The purpose of this study is to compare the genes of African American children and adults who have inflammatory bowel disease (IBD) with the genes of those who do not have IBD. Genes are pieces of hereditary material found in human cells. How an individual’s genes cause intestinal inflammation in IBD is still being tested and not much is known about the association between genes and IBD in individuals with African ancestry. We hope to understand which genes cause IBD and if certain genes can help doctors personalize treatment for patients with IBD. For more information please contact IBDResearch@email.chop.edu. IRB 11-008363
Center for Pediatric Inflammatory Bowel Disease Clinical Studies
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The purpose of this research study is to collect different types of samples (such as stool, swabs, urine) to form a biorepository. This repository will provide valuable samples from people with and without IBD so that investigators can learn more about the cause of IBD, and different therapies that could be used to treat it. These samples will be used for future gastrointestinal research. Because technology and scientific understanding may advance quickly, it is not yet known what specific studies the samples may be used for. IRB 11-008158
The purpose of this research study is to identify genes that are involved in the development of Inflammatory Bowel Disease (IBD) at a young age (less than 8 years of age). This is a case-control study of IBD patients which compares children with symptoms and/or diagnosis of IBD at <8 years of age with those not diagnosed until ≥8 years of age, as well as with family members, and other children without a diagnosis of IBD. Samples are collected for testing, such as blood, stool, oral or rectal swabs, and/or tissue samples. IRB 14-010826
The purpose of this study is to characterize the microbiome in children with Crohn’s disease who have perianal fistula and to compare it to other children with Crohn’s disease who do not have perianal disease. Studying the role of the microbiome in perianal fistula may help us to develop new therapies. IRB 17-014618
This study aims to prospectively explore the real life short and longer term outcomes of Vedolizumab in pediatric inflammatory bowel disease and to develop a prediction model for treatment success based on Vedolizumab trough levels and other clinical and laboratory markers. Children under 18 years of age that have been diagnosed with IBD and their physician is starting treatment with Vedolizumab may be eligible.