Pamela F. Weiss, MD, MSCE

Pamela F. Weiss, MD, MSCE

Pamela F. Weiss, MD, MSCE, is an Attending Physician in the Division of Rheumatology at Children's Hospital of Philadelphia.

Areas of Expertise: Enthesitis-related arthritis, Juvenile arthritis, Juvenile spondyloarthritis, Vasculitis
Locations: Specialty Care & Surgery Center, Brandywine Valley; Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Pamela F. Weiss, MD, MSCE, is an Attending Physician in the Division of Rheumatology and a Core Faculty Member of the Center for Pediatric Clinical Effectiveness at CHOP, and an Associate Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

Dr. Weiss is the recipient of the Arthritis Foundation Professional Educator award (2012) and the Spondylitis Association of America-Jane Bruckel Young Investigator Award (2014). She is also vice-chair of the Childhood Arthritis and Rheumatology Research Alliance’s JIA Research committee.

Her research on the clinical and imaging features associated with early juvenile spondyloarthritis (JSpA) has led to several significant publications, a national reputation in juvenile idiopathic arthritis (JIA) research, and continuous foundation and federal funding. She strives to provide superior clinical care for children with rheumatic disease, use pediatric rheumatology as a platform to share her enthusiasm with students at all levels, and make meaningful contributions to advancing the care of children with JSpA through clinical research activities.

Education and Training

Medical School

MD - Albert Einstein College of Medicine, New York, NY

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Rheumatology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Rheumatology
Pediatrics
Rheumatology

Graduate Degree

MSCE - University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Director of Clinical Research, Division of Rheumatology

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Associate Professor of Epidemiology, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Pharmacoepidemiology and outcomes research in pediatric juvenile idiopathic arthritis (JIA) and juvenile spondyloarthritis

Publications

Papers

2017

Kishi T, Rider LG, Pak K, Barillas-Arias L, Henrickson M, McCarthy PL, Shaham B, Weiss PF, Horkayne-Szakaly I, Targoff IN, Miller FW, Mammen AL; Childhood Myositis Heterogeneity Study Group. Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies are Associated with DRB1*07:01 and Severe Myositis in Pediatric Myositis Patients. Arthritis Care Res (Hoboken). 2017 Jan 27. doi: 10.1002/acr.23113. [Epub ahead of print]

2016

James K, Xiao R, Merkel P, Weiss PF. Variation in treatment of children hospitalized with antineutrophil cytoplasmic antibody- associated vasculitis in the United States. Arthritis Care & Research. 2016 Nov 3. doi: 10.1002/acr.23142. [Epub ahead of print]

Zeft A, Prahalad S, Schneider R, Dedeoglu F, Weiss P, Grom A, Mix C, Pope C. Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution. Clinical and Experimental Rheumatology. 2016. 34 (5): 946-952.

Brandon TG, Becker BD, Bevans KB, Weiss PF. Patient Reported Outcomes Measurement Information System (PROMIS) Tools for Collecting Patient Reported Outcomes in Children with Juvenile Arthritis. Arthritis Care & Research. 2016 May 9, doi: 10.1002/acr.22937.

Weiss PF, Xiao R, Biko DM, Chauvin NA. Assessment of Sacroiliitis at diagnosis of juvenile spondyloarthritis by radiography, magnetic resonance imaging, and clinical examination. Arthritis Care & Research. 2016 Feb; 68(2): 187-194. PMCID: PMC4720597.

Ward M, Deodhar A, Akl E, Lui A, Ermann J, Gensler L, Smith J, Borenstein D, Hiratzka J, Weiss PF, Inman R, Majithia V, Haroon N, Maksymowych W, Joyce J, Clark B, Colbert R, Figgie M, Hallegua D, Prete P, Rosenbaum J, Stebulis J, van den Bosch F, Yu D, Miller A, Reveille J, Caplan L. American College of Rheumatology/ Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis. Arthritis Care & Research. 2016. 68 (2): 151-166. 

Ward M, Deodhar A, Akl E, Lui A, Ermann J, Gensler L, Smith J, Borenstein D, Hiratzka J, Weiss PF, Inman R, Majithia V, Haroon N, Maksymowych W, Joyce J, Clark B, Colbert R, Figgie M, Hallegua D, Prete P, Rosenbaum J, Stebulis J, van den Bosch F, Yu D, Miller A, Reveille J, Caplan L. American College of Rheumatology/ Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis.  Arthritis & Rheumatology. 2016 Feb; 68(2): 282-298. 

2015

Basaiga M, Weiss PF, Behrens EM. BIRC4 mutation: An important rare cause of uveitis. Journal of Clinical Rheumatology. 2015 Dec: 21(8): 44-7.

Sherry DD, Brake L, Tress JL, Sherker J, Fash K, Ferry K, Weiss PF. The Treatment of Juvenile Fibromyalgia with an Intensive Physical and Psychosocial Program. Journal of Pediatrics. 2015: 167(3): 731-737.

Knight A, Weiss P, Morales K, Gerdes M, Rearson M, Vickery M, Keren R. Identifying Differences in Risk Factors for Depression and Anxiety in Pediatric Chronic Disease: A Matched Cross-Sectional Study of Youth with Lupus/Mixed Connective Tissue Disease and Their Peers with Diabetes. Journal of Pediatrics. 2015. Dec;167(6):1397-1403.

Taxter AJ, Wileyto EP, Behrens EM, and Weiss PF. Patient Reported Outcomes Across Categories of Juvenile Idiopathic Arthritis. Journal of Rheumatology. 2015 Oct: 42(10): 1914-1921. PMCID: PMC4592479.

Weiss PF, Xiao R, Biko DM, Johnson AM, Chauvin NA. Detection of inflammatory sacroiliitis in children with magnetic resonance imaging: is gadolinium-contrast enhancement necessary? Arthritis & Rheumatology. 2015 May; 67(8): 2250-6. PMCID: PMC4526191.

2014

Weiss PF, Colbert RA, Xiao R, Feudtner C, Beukelman T, Morgan DeWitt E, Pagnini I, Wright TB, Wallace CA. Development and retrospective validation of the juvenile spondyloarthritis disease activity (JSpADA) index. Arthritis Care Res (Hoboken). 2014 Dec;66(12):1775-82. doi: 10.1002/acr.22411.

Weiss PF, Chauvin NA, Klink AJ, Localio R, Feudtner C, Jaramillo D, Colbert RA, Sherry DD, Keren R. Detection of enthesitis in children with enthesitis-related arthritis: dolorimetry compared to ultrasonography. Arthritis Rheumatol 66(1): 218-27, Jan 2014.

Ringold S*, Weiss PF*, Colbert RA, Dewitt EM, Lee T, Onel K, Prahalad S, Schneider R, Shenoi S, Vehe RK, Kimura Y; for the Juvenile Idiopathic Arthritis Research Committee of the Children's Arthritis and Rheumatology Research Alliance (CARRA) (*co-first authors), Childhood arthritis and rheumatology research alliance consensus treatment plans for new onset polyarticular juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2013 Dec 10.

Weiss PF, Klink AJ, Faerber J, Feudtner C. The pediatric rheumatology quality of life scale: validation of the English version in a US cohort of juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2013 Nov 8;11(1):43.

Ringold S*, Weiss PF*, Beukelman T, Morgan-DeWitt E, Ilowite N, Kimura Y, Laxer RM Lovell D, Nigrovic P, Robinson A, Vehe R (*co-first authors). 2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications. Arthritis Care Res (Hoboken). 2013 Oct;65(10):1551-63.

Ringold S* and Weiss PF*, Beukelman T, Morgan-DeWitt E, Ilowite N, Kimura Y, Laxer RM Lovell D, Nigrovic P, Robinson A, Vehe R (*co-first authors). 2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications. Arthritis Rheum. 2013 Oct;65(10):2499-512.

Weiss PF, Beukelman T, Schanberg LE, Kimura Y, Colbert RA; CARRA Registry Investigators. Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry. J Rheumatol. 2012 Dec;39(12):2341-51

Beukelman T, Ringold S, Davis TE, DeWitt EM, Pelajo CF, Weiss PF, Kimura Y; CARRA Registry Investigators. Disease-modifying antirheumatic drug use in the treatment of juvenile idiopathic arthritis: a cross-sectional analysis of the CARRA Registry. J Rheumatol. 2012 Sep;39(9).

DeWitt EM, Kimura Y, Beukelman T, Nigrovic PA, Onel K, Prahalad S, Schneider R, Stoll ML, Angeles-Han S, Milojevic D, Schikler KN, Vehe RK, Weiss JE, Weiss P, Ilowite NT, Wallace CA. Juvenile Idiopathic Arthritis Disease-specific Research Committee of Childhood Arthritis Rheumatology and Research Alliance: Consensus treatment plans for new-onset systemic juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2012 Jul;64(7):1001-10.

Abstracts

2017

Stoll ML, Weiss PF, Weiss J, Cron RQ, Elson CO, Morrow C, Lefkowitz E, Schoeb T. Akkermansia Muciniphila May Be Permissive to Arthritis in the K/BxN Mouse Model of Arthritis. (Pediatric Rheumatology Symposium, 2017, Houston, TX). Arthritis Rheum. 66 (Supp 11): S75.

Manos C, Xiao R, Ogdie A, Weiss P. The Association of Obesity with Pediatric Psoriatic Arthritis. (Pediatric Rheumatology Symposium, 2017, Houston, TX). Arthritis Rheum. 66 (Supp 11): S75.

Gmuca S, Waldman A, Weiss P, Gerber J. Use of Rituximab and Risk of Re-hospitalization for Children with Neuromyelitis Optica Spectrum Disorder. (Pediatric Rheumatology Symposium, 2017, Houston, TX). Arthritis Rheum. 66 (Supp 11): S75.

Ringold S, Tomlinson G, Weiss P, Schanberg L, Feldman B, Riordan ME, Dennos A, DelGaizo V, Murphy K, Kimura Y. Baseline characteristics of the first 123 patients enrolled in the CARRA Start Time Optimization of Biologic Therapy in Polyarticular JIA (STOP-JIA) comparative effectiveness study. (Pediatric Rheumatology Symposium, 2017, Houston, TX). Arthritis Rheum. 66 (Supp 11): S75.

Chauvin N, Maksymowych W, Lambert R, Jaremko J, Biko D, Paschke J, Brandon T, Weiss PF. Feasibility of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Structural Score and Inflammation Score for Children with Spondyloarthritis. (Society of Pediatric Radiology Annual Scientific Meeting 2017, Vancouver, CA). Oral presentation.

2015

Y Kimura, EM DeWitt, K Mieszkalski, T Beukelman, TB Graham, M Ibarra, N Ilowite, M Klein-Gitelman, K Onel, S Prahalad, M Punaro, S Ringold, D Toib, H Van Mater, PF Weiss, LE Schanberg. Results from the Childhood Arthritis and Rheumatology Research Alliance Systemic JIA Consensus Treatment Plans Pilot Study. (ACR/ARHP Annual Scientific Meeting 2015, San Francisco, CA).  Oral presentation.

Chauvin NA, Biko DM, Johnson AM, Jaramillo D, Weiss PF. Detection of Inflammatory Sacroiliitis in Children: Is MR Contrast necessary? (Society of Pediatric Radiology Annual Meeting 2015, Bellevue, Washington). Oral presentation.

Books

Chapters

2015

Weaver L, Weiss PF. Henoch Schönlein Purpura. In: Parnam M (Ed). Encyclopedia of Inflammatory Diseases. Springer-Verlag Berlin Heidelberg, 2015. doi: 10.1007/978-3-034800620-6_199-2.

Weiss PF, Colbert RA. Ankylosing Spondylitis and Other Spondyloarthritides. In: Kliegman RM, Stanton BF, St Geme J, Schor N (Eds). Nelson’s Textbook of Pediatrics, 20th Edition. Philadelphia, PA: Saunders, 2015.

Weiss PF, Colbert RA. Reactive and Post-infectious Arthritis. In: Kliegman RM, Stanton BF, St Geme J, Schor N (Eds). Nelson’s Textbook of Pediatrics, 20th Edition. Philadelphia, PA: Saunders, 2015.

2013

Weiss PF, Wright DA. Juvenile idiopathic arthritis and seronegative spondyloarthropathies. In: Weinstein SL, Flynn JM (Eds). Lovell & Winter’s Pediatric Orthopaedics, 7th Edition. Philadelphia, PA: Lippincott Williams and Wilkins, 2013.

2011

Brown N, Lieberman SM, Bonafide CP, Linton JM, Rahimi H, Weiss PF. Rheumatology. In: Florin TA, Ludwig S (Eds). Netter's Pediatrics.  Philadelphia: Elsevier, 2011.

2010

Weiss PF. Henoch Schönlein Purpura. In: Shah SS, Frank G (Eds).  Patient Encounters: The Inpatient Pediatrics Work-up.  Malden, MA: Lippincott, Williams, and Wilkins, 2010.

2004

Fitch PG, DeVore E, Klick J, Burnham JM: Rheumatology.  The Philadelphia Manual of Inpatient Pediatrics. Frank G, Shah SS, Catallozzi M, Zaoutis L (Eds.). Blackwell Publishing, 2004.

Posters and Presentations

Poster Presentations

2016

Chauvin N, Maksymowych W, Lambert R, Jaremko J, Biko D, Paschke J, Brandon T, Weiss PF. Feasibility and Reliability of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Structural Score for Children with Spondyloarthritis. (ACR/ARHP Annual Scientific Meeting 2016, Washington D.C.). Poster presentation.

Chauvin N, Maksymowych W, Lambert R, Jaremko J, Biko D, Paschke J, Brandon T, Weiss PF. Feasibility and Reliability of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Inflammation Score for Children with Spondyloarthritis. (ACR/ARHP Annual Scientific Meeting 2016, Washington D.C.). Poster presentation.

Manos C, Xiao R, Ogdie A, Brandon T, Weiss PF. Comorbidities Associated with Pediatric Psoriatic Arthritis. (ACR/ARHP Annual Scientific Meeting 2016, Washington D.C.). Poster presentation.

James K, Xiao R, Merkel P, Weiss PF. Initiation of Dialysis in Pediatric ANCA-Associated Vasculitis. (ACR/ARHP Annual Scientific Meeting 2016, Washington D.C.). Poster presentation.

Gmuca S, Xiao R, Gerber JS, Weiss PF. Neuromyelitis Optica and Systemic Autoimmunity: Patient Characteristics and Treatment Patterns Among Rheumatologists. (ACR/ARHP Annual Scientific Meeting 2016, Washington D.C.). Poster presentation.

Stoll ML, Weiss PF, Weiss J, Cron RQ, Elson CO, Morrow C, Lefkowitz E, Schoeb T. Human Gut Microbial Species Correlate with Arthritis in the K/BxN Mouse Model. (ACR/ARHP Annual Scientific Meeting 2016, Washington D.C.). Poster presentation.

Kishi T, Mammen AL, Pak K, Barilllas-Arias L, Henrickson M, McCarthy PL, Shaham B, Weiss PF, Horkayne-Szekaly I, Miller FW, Rider LG for the Childhood Myositis Heterogeneity Study group. Characterization of anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies. (ACR/ARHP Annual Scientific Meeting 2016, Washington D.C.). Poster presentation.

2015

Stoll ML, Weiss PF, Weiss JE, Nigrovic PA, Punaro L, Spencer C, Schikler K, Morrow C, Lefkowitz E. Enteric Flora in Newly Diagnosed Spondyloarthritis: A Collaborative Study. (ACR/ARHP Annual Scientific Meeting 2015, San Francisco, CA). Poster presentation.

Brandon T, Becker B, Bevans K, Weiss PF. PROMIS tools for measurement of Patient-reported outcomes in children with juvenile arthritis. (ACR/ARHP Annual Scientific Meeting 2015, San Francisco, CA). Poster presentation.

James K, Xiao R, Merkel P, Weiss PF. Use of Plasma Exchange for Children Hospitalized with ANCA-Associated Vasculitis in the United States. (ACR/ARHP Annual Scientific Meeting 2015, San Francisco, CA). Poster presentation.

Manos C, Brandon T, Xiao R, Burnham JM, Weiss PF. Obesity and Pediatric Psoriatic Arthritis.(ACR/ARHP Annual Scientific Meeting 2015, San Francisco, CA). Poster presentation.

Gmuca S, Brandon T, Xiao R, Pagnini I, Wright TB, Beukelman T, Morgan-Dewitt E, Weiss PF. Pediatric Enthesitis-Related Arthritis: Variation in Disease Characteristics and Treatments Among 5 Large Centers. (ACR/ARHP Annual Scientific Meeting 2015, San Francisco, CA). Poster presentation.

Gmuca S, Brandon T, Xiao R, Pagnini I, Wright TB, Beukelman T, Morgan-Dewitt E, Weiss PF. Phenotypic Differences Between HLA-B27 Positive and Negative Children with Enthesitis Related Arthritis. (ACR/ARHP Annual Scientific Meeting 2015, San Francisco, CA). Poster presentation.

 

Lectures by Invitation

2016

Weiss PF. Pediatric Perspective on Axial Spondyloarthritis and Psoriatic Arthritis. Psoriasis Foundation-GRAPPA Educational Symposium on Psoriasis and Psoriatic Arthritis; 2016; New York City, NY.

Weiss Pf. Spondyloarthritis in Children: Optimizing Evaluation and Outcomes. Children’s Hospital at Montefiore Research Seminar; 2016; Bronx, NY.

Weiss PF. Spondyloarthritis: A Primer for Parents. Arthritis Foundation National Juvenile Arthritis Conference; 2016; Philadelphia, PA.

Weiss P. Juvenile Spondyloarthritis. Rheumatology CHOP CME; 2016; Glen Mills, PA.

Weiss PF. Challenges in Pediatric Spondyloarthritis: Axial disease. Panamerican League of Associations for Rheumatology (PANLAR); 2016; Panama City, Panama.

Weiss PF. The Role of HLA-B27 misfolding and the TH17 axis in SpA. Panamerican League of Associations for Rheumatology (PANLAR); 2016; Panama City, Panama.

2015

Weiss PF. Pediatric Perspective on Psoriasis and Psoriatic Arthritis. SPARTAN-GRAPPA Educational Symposium on Axial Spondyloarthritis and Psoriatic Arthritis; 2015; Philadelphia, PA.

Weiss PF. Ultrasound ‘Hands-on’ Assessment of Psoriatic Arthritis. SPARTAN-GRAPPA Educational Symposium on Axial Spondyloarthritis and Psoriatic Arthritis; 2015; Philadelphia, PA.

Weiss PF. SPARTAN-GRAPPA Educational Symposium on Axial Spondyloarthritis and Psoriatic Arthritis. Arthritis Foundation Educational Webinar; 2015.

Weiss PF. Spondyloarthritis: Adult versus pediatric onset disease. Jefferson Hospital Rheumatology Grand Rounds; 2015; Philadelphia, PA.

Awards and Honors

2014, Spondylitis Association of America-Jane Bruckel Young Investigator Award 

2012, Arthritis Foundation Professional Educator Award

2008, American College of Rheumatology Distinguished Fellow Award

2005, American College of Rheumatology/ Research Education Fund Medical and Pediatric Resident Research Award

2002, American Women's Medical Association Janet M. Glasgow Achievement Citation, Albert Einstein College of Medicine

2001, Alpha Omega Alpha, Albert Einstein College of Medicine

1998, Sigma Xi, the Scientific Research Society, Princeton University 

1998, E.R. Squibb and Sons Senior Thesis Prize of Contribution of Scientific Research, Princeton University

Editorial and Academic Positions

Editorial Positions

Editorial Board

Journal of Rheumatology (2015- present)
Arthritis Care & Research (2016-2018)
Arthritis Research & Therapy (2016- present)

Guest Editor

Guest Editor, “Imaging in Rheumatic Disease”, Rheumatic Disease Clinics,  (Fall 2016)

Ad hoc Reviewer

Archives of Pediatric and Adolescent Medicine
Arthritis Care and Research
Arthritis and Rheumatology
JAMA Pediatrics
Pediatrics
Pediatric Emergency Care
Pediatric Nephrology
Pediatric Rheumatology

Academic and Institutional Committees

Masters of Science in Clinical Epidemiology Admissions Committee, 2015-present 
School of Medicine Clinical Epidemiology Curriculum Committee, 2015-present
K Grant Advisory Committee, 2014-present
Rheumatology Scientific Review Committee, 2013-present
Center for Pediatric Clinical Effectiveness Pilot Grant Selection Committee, 2009-present
Center for Pediatric Clinical Effectiveness Scientific Review Committee, 2008-present

Leadership and Memberships

Childhood Arthritis and Rheumatology Research Alliance
American College of Rheumatology 
SPondyloArthritis Research & Treatment Network (SPARTAN)
American Academy of Pediatrics
Alpha Omega Alpha
Sigma Xi, the Scientific Research Society
Arthritis Foundation
Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)