Immunology Program

Questions About the COVID-19 Vaccines for Immunology Patients

Providers from the Division of Allergy and Immunology answer questions about the COVID-19 vaccine for people with immunodeficiencies.

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The Immunology Program at Children's Hospital of Philadelphia (CHOP) provides sensitive, patient-centered care to children and young adults with immune deficiencies. Our team works closely with your whole family to provide education about immune deficiencies, as well as comprehensive immunology therapies.

We also help connect you with other families facing similar medical challenges, so you can learn from others who understand your experiences.

The Immunology Program is part of CHOP's Division of Allergy and Immunology.

Diagnostic services

Primary immune deficiency disease can present in many ways including recurrent infections, unusual infections and autoimmune diseases. Our expert staff is world renowned in the diagnosis of these diseases. Our Clinical Immunology Laboratory provides advanced diagnostic tools, which are critical to finding an accurate diagnosis for your child and beginning a treatment plan that will improve her quality of life.

Particular areas of clinical emphasis include:

Comprehensive immunology therapy

Each of the nearly 500 primary immunodeficiency disorders has a specific therapy. We offer the most up-to-date therapies for our patients and emphasize approaches that are sensitive to lifestyle.

Our Transition Clinic supports young adults as they become more independent and their medical needs change. We emphasize management of immunodeficiencies as a way of life rather than an illness that restricts opportunities.

We have a close partnership with the bone marrow transplant and cellular therapy program. In our joint clinic we work collaboratively to support patients and closely monitor immune system recovery from hematopoietic stem cell transplant for primary immunodeficiency and well beyond the immediate post transplant period.


The Immunology Service participates in longitudinal registries of patients with immune deficiencies that aim to define optimal treatments of these diseases. These studies include USIDNET, CIBMTR and PIDTC. We are also a Jeffrey Modell Center for the study of primary immunodeficiencies.  Ongoing research efforts are focused on:

  • Autoimmunity caused by genetic conditions
  • Chromosome 22q11.2 deletion syndrome
  • Common variable immune deficiency
  • Cornelia de Lange syndrome
  • Lack of a thymus
  • Severe allergy as a feature of immunodeficiency
  • The genetic basis of inborn errors of immunity
  • Scid
  • CgD
  • Immune Regulatory disorders
  • Outcomes after HSCT for PID
  • Immune System Abnormalities associated with post Fontan Physiology

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