Why Choose CHOP for HI Treatment

Vast experience

The Congenital Hyperinsulinism Center was established in 1998, the first of its kind in the United States. We have treated more than 1,600 children with congenital HI, and performed more than 600 pancreatectomies — making our Center the largest and most active HI Center in the world. The HI center was recently named a Center of Excellence by Congenital Hyperinsulinism International.

Unparalleled expertise

Our experience, combined with unique expertise in areas such as gene research, surgery and innovative treatment strategies, puts us at the forefront of clinical care for congenital hyperinsulinism.

Pioneering treatments

Our specialists are pioneers in the diagnosis and treatment of congenital HI, offering groundbreaking approaches that have set the standards for care worldwide.

Great outcomes

Our cure rate for focal hyperinsulinism is 95%; about 50% of children who require a pancreatectomy for HI are diagnosed with focal HI. 

Diffuse Patients

Outcomes data from 2004 to June 2023

Total cases: 174

Medical therapy for persistent hypoglycemia: 91
Euglycemic: 30
Insulin therapy for hyperglycemia: 53



Focal Patients

Outcomes data from 2004 to June 2023

Total cases: 236

Cured/no meds: 234
Not cured: 7



Focal vs. Diffuse Patients

Outcomes data from 2004 to June 2023

Total cases: 410

Focal: 236
Diffuse: 174



Multidisciplinary team

Our multidisciplinary team of experts includes pediatric endocrinologists, surgeons, radiologists, pathologists, anesthesiologists, psychologists, geneticists, nurses, social workers, researchers, genetics counselors, speech and feeding therapists, and dieticians — all working together to provide specialized, patient-centered and seamless care for children with congenital HI and their families.

Groundbreaking research

Since 2004, and under an FDA protocol, we have been performing the 18F-DOPA PET scan to identify focal HI lesions for the surgeons to remove. We have performed more than 430 18F-DOPA PET scans, by far the most of any institution in the world. This is only part of the innovative research being performed here at CHOP.

Compassionate, family-centered care

Each and every patient and family we care for is unique, and we aim to tailor our care for each child. We encourage parents to actively participate in their child’s treatment and the decision-making process.


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Your Child's HI Appointment

Your first visit will be either an outpatient or inpatient visit, depending on your child’s needs.