Lehn Weaver, MD, PhD

Lehn Weaver, MD, PhD

Lehn Weaver, MD, PhD, is an Attending Physician in the Division of Rheumatology at Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Lehn Weaver, MD, PhD, is an Attending Physician in the Division of Rheumatology at Children's Hospital of Philadelphia and an Instructor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

 

Dr. Weaver is the recipient of the Scientist Development Award from the Rheumatology Research Foundation (2015) and is an active researcher studying how inflammatory mediators contribute to the development and propagation of autoimmunity, specifically in arthritis and lupus.  Dr. Weaver has uncovered that early inflammatory cues lead to the generation of new effector cells called monocytes that are capable of sustaining and enhancing subsequent inflammatory responses.  Enhanced monocyte production has also been observed in patients with rheumatic diseases raising the possibility that early changes to the body's immune system contribute to the subsequent development of frank autoimmunity. Furthermore, recent evidence suggests that early inflammatory cues are influenced by environmental factors including prior infections, diet, and the microbial composition of our body.  By better understanding these interactions, Dr. Weaver is poised to help uncover novel therapeutic targets for the treatment of pediatric rheumatic diseases.  This is of particular interest in the pediatric population he treats where there may be an early window for intervention to reverse and/or cure pediatric rheumatic diseases. 

 

In addition to pursuing his research interests, Dr. Weaver has the privilege of taking care of numerous children and young adults afflicted with musculoskeletal, inflammatory, and rheumatic diseases in the Pediatric Rheumatology clinic at The Children's Hospital of Philadelphia. 

Education and Training

Medical School

MD - Dartmouth Medical School, Hanover, NH

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia PA

Fellowship

Pediatric Rheumatology - The Children's Hospital of Philadelphia, Philadelphia PA

Board Certification

Pediatric Advanced Life Support (PALS)

Graduate Degree

PhD in Immunology - Dartmouth College, Hanover, NH

Titles and Academic Titles

Attending Physician

Instructor, Perelman School of Medicine at the University of Pennsylvania

Publications

Papers

2015

Minoia F, Davì S, Horne A, Bovis F, Demirkaya E, Akikusa J, Ayaz NA, Al-Mayouf S, Barone P, Bica B, Bolt I, Breda L, De Cunto C, Enciso S, Gallizzi R, Griffin T, Hennon T, Horneff G, Jeng M, Kapovic AM, Lipton JM, Magni-Manzoni S, Rumba I, Magalhaes CS, Sewairi WM, Stine KC, Vougiouka O, Weaver LK, Davidsone Z, De Inocencio J, Ioseliani M, Lattanzi B, Tezer H, Buoncompagni A, Picco P, Ruperto N, Martini A, Cron RQ, and Ravelli A. (2014). Dissecting the heterogeneity of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis. The Journal of Rheumatology.

2014

Weaver LK, Behrens EM. (2014). Hyperinflammation, rather than hemophagocytosis, is the common link between Macrophage Activation Syndrome and Hemophagocytic Lymphohistiocytosis. Current Opinion Rheumatology. 26(5):562-9.

2013

Costa-Reis P, Weaver LK, Behrens EM, Sullivan KE. (2013). Chronic Recurrent Multifocal Osteomyelitis in a Patient with Common Variable Immunodeficiency. Joint Bone Spine. 81(2):193-194.

Weaver LK, Behrens EM. (2013). How to use… antinuclear antibodies in paediatric rheumatic diseases. Archives of Disease in Childhood. 98:64-70.

Posters and Presentations

2015

Weaver LK and Behrens EM. (2015). Enhanced Myelopoiesis Downstream of Toll-Like Receptor 9 Activation Drives a Feed-Forward Inflammatory Response. 2015 ACR/ARHP Annual Meeting. San Francisco, CA.

Biswas C, Weaver LK, and Behrens EM. (2015). Antibiotics alter TLR9 responses in vivo. 2015 PENN/CHOP Microbiome Symposium. Philadelphia, PA.

Biswas C, Weaver LK, and Behrens EM. (2015). Antibiotics alter TLR9 responses in vivo. IgG Retreat. Harbourtowne, MD.

Weaver LK and Behrens EM. (2015). Enhanced Myelopoiesis Downstream of Toll-Like Receptor 9 Activation Drives a Feed-Forward Inflammatory Response. IgG Retreat. Harbourtowne, MD.

Weaver LK and Behrens EM. (2015). Extramedullary Myelopoiesis Drives Persistent Toll-like Receptor-Mediated Inflammation. CHOP Poster Day. Philadelphia, PA.

2014

Minoia F, Davì S, Horne A, Bovis F, Demirkaya E, Akikusa J, Ayaz NA, Al-Mayouf S, Barone P, Bica B, Bolt I, Breda L, De Cunto C, Enciso S, Gallizzi R, Griffin T, Hennon T, Horneff G, Jeng M, Kapovic AM, Lipton JM, Magni-Manzoni S, Rumba I, Magalhaes CS, Sewairi WM, Stine KC, Vougiouka O, Weaver LK, Davidsone Z, De Inocencio J, Ioseliani M, Lattanzi B, Tezer H, Buoncompagni A, Picco P, Ruperto N, Martini A, Cron RQ, and Ravelli A. (2014). Dissecting the Heterogeneity of Macrophage Activation Syndrome. 2014 ACR/ARHP Annual Meeting. Boston, MA.

Weaver LK and Behrens EM. (2014). Extramedullary Myelopoiesis Drives Persistent Toll-like Receptor-Mediated Inflammation. ACR/ARHP Annual Meeting. Boston, MA.

Minoia F, Davì S, Horne A, Bovis F, Demirkaya E, Akikusa J, Ayaz NA, Al-Mayouf S, Barone P, Bica B, Bolt I, Breda L, De Cunto C, Enciso S, Gallizzi R, Griffin T, Hennon T, Horneff G, Jeng M, Kapovic AM, Lipton JM, Magni-Manzoni S, Rumba I, Magalhaes CS, Sewairi WM, Stine KC, Vougiouka O, Weaver LK, Davidsone Z, De Inocencio J, Ioseliani M, Lattanzi B, Tezer H, Buoncompagni A, Picco P, Ruperto N, Martini A, Cron RQ, and Ravelli A. (2014). Dissecting the Heterogeneity of Macrophage Activation Syndrome. 21st European Pediatric Rheumatology Congress. Belgrade, Serbia.

Weaver LK and Behrens EM. (2014). CCR2+ Inflammatory Monocytes Bypass Toll-like Receptor 9 Tolerance during CpG-Induced Inflammation. Gordon Research Conference. Mount Snow, VT.

Burnham S, Behrens EM, Weiss P, Sherry DD, Lerman M, Knight A, Weaver LK, Taxter A, Ramsay E, Basaiga M, James K, Wiater L, Bieniakowski D, Peyton T, Lindsay M, Battle T, Taylor A, and Tanzer L. (2014). Improving methotrexate toxicity screening in juvenile idiopathic arthritis. CHOP Safety Day. Philadelphia, PA.

Weaver LK and Behrens EM. (2014). A158: CpG-Induced Macrophage Activation Syndrome Develops Through an Organism Level Resistance to Toll-like Receptor 9 Tolerance. Arthritis Rheumatol. 66(suppl 11:S204). PRYSM Basic Science Poster Session. Orlando, FL.

Weaver LK and Behrens EM. (2014). CpG-Induced Inflammation Develops Through an Organism Level Resistance to Toll-like Receptor 9 Tolerance. CHOP Poster Day. Philadelphia, PA.

2013

Weaver LK and Behrens EM. (2013). Innate Immune Cell Production of Interleukin-12 Drives CpG-Induced Macrophage Activation Syndrome. ACR/ARHP Annual Meeting. San Diego, CA.

Weaver LK and Behrens EM. (2013). Hematopoietic Cells are Necessary and Sufficient to Drive CpG-Induced Macrophage Activation Syndrome. 23rd Annual CHOP Research Poster Day. Philadelphia, PA.

Awards and Honors

2015, CHOP Research Poster Day Award

2015, Rheumatology Research Foundation Scientist Development Award

2014, ACR Pediatric Research Award

2014, Best Basic Science Abstract by a Fellow-in-Training, PRYSM 2014

2014, PRYSM Fellow-in-Training Travel Award

2012-2013, Amgen/Pfizer Rheumatology Fellowship Training Award

2011, American College of Rheumatology Fellow-in-Training Scholarship

2010, The Children's Hospital of Philadelphia Travel Award for the ACR Meeting

2009, American College of Rheumatology Resident Award

2009, Thomas Almy DMS Chapter of the Gold Humanism in Medicine Honor Society

2009, New Hampshire Pediatric Society Award

2006, Munck-Pfefferkorn Student Fellow, Dartmouth Medical School

2005, Travel Award, Society for Leukocyte Biology: Phagocytes in Innate Immunity

2005, SRC Poster Award, FASEB Summer Research Conference on Autoimmunity

2002, Presidential Fellow and University Scholar

2002, Beta Beta Beta National Biology Society

2000-2002, Barry Goldwater National Science Scholarship

2000, Organic Chemist of the Year, Susquehanna University

1998-2002, University Honors Program

1997, Participant in the Pennsylvania Governor’s School for Health Care

Editorial and Academic Positions

Ad-Hoc Reviewer

2011-present Journal of Leukocyte Biology

2011-present Pediatric Rheumatology On-line Journal

2015-present International Immunopharmacology

Leadership and Memberships

Memberships in Professional Organizations

2013-present, The Federation of Clinical Immunology Societies

2011-present, American College of Rheumatology