Research News from CHOP

Children’s Hospital of Philadelphia Receives $650,000 Donation to Advance Brain Tumor Research and Discoveries Within the Children’s Brain Tumor Network
The Lilabean Foundation’s support will accelerate pace of translational research, discovery of new treatments for children and young adults with brain tumors.
CHOP Researchers Show Early Developmental Delays Predict Poor Long-term Outcomes in Leigh Syndrome Patients
Study makes the case for Leigh syndrome to be considered a potential diagnosis for infants and children with early developmental delays.
CHOP-led Research Network Assesses Utility of Diagnostic Tools and Treatment Options for Pediatric Fungal Infection
In two separate studies, researchers present data specific to early diagnosis and treatment of candidiasis, a life-threatening fungal infection.
CHOP Study Shows Chemotherapy-Resistant Neuroblastoma Cells Have More Active Inflammatory Sensing and Signaling
CHOP researchers have found that chemo-resistant mesenchymal cells in neuroblastoma might be vulnerable to immunotherapy.
CHOP/Penn Study Shows CAR-T Cells Remain Active a Decade After Infusion
A new study in Nature has documented the longest persistence of CAR T cell therapy to date.
CHOP Researchers Use Deep Learning to Find Genetic Causes of Mental Health Disorders in Frequently Understudied African American Population
The method could eventually lead to more personalized medicine approaches as well as properly diagnose patients with multiple disorders.
CHOP Researchers Define a 3-Tiered Molecular Classification of Pediatric Differentiated Thyroid Cancer, where Fusion Oncogenes Predict the Most Invasive Behavior
CHOP researchers have defined a 3-tiered molecular classification of pediatric differentiated thyroid cancer, where fusion oncogenes predict the most invasive behavior.
CHOP Researchers Develop New Method for Measuring Movement Behavior in Children with Autism
Method measures motor imitation skills, which have been challenging to measure consistently and precisely.

Children’s Hospital of Philadelphia Features Innovative Autism Research at the UAE’s Ministry of Health and Prevention’s Arab Health 2022 Conference
As part of a longstanding partnership with the United Arab Emirates (UAE) Emirates Health Services (EHS), Children’s Hospital of Philadelphia (CHOP)will exhibit leading medical breakthroughs in the EHS booth at the annual Arab Health Exhibition and Congress, which is taking place at the Dubai International Convention and Exhibition Centre this week.
CHOP Researchers Develop New Clinical Diagnostic Test to Identify Genetic Sources of Mitochondrial Disease
New test analyzes mitochondrial DNA to find and quantify certain variations and deletions, providing a useful diagnostic tool that helps guide treatment.