Epilepsy Neurogenetics Initiative (ENGIN) News

Our ENGIN clinic has one of the largest epilepsy neurogenetics teams in the world. Our team of experts includes pediatric neurologists, genetic counselors, and physical and occupational therapists.

Nov 28, 2023

This major step allows for the creation of clinical trials to test key endpoints that will determine the efficacy of new therapies.

CHOP Researchers Show Epilepsy and Autism Symptoms in Dravet Syndrome May Be Caused by Separate Mechanisms

Aug 22, 2023

Dravet syndrome is a severe neurodevelopmental disorder defined by treatment-resistant epilepsy and features related to autism spectrum disorder.

CHOP Researchers Use Novel Technique to Analyze 53 Million Points of Clinical Data

Apr 6, 2023

Findings demonstrate how a new computational method could effectively analyze phenotypes and identify similarities among patient populations.

CHOP Researchers Identify Underreported Symptoms in Patients with Common Form of Genetic Epilepsy

Feb 9, 2023

STXBP1-related disorders include gastrointestional and respiratory symptoms in certain patients, according to extensive interviews with caregivers.

$25 Million Gift to Penn Medicine and Children’s Hospital of Philadelphia Establishes Center for Epilepsy and Neurodevelopmental Disorders

Feb 7, 2023

A $25 million gift from an anonymous donor to Penn Medicine and Children’s Hospital of Philadelphia (CHOP) will establish the Center for Epilepsy and Neurodevelopmental Disorders (ENDD), accelerating collaborative research in genetic therapies for neurodevelopmental disorders.

CHOP Researchers Discover Genetic Variant Associated with Earlier Onset Childhood Epilepsy

Nov 29, 2022

Patients with the identified variant may respond favorably to targeted treatment with a readily available anti-seizure medication.

CHOP Study Explores the Use of Telemedicine in Child Neurology in Largest Study to Date

Sep 15, 2022

Certain patients were more likely to use telemedicine even with the reopening of in-person appointments, while barriers to telemedicine remained for some families.

In New Age of Telemedicine, CHOP Researchers Identify Child Neurology Patients Who Still Require In-Person Visits

May 13, 2022

While telemedicine appeared to be effective in 95% of cases, some younger patients and those with neuromuscular disorders still required in-person visits.

Finding Answers Through Collaboration

Apr 28, 2022

Unique endocrinology-neurology collaboration seeks to understand the variation in seizure activity in patients with hyperinsulinism/hyperammonemia.

Finding Answers Through Collaboration

Apr 28, 2022

Unique endocrinology-neurology collaboration seeks to understand the variation in seizure activity in patients with hyperinsulinism/hyperammonemia.

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Epilepsy Neurogenetics Initiative (ENGIN) News

CHOP Researchers Define Seizure Burden, Developmental Outcomes for STXBP1-Related Disorders

CHOP Researchers Show Epilepsy and Autism Symptoms in Dravet Syndrome May Be Caused by Separate Mechanisms

CHOP Researchers Use Novel Technique to Analyze 53 Million Points of Clinical Data

CHOP Researchers Identify Underreported Symptoms in Patients with Common Form of Genetic Epilepsy

$25 Million Gift to Penn Medicine and Children’s Hospital of Philadelphia Establishes Center for Epilepsy and Neurodevelopmental Disorders

CHOP Researchers Discover Genetic Variant Associated with Earlier Onset Childhood Epilepsy

CHOP Study Explores the Use of Telemedicine in Child Neurology in Largest Study to Date

In New Age of Telemedicine, CHOP Researchers Identify Child Neurology Patients Who Still Require In-Person Visits

Finding Answers Through Collaboration

Finding Answers Through Collaboration