Hamid Bassiri, MD, PhD

Papers

2022

Harabuchi S, Khan O, Bassiri H, Yoshida T, Okada Y, Takizawa M, Ikeda O, Katada A, Kambayashi T. Manipulation of diacylglycerol and ERK-mediated signaling differentially controls CD8+ T cell responses during chronic viral infection. Frontiers in Immunology 13:1032113. doi: 10.3389/fimmu.2022.1032113 (2022).

Diorio C, Shraim R, Myers R, Behrens EM, Canna S, Bassiri H, Aplenc R, Burudpakdee C, Chen F, DiNofia AM, Gill S, Gonzalez V, Lambert MP, Leahy AB, Levine BL, Lindell RB, Maude SL, Melenhorst JJ, Newman H, Perazzelli J, Seif AE, Lacey SF, June CH, Barrett DM, Grupp SA, Teachey DT. Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19. Clinical Cancer Research 28(17):3804-3813. doi: 10.1158/1078-0432.CCR-22-0822 (2022).

McNerney KO, Karageorgos SA, Ferry GM, Wolpaw AJ, Burudpakdee C, Khurana P, Toland CN, Vemu R, Vu A, Hogarty MD, Bassiri H. TH-MYCNtumors, but not tumor-derived cell lines, are adrenergic lineage, GD2+, and responsive to anti-GD2 antibody therapy. Oncoimmunology 11(1) doi.org/10.1080/2162402X.2022.2075204 (2022).

Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Ferris A, Kernan KF, Schulert GS, Seo P, Son MB, Tremoulet AH, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta J. American College of Rheumatology clinical guidance for pediatric patients with Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 and hyperinflammation in COVID-19. Arthritis and Rheumatology Version 3: https://doi.org/10.1002/art.42062 (2022).

2021

Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrel A, Lambert MP, Sullivan KE, Wherry EJ, Teachey DT, Bassiri H, Behrens EM. Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. Nature Communications 12(1):7222. doi: 10.1038/s41467-021-27544-6 (2021).

Khurana P, Burudpakdee C, Grupp SA, Beier UH, Barrett DM, Bassiri H. Distinct bioenergetic features of human invariant natural killer T (iNKT) cells enable retained functions in nutrient-deprived states. Frontiers in Immunologydoi.org/10.3389/fimmu.2021.700374 (2021).

Moghimi B, Muthugounder S, Jambon S, Tibbetts R, Hung L, Bassiri H, Hogarty MD, Barrett DM, Shimada H, Asgharzadeh S: Efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma. Nature Communications12(1):511, doi.org/10.1038/s41467-020-20785-x (2021).

Vella LA, Giles JR, Baxter AE, Oldridge DA, Diorio C, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen C, Giannini HM, D'Andrea K, The UPenn COVID Processing Unit, Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MR, Wherry EJ. Deep immune profiling of MIS-C demonstrates marked but transient immune activation as compared to adult and pediatric COVID-19. Science Immunology 6(57): eabf7570, doi: 10.1126/sciimmunol.abf7570 (2021).

Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrel A, Lambert MP, Sullivan KE, Wherry EJ, Teachey DT, Bassiri H, Behrens EM. Proteomic profiling of MIS-C patients reveals heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. Nature Communications 12: 7222, doi.org/10.1038/s41467-021-27544-6 (2021).

Chang JC, Matsubara D, Morgan R, Diorio C, Nadaraj S, Teachey DT, Bassiri H, Behrens EM, Banerjee A. Skewed cytokine responses rather than the magnitude of the cytokine storm may be responsible for cardiac dysfunction in multi-system inflammatory syndrome in children. Journal of the American Heart Association10(16):e021428, doi.org/10.1161/JAHA.121.021428 (2021).

2020

Diorio C, Henrickson SE, Vella LA, McNerney K, Chase J, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell BL, Bernt KM, Blatz A, Chiotos K, Fisher BT, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh T, Odom John AR, Lambert M, Liebling EJ, Paessler M, Petrosa W, Phillips C, Romberg ND, Seif A, Sesok-Pizzini DA, Sullivan KE, Vardaro J, Behrens EM, Teachey DT, Bassiri H. MIS-C and COVID-19 are distinct pathophysiologic presentations of SARS-CoV-2. Journal of Clinical Investigation 130(11):5967-75 doi: 10.1172/JCI140970 (2020).

Chiotos K, Bassiri H, Behrens EM, Blatz AM, Chang J, Diorio C, Fitzgerald JC, Topjian A, John ARO. Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series. Journal of the Pediatric Infectious Diseases Society 9(3):393-398. doi: 10.1093/jpids/piaa069 (2020).

Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Ferris A, Kernan KF, Schulert GS, Seo P, Son MB, Tremoulet AH, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta J. American College of Rheumatology clinical guidance for pediatric patients with Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 and hyperinflammation in COVID-19. Arthritis and Rheumatology Version 1: 72(11): 1791-1805, doi.org/10.1002/art.41454 (2020); Version 2: http://dx.doi.org/10.1002/art.41616 (2020).

Dulek DE, Fuhlbrigge RC, Tribble AC, Connelly JA, Loi MM, El Chebib H, Chandrakasan S, Otto WR, Diorio C, Keim G, Walkovich K,Jaggi P, Girotto JE, Yarbrough A, Behrens EM, Cron RQ, Bassiri H. Multi-disciplinary guidance regarding the use of immunomodulatory therapies for acute COVID-19 in pediatric patients. Journal of the Pediatric Infectious Diseases Society 9(6):716-37, doi.org/10.1093/jpids/piaa098 (2020).

2019

Karageorgos S, Bassiri H, Siakalis G, Miligkos M, and Tsioutis C: Intravenous colistin use for infections due to multidrug-resistant gram-negative bacteria in critically ill paediatric patients: a systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy doi: 10.1093/jac/dkz165([Epub ahead of print]): pii: dkz165, May 2019.

2017

Freund-Brown J, Choa R, Singh BK, Robertson TF, Ferry GM, Viver E, Bassiri H, Burkhardt JK, Kambayashi T: Cutting Edge: Murine NK cells degranulate and retain cytotoxic function without store-operated calcium entry. Journal of Immunology Aug 2017 Notes: 10.4049/jimmunol.1700340. [Epub ahead of print]

2015

Altman JB, Benavides AD, Das R, Bassiri H. Antitumor Responses of Invariant Natural Killer T Cells. Journal of  Immunology Research 2015:652875. doi: 10.1155/2015/652875 (2015).

2014

Bassiri Hamid, Das Rupali, Guan Peng, Barrett David M, Brennan Patrick J, Banerjee Pinaki P, Wiener Susan J, Orange Jordan S, Brenner Michael B, Grupp Stephan A, Nichols Kim E: iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo. Cancer Immunology Research 2(1): 59-69, Jan 2014. PMCID: PMC3927984

2013

May Rebecca M, Okumura Mariko, Hsu Chin-Jung, Bassiri Hamid, Yang Enjun, Rak Gregory, Mace Emily M, Philip Naomi H, Zhang Weiguo, Baumgart Tobias, Orange Jordan S, Nichols Kim E, Kambayashi Taku: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood Feb 2013 Notes: Epub ahead of print Feb 13 2013.

Das Rupali, Bassiri Hamid, Guan Peng, Wiener Susan, Banerjee Pinaki P, Zhong Ming-Chao, Veillette André, Orange Jordan S, Nichols Kim E: The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood Feb 2013 Notes: Epub ahead of print Feb 21 2013.

Bassiri Hamid, Das Rupali, Nichols Kim E: Invariant NKT cells: Killers and conspirators against cancer. Oncoimmunology 2(12): e27440, Dec 2013. PMCID: PMC3926875

2012

Das R,  Bassiri H,  Banerjee PP,  Guan P,  Wiener S,  Orange JS,  Nichols KE.: Regulation of invariant natural killer T cell anti-tumor responses by the adaptor molecule Signaling Lymphocytic Activation Molecule-associated protein (SAP). The Journal of Immunology 188(1): 162.47, May 2012.

2009

Cen O, Ueda A, Guzman L, Jain J, Bassiri H, Nichols KE, Stein PL.: The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. Journal of Immunology 182(3): 1370-8, Feb 2009.

2008

Nunez-Cruz S, Yeo WCJ, Rothman J, Ojha P, Bassiri H, Juntilla M, Davidson D, Veillette A, Koretzky GA, Nichols KE.: Differential requirement for the SAP-Fyn interaction during NK T cell development and function. Journal of Immunology 181(4): 2311-20, Aug 2008.

2001

Bassiri H, Carding SR.: A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. Journal of Immunology  166(10): 5945-54, May 2001.

1998

Reya T, Bassiri H, Biancaniello R, Carding SR.: Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. Developmental Immunology 5(4): 287-302, Aug 1998 Notes: Shared first authorship.

Li B, Bassiri H, Rossman MD, Kramer P, Eyuboglu AF, Torres M, Sada E, Imir T, Carding SR.: Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. Journal of Immunology  161(3): 1558-67, Aug 1998.

Contractor NV, Bassiri H, Reya T, Park AY, Baumgart DC, Wasik MA, Emerson SG, Carding SR.: Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. Journal of Immunology  160(1): 385-94, Jan 1998 Notes: Shared first authorship.

1997

Samoilova EB, Horton JL, Bassiri H, Zhang H, Linsley PS, Carding SR, Chen Y.: B7 blockade prevents activation-induced cell death of thymocytes. International Immunology 9(11): 1663-8, Nov 1997.

1994

Markmann JF, Campos L, Bhandoola A, Kim JI, Desai NM, Bassiri H, Claytor BR, Barker CF.: Genetically engineered grafts to study xenoimmunity: a role for indirect antigen presentation in the destruction of major histocompatibility complex antigen deficient xenografts. Surgery 116(2): 242-8; discussion 248-9, Aug 1994.

Bhandoola A, Bassiri H, Markmann JF, Yui K, Hashimoto Y, Greene MI.: Delayed allograft rejection by T cell receptor V beta 8.1 transgenic mice peripherally tolerized to Mls-1. European Journal of Immunology 24(7): 1710-3, Jul 1994

Markmann JF, Desai NM, Bassiri H, Kim JI, Barker CF.: Prolonged survival of class I deficient mouse islet allografts but not xenografts. Transplantation Proceedings 26(2): 748, Apr 1994.

1993

Markmann JF,  Desai NM,  Kim JI,  Bassiri H.: Vulnerability of class I-deficient mouse islet allografts to secondary but not primary alloimmunity. Surgical Forum 44: 446-448, 1993.

Bassiri H, Markmann JF, Desai NM, Kim JI, Teh HS, Barker CF.: Allograft rejection by T cell receptor transgenic mice. The Journal of Surgical Research 54(5): 437-44, May 1993.

Markmann JF, Odorico JS, Bassiri H, Desai N, Kim JI, Barker CF.: Deletion of donor-reactive T lymphocytes in adult mice after intrathymic inoculation with lymphoid cells. Transplantation 55(4): 871-6; discussion 876-7, Apr 1993.

Desai NM, Bassiri H, Kim JI, Koller BH, Smithies O, Barker CF, Naji A, Markmann JF.: Islet allograft, islet xenograft, and skin allograft survival in CD8+ T lymphocyte-deficient mice. Transplantation 55(4): 718-22, Apr 1993.

Markmann JF, Bassiri H, Desai NM, Kim JI, Odorico JS, Barker CF.: Donor antigen-specific T-lymphocyte deletion after intrathymic inoculation. Transplantation Proceedings 25(1 Pt 1): 305-6, Feb 1993.

Desai NM, Bassiri H, Odorico JS, Koller BH, Smithies O, Naji A, Barker CF, Markmann JF.: Pancreatic islet allograft and xenograft survival in CD8+ T-lymphocyte-deficient recipients. Transplantation Proceedings 25(1 Pt 2): 961-2, Feb 1993.

1992

Markmann JF, Bassiri H, Desai NM, Odorico JS, Kim JI, Koller BH, Smithies O, Barker CF.: Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. Transplantation 54(6): 1085-9, Dec 1992.

Shachner MS, Markmann JF, Bassiri H, Kim JI, Naji A, Barker CF.: Direct assessment of the role of NK cells in autoimmune diabetes. The Journal of Surgical Research 52(6): 601-4, Jun 1992.

1991

Markmann JF, Posselt AM, Bassiri H, Brayman KL, Woehrle M, Hickey WF, Silvers WK, Barker CF, Naji A.: Major-histocompatibility-complex restricted and nonrestricted autoimmune effector mechanisms in BB rats. Transplantation 52(4): 662-7, Oct 1991.

1989

Markmann JF, Bassiri H, Barker CF, Naji A.: Effect of lymphokine-induced MHC antigen expression on islet allograft survival. Transplantation Proceedings 21(1 Pt 3): 2723-4, Feb 1989.

Abstracts

2023

Platt A, Bassiri H, Behrens E, Canna S, Gollomp K, Kelsen J, Lambert M, Petrosa W, Romberg N, Seif A, Sullivan K, Teachey D: Essential role of genetic counseling in a multidisciplinary immune dysregulation program. Genetics in Medicine Open 1(1): 95-96, doi.org/10.1016/j.gimo.2023.100297 P269, Jan 2023.

2022

Diorio C, Vincent TL, Fuller T, Shraim R, Glisovic-Aplenc T, Ryan T, Veliz K, Newman H, Wertheim G, Bassiri H, Vu A, Hogarty M, June CH, Grupp SA, Tasian SK, Aplenc R, Gill S, Teachey DT: Targeting CD38 in T-ALL upregulates the targetable polyamine metabolism pathway. Blood 140(Supplement 1): 10285-10286, Nov 2022.

Thompson R, Zoltowski M, Lim D, Diorio C, Margolskee E, Paessler M, Bochenek V, Behrens EM, Teachey DT, Bassiri H, Lambert MP, Gollomp K: Quantification of neutrophil extracellular traps (NETs) in pediatric patients with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) through plasma and peripheral smear analysis. Blood 140(Supplement 1): 5481-5482, Nov 2022.

Diorio C, Shraim R, Myers R, Aplenc R, Banwell B, Bassiri H, Burudpakdee C, Behrens E, Canna S, Chen F, Dinofia A, Gill S, Gonzalez V, Lambert M, Leahy A, Levine B, Lindell R, Maude S, Mcguire J, Newman H, Perazzelli J, Seif A, Lacey S, June C, Barrett D, Grupp S, Teachey D: Comprehensive proteomic profiling to identify biomarkers and therapeutic targets For immune effector cell associated neurotoxicity (ICANS) after treatment with chimeric antigen receptor T cells. Pediatric Blood and Cancer 69, Nov 2022.

Gallo P, McNerney K, Foley C, Kagami L, Wagner K, Petrosa W, Canna S, Diorio C, Sullivan K, Bassiri H, Teachey DT, Behrens EM, Paessler M, Lambert MP: Analysis of clinical cytokine panel profiles as diagnostic and prognostic biomarkers in pediatric hyperinflammatory conditions. Blood 140(Supplement 1): 8341-8342, Nov 2022.

2021

McNerney KO, Diorio C, Burudpakdee C, Chase J, Lee J, Henrickson SE, Lambert M, Paessler M, Vella L, Fitzgerald JC, Balamuth F, Behrens E, Bassiri H, Teachey DT, Maude SL: SARS-CoV-2 infections in CAR T cell recipients. Transplantation and Cellular Therapy 27(3): S210-S211, 10.1016/S2666-6367(21)00258-X, Jan 2021.

Bassiri H, McNerney KO, Diorio C, Chase JC, Liebling E, Burudpakdee C, Petrosa W, Lee JH, Vella L, Henrickson S, Gollomp K, Balamuth F, Blatz AM, Chiotos K, Fitzgerald J, Harris R, Paessler ME, Lambert M, Witmer C, Giglia T, Odom John AR, Sullivan KE, Teachey DT, Behrens EM : Inflammatory parameters distinguish severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pediatric presentations, coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C). Pediatric Blood and Cancer 68 (Supplement 1): S1, DOI:10.1002/pbc.28808, Jan 2021.

Chiem M, Rauova L, Diorio C, McNerney KO, Bassiri H, Sullivan K, Behrens EM, Teachey DT, Lambert MP: The role of PF4 antibodies in pediatric SARS-CoV-2 infections. Blood 138(Supplement 1): 1004, doi.org/10.1182/blood-2021-151529, Nov 2021.

Diorio C, Shraim R, Myers RM, Burudpakdee C, Barz Leahy A, Aplenc R, Lambert MP, Bassiri H, Behrens EM, Gonzalez VE, Chen F, Levine BL, Maude SL, DiNofia AM, Seif AE, Melenhorst JJ, Lacey SF, June CH, Barrett D, Grupp SA, Teachey DT: Comprehensive secretome profiling elucidates novel disease biology and identifies pre-infusion candidate biomarkers to predict the development of severe cytokine release syndrome in pediatric patients receiving CART19. Blood 138(Supplement 1): 167, doi.org/10.1182/blood-2021-149477, Nov 2021.

2020

Diorio C, McNerney KO, Lambert MP, Paessler M, Chase J, Gollomp K, Laskin BL, Vella LA, Henrickson SE, Liebling E, Burudpakdee C, Lee J, Balamuth F, Blatz AM, Chiotos K, Fitzgerald JC, Giglia T, Odom John AR, Petrosa W, Sullivan KE, Witmer CM, Bassiri H, Behrens EM, Teachey DT: Evidence of microangiopathy in children with SARS-CoV-2 regardless of clinical presentation. Blood 136(Supplement 1): 28-29, Nov 2020 Notes: doi.org/10.1182/blood-2020-137240.

2019

Khurana P, Ferry GM, Karageorgos S, Vu A, McNerney K, Hogarty MD, and Bassiri H: Investigating the metabolic and functional properties of invariant natural killer T (iNKT) cells in neuroblastoma. Abcam Immunometabolism: Fundamentals to prospective new therapies Jun 2019 Notes: Boston MA.

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Exploring the immunometabolism and anti-tumor properties of invariant natural killer T (iNKT) cells in neuroblastoma  University of Pennsylvania Institute for Immunology Year in Review Symposium Jun 2019 Notes: Philadelphia PA.

McNerney K, Karageorgos S, Khurana P, and Bassiri H: Induction of natural killer T cell-mediated neuroblastoma cytotoxicity with a novel fusion protein. American Society of Hematology and Oncology May 2019 Notes: New Orleans LA.

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Harnessing the anti-tumor activity of invariant natural killer T (iNKT) cells for neuroblastoma immunotherapy. American Association of Immunologists May 2019 Notes: San Diego CAAAI Travel award.

Karagerogos S, Ferry G, Vu A, Khurana P, Hogarty MD, and Bassiri H: Using preclinical modeling to understand the mechanisms by which antibody therapy alters immunity against high risk neuroblastoma and effects prolongation of survival. Pediatric Academic Societies Apr 2019 Notes: Baltimore MD.

McNerney K, Karageorgos S, Khurana P, and Bassiri H: Stimulating iNKT cell-mediated neuroblastoma cytotoxicity in a mouse model. Association for Clinical and Translational Science Mar 2019 Notes: Washington DCTL-1 Blue Ribbon award.

Karagerogos S, Ferry G, Vu A, Khurana P, Hogarty MD, and Bassiri H: Using preclinical modeling to understand the mechanisms by which antibody therapy alters immunity against high risk neuroblastoma and effects prolongation of survival. Eastern Society of Pediatric Research Mar 2019 Notes: Philadelphia PATravel award.

McNerney K, Karageorgos S, Khurana P, and Bassiri H: Activation of invariant natural killer T-cells in the treatment of neuroblastoma in an immunocompetent mouse model. Transplant and Cellular Therapy  Feb 2019 Notes: Houston TX.

2018

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Exploring the immunometabolism and anti-tumor properties of invariant natural killer T (iNKT) cells in neuroblastoma University of Pennsylvania Cell and Molecular Biology Symposium Oct 2018 Notes: Philadelphia PA.

2017

Bassiri H, Vu A, Hogarty MD, Benavides AD: Polyamine blockade alters the neuroblastoma microenvironment to favor control of tumor growth  Journal of Immunology 194: P660 (Abstr), May 2017.

Benavides AD, Vu A, Ferry GM, Hogarty MD, Bassiri H: Modulation of the neuroblastoma microenvironment via polyamineblockade. Proceedings of the American Association for Cancer Research 58: 417-418, Apr 2017.

Books

Chapters

2020

Bassiri H: Tuberculous meningitis  Decision-making in Adult Neurology. Cucchiara BL, Price RS (eds.). Elsevier Inc. eBook, Nov 2020 Notes: ISBN 9780323635837.

2019

Karageorgos SA and Bassiri H: Genetics of primary hemophagocytic lymphohistiocytosis. Cytokine Storm Syndromes. Springer, 2019.

2018

Bassiri H: Anaerobic infections. The 5-Minute Pediatric Consult. Cabana MD (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 8th Edition, Oct 2018 Notes: ISBN 978-1-4511-9102-8.

Bassiri H: Smallpox. The 5-Minute Pediatric Consult. Cabana MD (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 8th Edition, Oct 2018 Notes: ISBN 978-1-4511-9102-8.

Bassiri H: Tetanus. The 5-Minute Pediatric Consult. Cabana MD (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 8th Edition, Oct 2018 Notes: ISBN 978-1-4511-9102-8.

2012

Bassiri H, Wood J: Tetanus. The 5-Minute Pediatric Consult. M. William Schwartz (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 6th Edition: 866-7, 2012 Notes: ISBN 978-1451183382.

Bassiri H, Wood J: Smallpox. The 5-Minute Pediatric Consult. M. William Schwartz  (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 6th Edition: 806-7, 2012 Notes: ISBN 978-1451183382.

Bassiri H: Anaerobic infections. The 5-Minute Pediatric Consult. M. William Schwartz (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 6th Edition: 42-3, 2012 Notes: ISBN 978-1451183382.

Posters and Presentations

2023

Platt A, Bassiri H, Behrens E, Canna S, Gollomp K, Kelsen J, Lambert M, Petrosa W, Romberg N, Seif A, Sullivan K, Teachey D. : Essential role of genetic counseling in a multidisciplinary immune dysregulation program. Genetics in Medicine Open 1(1): 95-96, Jan 2023 Notes: https://doi.org/10.1016/j.gimo.2023.100297P269.

2022

Diorio C, Shraim R, Myers R, Aplenc R, Banwell B, Bassiri H, Burudpakdee C, Behrens E, Canna S, Chen F, Dinofia A, Gill S, Gonzalez V, Lambert M, Leahy A, Levine B, Lindell R, Maude S, Mcguire J, Newman H, Perazzelli J, Seif A, Lacey S, June C, Barrett D, Grupp S, Teachey D: Comprehensive proteomic profiling to identify biomarkers and therapeutic targets For immune effector cell associated neurotoxicity (ICANS) after treatment with chimeric antigen receptor T cells Pediatric Blood and Cancer 69, Nov 2022.

Diorio C, Vincent TL, Fuller T, Shraim R, Glisovic-Aplenc T, Ryan T, Veliz K, Newman H, Wertheim G, Bassiri H, Vu A, Hogarty M, June CH, Grupp SA, Tasian SK, Aplenc R, Gill S, Teachey DT: Targeting CD38 in T-ALL upregulates the targetable polyamine metabolism pathway. Blood 140(Supplement 1): 10285-10286, Nov 2022.

Gallo P, McNerney K, Foley C, Kagami L, Wagner K, Petrosa W, Canna S, Diorio C, Sullivan K, Bassiri H, Teachey DT, Behrens EM, Paessler M, Lambert MP: Analysis of clinical cytokine panel profiles as diagnostic and prognostic biomarkers in pediatric hyperinflammatory conditions. Blood 140(Supplement 1): 8341-8342, Nov 2022.

Thompson R, Zoltowski M, Lim D, Diorio C, Margolskee E, Paessler M, Bochenek V, Behrens EM, Teachey DT, Bassiri H, Lambert MP, Gollomp K: Quantification of neutrophil extracellular traps (NETs) in pediatric patients with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) through plasma and peripheral smear analysis. Blood 140(Supplement 1): 5481-5482, Nov 2022.

2021

Bassiri H, McNerney KO, Diorio C, Chase JC, Liebling E, Burudpakdee C, Petrosa W, Lee JH, Vella L, Henrickson S, Gollomp K, Balamuth F, Blatz AM, Chiotos K, Fitzgerald J, Harris R, Paessler ME, Lambert M, Witmer C, Giglia T, Odom John AR, Sullivan KE, Teachey DT, Behrens EM: Inflammatory parameters distinguish severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pediatric presentations, coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) Pediatric Blood and Cancer  68(Supplement 1): S1, Jan 2021 Notes: DOI:10.1002/pbc.28808.

McNerney KO, Diorio C, Burudpakdee C, Chase J, Lee J, Henrickson SE,  Lambert M, Paessler M, Vella L, Fitzgerald JC, Balamuth F,  Behrens E, Bassiri H, Teachey DT, Maude SL: SARS-CoV-2 infections in CAR T cell recipients. Transplantation and Cellular Therapy 27(3): S210-S211, Jan 2021 Notes: 10.1016/S2666-6367(21)00258-X. PMCID: PMC7847392

Chiem M, Rauova L, Diorio C, McNerney KO, Bassiri H, Sullivan K, Behrens EM, Teachey DT, Lambert MP: The role of PF4 antibodies in pediatric SARS-CoV-2 infections. Blood 138(Supplement 1): 1004, Nov 2021 Notes: https://doi.org/10.1182/blood-2021-151529.

Diorio C, Shraim R, Myers RM, Burudpakdee C, Barz Leahy A, Aplenc R, Lambert MP, Bassiri H, Behrens EM, Gonzalez VE, Chen F, Levine BL, Maude SL, DiNofia AM, Seif AE, Melenhorst JJ, Lacey SF, June CH, Barrett D, Grupp SA, Teachey DT: Comprehensive secretome profiling elucidates novel disease biology and identifies pre-infusion candidate biomarkers to predict the development of severe cytokine release syndrome in pediatric patients receiving CART19. Blood 138(Supplement 1): 167, Nov 2021 Notes: https://doi.org/10.1182/blood-2021-149477.

2020

Diorio C, McNerney KO, Lambert MP, Paessler M, Chase J, Gollomp K, Laskin BL, Vella LA, Henrickson SE, Liebling E, Burudpakdee C, Lee J, Balamuth F, Blatz AM, Chiotos K, Fitzgerald JC, Giglia T, Odom John AR, Petrosa W, Sullivan KE, Witmer CM, Bassiri H, Behrens EM, Teachey DT: Evidence of microangiopathy in children with SARS-CoV-2 regardless of clinical presentation. Blood 136(Supplement 1): 28-29, Nov 2020 Notes: doi.org/10.1182/blood-2020-137240.

2019

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Harnessing the anti-tumor activity of invariant natural killer T (iNKT) cells for neuroblastoma immunotherapy Children's Hospital of Philadelphia Research Poster Day and Scientific Symposium May 2019 Notes: Philadelphia PA Poster award.

McNerney KO, Bassiri H, Karageorgos S, Khurana P: Stimulating iNKT cell-mediated neuroblastoma cytotoxicity in a mouse model. Journal of Clinical and Translational Science 3(Supplement 1): 21, Mar 2019. PMCID: 6808287

McNerney K, Karageorgos S, Khurana P, and Bassiri H: Induction of natural killer T cell-mediated neuroblastoma cytotoxicity with a novel fusion protein. Pediatric Blood and Cancer 66(Supplement 2), Apr 2019.

2018

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Exploring the immunometabolism and anti-tumor properties of invariant natural killer T (iNKT) cells in neuroblastoma. University of Pennsylvania Immunology Graduate Group Retreat Nov 2018 Notes: Lancaster PA, podium presentation.

Karageorgos S, Ferry GM, Khurana P, Vu A, Hogarty MD, and Bassiri H: GD2-directed immunotherapy extends survival in a pre-clinical model of high risk neuroblastoma.  University of Pennsylvania Immunology Graduate Group Retreat Nov 2018 Notes: Lancaster PA, podium presentation.

Karageorgos S, Ferry GM, Benavides AD, Lubin J-B, Khurana P, Vu A, Silverman MA, Planet PJ, Hogarty MD, and Bassiri H: Alteration of neuroblastoma tumor microenvironment by polyamine blockade. University of Pennsylvania Postdoctoral Council Symposium Oct 2018 Notes: Philadelphia PA, podium presentation.

Ferry GM, Benavides AD, Lubin J-B, Khurana P, Vu A, Haber M, Norris MD, Silverman MA, Planet PJ, Hogarty MD, and Bassiri H: Polyamine blockade alters NK cell infiltration in the neuroblastoma tumor microenvironment to augment immunotherapy activity. Advances in Neuroblastoma Research May 2018 Notes: San Francisco CA, podium presentation.

Invited Lectures

2023

"Infectious Risk Factors in Solid Organ Transplant Donors and Recipients", Pediatric Infectious Diseases Society -- St. Jude Research Conference, Memphis TN

2022

"Pediatric COVID-19 and MIS-C", HHS Communications Workgroup, Online webinar

"Investigating the MISC-tery of the Multisystem Inflammatory Syndrome in Children", Pediatric Dialogs, Warsaw Poland (Online webinar, international audience)

"updates on Multisystem Inflammatory Syndrome in Children (MISC)", New Frontiers in Allergy and Immunology, Philadelphia PA

2021

"MIS-C", Pediatric Emergency Medicine podcast, Children's Hospital of Philadelphia, Philadelphia PA (national audience)

"Viral Specific T-cell Immunity Can Be Used to Determine Immune Competence Following Transplantation", St. Jude-Pediatric Infectious Diseases Society (PIDS)-ID Research Conference, Memphis TN (Web based presentation due to COVID-19 pandemic)

"Multisystem Inflammatory Syndrome in Children: Clues to unraveling the MISC-tery", St. Peter's University Hospital Pediatric Grand Rounds (via webinar due to COVID-19 pandemic)

"The nuts & bolts of immunity, and what happens when things go missing", St. Peter's University Hospital Pediatric Residency Professor Rounds lecture (via webinar due to COVID-19 pandemic)

"MIS-C and COVID-19 are distinct presentations of SARS-CoV-2", 9th annual James and Nancy Cassidy Rheumatology Symposium, Columbia MO

Multisystem Inflammatory Syndrome in Children: A MISC-tery Under Investigation, 38th Annual Day in Pediatrics, Tower Health Virtual Conference

2020

"Coronaviridae", "Fever and Rash Syndromes", "Immune System Primer", "Primary Immunodeficiencies", "Fever of Unknown Origin", American Austrian Foundation Open Medical Institute lecture series. Salzburg, Austria (invited week-long lecture series)

"COVID-19: What does the end-game look like", Vistage Group, Radnor PA, USA (virtual webinar)

"COVID-19 and our community", Histiocyte Association lecture (virtual webinar)

"The immune pathogenesis of COVID-19", Sharing Antimicrobial Reports for Pediatric Stewardship (SHARPS) Collaborative (virtual webinar)

"Defining the effects of inhibition of polyamine synthesis on the neuroblastoma immune microenvironment", Advances in Neuroblastoma Research, Amsterdam, Netherlands. (Accepted but meeting canceled due to COVID-19 pandemic).

"Multisystem Inflammatory Syndrome in Children (MIS-C): What we have learned", lecture for regional Non-CHOP physicians (virtual webinar)

"Distinct SARS-CoV-2- Associated Presentations: COVID-19 vs MIS-C", Dysregulated Immunity Symposium: Host Versus Pathogen: Who's Responsible for the Cytokine Storm? (virtual webinar)

"Multisystem Inflammatory Syndrome in Children: Hints into disease pathogenesis", North American Society For Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Foundation (virtual webinar)

"Investigations into the immune pathogenesis of Multisystem Inflammatory Syndrome in Children (MIS-C)", North American Immuno-Hematology Clinical Education and Research (NICER) Symposium (virtual web-based symposium)

"Inflammatory parameters distinguish SARS-CoV-2 pediatric presentations, COVID-19 and MIS-C", Histiocyte Society Annual Meeting (1 of only 6 invited oral presentation; delivered via virtual platform due to cancelation of in-person conference)

"Pediatric SARS-CoV-2: Insights into Disease Pathogenesis", Joe DiMaggio Children's Hospital Pediatric Grand Rounds, Hollywood, FL

"Multisystem Inflammatory Syndrome in Children: An Immune MISC-tery Under Investigation", Center for Disease Control COVID-19 Response and Multi-system Inflammatory Syndrome Investigation Unit, Webinar

2019

"Activation of invariant natural killer T-cells in the treatment of neuroblastoma in an immunocompetent mouse model", Transplantation & Cellular Therapy Meetings of ASBMT and CIBMTR, Houston TX, USA

"Using preclinical modeling to understand the mechanisms by which antibody therapy alters immunity against high risk neuroblastoma and effects prolongation of survival", Eastern Society of Pediatric Research Annual Meeting, Philadelphia PA, USA

"Stimulating iNKT cell-mediated neuroblastoma cytotoxicity in a mouse model",  Association for Clinical and Translational Science, Washington DC, USA

"Using preclinical modeling to understand the mechanisms by which antibody therapy alters immunity against high risk neuroblastoma and effects prolongation of survival", Pediatric Academic Societies, Baltimore MD, USA

"Induction of natural killer T cell-mediated neuroblastoma cytotoxicity with a novel fusion protein", American Society of Pediatric Hematology and Oncology, New Orleans LA, USA

"Harnessing the anti-tumor activity of invariant natural killer T (iNKT) cells for neuroblastoma immunotherapy", American Association of Immunologists, San Diego CA, USA

"Investigating the metabolic and functional properties of invariant natural killer T (iNKT) cells in neuroblastoma", Abcam Immunometabolism: Fundamentals to prospective new therapies, Boston MA, USA

2018

"Polyamine blockade alters NK cell infiltration in the neuroblastoma tumor microenvironment to augment immunotherapy activity", Advances in Neuroblastoma Research, San Francisco CA, USA

"Exploring the immunometabolism and anti-tumor properties of invariant natural killer T (iNKT) cells in neuroblastoma", University of Pennsylvania Cell and Molecular Biology Symposium, Philadelphia PA, USA (regional audience)

2017

Bassiri H. "Modulation of the Neuroblastoma Tumor Microenvironment via Polyamine Blockade", Eastern Society for Pediatric Research, Philadelphia, PA (Oral presentation). Mar, 2017.

Bassiri H. "Fever and Rash Syndromes", "Immune System Primer", "Primary Immunodeficiencies", "Fever of Unknown Origin", American Austrian Foundation Open Medical Institute lecture series. Salzburg, Austria (Invited lecture series). Feb, 2017.