Michael Silverman, MD, PhD, is an attending physician with the Division of Infectious Diseases at Children's Hospital of Philadelphia.
Areas of Expertise:
Immune system development, Infections in immunocompromised children, Eastern equine encephalitis, Type 1 Diabetes, Microbiome Locations:Main Hospital Appointments and Referrals: 1-800-TRY-CHOP(1-800-879-2467)
Education and Training
MD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Pediatrics - Boston Children's Hospital, Boston, MA
Pediatrics - Boston Children’s Hospital, Boston, MA
Post-Doctoral Fellow - Harvard Medical School, Boston, MA
Infectious Diseases - Boston Children’s Hospital, Boston, MA
Pediatric Infectious Diseases – American Board of PediatricsPediatrics – American Board of Pediatrics
PhD in Immunology - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Titles and Academic Titles
Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Assistant Professor of Microbiology, Perelman School of Medicine at the University of Pennsylvania
Dr. Silverman’s research focuses on how commensal microbes influence the development of the immune system and can be harnessed to prevent immune system dysfunction and invasive infection.
Tanca A, Palomba A, Fraumene C, Manghina V, Silverman M, Uzzau S.: Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice. mSphere 3(5): doi: 10.1128, October 2018.
Dixit A, Alexandrescu S, Boyer D, Graf, EH, Vargas SO, Silverman M: Mycoplasma hominis empyema in an 18 year-old stem cell and lung transplant recipient: Case report and review of the literature. J Pediatric Infect Dis Soc 6(4): 173-176, November 2017.
Silverman M, Kua L, Tanco A, Pala M, Palomba A,Tanes C, Bittenger K, Uzzau S, Benoist C, and Mathis D: Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny. Proceedings of the National Academy of Sciences 114(36): 9671-9676, September 2017.
Alessandro Tanca, Valeria Manghina, Cristina Fraumene, Antonio Palomba, Marcello Abbondio, Massimo Deligios, Michael Silverman, Sergio Uzzau: Metaproteogenomics reveals taxonomic and functional changes between cecal and fecal microbiota in mouse. Frontiers in Microbiology 8(391): doi: 10.3389, March 2017 Notes: ecollection 2017.
Silverman MA, Misasi J, Smole S, Feldman HA, Cohan AB, Santagata S, McManus M, Ahmed AA: Pediatric Eastern Equine encephalitis in Massachusetts and New Hampshire, 1970-2010. Emerging Infectious Diseases 19(2): 194-201, February 2013.
Kambayashi T, Larosa DF, Silverman MA, Koretzky GA: Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation. Immunol Rev 232(1): 99-114, November 2009.
Olenchock BA, Guo R, Silverman MA, Wu JN, Carpenter JH, Koretzky GA, Zhong XP.: Impaired degranulation but enhanced cytokine production after FcepsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. J Exp Med 205(5): 1471-80, May 2006.
Silverman MA, Shoag J, Wu J, Koretzky GA: Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol 26(5): 1826-38, March 2006.
Karnell FG, Brezski RJ, King LB, Silverman MA, Monroe JG: Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling. J Biol Chem 280(27): 25621-8, July 2005.
Artis D, Villarino A, Silverman M, He W, Thornton EM, Mu S, Summer S, Covey TM, Huang E, Yoshida H, Koretzky G, Goldschmidt M, Wu GD, de Sauvage F, Miller HR, Saris CJ, Scott P, Hunter CA: The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol 173(8): 5626-34, November 2004.
Wu JN, Jordan MS, Silverman MA, Peterson EJ, Koretzky GA: Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function. J Immunol 172(11): 6768-74, June 2004.
Newbrough SA, Mocsai A, Clemens RA, Wu JN, Silverman MA, Singer AL, Lowell CA, Koretzky GA.: SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity 19(5): 761-9, November 2003.
Chung JB, Silverman M, Monroe JG: Transitional B cells: step by step towards immune competence. Trends Immunol 24(6): 343-9, June 2003.
Sullivan PF, Neale MC, Silverman MA, Harris-Kerr C, Myakishev MV, Wormley B, Webb BT, Ma Y, Kendler KS, Straub RE: An association study of DRD5 with smoking initiation and progression to nicotine dependence. Am J Med Genet 105(3): 259-65, April 2001.
Silverman MA, Neale MC, Sullivan PF, Harris-Kerr C, Wormley B, Sadek H, Ma Y, Kendler KS, Straub RE.: Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. Am J Med Genet 96(5): 646-53, October 2000.
Straub RE, Sullivan PF, Ma Y, Myakishev MV, Harris-Kerr C, Wormley B, Kadambi B, Sadek H, Silverman MA, Webb BT, Neale MC, Bulik CM, Joyce PR, Kendler KS. : Susceptibility genes for nicotine dependence: a genome scan and follow up in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study. Mol Psychiatry 4(2): 129-44, March 1999.
Posters and Presentations
Silverman MA. "Role of the altered microbiome, GVHD and the risk of infection in the post-hematopoietic stem cell transplant patient", American Society of Pediatric Hematology/Oncology annual meeting, New Orleans, LA. May, 2019.
Silverman MA. "Microbiome in oncology". ASPHO - American Society of Pediatric Hematology/Oncology Annual Meeting, New Orleans, LA. May, 2019.
Silverman MA. "A Protective MHC-II Allele Prevents Autoimmune Diabetes by Shaping the Early-Life Microbiome". Multidisciplinary Immunology & Transplantation Interest Conference. The Hospital of the University of Pennsylvania, Philadelphia, PA (regional audience). Mar, 2018.
Silverman MA. "A protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny". Temple University, Philadelphia, PA. Oct, 2017.
Silverman MA. "A protective MHC allele prevents autoimmunity diabetes by shaping the intestinal microbiome early in ontogeny" International Congress of Mucosal Immunology, Washington DC. Jul, 2017.
Awards and Honors
2012, Trainee Travel Award for Excellence, Boston Children’s Hospital Alumni Association
2011, Fellowship Award, Pediatric Infectious Diseases Society
2011, Fellow Teaching Award, Boston Children’s Hospital
2011, Pediatric Residency Graduation Speaker, Boston Combined Residency Program
2011-2013, Pediatric Infectious Diseases Society Fellowship Award
2010, Senior Resident Teaching Award, Boston Combined Residency Program
2009-2011, The Fred Lovejoy Residency Research and Education Award
2006. Adolf J. Creskoff Prize for Research, University of Pennsylvania School of Medicine
2005, Travel Award, Mast cell signaling and function in health and disease research conference
Editorial and Academic Positions
2016-present, Ad hoc reviewer; PLOS one
2016-present, Reviewer, Journal of the Pediatric Infectious Diseases Society
Leadership and Memberships
Memberships in Professional Organizations
2018-present, American Association of Immunologists
2016-present, Society for Mucosal Immunology
2011-present, Infectious Diseases Society of America
2010-present, Pediatric Infectious Diseases Society
2007-present, American Academy of Pediatrics
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