Lea F. Surrey, MD

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Lea F. Surrey, MD, is a pathologist in the Department of Pathology and Laboratory Medicine at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Residency

Anatomic and Clinical Pathology - Hospital of the University of Pennsylvania, Philadelphia, PA

Fellowship

Molecular Genetic Pathology - Hospital of the University of Pennsylvania, Philadelphia, PA

Pediatric and Perinatal Pathology - Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification

Molecular Genetic Pathology
Anatomic and Clinical Pathology
Pediatric Pathology

Titles and Academic Titles

Pathologist

Assistant Professor of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2019

Jain Neil K, Mostoufi-Moab Sogol, Hawkes Colin P, Nelson Nya D, Surrey Lea F, Jones Zachary S, Adzick N Scott, Kazahaya Ken, Bauer Andrew J: Extrathyroidal Extension is an Important Predictor of Regional Lymph Node Metastasis in Pediatric Differentiated Thyroid Cancer. Thyroid Oct 2019 Notes: Epub ahead of print.

Lea F. Surrey, Payal Jain, Bo Zhang, Joshua Straka, Xiaonan Zhao, Brian Harding, Adam C. Resnick, Phillip B. Storm, Anna Maria Buccoliero, Lorenzo Genitori, Marilyn M. Li, Angela J. Waanders, Mariarita Santi: Genomic Analysis of Dysembryoplastic Neuroepithelial Tumor Spectrum Reveals a Diversity of Molecular Alterations Dysregulating the MAPK and PI3K/mTOR Pathways  Journal of Neuropathology and Experimental Neurology. J Neuropathol Exp Neurol. 2019 Dec 1;78(12):1100-1111. doi: 10.1093/jnen/nlz101.

Jennifer Picarsic, M.D.; Theodore Pysher; Holly Zhou; Mark Fluchel; Tristan Pettit; Martin Whitehead; Lea F Surrey; Brian Harding; Gal Goldstein; Yakov Fellig; Michael Weintraub; Brett Mobley; Peta Sharples; Maria Luisa Sulis; Eli L Diamond; Ronald Jaffe; Karuna V Shekdar; Mariarita Santi-Vicini: BRAF-V600E Mutation in Juvenile Xanthogranuloma Family Neoplasms of the Central Nervous System (CNS-JXG): A revised diagnostic algorithm to include pediatric Erdheim-Chester Disease. Acta Neuropathologica Communications. Acta Neuropathol Commun. 2019 Nov 4;7(1):168. doi: 10.1186/s40478-019-0811-6.

Chang Fengqi, Lin Fumin, Cao Kajia, Surrey Lea F, Aplenc Richard, Bagatell Rochelle, Resnick Adam C, Santi Mariarita, Storm Phillip B, Tasian Sarah K, Waanders Angela J, Hunger Stephen P, Li Marilyn M: Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers. The Journal of Molecular Diagnostics 21(5): 873-883, Sep 2019. PMCID: PMC6734859

Surrey Lea F, Oakley Fredrick D, Merker Jason D, Long Thomas A, Vasalos Patricia, Moncur Joel T, Kim Annette S: Next-Generation Sequencing (NGS) Methods Show Superior or Equivalent Performance to Non-NGS Methods on BRAF, EGFR, and KRAS Proficiency Testing Samples. Archives of pathology & laboratory medicine 143(8): 980-984, Aug 2019.

Shenoy Archana, Surrey Lea, Jain Payal, Foster Jessica, Straka Joshua, Resnick Adam, Waanders Angela, Luo Minjie, Li Marilyn, Kazahaya Ken, Bagatell Rochelle, Wojcik John, Pogoriler Jennifer: Sclerosing Epithelioid Fibrosarcoma of the Bone With Rare EWSR1-CREB3L3 Translocation Driving Upregulation of the PI3K/mTOR Signaling Pathway. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Page: 1093526619864230, Jul 2019.

Shenoy A, Surrey L, Jain P, Foster J, Straka J, Resnick A, Waanders A, Luo M, Li M, Kazahaya K, Bagatell R, Wojcik J, Pogoriler J: Sclerosing Epithelioid Fibrosarcoma of the Bone With Rare EWSR1-CREB3L3 Translocation Driving Upregulation of the PI3K/mTOR Signaling Pathway. Pediatr Dev Pathol July 2019 Notes: Epub ahead of print.

Surrey LF, MacFarland SP, Chang F, Cao K, Rathi KS, Akgumus GT, Gallo D, Lin F, Gleason A, Raman P, Aplenc R, Bagatell R, Minturn J, Mosse Y, Santi M, Tasian SK, Waanders AJ, Sarmady M, Maris JM, Hunger SP, Li MM.: Clinical utility of custom-designed NGS panel testing in pediatric tumors. Genome Medicine 11(1): 32, May 2019.

Merker JD, Devereaux K, Iafrate AJ, Kamel-Reid S, Kim AS, Moncur JT, Montgomery SB, Nagarajan R, Portier BP, Routbort MJ, Smail C, Surrey LF, Vasalos P, Lazar AJ, Lindeman NI: Proficiency Testing of Standardized Samples Shows Very High Interlaboratory Agreement for Clinical Next-Generation Sequencing-Based Oncology Assays. Arch Pathol Lab Med 143(4): 463-471, April 2019.

2018

Viaene AN, Santi M, Rosenbaum J, Li MM, Surrey LF, Nasrallah MP: SETD2 mutations in primary central nervous system tumors. Acta Neuropathol Commun 6(1): 123, Nov 2018.

MacFarland SP, Duffy K, Bhatti T, Bagatell R, Balamuth NJ, Brodeur GM, Ganguly A, Mattei P, Surrey LF, Balis FM, Kalish JM: Diagnosis of Beckwith-Wiedemann syndrome in children presenting with Wilms tumor. Pediatric Blood & Cancer 65(10): e27296, October 2018.

MacFarland S, Bauer AJ, Adzick NS, Surrey LF, Noyes J, Kazahaya K, Baloch Z, Mostoufi-Moab S: Disease Burden and Outcome in Children and Young Adults with Concurrent Graves Disease and Differentiated Thyroid Carcinoma. J Clin Endocrinol Metab 103(8): 2918-2925, Aug 1 2018.

Trusty PM, Wei Z, Rychik J, Russo PA, Surrey LF, Goldberg DJ, Fogel MA, Yoganathan AP: Impact of Hemodynamics and Fluid Energetics on Liver Fibrosis after Fontan Operation. Journal of Thoracic and Cardiovascular Surgery 156(1): 267-275, July 2018.

Jain P*, Surrey LF*, Straka J, Luo M, Lin F, Harding B, Resnick AC, Storm PB, Buccoliero AM, Santi M, Li MM, Waanders AJ: Novel FGFR2-INA Fusion Identified in Two Low-Grade Mixed Neuronal-Glial Tumors Drives Oncogenesis via MAPK and PI3K/mTOR Pathway Activation. Acta Neuropathologica 136(1): 167-169, Jul 2018 Notes: *Surrey and Jain are co-first authors.

Samuels SL, Surrey LF, Hawkes CP, Amberge M, Mostoufi-Moab S, Langer JE, Adzick NS, Kazahaya K, Bhatti TR, Baloch Z, LiVolsi VA, Bauer AJ: Characteristics of Follicular Variant Papillary Thyroid Carcinoma in a Pediatric Cohort. The Journal of Clinical Endocrinology & Metabolism 103(4): 1639-1648, April 2018.

2016

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen K, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, and Behrens EM: Life-threatening NLRC4-associated hyperinflammation successfully treated with Interleukin-18 inhibition. Journal of Allergy and Clinical Immunology November 2016.

Surrey LF, Russo P, Rychik J, Goldberg DJ, Dodds K, O'Byrne ML, Glatz AC, Rand EB, Lin HC.: Prevalence and characterization of fibrosis in surveillance liver biopsies of patients with Fontan circulation. Human Pathology 57: 106-115, November 2016.

Saul D, Degenhardt K, Iyoob SD, Surrey LF, Johnson AM, Johnson MP, Rychik J, Victoria T.: Hypoplastic left heart syndrome and the nutmeg lung pattern in utero: a cause and effect relationship or prognostic indicator? Pediatric Radiology 64(4): 483-489, April 2016.

Papasavvas E, Surrey LF, Glencross DK, Azzoni L, Joseph J, Omar T, Feldman MD, Williamson AL, Siminya M, Swarts A, Yin X, Liu Q, Firnhaber C, Montaner LJ.: High-risk oncogenic HPV genotype infection associates with increased immune activation and T cell exhaustion in ART-suppressed HIV-1-infected women. OncoImmunology 5(5): e1128612, Jan 2016.

Abstracts

2019

Zelley K, Surrey LF, Li MM, Luo M, Balamuth NJ, Womer RB, Brodeur GM, MacFarland SP: Genetic Predisposition in Pediatric Rhabdomyosarcoma: When to Worry? American College of Medical Genetics 2019 Notes: Annual Meeting, Seattle, Washington, April 2-6.

Cafferata B, Lopez-Nunez O, Alaggio R, Santoro L, Zin A, Ranganathan S, Santi M, Nasrallah M, Surrey L: EWSR1-driven tumors of the central nervous system: clinicopathological and molecular characterization of 8 pediatric cases. Pediatric and Developmental Pathology 2019 Notes: Society for Pediatric Pathology (SPP) and Pediatric Pathology Society (PPS) joint meeting 2019, Pittsburgh, PA, USA.

F. Lin; L. Surrey; G. Wertheim; M. Luo; X. Zhao; K. Cao; R. Aplenc; R. Bagatell; A. Bauer; T. Bhatti; S. MacFarland; J. Maris; Y. Mosse; A. Resnick; M. Santi; P. Storm; S. Tasian; A. Waanders; S. Hunger; M. Li: Driver fusions identified in 1,327 pediatric tumors and their implications in tumorigenesis and precision cancer care. ASHG 2019 Annual Meeting, Houston, Texas, Oct. 15-19, 2019 Oct 2019.

Lopez Nunez OF, John I, Panasiti RN, Ranganathan S, Surrey LF, Santoro L, Grelaud D, Alaggio R: Infantile inflammatory myofibroblastic tumors (IMT): A multi-institutional study. United States and Canadian Association for Pathology, Annual Meeting March 2019.

2018

Surrey LF, Russo P, Hogarty MD, Womer R, Jaffe R, Li MM, Picarsic J: Novel BRAF fusions Identified in Two Pediatric Histiocytic Neoplasms: Highlighting the Need for Histologic, Molecular, and Clinical Correlation for Best Diagnosis. Pediatric Blood and Cancer 66(S1): S45, Jan 2019 Notes: Histiocyte Annual Meeting, Lisbon, Portugal, October 22-23, 2018.

Picarsic J, Pysher T, Pettit T, Whitehead M, Surrey LF, Harding B, Fellig Y, Weintraub M, Jaffe R, Santi M: BRAF-V600E Mutation in Central Nervous System Juvenile Xanthogranuloma Lesions (CNS-JXG): A Variable Pathologic and Clinical Spectrum. Pediatric Blood and Cancer 66(S1): S35, Jan 2019 Notes: Histiocyte Society Annual Meeting, Lisbon, Portugal, October 22-23, 2018.

Surrey LF, Zhao X, Jain P, Storm PB, Waaders AJ, Harding B, Li MM, Buccoliero AM, Santi M: Molecular and Histologic Characterization of 40 Cases of Dysembryoplastic Neuroepithelial Tumors (DNTs): A Multi-Institutional Study. 19th International Congress of Neuropathology 2018 Notes: September 23-27th, Tokyo, Japan.

Balci TB, Strong A, Kalish JM, Zackai E, Maris J, Surrey LF, Marcadier JL, Graham GE, Carter MT: Tatton-Brown-Rahman Syndrome: Six Individuals with Novel Features, Including Possible Autonomic Dysfunction. 39th Annual David W Smith Workshop on Malformations and Morphogenesis 2018 Notes: August 24-29, Banff, Alberta, Canada.

Song SJ, Park KJ, Cooper K, Surrey L, Reyes MC: Human Papillomavirus-Negative, Poorly Differentiated Carcinoma of Cervical Origin in a 14-Year-Old Female: A Rare Entity with a Novel KAT6A-NCOA2 Translocation. Archives of Pathology and Laboratory Medicine 142(9): e114-5, September 2018.

Posters and Presentations

2019

Nya Nelson, Tricia Bhatti, Diana Corao, Dan Martinez, Bruce Pawel, Mariarita Santi, Lisa Sullivan, Paul J. Zhang, Lea F. Surrey: Pediatric Mismatch Repair Deficient Solid Tumors Detected by Immunohistochemistry are Rare but Enriched in the Central Nervous System: Implications for Checkpoint Inhibitor Therapy. Society for Pediatric Pathology Spring Meeting March 2019 Notes: Platform Presentation.

Nya Nelson, Mariarita Santi, Fumin Lin, Minjie Luo, Marilyn Li, Lea Surrey: Diagnostic Changes in Pediatric Tumors as a Result of Comprehensive Genomic Testing: An Institutional Experience. Society for Pediatric Pathology Spring Meeting March 2019 Notes: Platform Presentation.

2018

Surrey LF, Jain P, Straka J, Luo M, Resnick A, Storm PB, Li M, Waanders A, Santi M: Novel FGFR2 Fusions Identified in a Series of Dysembryoplastic Neuroepithelial Tumors Result in Proliferation and MAPK and PI3K/mTOR Pathway Activation. Society for Pediatric Pathology 2018 Notes: Platform Presentation, March 17.

Akgumus GT, Zelley K, Gallo DJ, Surrey LF, Aplenc R, Bagatell R, Bhatti T, Hunger SP, MacFarland S, Luo M, Maris JM, Mosse Y, Santi M, Tasian SK, Waanders AJ, Wertheim G, Brodeur GM, Li MM: A Practical Algorithm for Evaluation of Potential Germline Variants from Tumor-Only Sequencing. American College of Medical Genetics and Genomics Annual Meeting 2018 Notes: Abstract 7400, Platform presentation at the ACMG Annual Clinical Genetics Meeting, April 11 2018, Charlotte, North Carolina.

2017

Samuels SL, Surrey LF, Hawkes CP, Amberge M, Mostoufi-Moab S, Langer JE, Adzick NS, Kazahaya K, Bhatti T, Baloch Z, LiVolsi VA, Bauer AJ.: Characteristics of Follicular Variant Papillary Thyroid Carcinoma in a Pediatric Cohort. 87th Annual Meeting of the American Thyroid Association 2017 Notes: Poster presentation, October 18-22, 2017.

Jain NK, Surrey L, Mostoufi-Moab S, Adzick NS, Kazahaya K, Hufford J, Nelson N, Bauer AJ: Does extrathyroidal extension predict invasive and persistent differentiated thyroid cancer? 87th Annual Meeting of the American Thyroid Association 2017 Notes: Poster presentation, October 18-22, 2017.

Akgumus G, Gallo D, Surrey L, Aplenc R, Bagatell R, Bhatti T, Brodeur G, Fisher M, Hunger S, Luo M, Maris J, Mosse Y, Santi M, Tasian S, Waanders A, Chang F, Zelley K, Li M.: Cancer Predisposition Identified in Tumor-Only Next Generation Sequencing: Experience from the Children's Hospital of Philadelphia. American College of Medical Genetics Annual Meeting 2017 Notes: Abstract 139, Platform presentation at the ACMG Annual Clinical Genetics Meeting, March 23, 2017, Phoenix, AZ.

Surrey LF, MacFarland SP, Akgumus GT, Gallo DJ, Lin F, Chang F, Li MM: Integrated Genomic Profiling in Pediatric Solid Tumors: An Institutional Experience. Journal of Molecular Diagnostics 19(6): 1017, November 2017 Notes: Abstract ST39 presented at Association of Molecular Pathology Annual Meeting, Salt Lake City, Utah, November 16-18, 2017.

Lin F, Chang F, Surrey LF, Akgumus G, Cao K, Li M: Clinical Utility of Integrated Genomic Profiling in Pediatric Leukemia. Cancer Genomics Consortium Summer Meeting August 2017 Notes: Platform Presentation.

Surrey LF, Akgumus G, Zelley K, Fisher M, Luo M, Harding B, Li M, Santi M: Mosaic Post-zygotic Mutations Leading to Cancer Predisposition in Patients with Neural Tumors. Journal of Neuropathology & Experimental Neurology June 2017 Notes: Poster Presentation at the American Association of Neuropathologists Annual Meeting, Garden Grove California, June 10, 2017.

Invited Lectures

2019

Surrey L. "Clinical Utility of Integrated Genomic Profiling for Pediatric Tumors", British Columbia Children's Hospital, Vancouver, Canada. Apr 2019.

Surrey L. "Clinical Utility of Integrated Genomic Profiling for Pediatric Tumors", AI Dupont Hospital for Children, Wilmington, Delaware. Apr 2019.

2018

Surrey L. "Novel FGFR2 Fusions Identified in a Series of Dysembryoplastic Neuroepithelial Tumors Result in Proliferation and MAPK Activation", Platform Presentation at the Society for Pediatric Pathology Spring Meeting, Vancouver, British Columbia. Mar, 2018.

2017

Surrey L. "Precision Medicine in Pediatric Solid Tumors", Rutgers Robert Wood Johnson Medical School, Pathology Grand Rounds, New Brunswick, New Jersey. Dec, 2017.

Surrey L. "Molecular Pathology for the Pediatric Pathologist", AI Dupont Hospital, Wilmington, DE. May 2017.

Awards and Honors

2015, Gordon F. Vawter Pathologist-in-Training Award, Society for Pediatric Pathology
2010,  Jesse H. Frank M.D. Prize in Pathology, University of Pennsylvania School of Medicine
2010, Alpha Omega Alpha, University of Pennsylvania School of Medicine
2005, Phi Beta Kappa, Cornell University
2004, Howard Hughes Research Scholarship, Cornell University
2003, Golden Key International Honor Society, Cornell University
2003, National Society of Collegiate Scholars, Cornell University
2001-2005, Dean’s List, Cornell University
2001-2005, Diamond State Merit Scholarship

Editorial and Academic Positions

Editorial Positions

2017-present, Ad-hoc reviewer, Modern Pathology
2017-present, Ad-hoc reviewer, Pediatric and Developmental Pathology

Academic and Institutional Committees

2017-present, Molecular Genetic Pathology Program Evaluation Committee at the Hospital of the University of Pennsylvania

Leadership and Memberships

Memberships in Professional Organizations

International

2018-present, American Association of Cancer Research
 - 2018-present, Pathology Working Group, Project GENIE
2015-present, Association for Molecular Pathology
2015-present, Society for Pediatric Pathology
2011-present, United States & Canadian Academy of Pathology

National

2011-present, College of American Pathologists
 - 2019-present, Molecular Oncology Committee