Research News from CHOP

Using Social Cues to Adjust Conversational Behavior May Be Challenging for Autistic Children and Teens
Learning to adjust talkativeness could be an important growth opportunity for verbally fluent people with autism.
CHOP Researchers Refine Experimental Prodrug Treatment of High-Risk Neuroblastoma
CHOP researchers have shown that linking a tumor-killing prodrug to a macromolecular carrier of the Poloxamer family improves retention of the drug in treatment-resistant neuroblastoma tumors.
CHOP-Led Study Finds Bortezomib Improves Survival in Children with Newly Diagnosed T-Cell Lymphoblastic Lymphoma
In a COG trial, CHOP researchers found adding bortezomib to chemotherapy significantly improved overall survival in children and young adults with newly diagnosed T-cell lymphoblastic lymphoma (T-LL).
CHOP Study Suggests New Method for Measuring Quality of Life in Children with Severe Epilepsies
Measuring days children are minimally impacted by seizures could help researchers determine effectiveness of precision medicine clinical trials.
Medical Care and Recovery Differ for Patients Suffering from Concussions Related to Assaults
Study is first to show important disparities between concussions sustained from assaults compared with sports-related injuries.
Children’s Hospital of Philadelphia Receives $650,000 Donation to Advance Brain Tumor Research and Discoveries Within the Children’s Brain Tumor Network
The Lilabean Foundation’s support will accelerate pace of translational research, discovery of new treatments for children and young adults with brain tumors.
CHOP Researchers Show Early Developmental Delays Predict Poor Long-term Outcomes in Leigh Syndrome Patients
Study makes the case for Leigh syndrome to be considered a potential diagnosis for infants and children with early developmental delays.
CHOP-led Research Network Assesses Utility of Diagnostic Tools and Treatment Options for Pediatric Fungal Infection
In two separate studies, researchers present data specific to early diagnosis and treatment of candidiasis, a life-threatening fungal infection.
CHOP Study Shows Chemotherapy-Resistant Neuroblastoma Cells Have More Active Inflammatory Sensing and Signaling
CHOP researchers have found that chemo-resistant mesenchymal cells in neuroblastoma might be vulnerable to immunotherapy.
CHOP/Penn Study Shows CAR-T Cells Remain Active a Decade After Infusion
A new study in Nature has documented the longest persistence of CAR T cell therapy to date.