Fetal complications in twin pregnancies are challenging to diagnose, can threaten the survival of one or both twins, and often result in secondary complications that put pregnancies at risk for early delivery. Successful diagnosis and treatment require an experienced multidisciplinary team that employs cutting-edge diagnostic techniques, advanced surgical skill and a comprehensive approach to care.
Complicated twin pregnancies: referrals & interventions
The multidisciplinary team at the Center for Fetal Diagnosis and Treatment at The Children’s Hospital of Philadelphia has more than 20 years of experience managing twin and triplet pregnancies — among the greatest collective experience in the world. The team evaluates more than 200 multiple gestation pregnancies a year using state-of-the-art imaging technology, including high-resolution ultrasound and detailed fetal echocardiography. On occasion, fetal MRI — a technique pioneered at CHOP in the 1990s — may be used.
Complications in twin pregnancies can include twin-twin transfusion syndrome (TTTS), selective (only one twin involved) severe placental insufficiency and growth restriction, in utero demise of one twin, one twin with a birth defect or genetic abnormality, twin reversed arterial perfusion (TRAP) sequence, both twins within one amniotic sac (monoamniotic) with entanglement of their umbilical cords, and conjoined twins.
Specialists at the Center will partner with you to provide a seamless continuum of care, discussing the diagnosis and treatment options, offering suggestions for follow-up if fetal surgery is required, and remaining available for consultation for the remainder of the pregnancy as part of the patient's ongoing prenatal management team.
A quick look at our patient volumes prove the Center is a nationally recognized resource for evaluation and treatment of complicated twin pregnancies — specifically those affected by twin-twin transfusion syndrome.
Find more information about our experience and outcomes treating complicated monochorionic twin pregnancies »
Resources for professionals
To better partner with you, the Center has created a number of professional-focused resources about TTTS (and other complicated twin pregnancies), as well as information you can share with your patients.
Twin-Twin Transfusion Syndrome: Making the Right Connections
This flipchart for healthcare professionals provides an overview of TTTS incidence, diagnosis, physiology and treatment options. Contact us to request a copy of this resource.
The CHOP cardiac scoring system
CHOP’s unique cardiovascular scoring system, created in collaboration with the Fetal Heart Program, measures the existence and progression of adaptive cardiovascular changes, a common complication in twin anomalies, resulting in more informed treatment decisions for TTTS. When laser therapy is indicated, the team studies the patient's cardiac function scores before treatment, 24 hours after the procedure and at the patient's one-week follow-up appointment to determine the response to the intervention.
Referral Guidelines for Stage 1 Twin-Twin Transfusion Syndrome Trial
The Children’s Hospital of Philadelphia is participating in a randomized controlled trial comparing conservative management and selective laser photocoagulation (SLPC) surgery in stage 1 TTTS. SLPC will be offered within 72 hours if a patient is randomized into the laser group. Find detailed referral guidelines for physicians.
In Utero Insights Newsletter
The twin-twin transfusion syndrome edition of In Utero Insights, the Center's newsletter to healthcare professionals, includes information on how the Center supports families with TTTS from evaluation through follow up, sonography of complicated monochorionic twin pregnancies, research updates and more.
The following case studies examine the implications and outcomes of specific diagnoses in complicated monochorionic pregnancies:
Resources you can share with patients
The Center has detailed diagnosis-specific information about TTTS, sIUGR, and TRAP written for families.
Lives in the Balance: Understanding Twin-Twin Transfusion Syndrome, an educational DVD created by the Center for clinicians and patient families, provides updated information on treatment protocols and the exclusive CHOP Cardiac Scoring System.
To request a copy, call 1-800-IN-UTERO (1-800-468-8376) or complete our online contact form.
Recent publications on CHOP's twin experiences
Our team members have written extensively about the management of pregnancies with complicated multiples. Find a full list of publications about complex twin pregnancies authored by our team.