Hamid Bassiri, MD, PhD

Hamid Bassiri, MD, PhD
Hamid Bassiri, MD, PhD, is an attending physician in the Division of Infectious Diseases at Children's Hospital of Philadelphia.

Areas of Expertise: Cellular immunotherapy for cancer, Invariant natural killer T (iNKT) cell development and function, Primary immunodeficiencies, Hemophagocytic lymphohistiocytosis
Locations: Main Campus

Education and Training

Medical School

MD - University of Pennsylvania School of Medicine, Philadelphia, PA

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Infectious Diseases - The Children's Hospital of Philadelphia, Philadelphia, PA
Postdoctoral Research - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Infectious Diseases
Pediatrics

Graduate Degree

PhD in Immunology - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Associate Program Director, Pediatric Infectious Diseases Fellowship Program

Associate Director, Clinical Immunnology Laboratory

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Mechanisms of tumor immune surveillance and ways to harness the activity of innate lymphocytes for cellular cancer immunotherapy.

Publications

Papers

2019

Karageorgos S, Bassiri H, Siakalis G, Miligkos M, and Tsioutis C: Intravenous colistin use for infections due to multidrug-resistant gram-negative bacteria in critically ill paediatric patients: a systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy doi: 10.1093/jac/dkz165([Epub ahead of print]): pii: dkz165, May 2019.

2017

Freund-Brown J, Choa R, Singh BK, Robertson TF, Ferry GM, Viver E, Bassiri H, Burkhardt JK, Kambayashi T: Cutting Edge: Murine NK cells degranulate and retain cytotoxic function without store-operated calcium entry. Journal of Immunology Aug 2017 Notes: 10.4049/jimmunol.1700340. [Epub ahead of print]

2014

Bassiri Hamid, Das Rupali, Guan Peng, Barrett David M, Brennan Patrick J, Banerjee Pinaki P, Wiener Susan J, Orange Jordan S, Brenner Michael B, Grupp Stephan A, Nichols Kim E: iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo. Cancer Immunology Research 2(1): 59-69, Jan 2014. PMCID: PMC3927984

2013

May Rebecca M, Okumura Mariko, Hsu Chin-Jung, Bassiri Hamid, Yang Enjun, Rak Gregory, Mace Emily M, Philip Naomi H, Zhang Weiguo, Baumgart Tobias, Orange Jordan S, Nichols Kim E, Kambayashi Taku: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood Feb 2013 Notes: Epub ahead of print Feb 13 2013.

Das Rupali, Bassiri Hamid, Guan Peng, Wiener Susan, Banerjee Pinaki P, Zhong Ming-Chao, Veillette André, Orange Jordan S, Nichols Kim E: The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood Feb 2013 Notes: Epub ahead of print Feb 21 2013.

Bassiri Hamid, Das Rupali, Nichols Kim E: Invariant NKT cells: Killers and conspirators against cancer. Oncoimmunology 2(12): e27440, Dec 2013. PMCID: PMC3926875

2012

Das R,  Bassiri H,  Banerjee PP,  Guan P,  Wiener S,  Orange JS,  Nichols KE.: Regulation of invariant natural killer T cell anti-tumor responses by the adaptor molecule Signaling Lymphocytic Activation Molecule-associated protein (SAP). The Journal of Immunology 188(1): 162.47, May 2012.

2009

Cen O, Ueda A, Guzman L, Jain J, Bassiri H, Nichols KE, Stein PL.: The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. Journal of Immunology 182(3): 1370-8, Feb 2009.

2008

Nunez-Cruz S, Yeo WCJ, Rothman J, Ojha P, Bassiri H, Juntilla M, Davidson D, Veillette A, Koretzky GA, Nichols KE.: Differential requirement for the SAP-Fyn interaction during NK T cell development and function. Journal of Immunology 181(4): 2311-20, Aug 2008.

2001

Bassiri H, Carding SR.: A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. Journal of Immunology  166(10): 5945-54, May 2001.

1998

Reya T, Bassiri H, Biancaniello R, Carding SR.: Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. Developmental Immunology 5(4): 287-302, Aug 1998 Notes: Shared first authorship.

Li B, Bassiri H, Rossman MD, Kramer P, Eyuboglu AF, Torres M, Sada E, Imir T, Carding SR.: Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. Journal of Immunology  161(3): 1558-67, Aug 1998.

Contractor NV, Bassiri H, Reya T, Park AY, Baumgart DC, Wasik MA, Emerson SG, Carding SR.: Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. Journal of Immunology  160(1): 385-94, Jan 1998 Notes: Shared first authorship.

1997

Samoilova EB, Horton JL, Bassiri H, Zhang H, Linsley PS, Carding SR, Chen Y.: B7 blockade prevents activation-induced cell death of thymocytes. International Immunology 9(11): 1663-8, Nov 1997.

1994

Markmann JF, Campos L, Bhandoola A, Kim JI, Desai NM, Bassiri H, Claytor BR, Barker CF.: Genetically engineered grafts to study xenoimmunity: a role for indirect antigen presentation in the destruction of major histocompatibility complex antigen deficient xenografts. Surgery 116(2): 242-8; discussion 248-9, Aug 1994.

Bhandoola A, Bassiri H, Markmann JF, Yui K, Hashimoto Y, Greene MI.: Delayed allograft rejection by T cell receptor V beta 8.1 transgenic mice peripherally tolerized to Mls-1. European Journal of Immunology 24(7): 1710-3, Jul 1994

Markmann JF, Desai NM, Bassiri H, Kim JI, Barker CF.: Prolonged survival of class I deficient mouse islet allografts but not xenografts. Transplantation Proceedings 26(2): 748, Apr 1994.

1993

Markmann JF,  Desai NM,  Kim JI,  Bassiri H.: Vulnerability of class I-deficient mouse islet allografts to secondary but not primary alloimmunity. Surgical Forum 44: 446-448, 1993.

Bassiri H, Markmann JF, Desai NM, Kim JI, Teh HS, Barker CF.: Allograft rejection by T cell receptor transgenic mice. The Journal of Surgical Research 54(5): 437-44, May 1993.

Markmann JF, Odorico JS, Bassiri H, Desai N, Kim JI, Barker CF.: Deletion of donor-reactive T lymphocytes in adult mice after intrathymic inoculation with lymphoid cells. Transplantation 55(4): 871-6; discussion 876-7, Apr 1993.

Desai NM, Bassiri H, Kim JI, Koller BH, Smithies O, Barker CF, Naji A, Markmann JF.: Islet allograft, islet xenograft, and skin allograft survival in CD8+ T lymphocyte-deficient mice. Transplantation 55(4): 718-22, Apr 1993.

Markmann JF, Bassiri H, Desai NM, Kim JI, Odorico JS, Barker CF.: Donor antigen-specific T-lymphocyte deletion after intrathymic inoculation. Transplantation Proceedings 25(1 Pt 1): 305-6, Feb 1993.

Desai NM, Bassiri H, Odorico JS, Koller BH, Smithies O, Naji A, Barker CF, Markmann JF.: Pancreatic islet allograft and xenograft survival in CD8+ T-lymphocyte-deficient recipients. Transplantation Proceedings 25(1 Pt 2): 961-2, Feb 1993.

1992

Markmann JF, Bassiri H, Desai NM, Odorico JS, Kim JI, Koller BH, Smithies O, Barker CF.: Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. Transplantation 54(6): 1085-9, Dec 1992.

Shachner MS, Markmann JF, Bassiri H, Kim JI, Naji A, Barker CF.: Direct assessment of the role of NK cells in autoimmune diabetes. The Journal of Surgical Research 52(6): 601-4, Jun 1992.

1991

Markmann JF, Posselt AM, Bassiri H, Brayman KL, Woehrle M, Hickey WF, Silvers WK, Barker CF, Naji A.: Major-histocompatibility-complex restricted and nonrestricted autoimmune effector mechanisms in BB rats. Transplantation 52(4): 662-7, Oct 1991.

1989

Markmann JF, Bassiri H, Barker CF, Naji A.: Effect of lymphokine-induced MHC antigen expression on islet allograft survival. Transplantation Proceedings 21(1 Pt 3): 2723-4, Feb 1989.

Abstracts

2019

Khurana P, Ferry GM, Karageorgos S, Vu A, McNerney K, Hogarty MD, and Bassiri H: Investigating the metabolic and functional properties of invariant natural killer T (iNKT) cells in neuroblastoma. Abcam Immunometabolism: Fundamentals to prospective new therapies Jun 2019 Notes: Boston MA.

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Exploring the immunometabolism and anti-tumor properties of invariant natural killer T (iNKT) cells in neuroblastoma  University of Pennsylvania Institute for Immunology Year in Review Symposium Jun 2019 Notes: Philadelphia PA.

McNerney K, Karageorgos S, Khurana P, and Bassiri H: Induction of natural killer T cell-mediated neuroblastoma cytotoxicity with a novel fusion protein. American Society of Hematology and Oncology May 2019 Notes: New Orleans LA.

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Harnessing the anti-tumor activity of invariant natural killer T (iNKT) cells for neuroblastoma immunotherapy. American Association of Immunologists May 2019 Notes: San Diego CAAAI Travel award.

Karagerogos S, Ferry G, Vu A, Khurana P, Hogarty MD, and Bassiri H: Using preclinical modeling to understand the mechanisms by which antibody therapy alters immunity against high risk neuroblastoma and effects prolongation of survival. Pediatric Academic Societies Apr 2019 Notes: Baltimore MD.

McNerney K, Karageorgos S, Khurana P, and Bassiri H: Stimulating iNKT cell-mediated neuroblastoma cytotoxicity in a mouse model. Association for Clinical and Translational Science Mar 2019 Notes: Washington DCTL-1 Blue Ribbon award.

Karagerogos S, Ferry G, Vu A, Khurana P, Hogarty MD, and Bassiri H: Using preclinical modeling to understand the mechanisms by which antibody therapy alters immunity against high risk neuroblastoma and effects prolongation of survival. Eastern Society of Pediatric Research Mar 2019 Notes: Philadelphia PATravel award.

McNerney K, Karageorgos S, Khurana P, and Bassiri H: Activation of invariant natural killer T-cells in the treatment of neuroblastoma in an immunocompetent mouse model. Transplant and Cellular Therapy  Feb 2019 Notes: Houston TX.

2018

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Exploring the immunometabolism and anti-tumor properties of invariant natural killer T (iNKT) cells in neuroblastoma University of Pennsylvania Cell and Molecular Biology Symposium Oct 2018 Notes: Philadelphia PA.

2017

Bassiri H, Vu A, Hogarty MD, Benavides AD: Polyamine blockade alters the neuroblastoma microenvironment to favor control of tumor growth  Journal of Immunology 194: P660 (Abstr), May 2017.

Benavides AD, Vu A, Ferry GM, Hogarty MD, Bassiri H: Modulation of the neuroblastoma microenvironment via polyamineblockade. Proceedings of the American Association for Cancer Research 58: 417-418, Apr 2017.

Books

Chapters

2019

Karageorgos SA and Bassiri H: Genetics of primary hemophagocytic lymphohistiocytosis. Cytokine Storm Syndromes. Springer, 2019.

2018

Bassiri H: Anaerobic infections. The 5-Minute Pediatric Consult. Cabana MD (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 8th Edition, Oct 2018 Notes: ISBN 978-1-4511-9102-8.

Bassiri H: Smallpox. The 5-Minute Pediatric Consult. Cabana MD (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 8th Edition, Oct 2018 Notes: ISBN 978-1-4511-9102-8.

Bassiri H: Tetanus. The 5-Minute Pediatric Consult. Cabana MD (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 8th Edition, Oct 2018 Notes: ISBN 978-1-4511-9102-8.

2012

Bassiri H, Wood J: Tetanus. The 5-Minute Pediatric Consult. M. William Schwartz (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 6th Edition: 866-7, 2012 Notes: ISBN 978-1451183382.

Bassiri H, Wood J: Smallpox. The 5-Minute Pediatric Consult. M. William Schwartz  (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 6th Edition: 806-7, 2012 Notes: ISBN 978-1451183382.

Bassiri H: Anaerobic infections. The 5-Minute Pediatric Consult. M. William Schwartz (eds.). Wolters Kluwer, Lippincott William Wilkins (Philadelphia), 6th Edition: 42-3, 2012 Notes: ISBN 978-1451183382.

Posters and Presentations

2019

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Harnessing the anti-tumor activity of invariant natural killer T (iNKT) cells for neuroblastoma immunotherapy Children's Hospital of Philadelphia Research Poster Day and Scientific Symposium May 2019 Notes: Philadelphia PAPoster award.

2018

Khurana P, Ferry GM, Benavides AD, Vu A, Karageorgos S, Hogarty MD, and Bassiri H: Exploring the immunometabolism and anti-tumor properties of invariant natural killer T (iNKT) cells in neuroblastoma. University of Pennsylvania Immunology Graduate Group Retreat Nov 2018 Notes: Lancaster PA, podium presentation.

Karageorgos S, Ferry GM, Khurana P, Vu A, Hogarty MD, and Bassiri H: GD2-directed immunotherapy extends survival in a pre-clinical model of high risk neuroblastoma.  University of Pennsylvania Immunology Graduate Group Retreat Nov 2018 Notes: Lancaster PA, podium presentation.

Karageorgos S, Ferry GM, Benavides AD, Lubin J-B, Khurana P, Vu A, Silverman MA, Planet PJ, Hogarty MD, and Bassiri H: Alteration of neuroblastoma tumor microenvironment by polyamine blockade. University of Pennsylvania Postdoctoral Council Symposium Oct 2018 Notes: Philadelphia PA, podium presentation.

Ferry GM, Benavides AD, Lubin J-B, Khurana P, Vu A, Haber M, Norris MD, Silverman MA, Planet PJ, Hogarty MD, and Bassiri H: Polyamine blockade alters NK cell infiltration in the neuroblastoma tumor microenvironment to augment immunotherapy activity. Advances in Neuroblastoma Research May 2018 Notes: San Francisco CA, podium presentation.

Invited Lectures

2017

Bassiri H. "Modulation of the Neuroblastoma Tumor Microenvironment via Polyamine Blockade", Eastern Society for Pediatric Research, Philadelphia, PA (Oral presentation). Mar, 2017.

Bassiri H. "Fever and Rash Syndromes", "Immune System Primer", "Primary Immunodeficiencies", "Fever of Unknown Origin", American Austrian Foundation Open Medical Institute lecture series. Salzburg, Austria (Invited lecture series). Feb, 2017.

Awards and Honors

2015, Society for Pediatric Research inductee
2014, Young Faculty Investigator finalist, Eastern Society for Pediatric Research
2010, Clinical Immunology Society/Talecris Biotherapeutics Senior Fellow Award
2009-2015, NIH Loan Repayment Award
2009, Clinical Immunology Society/Talecris Biotherapeutics Fellowship Award
2007, Senior Resident Clinician of the Year, Children's Hospital of Philadelphia
2006, Teddy Bedrosian Compassionate Care Award, Children's Hospital of Philadelphia
2002, Mary Ellis Bell Prize, University of Pennsylvania School of Medicine
1993, National Science Foundation Fellowship (honorable mention)
1989 & 1990, Juvenile Diabetes Foundation Student Fellowship Award

Editorial and Academic Positions

Editorial Positions

2016-present, Scandinavian Journal of Immunology, ad hoc reviewer
2016-present, Cellular Immunology, ad hoc reviewer
2015-present, Journal of Cytokine Biology, ad hoc reviewer
2015-present, Journal of Immunology and Serum Biology, associate editor
2015-present, Journal of Molecular Cytotherapy, ad hoc reviewer
2012-present, Journal of the Pediatric Infectious Diseases Society, ad hoc reviewer
2010-present, Pediatric Emergency Care, ad hoc reviewer

Academic and Institutional Committees

2018-present, Dysregulated Immunity Response Team
2018-present, Cancer Grant Proposal Success, Organizer
2017-2019, Sarcoma Research Faculty Search Committee
2015-2019, The Richards Society, Steering Committee Member
2015-present, Bioresponse Steering Committee
2014-present, K08 Grant Review Committee

Leadership and Memberships

Memberships in Professional Organizations

International

2015-present, Society for Pediatric Research
2015-present, Pediatric Academic Societies
 - 2015-present, Abstract reviewer and poster facilitator
2008-present, Clinical Immunology Society
 - 2015-present, Communications Committee

National

2016-present, American Association of Immunologists
2016-present, American Association for Cancer Research
 - 2016-present, TME Subgroup
2013-present, National Institutes of Health
 - 2013-present, SBIR/STTR Study Section Reviewer - Ad hoc
2011-present, American Association of Pediatrics, Fellow
2007-present, Pediatric Infectious Diseases Society
2007-present, Infectious Diseases Society of America