monitor, Ad hoc reviewer
Pediatric Research, Ad hoc reviewer
Journal of Clinical Microbiology, Ad hoc reviewer
Journal of Infectious Diseases, Ad hoc reviewer
PLOS ONE, Ad hoc reviewer
Patient Experience Ratings
About the Patient Experience Rating System
The Patient Experience Rating is an average of all responses to the care provider related questions shown above from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
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