Scott W. Canna, MD

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Scott W. Canna, MD, is an attending physician in the Division of Rheumatology and the Immune Dysregulation Program at Children's Hospital of Philadelphia. 

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - George Washington University, Washington, DC

Internship

Pediatrics - University of Colorado, Colorado Children’s Hospital,  Denver, CO

Residency

Pediatrics - University of Colorado, Colorado Children’s Hospital,  Denver, CO

Fellowship

Pediatric Rheumatology - University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification

American Board of Pediatrics - Rheumatology

Titles and Academic Titles

Attending Physician

Departments and Services

Publications

Papers

2021

Van Der Kraak LA, Schneider C, Dang V, Burr AHP, Weiss ES, Hand TW, Canna SW. Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNg. Under Revision.

Janda A, Schuetz C, Canna SW, Gorelik M, Heeg M, Minden K, Hinze C, Schulz A, Debatin KM, Hedrich C, Speth F. Therapeutic approaches to pediatric COVID-19: an online survey of pediatric rheumatologists. Rheum International. In Press

Segal JE, Daley JD, Barnum JL, Salgado CM, Reyes-Mugica M, Schneider C, Gumus S, Thakrar D, Allen SW, Canna SW. Systemic and Nodular Hyperinflammation in a Patient with Refractory Familial Hemophagocytic Lymphohistiocytosis 2. Journal of Clin Immunol. 2021. Epub 2/11/21. PMID 33570715.

2020

Abers MS, Delmonte OM, Ricotta EE, Fintzi J, Fink D, de Jesus AA, Zarember KA, Alehashemi S, Oikonomou V, Desai JV, Canna SW, Shakoory B, Dobbs K, Imberti L, Sottini A, Quiros-Roldan E, Castelli F, Rossi C, Brugnoni D, Biondi A, Bettini LR, D'Angio' M, Bonfanti P, Castagnoli R, Montagna D, Licari A, Marseglia GL, Gliniewicz E, Shaw ER, Kahle D, Rastegar AT, Stack MA, Myint-Hpu K, Levinson SL, DiNubile MJ, Chertow DW, Burbelo P, Cohen JI, Calvo KR, Tsang JS, Su HC, Gallin JI, Kuhns DB, Goldbach-Mansky R, Lionakis MS, Notarangelo LD. An immune-based biomarker signature is associated with mortality in COVID-19 patients. JCI Insight. 2020 epub Nov 24. PMID 33232303

Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Ferris A, Kernan KF, Schulert GS, Seo P, F Son MB, Tremoulet AH, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta JJ. American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID-19. Arthritis Rheumatol. 2020 online ahead of print Jul 23, 2020. PMID 32705809.

Canna SW*, Schulert GS*, de Jesus A, Pickering A, Brunner H, Gadina M, Levine S, Goldbach-Mansky R, Boutelle J, Sinha R, DeBenedetti F, Grom A, NextGen 2019 Participants. Proceedings from the 2nd Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019. Version 2. Pediatr Rheumatol Online J. 2020 18(Suppl 1):53. PMID: 32664935

Tsoukas P, Rapp E, Van Der Kraak L, Weiss E, Dang V, Schneider C, Klein E, Picarsic J, Salcedo R, Stewart CA, Canna SW. Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation. Blood. 2020. 136(19):2162-74. PMID 32589707. Featured in:

  • Behrens EM. The Perfect Storm. Blood. 2020 136(19):2096-7. PMID: 33152085

Bin Mohamad S, Chear CT, Nallusamy R, Canna S, Chan KC, Baharin MF, Hishamshah M, Ghani H, Ripen AM. A novel de novo NLRC4 mutation reinforces the likely pathogenicity of specific LRR domain mutation. Clinical Immunology, 2020 211:108328. PMID 31870725.

De Jesus AA, Hou Y, Brooks S, Malle, L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Canna SW, Goldbach-Mansky R. Distinct Interferon Signatures and Cytokine Patterns Define Novel Autoinflammatory Diseases. J Clin Invest. 2020 130(4):1669-82. PMID 31874111.

Lee PY, Schulert GS, Canna SW, Huang Y, Sundel J, Li Y, Hoyt, K, Blaustein R, Do T, Halyabar H, Chang M, Dedeoglu F, Meidan E, Lo M, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic P. Adenosine Deaminase 2 as a biomarker of Macrophage Activation Syndrome. Ann Rheum Dis. 2020 79(2):225-231. PMID 31707357.

Yasin S, Solomon K, Canna SW, Girard-Guyonvarc'h C, Gabay C, Schiffrin E, Sleight A, Grom AA, Schulert GS. IL-18 as therapeutic target in a patient with resistant systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome. Rheumatology (Oxford). 2020 59(2)442-445. PMID: 31359055.

Yasin S, Fall N, Brown RA, Henderlight M, Canna SW, Girard-Guyonvarc'h C, Gabay C, Grom AA, Schulert GS. IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome. Rheumatology (Oxford). 2020 59(2):361-366. PMID: 31326996.

2019

Castillo P, Wanek AG, Kumar P, Chen K, An X, Elsegeiny W, Horne W, Fitch A, Methe BA, Burr A, Gopalakrishna K, Canna S, Hand TW, Kolls JK. Intestinal IL-17R signaling constrains IL-18 driven liver inflammation by the regulation of microbioma-derived products. Cell Reports. 2019 19;29(8). PMID 31747600.

Saper VE, Chen G, Deutsch GH, Guillerman RP, Birgmeier J, Jagadeesh K, Canna S, Schulert G, Deterding R, Xu J, Leung AN, Bouzoubaa L, Abulaban K, Baszis K, Behrens EM, Birmingham J, Casey A, Cidon M, Cron RQ, De A, De Benedetti F, Ferguson I, Fishman MP, Goodman SI, Graham TB, Grom AA, Haines K, Hazen M, Henderson LA, Ho A, Ibarra M, Inman CJ, Jerath R, Khawaja K, Kingsbury DJ, Klein-Gitelman M, Lai K, Lapidus S, Lin C, Lin J, Liptzin DR, Milojevic D, Mombourquette J, Onel K, Ozen S, Perez M, Phillippi K, Prahalad S, Radhakrishna S, Reinhardt A, Riskalla M, Rosenwasser N, Roth J, Schneider R, Schonenberg-Meinema D, Shenoi S, Smith JA, Sonmez HE, Stoll ML, Towe C, Vargas SO, Vehe RK, Young LR, Yang J, Desai T, Balise R, Lu Y, Tian L, Bejerano G, Davis MM, Khatri P, Mellins ED, Childhood A, Rheumatology Research Alliance Registry I. Emergent high fatality lung disease in systemic juvenile arthritis. Ann Rheum Dis. 2019 78(12):1722-1731. PMID: 31562126.

Gernez Y, de Jesus AA, Alsaleem H, Macaubas C, Roy A, Lovell D, Jagadeesh KA, Alehashemi S, Erdman L, Grimley M, Talarico S, Bacchetta R, Lewis DB, Canna SW, Laxer RM, Mellins ED, Goldbach-Mansky R, Weinacht KG. Severe autoinflammation in 4 patients with C-terminal variants in cell division control protein 42 homolog (CDC42) successfully treated with IL-1beta inhibition. The Journal of allergy and clinical immunology. 2019. PMID: 31271789.

2018

Moghaddas F, Zeng P, Zhang Y, Schutzle H, Brenner S, Hofmann SR, Berner R, Zhao Y, Lu B, Chen X, Zhang L, Cheng S, Winkler S, Lehmberg K, Canna SW, Czabotar PE, Wicks IP, De Nardo D, Hedrich CM, Zeng H, Masters SL. Autoinflammatory mutation in NLRC4 reveals an LRR-LRR oligomerization interface. The Journal of allergy and clinical immunology. 2018. PMID: 29778503.

Weiss ES, Girard-Guyonvarc'h C, Holzinger D, de Jesus AA, Tariq Z, Picarsic J, Schiffrin EJ, Foell D, Grom AA, Ammann S, Ehl S, Hoshino T, Goldbach-Mansky R, Gabay C, Canna SW. Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood. 2018;131(13):1442-55. PMID: 29326099; PMCID: PMC5877443. Featured in:

  • Lieben L. Autoinflammatory diseases: Free IL-18 causes macrophage activation syndrome. Nat Rev Rheumatol. 2018; epub. PMID 29386593
  • McClain KL and Allen CE. Fire behind the fury: IL-18 and MAS. Blood. 2018; 131(133)1393-4. PMID 29599143

Aeschlimann FA, Batu ED, Canna SW, Go E, Gul A, Hoffmann P, Leavis HL, Ozen S, Schwartz DM, Stone DL, van Royen-Kerkof A, Kastner DL, Aksentijevich I, Laxer RM. A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease. Ann Rheum Dis. 2018;77(5):728-35. PubMed PMID: 29317407

2017

Moghaddas F, Llamas R, De Nardo D, Martinez-Banaclocha H, Martinez-Garcia JJ, Mesa-Del-Castillo P, Baker PJ, Gargallo V, Mensa-Vilaro A, Canna S, Wicks IP, Pelegrin P, Arostegui JI, Masters SL. A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever. Ann Rheum Dis. 2017;76(12):2085-94. PMID: 28835462; PMCID: PMC5687562.

Canna SW, Shi G, Gery I, Sen HN. Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2017;58(3):1764-5. PMID: 28334374; PMCID: PMC5374878.

Rood JE, Canna SW, Weaver LK, Tobias JW, Behrens EM. IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation. J Leukoc Biol. 2017;101(4):1037-44. PMID: 28034913; PMCID: PMC5346180.

Books

2019

Canna SW. The Intersections of Autoinflammation and Cytokine Storm, chapter in Cytokine Storm Syndromes, Cron RQ and Behrens EM, eds. Springer Publishing 2019.

 Jeru I, Canna SW, Hanson EP. Chapter 29: Other Rare Monogenic Autoinflammatory Disorders. Textbook of Autoinflammation. Eds. R Laxer, P Hashkes, A Simon, eds. Springer 2019.

Awards and Honors

2020, Elected Member of the Henry Kunkel Society

2020, Associazione Italiana Linfoistiocitosi Emofagocitica (AILE) Ricciardi Award

  • Best scientific article of 2018-2019

2019, Elected Member of the Society for Pediatric Research (SPR)

2018, American Society of Clinical Investigation (ASCI) Young Physician-Scientist Award 

2018, American Society of Clinical Investigation (ASCI) Young Physician-Scientist Outstanding Poster Award

Leadership and Memberships

2019-present, International Cytokine and Interferon Society (ICIS)

2019-present, Clinical Immunology Society (CIS)

2020-present, Society for Pediatric Research (SPR)

2020-present, Henry Kunkel Society