Denise Gruccio, DNP, CRNP

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Denise Gruccio, DNP, CRNP, is a nurse practitioner in the Division of Endocrinology and Diabetes, the Turner Syndrome Program, and the Growth Center at Children's Hospital of Philadelphia.

Areas of Expertise: Disorders of growth and puberty in children, Endocrine disorders in pediatric cancer survivors, Turner syndrome
Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


Denise is a Nurse Practitioner in the Diagnostic and Research Growth Center and Turner Syndrome Program in the Division of Endocrinology at Children’s Hospital of Philadelphia. Denise’s area of clinical practice includes the care of children and adolescents with growth disorders with a particular focus on endocrine disorders in childhood cancer survivors and the care of patients with Turner syndrome. Denise has published extensively on growth disorders in pediatrics including journal articles, book chapters and manuscripts. She is an invited speaker on the topic of growth disorders on the regional and national level. Denise is the 2010 recipient of the Caroline Langstader Advanced Practice Award for Excellence in Clinical Practice.

Education and Training

Board Certification

Pediatric Primary Care Nurse Practitioner (PPCNP-BC)
Basic Life Support (BLS)
Certified Pediatric Nurse Practitioner - Primary Care (CPNP-PC)

Graduate Degree

DNP - Villanova University, Villanova, PA
MSN - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Nurse Practitioner

Departments and Services

Research Interests

Growth disorders
Turner syndrome
Endocrine disorders in childhood cancer survivors




Gruccio D, Bamba V. Turner syndrome: Care of the Patient form Birth to Late Adolescence. Pediatr Endocrinol Rev. 2017 Jun;14(Suppl 2):454-461.


Mostoufi-Moab S, Isaacoff EJ, Spiegel D, Gruccio D, Ginsberg JP, Hobbie W, Shults J, Leonard MB.  Childhood cancer survivors exposed to total body irradiation are at significant risk for slipped capital femoral epiphysis during recombinant growth hormone therapy. Pediatr Blood Cancer. 2013 Nov;60(11):1766-71. doi: 10.1002/pbc.24667. Epub 2013 Jul 2.

Stanescu, D, Gruccio, D. 50 Years Ago in The Journal of Pediatrics: The XO Syndrome: A Study of the Different Phenotype in 25 Patients. Journal of Pediatrics  1044, 2013.


Hobbie Wendy L, Moab Sogol Mostoufi-, Carlson Claire A, Gruccio Denise, Ginsberg Jill P. Prevalence of advanced bone age in a cohort of patients who received cis-retinoic acid for high-risk neuroblastoma.. Pediatr Blood Cancer. 56(3): 474-6, 2011.


Lipman, T PhD, CRNP,FAAN, Gruccio, D MSN, CRNP. Pediatric Growth Monitoring. Advance For Nurses  25: 21-23, 2005.


Gruccio, D MSN, CRNP, Steinkrauss, L MSN, CRNP.Challenges of Decision Making for Families of Children with Single or Multiple Chronic Conditions. Nurse Practitioner Forum 11: 15-19, 2000.


Wang E, Drummond DS, Dormans JP, Moshang T, Gruccio D. Scoliosis in patients treated with growth hormone. J Ped Orthopedics  17: 708-711, 1997.


Alter C, Thornton P, Willi S, Levitt-Katz L, Gruccio D, Moshang T Jr. Growth following bone marrow transplantation in acute myelogenous leukemia as compared to acute lymphoblastic leukemia. Ped Endo Metab  9:51-57, 1996.

Satin-Smith M, Levitt-Katz L, Thornton P, Gruccio D, Moshang T Jr. Arm span measurements evaluating response to growth hormone therapy in children with meningomyelocoel and growth hormone deficiency. J Clin Endocrinol Metab 81:1654-1656, 1996.


Moshang T Jr., Gruccio D, Camargo A and Goldwein J. Long term growth response to growth hormone treatment (GH) in growth hormone deficient medulloblastoma (PNET) survivors Ped Res.33 (Supp): 50,1993.

Olshan JS, Willi, SM, Gruccio D and Moshang T Jr. Growth hormone function and treatment following bone marrow transplant for neuroblastoma. Bone Marrow Transplantation 12: 381-385, 1993.


Thornton P, Alter C, Olshan J, Gruccio D and Moshang T Jr. Diagnosis of partial ACTH deficiency using IRMA ACTH in conjunction with the short metyrapone test. Pediatric Research; 31, 1992.


Moshang T Jr., Gruccio D, Alter C, Thornton P. Non- classical 3 beta-hydroxysteriod dehydrogenase (HSD) deficiency in male child. Pediatric Research. 29: 82A, 1991.




Gruccio, D. Late to Diagnosis: Turner Syndrome. Children’s Doctor: The Children’s Hospital of Philadelphia. Spring, 2013.


Gruccio, D. The Child with Normal Variant Short Stature: When Treatment is not indicated. Evolving Paradigms in the Clinical Diagnosis and Treatments of Short Stature. August, 2009.


Gruccio, D. Working with Families of Children with Short Stature. Evolving Paradigms in the Clinical Diagnosis and Treatment of Short Stature. August, 2008.


Gruccio D. Endocrine Overview: Short stature, Delayed Puberty and Precocious Puberty. In Fox; Primary Care of Children. St. Louis, Missouri: Mosby, 1996.

Posters and Presentations


Gruccio D. Development and Implementation of a Clinical Practice Guideline for Feminization in Girls with Turner Syndrome, Eastern Nursing Research Symposium, Philadelphia, PA. May, 2017.

Invited Lectures

Gruccio D. Development and Implementation of a Clinical Practice Guideline for Feminization in Girls with Turner Syndrome, Pediatric Endocrine Nursing Society, Minneapolis, MN. April, 2017.

Awards and Honors

2010, Caroline Langstader Advanced Practice Award for Excellence in Clinical Practice

Editorial and Academic Positions

Academic and Institutional Committees

2012-present, Safety/Quality Improvement Committee, Department of Endocrinology and Diabetes

Leadership and Memberships

Memberships in Professional Organizations

National Association of Pediatric Nurse Associates and Practitioners
Pediatric Endocrinology Nursing Society
Sigma Theta Tau- Mu Chi Chapter