Lehn Weaver, MD, PhD

Lehn Weaver, MD, PhD

Lehn Weaver, MD, PhD, is an attending physician in the Division of Rheumatology at Children's Hospital of Philadelphia.

Areas of Expertise: Rare rheumatic diseases and autoinflammatory syndromes
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


Lehn Weaver, MD, PhD, completed his medical training and doctoral degree in Immunology at Dartmouth Medical School before joining Children's Hospital of Philadelphia to complete his internship and residency in General Pediatrics. He continued his training at Children's Hospital of Philadelphia as a fellow and junior faculty member within the Division of Pediatric Rheumatology. During his training, Dr. Weaver studied basic mechanisms of inflammation in models of rheumatic diseases including lupus, psoriasis and arthritis. He has a particular interest in rare rheumatic diseases and autoinflammatory syndromes, and currently cares for numerous children and young adults with a wide variety of musculoskeletal, inflammatory and rheumatic diseases in the Pediatric Rheumatology clinic at Children's Hospital of Philadelphia.

Education and Training

Medical School

MD - Dartmouth Medical School, Hanover, NH


Pediatrics - The Children's Hospital of Philadelphia, Philadelphia PA


Pediatric Rheumatology - The Children's Hospital of Philadelphia, Philadelphia PA

Board Certification

General Pediatrics
Pediatric Rheumatology

Graduate Degree

PhD in Immunology - Dartmouth College, Hanover, NH

Titles and Academic Titles

Attending Physician

Departments and Services




Weaver LK, Chu N, Behrens EM. Toll-like receptor 9 activation potentiates interferon-γ-mediated immunopathology in a murine model of Macrophage Activation Syndrome. Arthritis Rheumatol. 2018 Aug 2. doi: 10.1002/art.40683. [Epub ahead of print]


Weaver LK, Behrens EM. Weathering the Storm: Improving Therapeutic Interventions for Cytokine Storm Syndromes by Targeting Disease Pathogenesis. Curr Treatm Opt Rheumatol. 2017 Mar;3(1):33-48. doi: 10.1007/s40674-017-0059-x. Epub 2017 Feb 7.

Weaver LK. Combining multiple biomarkers differentiates between active sJIA, sJIA-MAS, and EBV-HLH. Clin Exp Immunol. 2018 Mar;191(3):253-254. doi: 10.1111/cei.13063. Epub 2017 Oct 26.


Weaver LK, Chu N, Behrens EM. TLR9-mediated inflammation drives a Ccr2-independent peripheral monocytopoiesis through enhanced extramedullary monocytopoiesis. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10944-9. doi: 10.1073/pnas.1524487113. Epub 2016 Sep 12.

Rood JE, Canna SW, Weaver LK, Tobias JW, Behrens EM. IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation. J Leukoc Biol. 2017 Apr;101(4):1037-1044. doi: 10.1189/jlb.3A0916-221RR. Epub 2016 Dec 29.


Minoia F, Davì S, Horne A, Bovis F, Demirkaya E, Akikusa J, Ayaz NA, Al-Mayouf S, Barone P, Bica B, Bolt I, Breda L, De Cunto C, Enciso S, Gallizzi R, Griffin T, Hennon T, Horneff G, Jeng M, Kapovic AM, Lipton JM, Magni-Manzoni S, Rumba I, Magalhaes CS, Sewairi WM, Stine KC, Vougiouka O, Weaver LK, Davidsone Z, De Inocencio J, Ioseliani M, Lattanzi B, Tezer H, Buoncompagni A, Picco P, Ruperto N, Martini A, Cron RQ, and Ravelli A. (2014). Dissecting the heterogeneity of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis. The Journal of Rheumatology.


Weaver LK, Behrens EM. (2014). Hyperinflammation, rather than hemophagocytosis, is the common link between Macrophage Activation Syndrome and Hemophagocytic Lymphohistiocytosis. Current Opinion Rheumatology. 26(5):562-9.


Costa-Reis P, Weaver LK, Behrens EM, Sullivan KE. (2013). Chronic Recurrent Multifocal Osteomyelitis in a Patient with Common Variable Immunodeficiency. Joint Bone Spine. 81(2):193-194.

Weaver LK, Behrens EM. (2013). How to use… antinuclear antibodies in paediatric rheumatic diseases. Archives of Disease in Childhood. 98:64-70.

Awards and Honors

2017, PennCHOP Microbiome Pilot and Feasibility Award
2015, CHOP Research Poster Day Award
2015, Rheumatology Research Foundation Scientist Development Award
2014, ACR Pediatric Research Award
2014, Best Basic Science Abstract by a Fellow-in-Training, PRYSM 2014
2014, PRYSM Fellow-in-Training Travel Award
2012-2013, Amgen/Pfizer Rheumatology Fellowship Training Award
2011, American College of Rheumatology Fellow-in-Training Scholarship
2010, The Children's Hospital of Philadelphia Travel Award for the ACR Meeting
2009, American College of Rheumatology Resident Award
2009, Thomas Almy DMS Chapter of the Gold Humanism in Medicine Honor Society
2009, New Hampshire Pediatric Society Award

Editorial and Academic Positions

Editorial positions


2017-present, Frontiers in Immunology (Specialty: Autoimmunity and Autoinflammatory Diseases), Review Editor of the Editorial Board

Ad-Hoc Reviewer

2018-present, Arthritis Research & Therapy
2017-present, Clinical & Experimental Immunology
2017-present, BMJ Case Reports
2016-present, Arthritis & Rheumatology
2016-present, Current Pediatrics Research
2015-present, International Immunopharmacology
2011-present, Journal of Leukocyte Biology
2011-present, Pediatric Rheumatology On-line Journal


Leadership and Memberships

Memberships in Professional Organizations

2013-present, The Federation of Clinical Immunology Societies
2011-present, American College of Rheumatology