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Insights from the Gut Cell Atlas Convening 2024
The 2024 Gut Cell Atlas (GCA) Convening highlighted the most recent research advances into understanding the biology of Crohn’s disease. Drs. Kate Hamilton and Tatiana Karakasheva represent the Children’s Hospital of Philadelphia Research Institute in this initiative, which aims to build a detailed catalog the cell types composing human small and large intestines, further our understanding of Crohn's disease, and identify pathways towards curative therapy and ultimately, prevention.
2024 Research Annual Report, Did You Know: With Kathryn Hamilton, PhD, and Amanda Muir, MD
Doctors Amanda Muir and Kate Hamilton share a common interest in using patient-derived organoids to study pediatric gastrointestinal (GI) diseases. In 2019, they established the Gastrointestinal Epithelium Modeling Program, a collaborative effort dedicated to accelerating discovery and innovation in the search for cures and prevention strategies for these diseases.
Q&A with Dr. Cassandra Ligh
Meet pediatric plastic surgeon Cassandra Ligh, MD, FACS, the new Director of CHOP’s Pediatric and Adolescent Breast and Chest Program.
CHOP Researchers Use Lab-Grown “Mini-Intestines” to Study Inner Lining of Gastrointestinal Tract for Crohn’s Disease Patients
Researchers from Children’s Hospital of Philadelphia (CHOP) confirmed that “mini-intestines” generated from patient tissue samples and grown in a lab can accurately replicate certain features of Crohn’s disease, which will allow them to study the epithelium, the thin layer of cells lining the intestine, that is broken down in patients with inflammatory bowel disease.
Growing Mini-Organs for Personalized GI Solutions
Researchers from CHOP and Penn are working to perfect 3D models of GI disease and create more personalized treatments for patients.
CHOP Intern Earns Two First-Place Awards for Research
In a new partnership between the Office of Academic Training and Outreach Programs with Central High School of the School District of Philadelphia, three students selected by their teachers conducted research at Children’s Hospital of Philadelphia Research Institute.
Faculty Spotlight: Meet Our 2022 Excellence in Mentoring Award Winners
Alongside conducting critical research, many faculty members at Children’s Hospital of Philadelphia play dual roles as mentors to postdocs and fellows in their labs, imparting scientific knowledge about their respective fields, sharing career guidance, and creating an environment conducive to building the next generation of successful scientists.
Three More Recognized as ‘Emerging Innovators’ at CHOP Research Institute
The Emerging Innovators Collaborative Research program is organized by the Office of Academic Training and Outreach Programs (ATOP). The programs recognize exceptional non-faculty researchers-in-training and research staff who contributed to a collaborative project, producing high-impact research.
Getting Unstuck
Personalized therapeutic approaches for children with eosinophilic esophagitis are gaining ground at CHOP.
Mini Guts
Bench-to-bedside research supports GI innovation at CHOP.