Nadir Yehya, MD

Nadir Yehya, MD

Nadir Yehya, MD, is an attending physician in the Pediatric Sepsis Program and the Division of Critical Care Medicine at Children's Hospital of Philadelphia.

Areas of Expertise: Ventilation strategies
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children’s Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children’s Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.

Dr. Yehya’s research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.

Education and Training

Medical School

MD - David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA

Residency

Pediatrics - Children’s Hospital Los Angeles, Los Angeles, CA

Fellowship

Pediatric Critical Care Medicine - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Critical Care Medicine
Pediatrics

Titles and Academic Titles

Attending Physician, Pediatric Critical Care Medicine

Departments and Services

Research Interests

Ventilator induced lung injury
Pediatric respiratory failure
Pediatric acute respiratory syndrome (ARDS)
Mechanical ventilation

Publications

Papers

2018

Zubrow ME, Thomas NJ, Friedman DF, Yehya N: RBC transfusions are associated with prolonged mechanical ventilation in pediatric acute respiratory distress syndrome. Pediatric Critical Care Medicine Epub ahead of print 2018.

Yehya N, Thomas NJ, Khemani RG: Risk stratification using oxygenation in the first 24 hours of pediatric acute respiratory distress syndrome. Critical Care Medicine Epub ahead of print 2018.

Yehya N, Wong HR: Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 46(1): e9-e16, Jan 2018.

2017

Dowell JC, Thomas NJ, Yehya N.: Association of Response to Inhaled Nitric Oxide and Duration of Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatric Critical Care Medicine 18(11): 1019-1026, Nov 2017.

Yehya N, Thomas NJ: Disassociating lung mechanics and oxygenation in pediatric acute respiratory distress syndrome. Critical Care Medicine 45(7): 1232-1239, July 2017.

2016

Yehya N, Thomas NJ, Meyer NJ, Christie JD, Berg RA, Margulies SS: Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome. Intensive Care Medicine 42(7): 1137-1145, July 2016.

Yehya N, Thomas NJ, Margulies SS: Circulating nucleosomes are associated with mortality in pediatric acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol  310(11): L1177-84, Jun 2016

Yehya N, Bhalla AK, Thomas NJ, Khemani RG: Alveolar dead space fraction discriminates mortality in pediatric acute respiratory distress syndrome. Pediatric Critical Care Medicine 17(2): 101-109, February 2016.

2015

Yehya N. Servaes S, Thomas NJ, Nadkarni VM, Srinivasan V: Corticosteroid exposure in pediatric acute respiratory distress syndrome. Intensive Care Medicine 41(9): 1658-1666, September 2015.

Yehya N, Servaes S, Thomas NJ: Characterizing degree of lung injury in pediatric acute respiratory distress syndrome. Critical Care Medicine 43(5): 937-946, May 2015.

Abstracts

2017

Zubrow M, Margulies, SS, Yehya N: NDGA Improves Survival and Degree of Lung Injury in Rats After Cecal Ligation and Puncture. Critical Care Medicine December 2017 Notes: Star Research Presentation Annual Congress SCCM (oral presentation by M Zubrow).

Yehya N, Wong H: A Biomarker-Based Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine December 2017 Notes: Annual Congress SCCM.

Yehya N, Thomas NJ: Clinical Endotypes of Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine December 2017 Notes: Annual Congress SCCM.

Yehya N, Dowell, J, Thomas, NJ: Epidemiology of Cause of Death in Children with Acute Respiratory Distress Syndrome. Critical Care Medicine December 2017 Notes: Annual Congress SCCM.

Whitney J, Yehya N, Weiss SL: Increased endothelial activation is evident if pediatric extrapulmonary sepsis complicated by ARDS. Critical Care Medicine December 2017 Notes: Research snapshot Presentation at 47th Critical Care Congress, February 2018, San Antonio, TX.

Himebauch AS, Wang Y, Yehya N, Conlon TW, Kilbaugh TJ, McGowan F, Mercer-Roisa L: PARDS etiology is an important determinant of early RV dysfunction and pulmonary hypertension. Critical Care Medicine December 2017 Notes: Star Research Presentation at 47th Critical Care Congress, February 25, 2018, San Antonio, TX (Oral Presentation by Himebauch AS)

Sina Saffaran, Anup Das, Jonathan G. Hardman, Nadir Yehya, Declan Gerard Bates: Modeling Pediatric ARDS Patients. 39th Annual International Conference of the IEEE Engineering in Medicine & Biology Society, JeJu Island, South Korea  July 2017.

Yehya N, Song MJ, Lawrence GG, Margulies SS: Human epidermal growth factor receptor (HER) ligands implicated in regulating alveolar epithelial permeability with cyclic stretch American Thoracic Society International Conference, Washington, DC May 2017.

Yehya N, Lawrence GG, Margulies SS: Isolation of individual histones from circulating nucleosomes. American Thoracic Society International Conference, Washington, DC May 2017.

2016

Zubrow M, Yehya N: Red blood cell transfusion is associated with prolonged mechanical ventilation in pediatric ARDS. Critical Care Medicine 44(12 Suppl): 90, December 2016 Notes: Star Research Presentation at the 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Zubrow M, Yehya N: Present hypoalbuminemia is associated with prolonged mechanical ventilation in pediatric ARDS. Critical Care Medicine 44(12 Suppl): 943, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Keim G, Yehya N: Discharge disposition and one-year mortality after pediatric acute respiratory distress syndrome. Critical Care Medicine 44(12 Suppl): 317, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Glau C, Conlon TW, Weiss SL, Yehya N, Himebauch AS, Nishisaki A: Progressive diaphragm atrophy is present in pediatric acute respiratory failure. Critical Care Medicine 44(12 Suppl): 1038, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Dowell J, Yehya N: Inhaled nitric oxide decreases ventilator day sin pediatric acute respiratory distress syndrome. Critical Care Medicine 44(12 Suppl): 316, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Chiotos K, Fowler J, Kitt E, Wolfe HA, Yehya N, Kilbaugh TJ: Severe legionella pneumophila pneumonia in an immunocompromised child. Critical Care Medicine 44(12 Suppl): 523, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Bhalala A, Yehya N, Newth C, Mack W, Khemani R: The association of inhaled nitric oxide with outcomes in children with ARDS. Critical Care Medicine 44(12 Suppl): 311, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Yehya N, Thomas NJ, Margulies SS: Circulating nucleosomes discriminate mortality in pediatric acute respiratory distress syndrome. American Thoracic Society International Conference, San Francisco, CA  May 2016.

Yeha N, Dolinay T, Thomas NJ, Howrylak JA, Margulies SS: Biomarkers of endothelial and epithelial dysfunction in adult and pediatric acute respiratory distress syndrome. American Thoracic Society International Conference, San Francisco, CA  May 2016.

Books

Chapters

2009

Vilain E, Sarafoglou K, Yehya N: Disorders of sex development. Pediatric Endocrinology and Inborn Errors of Metabolism. Sarafoglou K, Hoffmann GF, Roth KS (eds.). McGraw-Hill Companies, Page: 527-555, 2009.

Posters and Presentations

Invited Lectures

2018

Yehya N. "Adjunctive therapy in PARDS."  9th World Federation of Pediatric Intensive and Critical Care Societies Congress, Singapore. Jun, 2018.

Yehya N. "Oxygenation Index 12 Hours After Pediatric Acute Respiratory Distress Syndrome Onset Stratifies Risk."  Yehya N, Thomas NJ, Khemani R.  Oral presentation at 47th Critical Care Congress of the Society of Critical Care Medicine.  San Antonio, TX. Jan, 2018.

2017

Yehya N. "Other ventilatory modes in ARDS."  Curso Internacional en Cuidados Intensivos Pediatricos, Hospital Juarez de Mexico, Mexico City, Mexico. Oct, 2017.

Yehya N. "Ventilator management and PEEP use in children."  Curso Internacional en Cuidados Intensivos Pediatricos, Hospital Juarez de Mexico, Mexico City. Oct, 2017.

Yehya N. "High frequency ventilation modes in children."  The First International Consortium on Mechanical Ventilation in Children, Montreal, Canada. Sep, 2017.

Yehya N. "What does pediatric ARDS actually mean?" Cardiac Intensive Care Unit Research Series, Division of Cardiac Critical care, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia. Jul, 2017.

Yehya N. "What does pediatric ARDS actually mean?"  Pulmonary Medicine Lecture Series, Division of Pulmonary Medicine, Department of Pediatrics, Children's Hospital of Philadelphia. Jun, 2017.

Yehya N. "Can biomarkers in pediatric ARDS guide treatment?", Invited Presentation at the 28th European Society of Pediatric and Neonatal Intensive Care, June 2017, Lisbon, Portugal. Jun, 2017.

2016

Yehya N. "Disassociating Lung Mechanics and Oxygenation in Early Pediatric Acute Respiratory Distress Syndrome."  Yehya N, Thomas NJ.  Oral Presentation at the 45th Critical Care Congress Meeting, February 2016, Orlando, FL. Feb, 2016.

Awards and Honors

2016, Star Research Achievement Award, 45th Annual Congress of the Society of Critical Care Medicine, Orlando, FL

2013, Pediatric Residency Faculty Honor Roll 2012-2013, The Children's Hospital of Philadelphia

2006, Teaching Award, Children's Hospital Los Angeles Pediatric Residency Program

Editorial and Academic Positions

Editorial Positions

2014-present, Reviewer, Anesthesiology
2014-present, Reviewer, American Journal of Physiology - Lung Cellular and Molecular Physiology

Academic and Institutional Committees

2016-present, Junior Member, Anesthesiology/Critical Care Medicine Research Council
2016-present, Chair, Scientific Oversight Committee, Pediatric Critical Care fellowship class of 2018
2014-present, Faculty Director, Pediatric Critical Care Medicine Case Conference
2011-present, PICU/PCU Patient Safety and Quality Improvement Committee

Leadership and Memberships

Memberships in Professional Organizations

2009-present, American Thoracic Society
2008-present, Society of Critical Care Medicine