Dr. Chiotos is a graduate of the College of William and Mary and the George Washington University School of Medicine, and recently earned a Master’s of Science in Clinical Epidemiology from the University of Pennsylvania. She completed pediatrics residency training at Children’s Hospital of Philadelphia (CHOP), followed by a combined fellowship in pediatric infectious diseases and pediatric critical care medicine.
Dr. Chiotos joined the faculty at the University of Pennsylvania in 2017 and is currently an Assistant Professor of Anesthesia, Critical Care, and Pediatrics with a secondary appointment in pediatric infectious diseases.
Dr. Chiotos’ research focuses on the epidemiology of antibiotic resistant organisms in the pediatric intensive care unit setting as well as antibiotic stewardship in this population. She is involved with several quality improvement initiatives surrounding optimizing antibiotic use and diagnostic evaluation for patients with suspected sepsis at CHOP.
Education and Training
MD - George Washington University School of Medicine, Washington, DC
Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatric Infectious Diseases and Critical Care Medicine - Children's Hospital of Philadelphia, Philadelphia, PA
Research Fellow, Pediatric Hospital Epidemiology and Outcomes Training (PHEOT) Program - Children's Hospital of Philadelphia, PA
General PediatricsPediatric Infectious DiseasesPediatrics
MSCE - Master of Science in Clinical Epidemiology
Titles and Academic Titles
Assistant Professor of Anesthesia and Critical Medicine, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Antibiotic resistant pathogens
Menon K, Schlapbach S, Akech S, Argent A, Chiotos K, Chisti M, Hamid J, Inwald D, Ishimine P, Kissoon N, Lodha R, Oliveira C, Peters M, Tissieres P, Watson RS, Wiens M, Wynn J, Sorce L, for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine: Pediatric Sepsis Definition - A Systematic Review Protocol by the Pediatric Sepsis Definitions Taskforce. Critical Care Explorations 2(6): e28693, June 2020.
Chiotos K, Bassiri H, Behrens EM, Blatz AM, Chang J, Diorio C, Fitzgerald JC, Topjian AA, Odom John AR: Multisystem inflammatory syndrome in children during the COVID-19 pandemic: a case series. Journal of the Pediatric Infectious Diseases Society 9(3): 393-398, July 2020.
Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase JM, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell B, Bernt K, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, Odom John A, Lambert MP, Liebling EJ, Paessler M, Petrosa W, Phillips CA, Reilly AF, Romberg N, Seif AE, Sesok-Pizzini D, Sullivan K, Vardaro J, Behrens EM, Teachey DT, Bassiri H: Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. J Clin Invest July 2020.
Corwin DJ, Sartori LF, Chiotos K, Odom John AR, Cohn K, Bassiri H, Edward EM, Teachey DT, Henrickson SE, Diorio CJ, Zorc JJ, Balamuth F: Distinguishing multisystem inflammatory syndrome in children (MIS-C) from Kawasaki Disease and benign inflammatory illnesses in the SARS-CoV-2 pandemic. Pediatr Emerg Care 36(11): 554-558, November 2020.
Levy E, Blumenthal J, Chiotos K, et al.: COVID-19 FAQ in pediatric cardiac surgery-a sequel. World J Pediiatr Congenit Heart Surg 11(6): 760-64, November 2020.
Diorio C, Anderson EM, McNerney K, Goodwin EC, Chase, JC, Bolton MJ, Arevalo CP, Weirick ME, Gouda S, Vella LA, Henrickson SE, Chiotos K, Fitzgerald JC, Kilbaugh TJ, Odom John, A, Blatz AM, Lambert MP, Sullivan KE, Tartaglione MR, Zambrano D, Martin M, Lee JH, Young. P, Friedman D, Sesok-Pizzini DA, Hensley SE, Behrens EM, Bassiri H, Teachey DT: Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome. Pediatr Blood Cancer 67(11): e28693, November 2020.
Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT: Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Blood Adv. 4(23): 6051-6063, December 2020.
Rhee C, Chiotos K, Cosgrove S, Heil E, Kadri S, Kalil A, Gilbert D, Masur H, Septimus E, Sweeney D, Strich J, Winslow D, Klompas M: Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure. Clin Infect Dis Epub ahead of print 2020.
Levy E, Blumenthal J, Chiotos K, Dearani JA: COVID-19 FAQ's in Pediatric Cardiac Surgery. World J Pediatr Congenit Heart Surg 11(4): 485-87, 2020.
Chiotos K, Hayes M, Gerber JS, Tamma PD: Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Children. J Pediatr Infect Dis Soc 9(1), 2020.
Szymczak JE, Kitt E, Hayes M, Chiotos K, Coffin SE, Schriver ER, Patton AM, Metjian TA, Gerber JS: Threatened efficiency not autonomy: Prescriber perceptions of an established pediatric antimicrobial stewardship program. Infect Control Hosp Epidemiol 40(5): 522-527, May 2019.
Chiotos K, Tamma PD, Gerber JS: Antibiotic stewardship in the intensive care unit: Challenges and opportunities. Infect Control Hosp Epidemiol 40(6): 693-698, June 2019.
Chiotos K, Rock C, Schweizer M, Delaney V, Morgan DJ, Milstone AM, Henderson D, Harris AD, Han JH: Current Infection Prevention and Antibiotic Stewardship Program Practices: a Survey of the Society for Healthcare Epidemiology of America (SHEA) Research Network (SRN). Infect Control Hosp Epidemiol 40(9): 1046-1049, September 2019.
Chiotos K, Tamma PD, Flett KB, Naumann M, Karandikar MV, Bilker WB, Zaoutis T, Han JH. Multicenter Study of the Risk Factors for Colonization or Infection with Carbapenem-Resistant Enterobacteriaceae in Children. Antimicrobial Agents and Chemotherapy 61: e01440-17, 2017.
Chiotos K, Ross R, Han J, Miller M, Gerber J. Use of carbapenems, polymyxins, and tigecycline in United States Children’s Hospitals, 2010-2014. Open Forum Infectious Diseases 4: ofx039, 2017.
Chiotos K, Gerber JS, Himebauch AS: How can we optimize antibiotic use in the pediatric intensive care unit? Pediatric Critical Care Medicine 18(9): 903-904, September 2017.
Chiotos K, Vendetti N, Zaoutis T, Baddley J, Ostrosky-Zeichner, Pappas P, Fisher BT. Comparative effectiveness of echinocandins versus fluconazole therapy for the treatment of adult candidemia due to Candida parapsilosis: a retrospective observational cohort study of the Mycoses Study Group (MSG-12). Journal of Antimicrobial Chemotherapy 71: 3536-3539, 2016.
Lancaster DP, Friedman DF, Chiotos K, Ota, KV: Blood volume required for detection of low-levels and ultra low-levels of organisms responsible for neonatal bacteremia using BACTEC Peds Plus/F, Plus Aerobic/F Media, and the BD BACTEC FX system: an in vitro Study. Journal of Clinical Microbiology 53: 3609-3613, 2015.
Kajiyama H, Titus S, Austin CP, Chiotos K, Matsumoto T, Sakairi T, Kopp JB: Tetracycline inducible gene expression in conditionally immortalized mouse podocytes. American Journal of Nephrology 19: 153-163, 2009.
Chiotos K, Handy L, Sulieman S, Gerber JS: Infectious Diseases. The Philadelphia Guide: Inpatient Pediatrics, 2nd Edition. Shah S, Zaoutis L, Catallozzi M, Frank G (eds.). McGraw Hill, New York, NY, Page: 237-302, 2016.
Bhalala US, Boyer DL, Chiotos K: Clinical Toxidromes. Comprehensive Critical Care: Pediatrics, 2nd Edition. Stockwell J, Kutko M (eds.). Society of Critical Care Medicine, Mt. Prospect, IL, Page: 707-712, 2016.
Posters and Presentations
Stinson H, Dashefsky H, Chiotos K, Woods-Hill C, Weiss SL, Fitzgerald JC: Care delivery related to sepsis in a SARS-CoV-2 Pediatric Intensive Care Unit. Critical Care Medicine 49(1): 150, January 2021 Notes: Research Snapshot Presentation at the 50th Critical Care Congress, February, 2021 (Virtual).
Chiotos K, Blumenthal J, Boguniewicz J, Palazzi DL, Stalets EL, Rubens J, DeSilva SC, Crandall H, Berkman E, Kavanagh RP, Stinson HR, Liston KM, Gerber JS: Multicenter study of antibiotic indications and appropriateness in the PICU. Critical Care Medicine 48(1): 310, January 2020 Notes: Research Snapshot Presentation at 49th Critical Care Congress, February 2020, Orlando, FL.
Chiotos K, Blumenthal J, Boguniewicz J, Palazzi D, Berkman E, Crandall H, Stalets E, Rubens J, DeSilva S, Kavanagh R, Stinson H, Liston K, Gerber J: Antibiotic indications and appropriateness in the pediatric intensive care unit: a ten center point prevalence study. IDWeek 2019, Washington, DC 2020.
Chiotos K, Biedron L, Fitzgerald J, Robbins-Tighe S, Weiss SL, Woods-Hill C: Sepsis huddles in the PICU: Understanding the impact on timely antibiotics, perceptions, and barriers. Critical Care Medicine 47(1): 820, January 2019 Notes: Poster Presentation at the 48th Society of Critical Care Medicine Annual Congress, February 2019, San Diego, CA.
Chiotos K, Cardenas AM, Orenstein E, Migliore B, Burlingame C, Hart J, Ware E, Dunn M: Optimizing use of respiratory viral testing in the pediatric intensive care unit. Critical Care Medicine 47(1): 690, January 2019 Notes: Poster Presentation at the 48th Society of Critical Care Medicine Annual Congress, February 2019, San Diego, CA.
Yeung T, Chiotos K, Graham K, Wolfe HA, Niles DE, Nadkarni VM, Kilbaugh TJ, Berg RA, Topjian AA, Sutton RM, Morgan RW: Incidence of bacteremia following pediatric in-hospital cardiac arrest. Critical Care Medicine 47(1): 749, January 2019 Notes: Research Snapshot Presentation at 48th Critical Care Congress, February 2019, San Diego, CA
Chiotos K, D'Arinzo L, Kitt E, Ross R, Gerber JS: Empiric antibiotic use in United States children's hospitals: a novel opportunity for antibiotic stewardship. Society for Healthcare Epidemiology of America Spring Conference, Boston, MA April 2019 Notes: Poster Presentation.
Chiotos K, Tamma PD, Flett KB, Naumann M, Karandikar MV, Bilker WB, Zaoutis T, Han JH: Increased 30-day mortality among children with carbapenem-resistant Enterobacteriaceae. Society for Healthcare Epidemiology of America Spring Conference, Portland, OR April 2018 Notes: Poster Presentation.
Dunn M, Cardenas AM, Chiotos K, Orenstein E, Burlingame C, Migliore B, Hart J, Ware E: Increasing the Value in Viral Respiratory Testing. Pediatric Academic Societies Meeting, Toronto, Canada May 2018 Notes: Poster Presentation.
Hayes M, Schriver E, Chiotos K, Metjian T, Gerber J: Use of local data to inform antimicrobial stewardship interventions in the neonatal and infant intensive care unit (NI/ICU). International Pediatric Antimicrobial Stewardship Conference, St. Louis, MO June 2018 Notes: Poster Presentation.
Chiotos K. “Empiric Antibiotic Use in Pediatrics: a Potential Opportunity for Antibiotic Stewardship,” 8th Annual Pediatric Antimicrobial Stewardship Conference, St. Louis, MO June 2017
Awards and Honors
2019, National Institutes of Health Loan Repayment Award
2018, Top Poster Abstract, Society for Healthcare Epidemiology of America
2017, National Institutes of Health Loan Repayment Award
2016, ID Week Poster in the Park Presenter, Children’s Hospital of Philadelphia
2016, Jonathan Freeman Scholarship, Society for Healthcare Epidemiology of America
2016, Antimicrobial Stewardship Aware, Pediatric Infectious Disease Society
2016, ID Week 2016 Trainee Travel Award, Children's Hospital of Philadelphia
2009, John Ordronanux Valedictorian Award, George Washington University School of Medicine
2009, Lawrence A. Rapee Valedictorian Award, George Washington University Medical Center
2009, ID Week Poster in the Park Presenter, Children's Hospital of Philadelphia
2009, Department of Pediatrics Award, Children's Hospital of Philadelphia
2009, Alpha Omega Alpha Honor Medical Society
2004, Summa Cum Laude Graduation Honors, College of William and Mary
2001-2004, Dean's List, College of William and Mary
Editorial and Academic Positions
2017, Ad Hoc Reviewer, Journal of the Pediatric Infectious Disease Society
2017, Ad Hoc Reviewer, Journal of Hospital Medicine
2016, Ad Hoc Reviewer, Pediatrics
2016-present, Fellow Member of the Editorial Board, Journal of the Pediatric Infectious Disease Society
Academic and Institutional Committees
2017-present, Physician Co-Lead, PICU/PCU Sepsis Quality Improvement Committee
2017-present, PICU Blood Culture Pathway Development Committee
2017-present, Neonatal Intensive Care Unit Sepsis Pathway Development Committee
2013-present, PICU and Progressive Care Unit (PCU) Patient Safety and Continuous Quality Improvement Committee
Leadership and Memberships
Memberships in Professional Organizations
2013-present, Society of Critical Care Medicine
2018-present, SHEA Research Committee
2016-present, Society for Healthcare Epidemiology of America (SHEA)
2015-present, Pediatric Infectious Disease Society
2014-present, Society of Pediatric Research
2012-present, Infectious Disease Society
2009-present, American Academy of Pediatrics
Patient Experience Ratings
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