Research News from CHOP

MIS-C Patients Have Deeply Dysregulated Protein Profiles, According to New CHOP Research
CHOP researchers found that levels of proteins in the plasma of patients with MIS-C are significantly dysregulated and share features with two other inflammatory syndromes.
Researchers Point to Need for Implementation Science in Pediatric Oncology
CHOP researchers have found that implementation science is underused in pediatric oncology and call for more research in this area to improve patient care.
Study Shows Climate Change Will Lead to Increase in Kidney Stones
CHOP researchers found rising temperatures due to climate change will lead to an increase in cases of kidney stones over the next seven decades.

CHOP Study Finds Infants with Low-Risk Deliveries Should Not Need Antibiotics at Birth
CHOP researchers have found infants born via uncomplicated cesarean delivery should not need antibiotics at birth to prevent early-onset sepsis.
CHOP Study Finds Poverty Affects Risk of Cleft Lip and Cleft Palate
CHOP researchers have found that indicators of lower socioeconomic status are associated with an increased risk of cleft lip with or without cleft palate.
Aberrant Splicing of CD22 in Acute Lymphoblastic Leukemia Underlies Resistance to Immunotherapy
Aberrant splicing leads to downregulation of CD22 in pediatric B-ALL, rendering malignant cells resistant to the effects of CD22-directed immunotherapies.
New Study Seeks to Preserve Kidney Function in Children with CKD
CHOP's Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE) study was recently awarded funding from the Patient-Centered Outcomes Research Institute (PCORI). PRESERVE is a three-year, multi-institutional clinical trial evaluating blood pressure management and urine protein monitoring strategies to preserve kidney function in pediatric chronic kidney disease (CKD) patients.
CHOP Researchers Find Possible Increased Tumor Risk in Some Patients with Beckwith-Wiedemann Spectrum
Researchers have unlocked patterns to improve the diagnosis of the most common epigenetic childhood cancer disorder.
CHOP Researchers Publish Most Comprehensive Clinical Description of WAGR Syndrome to Date
New research has identified several new clinical considerations and provides guidance for proper diagnosis and management of very rare disease.
CHOP Research Examines the History of Head Injuries in Classic Nursery Rhymes
From Humpty Dumpty to Jack and Jill, many classic fictional characters sustain their fair share of serious head injuries.