Apert Syndrome

What is Apert Syndrome?

Apert syndrome, also called acrocephalosyndactyly, is a genetic syndrome characterized by anomalies of the skull, face and limbs. Gene mutations are responsible for causing the early fusion of the skull, hand and feet bones.

Individuals with Apert syndrome typically have the following conditions:

  • Craniosynostosis: early closure of one or more of the seams between the skull bones causing an abnormal skull. This results in a skull shape with increased vertical height.
  • Midface hypoplasia: decreased growth of the midface. This causes a crescent moon or sunken facial appearance with depressed nasal bridge and beak nose. Decreased growth of the central face can contribute obstructive sleep apnea and airway concerns.
  • Syndactyly: fusion of the fingers and toes. The hand can resemble a spade, mitten or rosebud.

Other common characteristics include large elongated forehead, shallow eye sockets causing prominent eyes, narrow palate with or without a cleft, fused bones in the arms, elbows and hips, and hearing loss. The characteristic feature that distinguishes Apert syndrome from other types of syndromic craniosynostosis is the presence of hand anomalies, most commonly fused or webbed fingers (syndactyly).

aperts 6 month old

6-month-old male with Apert syndrome. Note tall shape and characteristic flatness of the back of the head. Eyes that appear wide set and have a bulging appearance are also a characteristic of this syndrome.

 

Type I ("spade")

Type II ("mitten")

Type III ("rosebud")

First

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Simple syndactyly

Simple syndactyly

Complex syndactyly

Middle three fingers

Side-to-side fusion with flat palm

Fusion of fingertips forming a concave palm

Tight fusion of all digits with one conjoined nail

Fourth webspace

Simple and incomplete syndactyly

Simple and complete syndactyly

Simple and complete syndactyly

aperts 6 month old

Complex syndactyly, when fingers are webbed together, benefit from specialty surgical care to release and result in the greatest degree of function that can be achieved.

Apert syndrome complications and treatment

Patients with Apert syndrome can have related health and developmental issues, reinforcing the need for coordinated, multidisciplinary care and access to a variety of pediatric subspecialists.

At CHOP we have a comprehensive Craniofacial Program where patients are seen by the following specialties:

  • Plastic surgeons: craniofacial and hand surgeons
  • Oral surgeons
  • Neurosurgeons
  • Otolaryngologists (ear, nose and throat specialists)
  • Pediatric dentists
  • Craniofacial-trained orthodontists
  • Geneticists
  • Speech and language pathologist
  • Audiologist
  • Psychologists
  • Advanced Practice Providers – NPs and PAs
  • Nurses
  • Pulmonary Medicine
aperts 6 month old

4-month-old female with Apert syndrome. Note the retruded brow and flattened forehead as well as sunken appearance of the face from the middle of the eyes to the upper jaw.

The treatment of Apert syndrome is dependent upon both functional and appearance-related needs, and should be addressed immediately after your child is born. Because of the complex issues that can be associated with Apert syndrome, your child should be treated at a medical center where she will have access to pediatric specialists across the many clinical areas she may need.

At Children’s Hospital of Philadelphia, coordinated care of patients with Apert syndrome is typically managed through the Craniofacial Program. At CHOP, our experienced Craniofacial Surgeons will help guide your child through craniosynostosis repair and other surgeries to address symptoms related to airway, dental/jaw relationships and craniofacial relations.  Referral to a specialized hand surgeon with expertise in treating and repairing hand deformities is an important element of care for children with Apert syndrome. The Hand and Arm Disorders Program at CHOP is the region’s largest multidisciplinary center treating children with congenital deformities of the hand.

Children with Apert Syndrome benefit from routine psychosocial support to address any behavioral, developmental, academic, emotional or social difficulties associated with their condition, appearance differences, and surgical treatments throughout childhood.

Additionally, our Craniofacial Team maintains close collaboration with Genetics, Ophthalmology, Speech, Otolaryngology (ENT), Audiology and Neurosurgery to help provide comprehensive craniofacial care.  

Families also benefit from specialized programs such as CHOP’s Center for Pediatric Airway Disorders and the Division of Pulmonary Medicine to address breathing issues, as well as the Pediatric Feeding and Swallowing Center to manage feeding issues.

Watch our educational video to learn more about the services and treatment options CHOP offers to children with craniofacial conditions such as Apert syndrome.

Reviewed by Scott P. Bartlett, MD, Jesse A. Taylor, MD

Craniofacial Patient Daniel

Watch: All About Craniofacial Conditions

Learn about the diagnosis and treatment of craniofacial conditions, including craniosynostosis, hemifacial microsomia, and other syndromes.

craniofacial patient playing basketball

Why Choose the Craniofacial Program

CHOP’s Craniofacial Program is one of the Nation’s leading treatment programs for children with both congenital and acquired anomalies of the face and skull.