CHOP’s 2025 Chronic Lung Disease Conference brought together global experts in BPD care for record-breaking attendance, research and collaboration.

It’s an exciting time for research in the bronchopulmonary dysplasia (BPD) population here at Children’s Hospital of Philadelphia (CHOP). 

In this article, we review a case of a preterm infant with severe bronchopulmonary dysplasia (BPD), a history of S. aureus pneumonia, and subsequent large pneumatocele, managed with a less typical treatment modality.

Researchers found daycare attendance was associated with increased emergency department visits, steroid use, and chronic respiratory symptoms in preterm children with chronic lung disease.

Investigators in our Chronic Lung Disease Program have developed a treatment-based classification of BPD disease severity that helps us improve longer-term outcomes.

On March 9 and 10, 2021, more than 400 medical professionals tuned in via a virtual platform for the Seventh Annual Children’s Hospital of Philadelphia (CHOP) Chronic Lung Disease Conference.

CHOP researchers have found mice exposed to neonatal hyperoxia have increased influenza susceptibility and disrupted lung circadian clocks.

One of the first of its kind in the world, the CHOP Neonatology chronic lung disease program was designed to be a clinical and research home for infants with BPD receiving neonatal intensive care throughout the surrounding region and nation at large.

A patient was able to be weaned off mechanical ventilation for the first time of his life just 16 days after a lobectomy at Children's Hospital of Philadelphia.

This case study illustrates how infants with severe chronic lung disease can make great improvements with multidisciplinary, individualized care.