Hamid Bassiri Laboratory

Led by Hamid Bassiri, MD, PhD, researchers in the Bassiri Laboratory are studying the underlying mechanisms by which specialized immune effector cells communicate with one another in tumor microenvironments. The long-term goal of the work is to identify novel drug targets and develop treatment strategies to potentiate the antitumor activity of immune effector cells in tumor microenvironments.

Selected Publications

iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo. Cancer Immunol Res. 2014 Jan;2(1):59-69.
Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE.

Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood. 2013 Apr 18;121(16):3135-46.
May RM, Okumura M, Hsu CJ, Bassiri H, Yang E, Rak G, Mace EM, Philip NH, Zhang W, Baumgart T, Orange JS, Nichols KE, Kambayashi T.

The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood. 2013 Apr 25;121(17):3386-95.
Das R, Bassiri H, Guan P, Wiener S, Banerjee PP, Zhong MC, Veillette A, Orange JS, Nichols KE.