Nadir Yehya, MD

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Nadir Yehya, MD, is an attending physician in the Pediatric Sepsis Program and the Division of Critical Care Medicine at Children's Hospital of Philadelphia.

Areas of Expertise: Ventilation strategies
Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children’s Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children’s Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.

Dr. Yehya’s research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.

Education and Training

Medical School

MD - David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA

Residency

Pediatrics - Children’s Hospital Los Angeles, Los Angeles, CA

Fellowship

Pediatric Critical Care Medicine - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Critical Care Medicine – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Attending Physician, Pediatric Critical Care Medicine

Departments and Services

Research Interests

Ventilator induced lung injury
Pediatric respiratory failure
Pediatric acute respiratory syndrome (ARDS)
Mechanical ventilation

Publications

Papers

2022

Yehya N, Fitzgerald JC, Hayes K, Zhang D, Bush J, Koterba N, Chen F, Tuluc F, Teachey DT, Balamuth F, Lacey SF, Melenhorst JJ, Weiss SL: Temperature Trajectory Sub-Phenotypes and The Immuno-Inflammatory Response In Pediatric Sepsis. Shock 57(5): 645-651, May 2022.

Mehta SD, Muthu N, Yehya N, Galligan M, Porter E, McGowan N, Papili K, Favatella D, Liu H, Griffis H, Bonafide CP, Sutton RM : Leveraging EHR Data to Evaluate the Association of Late Recognition of Deterioration With Outcomes. Hosp Pediatr 12(5): 447-460, May 2022.

Xin Y, Cereda M, Yehya N, Humayun S, Delvecchio P, Thompson JM, Martin K, Hamedani H, Martorano P, Duncan I, Kadlecek S, Makvandi M, Brenner JS, Rizi RR: Imatinib Alleviates Lung Injury and Prolongs Survival in Ventilated Rats. Am J Physiol Lung Cell Mol Physiol Page: epub ahead of print, Apr 2022.

Mistry S, Das A, Saffaran S, Yehya N, Scott TE, Chikhani M, Laffey JG, Hardman JG, Camporota L, Bates DG: Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation. Respir Res 23(1): 101, Apr 2022.

Weaver L, Das A, Saffaran S, Yehya N, Chikhani M, Scott TE, Laffey JG, Hardman JG, Camporota L, Bates DG: Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study. Br J Anaesth Page: S0007-0912(22)00130-1, Mar 2022.

Patel B, Thomas NJ, Yehya N: Agreement Between Peak Inspiratory Pressure in Decelerating-Flow Ventilation and Plateau Pressure in Square-Flow Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med 23(3): 201-204, Mar 2022.

Gandhi CK, Thomas NJ, Meixia Y, Spear D, Fu C, Zhou S, Wu R, Keim G, Yehya N, Floros J: SNP-SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children. Front Genet 13: 815727, Mar 2022.

Faust HE, Oniyide O, Wang Y, Forker CM, Dunn T, Yang W, Lanken PN, Sims CA, Yehya N, Christie JD, Meyer NJ, Reilly JP, Mangalmurti NS, Shashaty MGS: Early Plasma Nuclear DNA, Mitochondrial DNA, and Nucleosome Concentrations Are Associated With Acute Kidney Injury in Critically Ill Trauma Patients  Crit Care Explor 4(4): e0663, Mar 2022.

Yehya N, Fazeliniah H, Taylor DM, Gray Lawrence G, Spruce LA, Thompson JM, Margulies SS, Seeholzer SH, Worthen GS: Differentiating septic children with and without acute respiratory distress syndrome using proteomics. Am J Physiol Lung Cell Mol Physiol Page: epub ahead of print, Jan 2022.

Bhalla AK, Klein MJ, Modesto I Alapont V, Emeriaud G, Kneyber MCJ, Medina A, Cruces P, Diaz F, Takeuchi M, Maddux AB, Mourani PM, Camilo C, White BR, Yehya N, Pappachan J, Di Nardo M, Shein S, Newth C, Khemani R; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study. Crit Care 26(1): 2, Jan 2022.

2021

Gardner MM, Kirschen MP, Wong HR, McKeone DJ, Halstead ES, Thompson JM, Himebauch S, Topjian AA, Yehya N: Biomarkers Associated with Mortality in Pediatric Patients with Cardiac Arrest and Acute Respiratory Distress Syndrome. Resuscitation 170: 184-193, Dec 2021.

Yehya N, Venkataramani A, Harhay MO: Statewide Interventions and Covid-19 Mortality in the United States: An Observational Study. Clin Infect Dis 73(7): e1863-e1869, Oct 2021.

Shein SL, Maddux AB, Klein MJ, Bhalla A, Briassoulis G, Dahmer MK, Emeriaud G, Flori HR, Gedeit R, Ilia S, Kneyber MCJ, Napolitano N, Ohshimo S, Pons-Òdena M, Rubin S, White BR, Yehya N, Khemani R, Smith L; V4 PARDIE Investigators and the PALISI Network: Epidemiology and Outcomes of Critically Ill Children at Risk for Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study. Crit Care Med Page: epub ahead of print, Sep 2021.

Yehya N, Harhay MO: Severity of hypoxemia may explain indeterminate results in pediatric trials of inhaled nitric oxide. Intensive Care Med 47(8): 913-915, Aug 2021.

Yehya N, Fazelinia H, Lawrence GG, Spruce LA, Mai MV, Worthen GS, Christie JD: Plasma Nucleosomes Are Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med 49(7): 1149-1158, Jul 2021.

Weaver L, Das A, Saffaran S, Yehya N, Scott TE, Chikhani M, Laffey JG, Hardman JG, Camporota L, Bates DG: High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study. Ann Intensive Care 11(1): 109, Jul 2021.

Black CG, Thomas NJ, Yehya N: Timing and Clinical Significance of Fluid Overload in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med Page: epub ahead of print, May 2021.

Yehya N: Assessment of the Temporal Trajectory of Clinical Trials for COVID-19 Interventions After Highly Publicized Lay and Medical Attention. JAMA Netw Open 4(3): e210689, Mar 2021.

Yehya N: Assessment of the Temporal Trajectory of Clinical Trials for COVID-19 Interventions After Highly Publicized Lay and Medical Attention. JAMA Netw Open 4(3): e210689, Mar 2021.

Himebauch AS, Wong W, Wang Y, McGowan FX, Berg RA, Mascio CE, Kilbaugh TJ, Lin KY, Goldfarb SB, Kawut SM, Mercer-Rosa L, Yehya N: Preoperative echocardiographic parameters predict primary graft dysfunction following pediatric lung transplantation. Pediatr Transplant 25(2): e13858, Mar 2021.

Mitchell HK, Reddy A, Montoya-Williams D, Harhay M, Fowler JC, Yehya N: Hospital outcomes for children with severe sepsis in the USA by race or ethnicity and insurance status: a population-based, retrospective cohort study. Lancet Child Adolesc Health 5(2): 103-112, Feb 2021.

Mehta SD, Martin K, McGowan N, Dominick CL, Madu C, Denkin BK, Yehya N: Ventilator-Weaning Pathway Associated With Decreased Ventilator Days in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med 49(2): 302-310, Feb 2021.

Reddy A, Jenssen B, Chidambaram A, Yehya N, Lindell RB: Characterizing E-Cigarette Vaping Associated Lung Injury (EVALI) in the Pediatric Intensive Care Unit. Pediatr Pulmonol 56(1): 162-170, Jan 2021.

2020

Yehya N, Varisco BM, Thomas NJ, Wong HR, Christie JD, Feng R  : Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome. Crit Care 24(1): 681, Dec 2020.

Whitney JE, Feng R, Koterba N, Chen F, Bush J, Graham K, Lacey SF, Melenhorst JJ, Parikh SM, Weiss SL, Yehya N: Endothelial Biomarkers Are Associated With Indirect Lung Injury in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome  Crit Care Explor 2(12): e0295, Dec 2020.

Butler AD, Dominick CL, Yehya N: High Frequency Percussive Ventilation in Pediatric Acute Respiratory Failure. Pediatr Pulmonol Page: epub ahead of print, Dec 2020.

Yehya N, Hodgson CL, Amato MBP, Richard JC, Brochard LJ, Mercat A, Goligher EC: Response to Ventilator Adjustments for Predicting ARDS Mortality: Driving Pressure versus Oxygenation. Ann Am Thorac Soc Page: epub ahead of print, Oct 2020.

Nickel AJ, Jiang S, Napolitano N, Yehya N, Fitzgerald JC, Bruins BB, Lockman JL, Nadkarni VM, Nishisaki A: Full Finger Reperfusion Time Measured by Pulse Oximeter Waveform Analysis in Children. Crit Care Med 48(10): e927-e933, Oct 2020.

Glau CL, Conlon TW, Himebauch AS, Yehya N, Weiss SL, Berg RA, Nishisaki A: Diaphragm Atrophy During Pediatric Acute Respiratory Failure Is Associated With Prolonged Noninvasive Ventilation Requirement Following Extubation. Pediatr Crit Care Med 21(9): e672-e678, Sep 2020.

Das A, Saffaran S, Chikhani M, Scott TE, Laviola M, Yehya N, Laffey JG, Hardman JG, Bates DG: In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications. Crit Care Explor 2(9): e0202, Sep 2020.

Zubrow ME, Margulies SS, Yehya N: Nordihydroguaiaretic acid reduces secondary organ injury in septic rats after cecal ligation and puncture. PLoS One 15(8): e0237613, Aug 2020.

Keim G, Yehya N, Spear D, Hall MW, Loftis LL, Alten JA, McArthur J, Patwari PP, Freishtat RJ, Willson DF, Straumanis JP, Thomas NJ; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: Development of Persistent Respiratory Morbidity in Previously Healthy Children After Acute Respiratory Failure. Crit Care Med 48(8): 1120-1128, Aug 2020.

Yehya N, Venkataramani A, Harhay MO: Statewide Interventions and Covid-19 Mortality in the United States: An Observational Study. Clin Infect Dis Page: epub ahead of print, Jul 2020.

Saffaran S, Das A, Laffey JG, Hardman JG, Yehya N, Bates DG: Utility of Driving Pressure and Mechanical Power to Guide Protective Ventilator Settings in Two Cohorts of Adult and Pediatric Patients With Acute Respiratory Distress Syndrome: A Computational Investigation. Crit Care Med 48(7): 1001-1008, Jul 2020.

Kirschen MP, Yehya N, Graham K, Kilbaugh T, Berg RA, Topjian A, Diaz-Arrastia R: Circulating Neurofilament Light Chain Is Associated With Survival After Pediatric Cardiac Arrest. Pediatr Crit Care Med 21(7): 656-661, Jul 2020.

Yehya N, Harhay MO, Klein MJ, Shein SL, Piñeres-Olave BE, Izquierdo L, Sapru A, Emeriaud G, Spinella PC, Flori HR, Dahmer MK, Maddux AB, Lopez-Fernandez YM, Haileselassie B, Hsing DD, Chima RS, Hassinger AB, Valentine SL, Rowan CM, Kneyber MCJ, Smith LS, Khemani RG, Thomas NJ: Predicting Mortality in Children With Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study. Crit Care Med 48(6): e514-e522, Jun 2020.

Rowan CM, Klein MJ, Hsing DD, Dahmer MK, Spinella PC, Emeriaud G, Hassinger AB, Piñeres-Olave BE, Flori HR, Haileselassie B, Lopez-Fernandez YM, Chima RS, Shein SL, Maddux AB, Lillie J, Kneyber MCJ, Smith LS, Khemani RG, Thomas NJ, Yehya N: Early Use of Adjunctive Therapies for Pediatric Acute Respiratory Distress Syndrome: A PARDIE Study. Am J Respir Crit Care Med 201(11): 1389-1397, Jun 2020.

Gandhi CK, Chen C, Wu R, Yang L, Thorenoor N, Thomas NJ, DiAngelo SL, Spear D, Keim G, Yehya N, Floros J: Association of SNP-SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure. J Clin Med 9(4): E1183, Apr 2020.

Whitney JE, Zhang B, Koterba N, Chen F, Bush J, Graham K, Lacey SF, Melenhorst JJ, Teachey DT, Mensinger JL, Yehya N, Weiss SL: Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis Crit Care Med 48(3): 344-352, Mar 2020.

Himebauch AS, Yehya N, Wang Y, McGowan FX, Mercer-Rosa L: New or Persistent Right Ventricular Systolic Dysfunction Is Associated With Worse Outcomes in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med 21(2): e121-e128, Feb

2019

Yehya N, Harhay MO, Curley MAQ, Schoenfeld DA, Reeder RW: Re-appraisal of Ventilator-free Days in Critical Care Research. Am J Respir Crit Care Med 200(7): 828-836,  Oct 2019.

Roberts AL, Sammons JS, Mourani PM, Thomas NJ, Yehya N: Specific Viral Etiologies Are Associated With Outcomes in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med 20(9): e441-e446, Sep 2019.

Saffaran S, Das A, Hardman JG, Yehya N, Bates DG: High-fidelity computational simulation to refine strategies for lung protective ventilation in paediatric acute respiratory distress syndrome. Intensive Care Med Epub ahead of print 2019.

Lockman JL, Yehya N, Schwartz AJ, Cronholm PF: Professionalism in Pediatric Anesthesiology: Affirmation of a definition based on results of a nationally-administered survey of pediatric anesthesiologists. Paediatr Anaesth 29(4): 345-352, Apr 2019.

Imber DA, Thomas NJ, Yehya N: Association between tidal volumes adjusted for ideal body weight and outcomes in pediatric acute respiratory distress syndrome. Pediatr Crit Care Med 20(3): e145-e153, Mar 2019.

Yehya N, Thomas NJ, Wong HR: Evidence of endotypes in pediatric acute hypoxemic respiratory failure caused by sepsis. Pediatr Crit Care Med 20(2): 110-112, Feb 2019.

Yehya N, Song MJ, Lawrence GG, Margulies SS: HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch. Int J Mol Sci 20(4): E948, Feb 2019.

Khemani RG, Smith L, Lopez-Fernandez YM, Kwok J, Morzov R, Klein MJ, Yehya N, Willson D, Kneyber MCJ, Lillie J, Fernandez A, Newth CJL, Jouvet P, Thomas NJ: Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. Lancet Respir Med 7(2): 115-128, Feb 2019.

Yehya N, Thomas NJ: Sepsis and Pediatric Acute Respiratory Distress Syndrome. J Pediatr Intensive Care 8(1): 32-41, Jan 2019.

2018

Keim G, Watson RS, Thomas NJ, Yehya N: New morbidity and discharge disposition of pediatric acute respiratory distress syndrome survivors. Crit Care Med 46(11): 1731-1738, Nov 2018.

Himebauch AS, Yehya N, Yan W, Conlon TW, Kilbuagh TJ, McGowan FX, Mercer-Rosa L: Early right ventricular systolic dysfunction and pulmonary hypertension are associated with worse outcomes in pediatric acute respiratory distress syndrome. Crit Care Med 46(11): e1055-e1062, Nov 2018.

Dowell JC, Parvathaneni K, Thomas NJ, Khemani RG, Yehya N: Epidemiology of cause of death in pediatric acute respiratory distress syndrome. Crit Care Med 46(11): 1811-1819, Nov 2018.

Bhalla AK, Yehya N, Mack WJ, Wilson ML, Khemani RG, Newth CJL: The Association Between Inhaled Nitric Oxide Treatment and ICU Mortality and 28-Day Ventilator-Free Days in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med 46(11): 1803-1810, Nov 2018.

Yehya N, Keim G, Thomas NJ: Subtypes of pediatric acute respiratory distress syndrome have different predictors of mortality. Intensive Care Med 44(8): 1230-1239, Aug 2018.

Khemani RG, Parvathaneni K, Yehya N, Bhalla AK, Thomas NJ, Newth CJL: PEEP Lower Than the ARDS Network Protocol is Associated with Higher Pediatric ARDS Mortality. Am J Respir Crit Care Med 198(1): 77-89, Jul 2018.

Stewart CA, Yehya N, Fei L, Chima RS: High frequency oscillatory ventilation in a cohort of children with respiratory failure. Pediatr Pulmonol 53(6): 816-823, Jun 2018.

Glau CL, Conlon TW, Himebauch AS, Yehya N, Weiss SL, Berg RA, Nishisaki A: Progressive Diaphragm Atrophy in Pediatric Acute Respiratory Failure. Pediatr Crit Care Med 19(5): 406-411, May 2018.

Zubrow ME, Thomas NJ, Friedman DF, Yehya N: RBC transfusions are associated with prolonged mechanical ventilation in pediatric acute respiratory distress syndrome. Pediatric Critical Care Medicine 19(2):e88-e96, Feb 2018.

Yehya N, Thomas NJ, Khemani RG: Risk stratification using oxygenation in the first 24 hours of pediatric acute respiratory distress syndrome. Critical Care Medicine 46(4):619-624, Apr 2018.

Yehya N, Wong HR: Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 46(1): e9-e16, Jan 2018.

2017

Dowell JC, Thomas NJ, Yehya N.: Association of Response to Inhaled Nitric Oxide and Duration of Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatric Critical Care Medicine 18(11): 1019-1026, Nov 2017.

Yehya N, Thomas NJ: Disassociating lung mechanics and oxygenation in pediatric acute respiratory distress syndrome. Critical Care Medicine 45(7): 1232-1239, July 2017.

2016

Yehya N, Thomas NJ, Meyer NJ, Christie JD, Berg RA, Margulies SS: Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome. Intensive Care Medicine 42(7): 1137-1145, July 2016.

Yehya N, Thomas NJ, Margulies SS: Circulating nucleosomes are associated with mortality in pediatric acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol  310(11): L1177-84, Jun 2016

Yehya N, Bhalla AK, Thomas NJ, Khemani RG: Alveolar dead space fraction discriminates mortality in pediatric acute respiratory distress syndrome. Pediatric Critical Care Medicine 17(2): 101-109, February 2016.

2015

Yehya N. Servaes S, Thomas NJ, Nadkarni VM, Srinivasan V: Corticosteroid exposure in pediatric acute respiratory distress syndrome. Intensive Care Medicine 41(9): 1658-1666, September 2015.

Yehya N, Servaes S, Thomas NJ: Characterizing degree of lung injury in pediatric acute respiratory distress syndrome. Critical Care Medicine 43(5): 937-946, May 2015.

Abstracts

2022

Mitchell HK, Radack J, Passarella M, Lorch S, Yehya N: Contribution of Area-Level Socioeconomic Deprivation to PICU Admission and Mortality. American Thoracic Society International Conference, San Francisco, CA May 2022 Notes: Oral Presentation.

Yehya N, Fitzgerald J, Hayes K, Zhang D, Bush J, Koterba N, Chen F, Tuluc F, Teachey D, Balamuth F, Lacey S, Melenhorst J, Weiss S: Temperature Trajectory Subphenotypes and the Immunoinflammatory Response in Pediatric Sepsis. Critical Care Medicine 50(1): 722, Jan 2022.

Shepard L, O'Halloran AJ, Graham, K, Kienzle M, Slovis J, Yehya N, Topjian AA, Sutton RM, Morgan RW: Pre-Arrest Invasive Ventilation Characteristics of Pediatric In-Hospital Cardiac Arrest Patients. Critical Care Medicine 50(1): 699, Jan 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, Februaryl 2022, San Juan, PR.

Patel B, Yver H, Woods-Hill C, Harhay MO, Yehya N: Statistical Power in Pediatric Critical Care Trials. Critical Care Medicine 50(1): 233, Jan 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, PR.

Patel B, Yehya N: Agreement Between Deceleration-Flow Pips and Square-Flow Plateau Pressures in Pediatric ARDS. Critical Care Medicine 50(1): 28, Jan 2022 Notes: STAR Research Presentation and Snapshot Presentation at the 51st Critical Care Congress, Februaryl 2022, San Juan, PR.

Mitchell H, Yehya : Hospital Specific Contribution to Mortality in Children with Severe Sepsis and Head Injury. Critical Care Medicine 50(1): 32, Jan 2022 Notes: STAR Research Presentation and Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, PR.

Mitchell H, Apple D, Lett E, Dowshen N, Yehya N: Attempted Suicide, Suicide Ideation and self-Harm In Pediatric Patients with Gender Dysphoria. Critical Care Medicine 50(1): 233, Jan 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, PR.

Mai M, Irving SY, Yehya N, Srinivasan V: Feasibility of Using EHR-based Extraction of Nutrition Data in Critically Ill Children. Critical Care Medicine 50(1): 303, Jan 2022 Notes: Bronze Snapshot Award and Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, PR.

Keim G, Pinto N, Christie J, Yehya N: Readmission After Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 50(1): 235, Jan 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, PR.

Ishizuka M, Yehya N, Keim G: Lung Function and Pulmonary Clinic Utilization After Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 50(1): 586, Jan 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, PR.

Himebauch AS, Yehya N, Wang Y, Burnett R, Kawut SM, McGowan FX, Berg RA, Mercer-Rosa L: NT-proBNP Correlates Poorly with Echocardiogram Measures of Myocardial Function in Early PARDS. Critical Care Medicine 50(1): 182, Jan 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, PR.

Himebauch AS, Sriram A, Slovis JC, Morgan RW, Connelly J, Berg RA, Keim G, Yehya N, Kilbaugh TJ: VVDL-ECMO is associated with decreased inotropic requirements in pediatric ARDS. Critical Care Medicine 50(1): 575, Jan 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February 2022, San Juan, PR.

Gardner M, Chen F, Koterba N, Reddy I, Thompson J, Mai A,McGowan F, Gaynor W, Lacey s, Yehya N: Preoperative Biomarkers Associated with Poor Outcome after Neonatal Cardiac Surgery Critical Care Medicine 50(1): 183, Jan 2022 Notes: Research Snapshot Presentation at the 51st Critical Care Congress, February  2022, San Juan, PR.

2021

Yehya N: Conditional Mortality and Probability of Extubation in Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 49(1): 482, Jan 2021 Notes: Research Snapshot Presentation at 50th Critical Care Congress, February 2021 (Virtual).

Reddy AR, Jenssen B, Chidambaram A, Yehya N, Lindell R: Characterizing E-cigarette vaping associated lung injury in the pediatric intensive care unit. Critical Care Medicine 49(1): 483, Jan 2021 Notes: Research Snapshot Poster Presentation at 50th Critical Care Congress, February 2021 (Virtual).

Mitchell H, Reddy A, Montoya-Williams D, Fowler J, Yehya N: Disparities by Race/Ethnicity and Insurance Status in Outcomes of Children With Severe Sepsis. Critical Care Medicine 49(1): 248, Jan 2021 Notes: Research Snapshot Presentation at 50th Critical Care Congress, February 2021 (Virtual).

Mehta S, Muthu N, Bonafide C, Galligan M, Favatella D, Papili K, Porter E, Liu H, Yehya N, Sutton RM: EHR defined emergency transfer is associated with mortality in hospitalized children. Critical Care Medicine 49(1): 245, Jan 2021 Notes: Research Snapshot Poster Presentation at 50th Critical Care Congress, February 2021 (Virtual).

Lenz K, Nishisaki A, Lindell RB, Yehya N, Bruins BB, Napolitano N, Craig N, Traynor D, Fitzgerald JC: Stem cell transplant status is not associated with adverse events during tracheal intubation. Critical Care Medicine 49(1): 462, Jan 2021 Notes: Research Snapshot Presentation at 50th Critical Care Congress, February 2021 (Virtual).

2020

Yehya N, Weiss SL, Mann D: Improved survival after surgical sepsis in rats using a novel vascular homing peptide to target endothelial delivery of hydrocortisone. American Thoracic Society International Conference May 2020 Notes: Poster Presentation at the American Thoracic Society International Conference, May 15-20, 2020, Philadelphia, PA (Cancelled due to COVID19).

Yehya N, Christie JD, Thomas NJ, Wong HR, Feng R: Development of a risk stratification tool for pediatric acute respiratory distress syndrome using peripheral gene expression. American Thoracic Society International Conference May 2020 Notes: Poster Presentation at the American Thoracic Society International Conference, May 15-20, 2020, Philadelphia, PA (Cancelled due to COVID19).

Wong W, Himebauch AS, Yehya N, Berg RA, Wang Y, Kawut SM, Mercer-Rosa L, Goldfarb S: Primary graft dysfunction is associated with worse outcomes following pediatric lung transplantation. American Thoracic Society International Conference May 2020 Notes: Poster Presentation at the American Thoracic Society International Conference, May 15-20, 2020, Philadelphia, PA (Cancelled due to COVID19).

Himebauch AS, Wong W, Berg RA, Kawut M, Goldfarb B, Mercer-Rosa L, Yehya N: The association of pre-operative echocardiographic parameters with grade 3 primary graft dysfunction following pediatric lung transplantation. American Thoracic Society International Conference May 2020 Notes: Poster Presentation at the American Thoracic Society International Conference, May 15-20, 2020, Philadelphia, PA (Cancelled due to COVID19).

Gandhi C, Wu R, Thomas NJ, Keim G, Yehya N, Floros J: Association of Surfactant Protein Gene Polymorphisms with Persistent Respiratory Morbidity in Previously Healthy Children after Acute Respiratory Failure. Pediatric Academic Societies Annual Meeting May 2020 Notes: Poster Presentation at the Pediatric Academic Societies 2020 Meeting, Philadelphia, PA (Cancelled due to COVID19).

Yheya N, Harhay MO: Severity of hypoxemia modifies the association between nitric oxide and mortality in pediatric ARDS. Critical Care Medicine 48(1): 565, Jan 2020 Notes: Research Snapshot Presentation at the 49th Critical Care Congress, Orlando, FL.

Whitney J, Yehya N, Weiss S, Christie JD: Angiopoietin-2/-1 ratio is associated with concurrent and subsequent MODS in pediatric sepsis. Critical Care Medicine 48(1): 13, Jan 2020 Notes: Oral Presentation at the 49th Critical Care Congress, Orlando, FL.

Kirschen M, Yehya N, Graham K, Berg RA, Topjian AA, Diaz- Arrastia R: Serum neurofilament light chain is associated with survival after pediatric cardiac arrest. Critical Care Medicine 48(1): 317, Jan 2020 Notes: Research Snapshot Presentation at the 49th Critical Care Congress, Orlando, FL.

Himebauch A, Yehya N, Wang Y, Sisko M, Quartermain M, McGowan FX, Mercer-Rosa L: The prevalence of RV and LV systolic dysfunction in pediatric ARDS using strain echocardiography. Critical Care Medicine 48(1): 71, Jan 2020 Notes: Research Snapshot Presentation at the 49th Critical Care Congress, Orlando, FL.

Himebauch A, Yehya N, Morgan R, Wang Y, Sisko M, Quartermain M, McGowan FX, Mercer-Rosa L: New or persistent pulmonary hypertension is associated with worse outcomes in pediatric ARDS. Critical Care Medicine 48(1): 564, Jan 2020 Notes: Research Snapshot Presentation at the 49th Critical Care Congress, Orlando, FL.

Faust H, Wang Y, Forker C, Dunn T, Zhang P, Lanken P, Sims C, Yehya N, Christie JD, Meyer N, Reilly J, Mangalmurti N, Shashaty M: Circulating nuclear and mitochondrial DNA are associated with acute kidney injury in trauma patients. Critical Care Medicine 48(1): 855, Jan 2020 Notes: Research Snapshot Presentation at the 49th Critical Care Congress, Orlando, FL.

Butler A, Dominick C, Yehya N: Predicting success of high-frequency percussive ventilation in pediatric acute respiratory failure. Critical Care Medicine 48(1): 580, Jan 2020 Notes: Research Snapshot Presentation at the 49th Critical Care Congress, Orlando, FL.

2019

Yehya N, Fazeliniah H, Spruce L, Lawrence GG, Margulies SS, Seeholzer S, Worthen GS: A Novel Proteomic Approach To Distinguishing Septic Children With Acute Respiratory Distress Syndrome. American Thoracic Society International Conference, Dallas, TX May 2019.

Keim G, Yehya N, Spear D, Hall M W, Loftis L, Alten J,  McArthur J, Patwari PP, Freishtat RJ, Willson D, Straumanis J, and Thomas N: Bacterial Pneumonia Predicts Ongoing Chronic Pulmonary Dysfunction in Previously Healthy Infants. American Thoracic Society International Conference, Dallas, TX May 2019.

Gandhi CK, Wu R, Thorenoor N, Keim G, Yehya N, DiAngelo S, Thomas NJ, Floros J: Association of surfactant protein gene polymorphisms in pediatric acute lung injury. Pediatric Academic Societies Annual Meeting, Baltimore, MD Apr 2019.

Whitney J, Yehya N, Weiss SL: IL-6 at sepsis recognition is associated with poor functional outcome. Pediatric Critical Care Medicine 20(2): e103, February 2019 Notes: Oral Presentation at the 25th Pediatric Critical Care Colloquium, October 5-7, 2018, Baltimore, MD.

Whitney J, Bush J, Graham K, Chen F, Kengle N, Lacey S, Melenhorst JJ, Yehya N, Weiss SL: Endothelial activation is more prominent in indirect versus direct pediatric ARDS. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: STAR Research Presentation at the 48th Critical Care Congress, San Diego, CA.

Roberts AL, Sammons JS, Thomas NJ, Yehya N: Specific viral etiologies affect outcomes in pediatric acute respiratory distress syndrome. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Snapshot Presentation at the 48th Critical Care Congress, San Diego, CA.

Morgan RW, Yeung T, Yehya N, Landis WP, Graham K, Nadkarni VM, Berg RA, Kilbaugh TJ, Topjian AA, Sutton RM: Influence of peri-arrest corticosteroid exposure on pediatric in-hospital cardiac arrest outcomes. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Snapshot Presentation at the 48th Critical Care Congress, San Diego, CA.

Imber DA, Thomas NJ, Yehya N: Tidal Volume adjusted for ideal body weight is not associated with outcomes in pediatric ARDS. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Snapshot Presentation at the 48th Critical Care Congress, San Diego, CA.

Himebauch AS, Wang Y, Yehya N, McGowan FX, Mercer-Rosa LM: New or persistent right ventricular dysfunction is Associated with worse outcomes in Pediatric ARDS. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: Research Snapshot Presentation at the 48th Critical Care Congress, San Diego, CA.

Glau CL, Conlon TW, Yehya N, Weiss SL, Himebauch AS, Nishisaki A: Pediatric diaphragm atrophy is associated with prolonged noninvasive support following extubation. Critical Care Medicine 47(1 Suppl 1), January 2019 Notes: STAR Research Presentation at the 48th Critical Care Congress, San Diego, CA.

2018

Miller TP, Masino A, Yehya N, Burrows E, Grundmeier R, and Aplenc R: Natural Language Processing of Radiology Reports to Capture Adult Respiratory Distress Syndrome in Pediatric Patients. Southeastern Pediatric Research Conference, Atlanta, GA June 2018 Notes: Poster Presentation.

Yehya N: Ventilator-Free Days Should Be Presented as Subdistribution Hazard Ratios Using Competing Risk Regression. American Journal of Respiratory and Critical Care Medicine 195: A4415, May 2018 Notes: Poster Presentation at the American Thoracic Society International Conference, San Diego, CA.

Zubrow M, Margulies, SS, Yehya N: NDGA Improves Survival and Degree of Lung Injury in Rats After Cecal Ligation and Puncture. Critical Care Medicine 46(1): 12, January 2018 Notes: Star Research Presentation at the 47th Critical Care Congress (oral presentation by M Zubrow), San Antonio, TX

Yehya N, Wong H: A Biomarker-Based Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 46(1): 566, January 2018 Notes: Research Snapshot Presentation at the 47th Critical Care Congress, San Antonio, TX.

Yehya N, Thomas NJ: Clinical Endotypes of Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 46(1): 560, January  2018 Notes: Research Snapshot Presentation at the 47th Critical Care Congress, San Antonio, TX.

Yehya N, Dowell, J, Thomas, NJ: Epidemiology of Cause of Death in Children with Acute Respiratory Distress Syndrome. Critical Care Medicine 46(1): 560, January 2018 Notes: Research Snapshot Presentation at the 47th Critical Care Congress, San Antonio, TX.

Whitney J, Yehya N, Weiss SL: Increased endothelial activation is evident if pediatric extrapulmonary sepsis complicated by ARDS. Critical Care Medicine 46(1): 745, January  2018 Notes: Research snapshot Presentation at 47th Critical Care Congress, San Antonio, TX.

Himebauch AS, Wang Y, Yehya N, Conlon TW, Kilbaugh TJ, McGowan F, Mercer-Roisa L: PARDS etiology is an important determinant of early RV dysfunction and pulmonary hypertension. Critical Care Medicine 46(1): 27, January 2018 Notes: Star Research Presentation at 47th Critical Care Congress, San Antonio, TX (Oral Presentation by Himebauch AS)

2017

Zubrow M, Margulies, SS, Yehya N: NDGA Improves Survival and Degree of Lung Injury in Rats After Cecal Ligation and Puncture. Critical Care Medicine December 2017 Notes: Star Research Presentation Annual Congress SCCM (oral presentation by M Zubrow).

Yehya N, Wong H: A Biomarker-Based Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine December 2017 Notes: Annual Congress SCCM.

Yehya N, Thomas NJ: Clinical Endotypes of Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine December 2017 Notes: Annual Congress SCCM.

Yehya N, Dowell, J, Thomas, NJ: Epidemiology of Cause of Death in Children with Acute Respiratory Distress Syndrome. Critical Care Medicine December 2017 Notes: Annual Congress SCCM.

Whitney J, Yehya N, Weiss SL: Increased endothelial activation is evident if pediatric extrapulmonary sepsis complicated by ARDS. Critical Care Medicine December 2017 Notes: Research snapshot Presentation at 47th Critical Care Congress, February 2018, San Antonio, TX.

Himebauch AS, Wang Y, Yehya N, Conlon TW, Kilbaugh TJ, McGowan F, Mercer-Roisa L: PARDS etiology is an important determinant of early RV dysfunction and pulmonary hypertension. Critical Care Medicine December 2017 Notes: Star Research Presentation at 47th Critical Care Congress, February 25, 2018, San Antonio, TX (Oral Presentation by Himebauch AS)

Sina Saffaran, Anup Das, Jonathan G. Hardman, Nadir Yehya, Declan Gerard Bates: Modeling Pediatric ARDS Patients. 39th Annual International Conference of the IEEE Engineering in Medicine & Biology Society, JeJu Island, South Korea  July 2017.

Yehya N, Song MJ, Lawrence GG, Margulies SS: Human epidermal growth factor receptor (HER) ligands implicated in regulating alveolar epithelial permeability with cyclic stretch American Thoracic Society International Conference, Washington, DC May 2017.

Saffaran S, Das A, Hardman JG, Yehya N, Bates DG: Development and validation of a computational simulator for pediatric acute respiratory distress syndrome patients. Conf Proc IEEE Eng Med Biol Soc.  2017: 1521-1524, July 2017 Notes: 39th Annual International Conference of the IEEE Engineering in Medicine & Biology Society, JeJu Island, South Korea

Yehya N, Lawrence GG, Margulies SS: Isolation of individual histones from circulating nucleosomes. American Thoracic Society International Conference, Washington, DC May 2017.

Yehya N, Lawrence GG, Margulies SS: Isolation of individual histones from circulating nucleosomes. American Thoracic Society International Conference, Washington, DC May 2017.

2016

Zubrow M, Yehya N: Red blood cell transfusion is associated with prolonged mechanical ventilation in pediatric ARDS. Critical Care Medicine 44(12 Suppl): 90, December 2016 Notes: Star Research Presentation at the 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Zubrow M, Yehya N: Present hypoalbuminemia is associated with prolonged mechanical ventilation in pediatric ARDS. Critical Care Medicine 44(12 Suppl): 943, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Keim G, Yehya N: Discharge disposition and one-year mortality after pediatric acute respiratory distress syndrome. Critical Care Medicine 44(12 Suppl): 317, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Glau C, Conlon TW, Weiss SL, Yehya N, Himebauch AS, Nishisaki A: Progressive diaphragm atrophy is present in pediatric acute respiratory failure. Critical Care Medicine 44(12 Suppl): 1038, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Dowell J, Yehya N: Inhaled nitric oxide decreases ventilator day sin pediatric acute respiratory distress syndrome. Critical Care Medicine 44(12 Suppl): 316, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Chiotos K, Fowler J, Kitt E, Wolfe HA, Yehya N, Kilbaugh TJ: Severe legionella pneumophila pneumonia in an immunocompromised child. Critical Care Medicine 44(12 Suppl): 523, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Bhalala A, Yehya N, Newth C, Mack W, Khemani R: The association of inhaled nitric oxide with outcomes in children with ARDS. Critical Care Medicine 44(12 Suppl): 311, December 2016 Notes: Research Snapshot Presentation at 46th Critical Care Congress, January 2017, Honolulu, Hawaii.

Yehya N, Thomas NJ, Margulies SS: Circulating nucleosomes discriminate mortality in pediatric acute respiratory distress syndrome. American Thoracic Society International Conference, San Francisco, CA  May 2016.

Yeha N, Dolinay T, Thomas NJ, Howrylak JA, Margulies SS: Biomarkers of endothelial and epithelial dysfunction in adult and pediatric acute respiratory distress syndrome. American Thoracic Society International Conference, San Francisco, CA  May 2016.

Books

Chapters

2020

Keim G, Yehya N: Pediatric Acute Respiratory Distress Syndrome. Pediatric Critical Care: Text and Study Guide, Second Edition. Lucking, Maffei, Tamburro, Zaritsky  (eds.). Springer, 2020.

2019

Yehya N: Clinical Outcomes in Pediatric Acute Respiratory Distress Syndrome. Pediatric Acute Respiratory Distress Syndrome - A Clinical Guide. Shein SL, Rotta AT (eds.). Springer, 2019.

Keim G, Yehya N: Pediatric Acute Respiratory Distress Syndrome. Pediatric Critical Care: Text and Study Guide, Second Edition. Lucking, Maffei, Tamburro, Zaritsky  (eds.). Springer, 2019.

2009

Vilain E, Sarafoglou K, Yehya N: Disorders of sex development. Pediatric Endocrinology and Inborn Errors of Metabolism. Sarafoglou K, Hoffmann GF, Roth KS (eds.). McGraw-Hill Companies, Page: 527-555, 2009.

Awards and Honors

2016-2022, Star Research Achievement Award
2013, Pediatric Residency Faculty Honor Roll
2012-2013, Children's Hospital of Philadelphia
2006, Teaching Award, Children's Hospital Los Angeles Pediatric Residency Program

Editorial and Academic Positions

Editorial Positions

2022-2025, Editorial Board Member, Pediatric Critical Care Medicine
2020-present, Advisor Member of Editorial Board, Critical Care
2019-present, Reviewer, Lancet Respiratory Medicine
2018-present, Reviewer, American Journal of Respiratory and Critical Care Medicine
2017-present, Reviewer, Critical Care Medicine
2017-present, Reviewer, Pediatric Critical Care Medicine
2016-present, Reviewer, Intensive Care Medicine
2014-present, Reviewer, Anesthesiology
2014-present, Reviewer, American Journal of Physiology - Lung Cellular and Molecular Physiology

Academic and Institutional Committees

2016-present, Junior Member, Anesthesiology/Critical Care Medicine Research Council
2016-present, Chair, Scientific Oversight Committee, Pediatric Critical Care fellowship class of 2018
2014-present, Faculty Director, Pediatric Critical Care Medicine Case Conference
2011-present, PICU/PCU Patient Safety and Quality Improvement Committee

Leadership and Memberships

Memberships in Professional Organizations

2009-present, American Thoracic Society

2008-present, Society of Critical Care Medicine