Dr. Chiotos is a graduate of the College of William and Mary and the George Washington University School of Medicine, and recently earned a Master’s of Science in Clinical Epidemiology from the University of Pennsylvania. She completed pediatrics residency training at Children’s Hospital of Philadelphia (CHOP), followed by a combined fellowship in pediatric infectious diseases and pediatric critical care medicine.
Dr. Chiotos joined the faculty at the University of Pennsylvania in 2017 and is currently an Assistant Professor of Anesthesia, Critical Care, and Pediatrics with a secondary appointment in pediatric infectious diseases.
Dr. Chiotos’ research focuses on the epidemiology of antibiotic resistant organisms in the pediatric intensive care unit setting as well as antibiotic stewardship in this population. She is involved with several quality improvement initiatives surrounding optimizing antibiotic use and diagnostic evaluation for patients with suspected sepsis at CHOP.
Education and Training
MD - George Washington University School of Medicine, Washington, DC
Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatric Infectious Diseases and Critical Care Medicine - Children's Hospital of Philadelphia, Philadelphia, PA
Research Fellow, Pediatric Hospital Epidemiology and Outcomes Training (PHEOT) Program - Children's Hospital of Philadelphia, PA
Pediatric Infectious Diseases – American Board of PediatricsPediatrics – American Board of Pediatrics
MSCE - Master of Science in Clinical Epidemiology
Titles and Academic Titles
Assistant Professor of Anesthesia and Critical Medicine, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Antibiotic resistant pathogens
Chiotos K, Fitzgerald JC, Hayes M, Dashefsky H, Metjian TA, Woods-Hill C, Biedron L, Stinson H, Ku BC, Tighe SR, Weiss SL, Balamuth F, Schriver E, Gerber JS: Improving Vancomycin Stewardship in Critically Ill Children. American Academy of Pediatrics March 2022 Notes: https://doi.org/10.1542/peds.2021-052165.
Woods-Hill CZ, Xie A, Lin J, Wolfe HA, Plattner AS, Malone S, Chiotos K, Szymczak J: Numbers and narratives: how qualitative methods can strengthen the science of paediatric antimicrobial stewardship. JAC-Antimicrobial Resistance 4(1): dlab195, February 2022 Notes: https://doi.org/10.1093/jacamr/dlab195.
Wolf J, Abzug M, Wattier R, Sue PK, Vora SB, Zachariah P, Dulek DE, Waghmare A, Olivero R, Downes KJ, James SH, Pinninti SG, Yarbrough A, Aldrich ML, MacBrayne CE, Soma VL, Grapentine SP, Oliveira CR, Hayes M, Kimberlin DW, Jones SB, Bio LL, Morton TH, Hankins JS, Maron-Alfaro GM, Timberlake K, Young JL, Orscheln RD, Schwenk HT, Goldman DL, Groves HE, Huskins WC, Rajapakse NS, Lamb GS, Tribble AC, Lloyd EE, Hersh AL, Thorell EA, Ratner AJ, Chiotos K, Nakamura MM: Initial guidance on use of monoclonal antibody therapy for treatment of COVID-19 in children and adolescents. J Pediatric Infect Dis Soc 10 (5): 629-634, May 2021.
Tripathi S, Gist K, Bjornstad EC, Kashyap R, Boman K, Chiotos K, et al: COVID-19 associated pediatric ICU admissions: A report from the SCCM Discovery network VIRUS Registry. Pediatr Crit Care Med In Press 2021.
Tripathi S, Christison AL, Levy E, McGravery J, Tekin A, Bolliger D, Kumar V, Bansal V, Chiotos K, Gist K, Dapul HR, Bhalala US, Gharpure VP, Heneghan JA, Gupta N, Bjornstad EC, Montgomery VL, Walkey A, Kashyap R, Arteaga GM: The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children with COVID-19. Hospital Pediatrics 2021.
Kitt E, Davis DH, Kerman C, Sammons JS, Handy LK, Gallagher E, O'Callaghan K, Harris RM, Coffin SE, Bell LM, Chiotos K: The Utility of Paired Upper and Lower COVID-19 Sampling in Patients with Artificial Airways. Infect Control Hosp Epidemiol: 1-3, May 2021.
Isserman RS, Cheung J, Varallo D, Cafone J, Lee J, Chiotos K, Metjian TA, Muhly WT, Swami S, Baldwin K, Tan JM: Increasing cefazolin use for perioperative antibiotic prophylaxis in penicillin-allergic children. Pediatrics In Press 2021.
Bhalala U, Gist KM, Tripathi S, Boman K, Kumar VK, Retford L, Chiotos K, et al. : Characterization and Outcomes of Hospitalized Children with COVID-19: A Report from a Multicenter, VIRUS (COVID-19) Registry. Crit Care Med 2021 Notes: Accepted for publication 6/2021.
Becker AE, Chiotos K, McGuire JL, Bruins BB, Alcamo AM: Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children (MIS-C). Journal of Pediatrics 233: 263-267, June 2021.
Blatz AM, Oboite M, Chiotos K, Castelo-Soccio L, Odom John AR; Children's Hospital of Philadelphia MIS-C Research Collaborative: Cutaneous findings in SARS-CoV-2-associated multisystem inflammatory disease in children. Open Forum Infectious Disease 8(3): Page numbers in progress, March 2021.
Menon K, Schlapbach S, Akech S, Argent A, Chiotos K, Chisti M, Hamid J, Inwald D, Ishimine P, Kissoon N, Lodha R, Oliveira C, Peters M, Tissieres P, Watson RS, Wiens M, Wynn J, Sorce L, for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine: Pediatric Sepsis Definition - A Systematic Review Protocol by the Pediatric Sepsis Definitions Taskforce. Critical Care Explorations 2(6): e28693, June 2020.
Chiotos K, Bassiri H, Behrens EM, Blatz AM, Chang J, Diorio C, Fitzgerald JC, Topjian AA, Odom John AR: Multisystem inflammatory syndrome in children during the COVID-19 pandemic: a case series. Journal of the Pediatric Infectious Diseases Society 9(3): 393-398, July 2020.
Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase JM, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell B, Bernt K, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, Odom John A, Lambert MP, Liebling EJ, Paessler M, Petrosa W, Phillips CA, Reilly AF, Romberg N, Seif AE, Sesok-Pizzini D, Sullivan K, Vardaro J, Behrens EM, Teachey DT, Bassiri H: Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. J Clin Invest July 2020.
Corwin DJ, Sartori LF, Chiotos K, Odom John AR, Cohn K, Bassiri H, Edward EM, Teachey DT, Henrickson SE, Diorio CJ, Zorc JJ, Balamuth F: Distinguishing multisystem inflammatory syndrome in children (MIS-C) from Kawasaki Disease and benign inflammatory illnesses in the SARS-CoV-2 pandemic. Pediatr Emerg Care 36(11): 554-558, November 2020.
Levy E, Blumenthal J, Chiotos K, et al.: COVID-19 FAQ in pediatric cardiac surgery-a sequel. World J Pediiatr Congenit Heart Surg 11(6): 760-64, November 2020.
Diorio C, Anderson EM, McNerney K, Goodwin EC, Chase, JC, Bolton MJ, Arevalo CP, Weirick ME, Gouda S, Vella LA, Henrickson SE, Chiotos K, Fitzgerald JC, Kilbaugh TJ, Odom John, A, Blatz AM, Lambert MP, Sullivan KE, Tartaglione MR, Zambrano D, Martin M, Lee JH, Young. P, Friedman D, Sesok-Pizzini DA, Hensley SE, Behrens EM, Bassiri H, Teachey DT: Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome. Pediatr Blood Cancer 67(11): e28693, November 2020.
Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT: Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Blood Adv. 4(23): 6051-6063, December 2020.
Rhee C, Chiotos K, Cosgrove S, Heil E, Kadri S, Kalil A, Gilbert D, Masur H, Septimus E, Sweeney D, Strich J, Winslow D, Klompas M: Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure. Clin Infect Dis Epub ahead of print 2020.
Levy E, Blumenthal J, Chiotos K, Dearani JA: COVID-19 FAQ's in Pediatric Cardiac Surgery. World J Pediatr Congenit Heart Surg 11(4): 485-87, 2020.
Chiotos K, Hayes M, Gerber JS, Tamma PD: Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Children. J Pediatr Infect Dis Soc 9(1), 2020.
Szymczak JE, Kitt E, Hayes M, Chiotos K, Coffin SE, Schriver ER, Patton AM, Metjian TA, Gerber JS: Threatened efficiency not autonomy: Prescriber perceptions of an established pediatric antimicrobial stewardship program. Infect Control Hosp Epidemiol 40(5): 522-527, May 2019.
Chiotos K, Tamma PD, Gerber JS: Antibiotic stewardship in the intensive care unit: Challenges and opportunities. Infect Control Hosp Epidemiol 40(6): 693-698, June 2019.
Chiotos K, Rock C, Schweizer M, Delaney V, Morgan DJ, Milstone AM, Henderson D, Harris AD, Han JH: Current Infection Prevention and Antibiotic Stewardship Program Practices: a Survey of the Society for Healthcare Epidemiology of America (SHEA) Research Network (SRN). Infect Control Hosp Epidemiol 40(9): 1046-1049, September 2019.
Chiotos K, Tamma PD, Flett KB, Naumann M, Karandikar MV, Bilker WB, Zaoutis T, Han JH. Multicenter Study of the Risk Factors for Colonization or Infection with Carbapenem-Resistant Enterobacteriaceae in Children. Antimicrobial Agents and Chemotherapy 61: e01440-17, 2017.
Chiotos K, Ross R, Han J, Miller M, Gerber J. Use of carbapenems, polymyxins, and tigecycline in United States Children’s Hospitals, 2010-2014. Open Forum Infectious Diseases 4: ofx039, 2017.
Chiotos K, Gerber JS, Himebauch AS: How can we optimize antibiotic use in the pediatric intensive care unit? Pediatric Critical Care Medicine 18(9): 903-904, September 2017.
Chiotos K, Vendetti N, Zaoutis T, Baddley J, Ostrosky-Zeichner, Pappas P, Fisher BT. Comparative effectiveness of echinocandins versus fluconazole therapy for the treatment of adult candidemia due to Candida parapsilosis: a retrospective observational cohort study of the Mycoses Study Group (MSG-12). Journal of Antimicrobial Chemotherapy 71: 3536-3539, 2016.
Lancaster DP, Friedman DF, Chiotos K, Ota, KV: Blood volume required for detection of low-levels and ultra low-levels of organisms responsible for neonatal bacteremia using BACTEC Peds Plus/F, Plus Aerobic/F Media, and the BD BACTEC FX system: an in vitro Study. Journal of Clinical Microbiology 53: 3609-3613, 2015.
Kajiyama H, Titus S, Austin CP, Chiotos K, Matsumoto T, Sakairi T, Kopp JB: Tetracycline inducible gene expression in conditionally immortalized mouse podocytes. American Journal of Nephrology 19: 153-163, 2009.
Chiotos K, Handy L, Sulieman S, Gerber JS: Infectious Diseases. The Philadelphia Guide: Inpatient Pediatrics, 2nd Edition. Shah S, Zaoutis L, Catallozzi M, Frank G (eds.). McGraw Hill, New York, NY, Page: 237-302, 2016.
Bhalala US, Boyer DL, Chiotos K: Clinical Toxidromes. Comprehensive Critical Care: Pediatrics, 2nd Edition. Stockwell J, Kutko M (eds.). Society of Critical Care Medicine, Mt. Prospect, IL, Page: 707-712, 2016.
Posters and Presentations
Chiotos K, Lee G, Sydney G, Wolfe HA, Blumenthal J, Stinson H, McGowan N, Harab J, Traynor D, Dudhia A, Piccione J, Burke J, Doll A, Keim G, Woods-Hill C, Jennings M, Harris R, Gerber JS: Indications for tracheal aspirate culture collection and their association with diagnosis of ventilator-associated infection. Society for Healthcare Epidemiology of America Spring Conference April 2021 Notes: Poster Presentation at the Society for Healthcare Epidemiology of America Spring Conference, (Virtual).
Beus JM, Ku BC, Pitts CE, Hamershock R, Hayes M, Metjian TA, Chiotos K, Gerber JS, Zorc JJ.: Clinical Decision Support Interventions Improve Adherence to Antibiotic Duration Guidelines for Community Acquired Pneumonia in the Pediatric ED. American Medical Informatics Association 2021 Clinical Informatics Conference: Virtual 2021. (Poster Presentation) 2021.
Chiotos K, Lee G, Sydney G, Wolfe H, Blumenthal J, Stinson H, McGowan N, Harab J, Traynor D, Dudhia A, Piccione J, Burke, J, Doll A, Keim G, Woods-Hill C, Jennings M, Harris R, Gerber J: Reducing collection of tracheal aspirate bacterial cultures: a diagnostic test stewardship intervention. IDWeek 2021 Annual Scientific Conference, Oct 2021, Virtual Event 2021.
Hayes M, Blowey B, Resendiz K, Grachen A, Shin J, Chiotos K, Downes K. : Optimization of vancomycin therapy: Implementation of area-under-the-curve (AUC)-based dosing. International Pediatric Antimicrobial Stewardship Conference, Virtual Conference, June 2021 (Oral Abstract Presentation). 2021.
Hwang M, Tierradentro-Garcia, Luis, Poznick L, Kilbaugh T, Chiotos K: Contrast-enhanced ultrasound (CEUS) in three patients with Multisystem Inflammatory Syndrome in Children (MIS-C) International Pediatric Radiology Conference (Virtual). Poster Presentation. 2021.
Keeler E, Beus J, Hayes M, Zorc JJ, Metjian TA, Ku B, Hamershock R, Gerber JS. : Evaluating an amoxicillin dosing regimen for community acquired pneumonia: a quality improvement initiative using clinical and laboratory data. IDWeek 2021 Annual Scientific Conference, Oct 2021, Virtual Event 2021.
Stinson H, Dashefsky H, Chiotos K, Woods-Hill C, Weiss SL, Fitzgerald JC: Care delivery related to sepsis in a SARS-CoV-2 Pediatric Intensive Care Unit. Critical Care Medicine 49(1): 150, January 2021 Notes: Research Snapshot Presentation at the 50th Critical Care Congress, February, 2021 (Virtual).
Chiotos K, Blumenthal J, Boguniewicz J, Palazzi DL, Stalets EL, Rubens J, DeSilva SC, Crandall H, Berkman E, Kavanagh RP, Stinson HR, Liston KM, Gerber JS: Multicenter study of antibiotic indications and appropriateness in the PICU. Critical Care Medicine 48(1): 310, January 2020 Notes: Research Snapshot Presentation at 49th Critical Care Congress, February 2020, Orlando, FL.
Chiotos K, Blumenthal J, Boguniewicz J, Palazzi D, Berkman E, Crandall H, Stalets E, Rubens J, DeSilva S, Kavanagh R, Stinson H, Liston K, Gerber J: Antibiotic indications and appropriateness in the pediatric intensive care unit: a ten center point prevalence study. IDWeek 2019, Washington, DC 2020.
Chiotos K, Biedron L, Fitzgerald J, Robbins-Tighe S, Weiss SL, Woods-Hill C: Sepsis huddles in the PICU: Understanding the impact on timely antibiotics, perceptions, and barriers. Critical Care Medicine 47(1): 820, January 2019 Notes: Poster Presentation at the 48th Society of Critical Care Medicine Annual Congress, February 2019, San Diego, CA.
Chiotos K, Cardenas AM, Orenstein E, Migliore B, Burlingame C, Hart J, Ware E, Dunn M: Optimizing use of respiratory viral testing in the pediatric intensive care unit. Critical Care Medicine 47(1): 690, January 2019 Notes: Poster Presentation at the 48th Society of Critical Care Medicine Annual Congress, February 2019, San Diego, CA.
Yeung T, Chiotos K, Graham K, Wolfe HA, Niles DE, Nadkarni VM, Kilbaugh TJ, Berg RA, Topjian AA, Sutton RM, Morgan RW: Incidence of bacteremia following pediatric in-hospital cardiac arrest. Critical Care Medicine 47(1): 749, January 2019 Notes: Research Snapshot Presentation at 48th Critical Care Congress, February 2019, San Diego, CA
Chiotos K, D'Arinzo L, Kitt E, Ross R, Gerber JS: Empiric antibiotic use in United States children's hospitals: a novel opportunity for antibiotic stewardship. Society for Healthcare Epidemiology of America Spring Conference, Boston, MA April 2019 Notes: Poster Presentation.
Chiotos K. "Optimized supportive care of children and young persons with critical COVID-19," World Health Organization, Virtual Presentation
Chiotos K. CHOP PEM Podcast: MIS-C
Chiotos K. "Oral antibiotic therapy is safe and effective for hospitalized children: pro," Pediatric Academic Societies (Virtual Conference)
Chiotos K. Lessons from Practitioners: Human Antibiotic Stewardship. National Institute for Animal Agriculture Antibiotics Symposium. Virtual Conference.
Chiotos K. "Introduction to Antibiotic Stewardship," Salzburg Pediatric Infectious Diseases Seminar, Open Medical Institute, Salzburg, Austria
Chiotos K. "Infectious Diseases in the Pediatric Intensive Care Unit," Salzburg Pediatric Infectious Diseases Seminar, Open Medical Institute, Salzburg, Austria
Chiotos K. "Oral Antibiotic Therapy for Serious Bacterial Infections," Salzburg Pediatric Infectious Diseases Seminar, Open Medical Institute, Salzburg, Austria
Chiotos K. "Community Acquired Pneumonia: an Update," Salzburg Pediatric Infectious Diseases Seminar, Open Medical Institute, Salzburg, Austria
Chiotos K. "Potential therapies for children with COVID-19/SARS-CoV-2," International PICU COVID-19 Collaborative Webinar
Chiotos K. "IDSA Guidelines for Treatment of Patients with COVID-19: Pediatric Considerations," International PICU COVID-19 Collaborative Webinar
Chiotos K. "Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2," Sharing Antimicrobial Reports for Pediatric Stewardship (SHARPS) Webinar, April 2nd, 2020
Chiotos K. "Pediatric COVID-19 Treatment Guidance and Multisystem Inflammatory Syndrome in Children (MIS-C)," Pediatric Infectious Diseases Society/Infectious Diseases Society of America Division Chief's teleconference, May 15th, 2020
Chiotos K. "Multisystem Inflammatory Syndrome in Children: the Intensivist's Perspective," Pediatric Infectious Diseases Society Townhall teleconference, May 19th, 2020
Chiotos K. "Oral Antibiotic Therapy is Safe and Effective for Serious Infections in Hospitalized Children: Pro," Pediatric Academic Societies (PAS), Philadelphia, PA (cancelled due to COVID-19)
Chiotos K. "Talking About COVID-19 Experience with CHOP's Experts," Panel of invited experts, June 8, 2020; Teleconference with Roosevelt Institute, Bogota, Columbia
Chiotos K. "Multisystem Inflammatory Syndrome in Children," Children's Hospital San Antonio teleconference, June 1st, 2020
Chiotos K. "Evidence-based therapies for pediatric COVID-19," Pediatric COVID-19 International Collaborative Webinar
Chiotos K. "Multisystem Inflammatory Syndrome in Children (MIS-C): Epidemiology and Clinical Considerations," October 24, 2021, CDC/IDSA Clinician Call Webinar
Chiotos K. "Hit or MIS-C: Challenges in the Diagnosis and Management of Multisystem Inflammatory Syndrome in Children," 37th Annual Innovation in Pediatric Emergency Medicine Conference, November 17, 2020, Philadelphia, PA (webinar)
Chiotos K. "Antibiotic Stewardship in the Pediatric Intensive Care Unit," International Pediatric Antimicrobial Stewardship Conference, St. Louis, MO
Chiotos K. "Procalcitonin Should be Implemented by all Stewardship Programs: Pro" International Pediatric Antimicrobial Stewardship Conference, St. Louis, MO
Awards and Honors
2019, National Institutes of Health Loan Repayment Award
2018, Top Poster Abstract, Society for Healthcare Epidemiology of America
2017, National Institutes of Health Loan Repayment Award
2016, ID Week Poster in the Park Presenter, Children’s Hospital of Philadelphia
2016, Jonathan Freeman Scholarship, Society for Healthcare Epidemiology of America
2016, Antimicrobial Stewardship Aware, Pediatric Infectious Disease Society
2016, ID Week 2016 Trainee Travel Award, Children's Hospital of Philadelphia
2009, John Ordronanux Valedictorian Award, George Washington University School of Medicine
2009, Lawrence A. Rapee Valedictorian Award, George Washington University Medical Center
2009, ID Week Poster in the Park Presenter, Children's Hospital of Philadelphia
2009, Department of Pediatrics Award, Children's Hospital of Philadelphia
2009, Alpha Omega Alpha Honor Medical Society
2004, Summa Cum Laude Graduation Honors, College of William and Mary
2001-2004, Dean's List, College of William and Mary
Editorial and Academic Positions
2017, Ad Hoc Reviewer, Journal of the Pediatric Infectious Disease Society
2017, Ad Hoc Reviewer, Journal of Hospital Medicine
2016, Ad Hoc Reviewer, Pediatrics
2016-present, Fellow Member of the Editorial Board, Journal of the Pediatric Infectious Disease Society
Academic and Institutional Committees
2017-present, Physician Co-Lead, PICU/PCU Sepsis Quality Improvement Committee
2017-present, PICU Blood Culture Pathway Development Committee
2017-present, Neonatal Intensive Care Unit Sepsis Pathway Development Committee
2013-present, PICU and Progressive Care Unit (PCU) Patient Safety and Continuous Quality Improvement Committee
Leadership and Memberships
Memberships in Professional Organizations
2013-present, Society of Critical Care Medicine
2018-present, SHEA Research Committee
2016-present, Society for Healthcare Epidemiology of America (SHEA)
2015-present, Pediatric Infectious Disease Society
2014-present, Society of Pediatric Research
2012-present, Infectious Disease Society
2009-present, American Academy of Pediatrics
Patient Experience Ratings
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