Ashley E. Sobel Leonard, MD, PhD

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Ashley E. Sobel Leonard, MD, PhD, is a fellow with the Division of Infectious Diseases at Children's Hospital of Philadelphia.

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Duke University School of Medicine – Durham, NC

PhD - Duke University School of Medicine – Durham, NC


Resident Physician, University of Washington Affiliated Hospitals, Seattle, WA

Titles and Academic Titles

Fellow, Division of Infectious Diseases

Departments and Services

Research Interests

Infectious disease, viral ecology and evolution, global health and pandemic preparedness.


Posters and Presentations


Manus, M., Bloomfield, G., Sobel Leonard, A., Guidera, L., Samson, D., Nunn, C. (2018).  High Prevalence of Hypertension in an Agricultural Village in Madagascar. PLoS One.


Sobel Leonard, A., Weissman, D., Greenbaum, B., Ghedin, E., & Koelle, K. (2017). Transmission Bottleneck Size Estimation from Pathogen Deep-Sequencing Data, with an Application to Human Influenza A Virus Bottleneck size inference from pathogen deep-sequencing data. Journal of Virology.91(14). pii: e00171-17. doi: 10.1128/JVI.00171-17.

Sobel Leonard, A., Mcclain, M. T. K., Smith, G. J. D., Wentworth, D., Rebecca, A., Lin, X., … Christopher, J. R. (2017). The Effective Rate of Influenza Reassortment is Limited During Human Infection. Plos Pathogens, 1–27.


Sobel Leonard, A., McClain, M. T., Smith, G. J. D., Wentworth, D. E., Halpin, R. A., Lin, X., … Koelle, K. (2016). Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification. Journal of Virology, 90(24), 11247–11258.

Leonard, J. A., Sobel Leonard, A., Chang, D. T., Edwards, S., Lu, J., Scholle, S., … Tan, Y. M. (2016). Evaluating the Impact of Uncertainties in Clearance and Exposure When Prioritizing Chemicals Screened in High-Throughput Assays. Environmental Science and Technology, 50(11), 5961–5971.

Abou-Donia, M. B., Siracuse, B., Gupta, N., & Sobel Leonard, A*. (2016). Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review. Critical Reviews in Toxicology, 8444(November), 1–31.

*Incorrectly listed as Ashley Sobel Sokol


Gwinn, W. M., Johnson, B. T., Kirwan, S. M., Sobel, A. E., Abraham, S. N., Gunn, M. D., & Staats, H. F. (2013). A comparison of non-toxin vaccine adjuvants for their ability to enhance the immunogenicity of nasally-administered anthrax recombinant protective antigen. Vaccine, 31(11), 1480–1489.


Staats, H. F., Fielhauer, J. R., Thompson, A. L., Tripp, A. A., Sobel, A. E., Maddaloni, M., … Pascual, D. W. (2011). Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits. PloS One, 6(1), e16532.

Awards and Honors

2015, Travel bursary to attend Viral Genomics and Evolution Conference in Hinxton, UK

2015, Mitchell Meritorious Travel award to attend Viral Genomics and Evolution Conference in Hinxton, UK

2014, cholarship to attend Summer Institute in Statistics and Modeling Infectious Diseases, Seattle. USA

2013, Travel award to attend Disease Dynamics conference, Vancouver, CV

2012, Scholarship to attend Ecology of Infectious Disease workshop, Ann Arbor, MI, USA

2008, William Griffith Service Award for Commitment to the Global Community

2007, Phi Beta Kappa, inducted Fall

2008, Phi Lambda Upsilon, inducted Spring

Leadership and Memberships

2015, Bass Connections Research team, Durham, NC

2010, AIDS Orphan Education Trust, Jinja, Uganda

2009-2010, Infectious Disease Interest Group, Durham, NC