Epilepsy Neurogenetics Initiative (ENGIN) News

Our ENGIN clinic has one of the largest epilepsy neurogenetics teams in the world. Our team of experts includes pediatric neurologists, genetic counselors, and physical and occupational therapists.

Mar 29, 2022

Recovery of normal signaling of a key brain cell may be a critical therapeutic target to reduce seizures and cognitive impairment.

CHOP Study Suggests New Method for Measuring Quality of Life in Children with Severe Epilepsies

Mar 3, 2022

Measuring days children are minimally impacted by seizures could help researchers determine effectiveness of precision medicine clinical trials.

CHOP Researchers Use Big Data to Assess Seizure Burden and Improve Outcomes in Pediatric Epilepsy Patients

Jun 3, 2021

CHOP is the only center to capture standardized clinical data from ongoing patient care.

Researchers Discover New Genetic Variants Responsible for Neurodevelopmental Disorders

May 14, 2021

A dozen patients have clinical features linked to the genetic variants, and preclinical models reveal more about how they affect normal function.

Applying New Framework Improves Big Data Analysis for Pediatric and Adult Epilepsies

May 5, 2021

When applying new terminology to existing data through computational methods, researchers increased the number of descriptive terms five-fold, improving diagnostic capabilities.

Genetic Causes of Severe Childhood Brain Disorders Found Using New Computational Methods

Aug 26, 2020

By standardizing how clinical information is analyzed, researchers found 11 causative genes associated with specific symptoms.

Researchers Combine Genetic Information with Electronic Medical Records to Pinpoint When Epilepsies Affect Children

Aug 11, 2020

Assessing clinical data across the lifespan identified the impact of genetic epilepsies on affected children’s lives.

Telemedicine Proven Effective Means of Monitoring Patients in Large Pediatric Neurology Network

Jun 9, 2020

Findings demonstrate that telemedicine will likely have an important role in clinical care that lasts far beyond the current pandemic that facilitated its necessity.

Researchers from ENGIN at CHOP Show How Variants in RNA Editing Can Cause Epilepsy

Mar 23, 2020

RNA editing is critical in brain development, and pinpointing this variant may lead to precision medicine developments for epilepsy in certain patients.

Revolutionizing Epilepsy Care

Nov 7, 2019

When Ryan was 5 months old, he went stiff in his mother’s arms, stopped breathing and turned blue. His parents, Jennifer and Derek, were petrified. Ryan was diagnosed with epilepsy, a condition that causes seizures.

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