Michael Silverman, MD, PhD

Michael Silverman, MD, PhD
Michael Silverman, MD, PhD, is an attending physician with the Division of Infectious Diseases at Children's Hospital of Philadelphia.

Areas of Expertise: Immune system development, Infections in immunocompromised children, Eastern equine encephalitis, Type 1 Diabetes, Microbiome
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Internship

Pediatrics - Boston Children's Hospital, Boston, MA

Residency

Pediatrics - Boston Children’s Hospital, Boston, MA

Fellowship

Post-Doctoral Fellow - Harvard Medical School, Boston, MA
Infectious Diseases - Boston Children’s Hospital, Boston, MA

Board Certification

Pediatric Infectious Diseases
Pediatrics

Graduate Degree

PhD in Immunology - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Assistant Professor of Microbiology, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Dr. Silverman’s research focuses on how commensal microbes influence the development of the immune system and can be harnessed to prevent immune system dysfunction and invasive infection.

Publications

Papers

2018

Tanca A, Palomba A, Fraumene C, Manghina V, Silverman M, Uzzau S.: Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice. mSphere 3(5): doi: 10.1128, October 2018.

2017

Dixit A, Alexandrescu S, Boyer D, Graf, EH, Vargas SO, Silverman M: Mycoplasma hominis empyema in an 18 year-old stem cell and lung transplant recipient: Case report and review of the literature. J Pediatric Infect Dis Soc 6(4): 173-176, November 2017.

Silverman M, Kua L, Tanco A, Pala M, Palomba A,Tanes C, Bittenger K, Uzzau S, Benoist C, and Mathis D: Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny. Proceedings of the National Academy of Sciences 114(36): 9671-9676, September 2017.

Alessandro Tanca, Valeria Manghina, Cristina Fraumene, Antonio Palomba, Marcello Abbondio, Massimo Deligios, Michael Silverman, Sergio Uzzau: Metaproteogenomics reveals taxonomic and functional changes between cecal and fecal microbiota in mouse. Frontiers in Microbiology 8(391): doi: 10.3389, March 2017 Notes: ecollection 2017.

2013

Silverman MA, Misasi J, Smole S, Feldman HA, Cohan AB, Santagata S, McManus M, Ahmed AA: Pediatric Eastern Equine encephalitis in Massachusetts and New Hampshire, 1970-2010. Emerging Infectious Diseases  19(2): 194-201, February 2013.

2009

Kambayashi T, Larosa DF, Silverman MA, Koretzky GA: Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation. Immunol Rev 232(1): 99-114, November 2009.

2006

Olenchock BA, Guo R, Silverman MA, Wu JN, Carpenter JH, Koretzky GA, Zhong XP.: Impaired degranulation but enhanced cytokine production after FcepsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. J Exp Med 205(5): 1471-80, May 2006.

Silverman MA, Shoag J, Wu J, Koretzky GA: Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol  26(5): 1826-38, March 2006.

2005

Karnell FG, Brezski RJ, King LB, Silverman MA, Monroe JG: Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling. J Biol Chem 280(27): 25621-8, July 2005.

2004

Artis D, Villarino A, Silverman M, He W, Thornton EM, Mu S, Summer S, Covey TM, Huang E, Yoshida H, Koretzky G, Goldschmidt M, Wu GD, de Sauvage F, Miller HR, Saris CJ, Scott P, Hunter CA: The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol  173(8): 5626-34, November 2004.

Wu JN, Jordan MS, Silverman MA, Peterson EJ, Koretzky GA: Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function. J Immunol  172(11): 6768-74, June 2004.

2003

Newbrough SA, Mocsai A, Clemens RA, Wu JN, Silverman MA, Singer AL, Lowell CA, Koretzky GA.: SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity 19(5): 761-9, November  2003.

Chung JB, Silverman M, Monroe JG: Transitional B cells: step by step towards immune competence. Trends Immunol  24(6): 343-9, June 2003.

2001

Sullivan PF, Neale MC, Silverman MA, Harris-Kerr C, Myakishev MV, Wormley B, Webb BT, Ma Y, Kendler KS, Straub RE: An association study of DRD5 with smoking initiation and progression to nicotine dependence. Am J Med Genet  105(3): 259-65, April 2001.

2000

Silverman MA, Neale MC, Sullivan PF, Harris-Kerr C, Wormley B, Sadek H, Ma Y, Kendler KS, Straub RE.: Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. Am J Med Genet 96(5): 646-53, October 2000.

1999

Straub RE, Sullivan PF, Ma Y, Myakishev MV, Harris-Kerr C, Wormley B, Kadambi B, Sadek H, Silverman MA, Webb BT, Neale MC, Bulik CM, Joyce PR, Kendler KS.   : Susceptibility genes for nicotine dependence: a genome scan and follow up in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study. Mol Psychiatry 4(2): 129-44, March 1999.

Posters and Presentations

Invited Lectures

2019

Silverman MA. "Role of the altered microbiome, GVHD and the risk of infection in the post-hematopoietic stem cell transplant patient", American Society of Pediatric Hematology/Oncology annual meeting, New Orleans, LA. May, 2019.

Silverman MA. "Microbiome in oncology". ASPHO - American Society of Pediatric Hematology/Oncology Annual Meeting, New Orleans, LA. May, 2019.

2018

Silverman MA. "A Protective MHC-II Allele Prevents Autoimmune Diabetes by Shaping the Early-Life Microbiome". Multidisciplinary Immunology & Transplantation Interest Conference. The Hospital of the University of Pennsylvania, Philadelphia, PA (regional audience). Mar, 2018.

2017

Silverman MA. "A protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny".  Temple University, Philadelphia, PA. Oct, 2017.

Silverman MA. "A protective MHC allele prevents autoimmunity diabetes by shaping the intestinal microbiome early in ontogeny" International Congress of Mucosal Immunology, Washington DC. Jul, 2017.

Awards and Honors

2012, Trainee Travel Award for Excellence, Boston Children’s Hospital Alumni Association

2011, Fellowship Award, Pediatric Infectious Diseases Society

2011, Fellow Teaching Award, Boston Children’s Hospital

2011, Pediatric Residency Graduation Speaker, Boston Combined Residency Program

2011-2013, Pediatric Infectious Diseases Society Fellowship Award

2010, Senior Resident Teaching Award, Boston Combined Residency Program

2009-2011, The Fred Lovejoy Residency Research and Education Award

2006. Adolf J. Creskoff Prize for Research, University of Pennsylvania School of Medicine

2005, Travel Award, Mast cell signaling and function in health and disease research conference

Editorial and Academic Positions

Editorial Positions

2016-present, Ad hoc reviewer; PLOS one
2016-present, Reviewer, Journal of the Pediatric Infectious Diseases Society

Leadership and Memberships

Memberships in Professional Organizations

2018-present, American Association of Immunologists

2016-present, Society for Mucosal Immunology

2011-present, Infectious Diseases Society of America

2010-present, Pediatric Infectious Diseases Society

2007-present, American Academy of Pediatrics