Adam J. Wolpaw, MD, PhD

male silhouette icon
Adam J. Wolpaw, MD, PhD, is an attending physician with the Division of Oncology at Children's Hospital of Philadelphia.

Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Columbia College of Physicians and Surgeons, New York, NY


Pediatrics - The Children’s Hospital of Philadelphia, Philadelphia, PA


Hematology-Oncology - The Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatrics – American Board of Pediatrics

Graduate Degree

PhD in Chemical Biology - Columbia University, New York, NY
Master of Philosophy in Pharmacology - Cambridge University, England

Titles and Academic Titles

Attending Physician

Assistant Professor, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Wolpaw AJ, Dang CV. “MYC-induced Metabolic Stress and Tumorigenesis.” Biochim Biophys Acta. (2018) 1870(1):43-50.


Wolpaw AJ, Dang CV. “Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy.” Trends Cell Biol. (2017) 28(3):201-212.


Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR. “Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.” Nat Chem Biol (2016) 12, 497-503.


Wolpaw AJ, Trella JD, Egan MA, Delgado EM. “New-Onset Hypoglycemia in a Medically Complex 6-Year-Old Girl.” Pediatr Emerg Care (2015) 31:883-886.


Wolpaw AJ, Stockwell BR. "Multidimensional profiling in the investigation of small-molecule-induced cell death." Methods in Enzymology (2014) 545:265-302.


Varma H, Gangadhar NM, Letso RR, Wolpaw AJ, Sriramaratnam R, and Stockwell BR “Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity.” Exp Cell Res (2013) 319, 1759-1773.


Wolpaw AJ, Shimada K, Skouta R, Welsch ME, Akavia UR, Pe’er D, Shaik F, Bulinski JC, Stockwell BR. “Modulatory profiling identifies mechanisms of small molecule-induced cell death.” Proc Natl Acad Sci U S A 108, E771-780 (2011)


Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR. “RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.” Nature 447 (2007) 864-868

Lim JC, Wolpaw AJ, Caldwell MA, Hladky SB, Barrand MA. “Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells.” Brain Research 1159 (2007) 67-76.


Wolpaw AJ, Aizer AA, Zimmt MB. “Synthesis of self-orienting triptycene adsorbates for STM investigations.” Tetrahedron Letters 44 (2003) 7613-7615 

Posters and Presentations


Wolpaw AJ, Volgina, D, Dang CV. “Modulation of Innate Immune Sensing Pathways in Neuroblastoma by MYCN.” Advances in Neuroblastoma Research, May 2018.

Invited Lectures


Wolpaw AJ. “Modulation of innate immune sensing pathways by N-MYC.” Children’s Oncology Group Fall Meeting. October 2018.

Awards and Honors

2012, Titus Munson Coan Prize for Best Essay in the Biological Sciences
2011, PhD with honors, Columbia University
2008, Student Travel Award, Gordon Conference on Cell Death
2007, Solomon Snyder Scholar, Academy of Achievement  Summit
2003, Honors in Chemistry, Brown University
2003, Magna Cum Laude, Brown University
2003, Churchill Fellowship
2002, Junior Award in Chemistry, Brown University
2002, Barry Goldwater Scholarship for Excellence in Education