Education and Training

Medical School

MD - University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ


Pediatrics - The University of Chicago Children's Hospital, Chicago, IL


Pediatrics - The University of Chicago Children's Hospital, Chicago, IL


Pediatric Gastroenterology - The Children's Hospital of Philadelphia, Philadelphia, PA
Research Fellow, Pediatric Gastroenterology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Gastroenterology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Attending Physician

GI Director, Center for Pediatric Airway Disorders

Associate Professor of Clinical Pediatrics (Gastroenterology, Hepatology and Nutrition), Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Pediatric liver disease
Bile duct development
Growth and remodeling
Notch signaling




Aileen Wertz, Matthew Ryan, Ian Jacobs, Joseph Piccione: Impact of Pre-operative Multidisciplinary Evaluation on Laryngotracheal Reconstruction Outcomes. The Laryngoscope 131(7): E2356-E2362, July 2021.


Underkoffler LA, Carr E, Nelson A, Ryan MJ, Schultz R, Loomes KM: Microarray data reveal relationship between Jag1 and Ddr1 in mouse liver. PLoS One 9(1), Jan 2014 Notes: doi: 10.1371/journal.pone.0084383. eCollection


Ryan Matthew J, Bales Christina, Nelson Anthony, Gonzalez Dorian M, Underkoffler Lara, Segalov Michelle, Wilson-Rawls Jeanne, Cole Susan E, Moran Jennifer L, Russo Pierre, Spinner Nancy B, Kusumi Kenro, Loomes Kathleen M: Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype. Hepatology (Baltimore, Md.) 48(6): 1989-97, Dec 2008.


Loomes KM, Russo P, Ryan M, Nelson A, Underkoffler L, Glover C, Hong F, Thomas G, Kaestner K, Oakley R.: Bile Duct Proliferation in Liver Specific Jag Conditional Knockout Mice: Effects of Gene Dosage. Hepatology 45(2): 323-30, January 2007.

Loomes, Kathleen M.  Stevens, Stacey A.  O'Brien, Megan L.  Gonzalez, Dorian M.  Ryan, Matthew J.  Segalov, Michelle.  Dormans, Nicholas J.  Mimoto, Mizuho S.  Gibson, Joshua D.  Sewell, William.  Schaffer, Alyssa A.  Nah, Hyun-Duck.  Rappaport, Eric F.  Pratt, Stephen C.  Dunwoodie, Sally L.  Kusumi, Kenro.: Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects. Developmental Dynamics 236(10): 2943-51, Oct 2007.





Ryan JM: Vomiting, Splenomegaly and Asplenia/Hyposplenia. The Five Minute Pediatric Consult, 5th edition. Lippincott Williams and Wilkins, 2008.

Posters and Presentations

Invited Lectures


Ryan M. "The ABCs or LFTs" CHOP Nursing lecture, Philadelphia,PA. Oct 2023.

Ryan M. "CHOP Experience with Unsedated Transnasal Endoscopy" EvoEndo Board, Boston. Sept 2023.

Ryan M. "Functional Abdominal Pain" CHOP Harborview Pediatrics. Sept 2023.

Ryan M. "What Goes Down, Sometimes Comes Up", Chester County Hospital. Sept 2023.


Ryan M. GERD in the NICU, Virtu Hospital, Voorhees - Virtual conference. Mar 2022.


Ryan M. To Thicken or Not To Thicken, NASPGHAN Single Topic Symposium, Virtual. Nov 2021.

Awards and Honors

2015-2018, Fellow's Teaching Award Honor Roll
2006-2008, CDHNF Young Investigator's Development Award
2006, 2nd place Komorov Competition-basic science
2004-2006, NIH Loan Repayment Program

Editorial and Academic Positions

Editorial positions

2011, Journal of Clinical Investigation, Ad hoc reviewer
2010, Human Immunology, Ad hoc reviewer

Academic and institutional committees

2015-present, Chair of the GI ACGME program evaluation committee - PEC
2011-present, Division of GI, Hepatology and Nutrition Second Opinion Committee

Leadership and Memberships

Memberships in professional organization


2003-present, North American Society of Pediatric Gastroenterology, Hepatology and Nutrition
- 2015-present, Ethics Committee


2007-present, American Association for the Study of Liver Diseases
2003-present, The American Gastroenterology Association
2000-present, American Academy of Pediatrics