Winnie Sigal, MD

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Winnie Sigal, MD, is an attending physician in the Division of Endocrinology and Diabetes at Children's Hospital of Philadelphia.

Areas of Expertise: Congenital Hyperinsulinism
Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


Dr. Sigal is from the Philadelphia area. She completed her undergraduate education at Georgetown University, and Medical school at Thomas Jefferson University. She completed her pediatric training at A.I. duPont Hospital for Children/Thomas Jefferson in Wilmington, DE and Philadelphia, and she completed her pediatric endocrine training at the Children’s Hospital of Philadelphia.

She is a board-certified pediatrician and is currently an attending physician in the Division of Endocrinology and Diabetes.

Education and Training

Medical School

MD - Sydney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA


Pediatrics - A.I. duPont Hospital for Children/Thomas Jefferson University Hospital, Philadelphia, PA


Pediatric Endocrinology - Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Endocrinology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Congenital Hyperinsulinism and Transgender Medicine




Sigal WM, Alzahrani O, Guadalupe GM, Guzman H, Radcliffe J, Thomas NH, Jawad AF, De Leon DD.: Natural history and neurodevelopmental outcomes in perinatal stress induced hyperinsulinism. Front Pediatr 10: 999274, Oct 2022.


Sigal, W, De Leon, DD. “Neonatal Hypoglycemia.” Evidence Based Neonatology, edited by Akhil Maheshwari and Sue Aucott, Elsevier. Submitted for publication.


Sigal W, De Leon DD. “Natural History and Neurodevelopmental Outcomes in Perinatal Stress Induced Hyperinsulinism”. Updates in Diagnosis and Management of Hyperinsulinism and Neonatal Hypoglycemia Conference, September 5-6th 2019, The Children’s Hospital of Philadelphia, Philadelphia, PA.

Sigal W, Williams C, Joshi A, Stanescu D, Hatch-Stein J, Pinney S. “Severe Infantile Insulin Resistance: A Novel Feature of MIRAGE Syndrome”. The Endocrine Society Meeting, March 24th 2019, New Orleans, LA, and the Pediatric Academic Societies / Pediatric Endocrine Society Meeting, April 27th, 2019, Baltimore, MD.



Sigal, Winnie: Neonatal Hypoglycemia. Principles of Neonatology. Akhil Maheshwari and Sue Aucott (eds.). Elsevier, 2023

Awards and Honors

2019, Outstanding Abstract Award, The Endocrine Society

2019, CHOP Poster Day Clinical Research Presentation Award

2018-2020, NIH T32 Ruth L. Kirschstein National Research Service Award Training Grant, The Children’s Hospital of Philadelphia

2018, Travel Award to National Meeting, Pediatric Endocrine Society

2016, Travel Award and invitation to attend the Pediatric Growth Conference and Pediatric Academic Society National Meeting

Leadership and Memberships

Pediatric Endocrine Society