David B. Frank, MD, PhD

male silhouette icon
David B. Frank, MD, PhD, is an attending physician in the Division of Cardiology at Children's Hospital of Philadelphia.

Areas of Expertise: Pulmonary hypertension, Pulmonary vascular remodeling in embryonic development, Transitional pulmonary circulation, Transplant
Locations: Main Hospital

Phone: 215-590-4040

Education and Training

Medical School

MD - Vanderbilt School of Medicine, Nashville, TN

Residency

Pediatrics - The Children’s Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Cardiology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Cardiology
Pediatrics

Graduate Degree

PhD - Vanderbilt School of Medicine, Nashville, TN

Titles and Academic Titles

Attending Physician

Assistant Program Director, Pediatric Cardiology T32 Training Grant

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2020

Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R 3rd, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kańduła MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN: The in vivo genetic program of murine primordial lung epithelial progenitors. Nat Commun 11(1): 635, January 2020.

Catherine M Avitabile, Yan Wang, Xuemei Zhang, Heather Griffin , Sofia Saavedra, Samantha Adams, Lisa Herkert, David B Frank, Michael D Quartermain , Natalie E Rintoul , Holly L Hedrick, Laura Mercer-Rosa : Right Heart Strain, Brain Natriuretic Peptide, and Mortality in Congenital Diaphragmatic Hernia. Annals of the American Thoracic Society Online ahead of print, July 2020.

Vanderver A, Adang L, Gavazzi F, McDonald K, Helman G, Frank DB, Jaffe N, Yum SW, Collins A, Keller SR, Lebon P, Meritet JF, Rhee J, Takanohashi A, Armangue T, Ulrick N, Sherbini O, Koh J, Peer K, Besnier C, Scher C, Boyle K, Dubbs H, Kramer-Golinkoff J, Pizzino A, Woidill S, Shults J: Janus Kinase Inhibition in the Aicardi-Goutières Syndrome. N Engl J Med 383(10): 986-989, Sep 2020.

Paris AJ, Hayer KE, Oved JH, Avgousti DC, Toulmin SA, Zepp JA, Zacharias WJ, Katzen JB, Basil MC, Kremp MM, Slamowitz AR, Jayachandran S, Sivakumar A, Dai N, Wang P, Frank DB, Eisenlohr LC, Cantu E 3rd, Beers MF, Weitzman MD, Morrisey EE, Worthen GS: STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nat Cell Biol 22(10): 1197-1210, Oct 2020.

Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP.: mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. Nat Commun 11(1): 5640, Nov 2020.

2019

Frank D.B., Penkala, I.J., Sivakumar, A., Linares, R.A., Zepp J.A., Zacharias W.J., Stolz, K.G., Pankin, J., Lu, M.Q., Wang, Q., Babu, A., Zhou, S., Li, L., Morley, M.P., Jain, R., Morrisey, E.E.: Early lineage specification defines alveolar epithelial ontogeny in the lung. PNAS Page: doi: 10.1073, February 2019 Notes: epub ahead of print.

Edwards JJ, Murali C, Pogoriler J, Frank DB, Handler SS, Deardorff MA, Hopper RK: Histopathologic and Genetic Features of Alveolar Capillary Dysplasia with Atypical Late Presentation and Prolonged Survival. Journal of Pediatrics 210(1): 214-219, July 2019.

2018

Swarr DT, Peranteau WH, Pogoriler J, Frank DB, Adzick NS, Hedrick HL, Morley M, Zhou S, Morrisey EE: Novel Molecular and Phenotypic Insights into Congenital Lung Malformations.  Am J Respir Crit Care Med January 2018.

Zacharias WJ*, Frank DB*, Zepp JA, Morley MP, Alkhaleel FA, Kong J, Zhou S, Cantu E, Morrisey EE.: Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature 555(7695): 251-255, February 2018.

Sivakumar, A., Mahadeven A., Lauer, M.E., Narvaez, R.J., Ramesh, S., Demler, C.M., Souchet, N.R., Hascall, V.C., Midura, R.J., Garantziotis, S., Frank D.B., Kimata, K., Kurpios, N.A. : Midgut laterality is driven by hyaluronan on the right. Developmental Cell 46(5): 533-551, September 2018.

Adang, L.A.*, Frank, D.B.*, Gilani, A., Takanohashi, A., Ulrick, N., Collins, A., Cross, Z., Galambos, C. Helman, G., Kanaan, U., Keller, S., Simon, D., Sherbini, O, Hanna, B.D., Vanderver, A.L. : Aicardi Goutieres Syndrome is associated with pulmonary hypertension. Mol Genet Metab 125(4): 351-358, December 2018.

2017

Zepp JA, Zacharias WJ, Frank DB, Cavanaugh CA, Zhou S, Morley MP, Morrisey EE: Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung. Cell 170(6): 1134-1148, Sep 2017.

Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML: Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis. Developmental Cell 43(3): 274-89, November 2017.

2016

Wang Yi, Frank David B, Morley Michael P, Zhou Su, Wang Xiaoru, Lu Min Min, Lazar Mitchell A, Morrisey Edward E: HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation. Developmental cell 36(3): 303-15, Feb 2016.

Frank David B, Peng Tien, Zepp Jarod A, Snitow Melinda, Vincent Tiffaney L, Penkala Ian J, Cui Zheng, Herriges Michael J, Morley Michael P, Zhou Su, Lu Min Min, Morrisey Edward E: Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell reports 17(9): 2312-2325, Nov 2016.

2015

Frank David B, Crystal Matthew A, Morales David L S, Gerald Ken, Hanna Brian D, Mallory George B, Rossano Joseph W: Trends in pediatric pulmonary hypertension-related hospitalizations in the United States from 2000-2009. Pulmonary circulation 5(2): 339-48, Jun 2015.

Peng Tien, Frank David B, Kadzik Rachel S, Morley Michael P, Rathi Komal S, Wang Tao, Zhou Su, Cheng Lan, Lu Min Min, Morrisey Edward E: Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature 526(7574): 578-82, Oct 2015.

2014

Lau Kelvin C, Frank David B, Hanna Brian D, Patel Akash R: Utility of electrocardiogram in the assessment and monitoring of pulmonary hypertension (idiopathic or secondary to pulmonary developmental abnormalities) in patients less than 18 years of age. The American journal of cardiology 114(2): 294-9, Jul 2014.

2011

Kruithof Boudewijn P T, Fritz David T, Liu Yijun, Garsetti Diane E, Frank David B, Pregizer Steven K, Gaussin Vinciane, Mortlock Douglas P, Rogers Melissa B: An autonomous BMP2 regulatory element in mesenchymal cells. Journal of cellular biochemistry 112(2): 666-74, Feb 2011.

Frank David B, Patel Akash R, Sanchez Guillermo R, Shah Maully J, Bonney William J: Junctional tachycardia in a child with Lyme carditis. Pediatric cardiology 32(5): 689-91, Jun 2011.

2010

Anderson Lynda, Lowery Jonathan W, Frank David B, Novitskaya Tatiana, Jones Mark, Mortlock Douglas P, Chandler Ronald L, de Caestecker Mark P: Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension. American journal of physiology. Regulatory, integrative and comparative physiology 298(3): R833-42, Mar 2010.

Miller J Davin, Benjamin John T, Kelly David R, Frank David B, Prince Lawrence S: Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. American journal of physiology. Lung cellular and molecular physiology 298(5): L637-45, May 2010.

2008

Frank David B, Lowery Jonathan, Anderson Lynda, Brink Monique, Reese Jeff, de Caestecker Mark: Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. American journal of physiology. Lung cellular and molecular physiology 294(1): L98-109, Jan 2008.

2005

Frank David B, Abtahi Amir, Yamaguchi D J, Manning Suzanne, Shyr Yu, Pozzi Ambra, Baldwin H Scott, Johnson Joyce E, de Caestecker Mark P: Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circulation research 97(5): 496-504, Sep 2005.

2001

Parks W T, Frank D B, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker M P, McNally J G, Reddi A, Taylor S I, Roberts A B, Wang T, Lechleider R J: Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. The Journal of biological chemistry 276(22): 19332-9, Jun 2001.

Wurthner J U, Frank D B, Felici A, Green H M, Cao Z, Schneider M D, McNally J G, Lechleider R J, Roberts A B: Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. The Journal of biological chemistry 276(22): 19495-502, Jun 2001.

 

Abstracts

2020

A. Naik, Y. Issah, K. Forrest, D. B. Frank, A. Paris, A. Vaughan, S. Sengupta: Role of Circadian Clock in Lung Repair and Regeneration. American Thoracic Society International Conference Abstracts > C62. EPITHELIUM, INJURY, AND REPAIR May 2020.

D. B. Frank, K. Quansah, S. Jayachandran, M. Lu, J. Pankin, A. Sivakumar: Spatiotemporal Lineage Mapping to Define Molecular Crossroads of Heart Versus Lung Mesodermal Fate. American Journal of Respiratory and Critical Care Medicine 2020 201(A5985), May 2020.

D. B. Frank, S. Jayachandran, A. Sivakumar, M. Lu, K. Quansah, J. Pankin: Re-Initiation of Developmental Paradigms for Regeneration After Neonatal Lung Injury. American Journal of Respiratory and Critical Care Medicine 2020 201(A7679), May 2020.

Posters and Presentations

2019

Aravind Sivakumar, Derek Liberti, Jarod Zepp, Josh Pankin, MinQi Lu, Michael Morley, Apoorva Babu, Edward E Morrisey, David B Frank: Mechanisms regulating pulmonary arterial morphogenesis during development and disease. Poster-University of Pennsylvania 25th Annual Respiratory Research Retreat, Philadelphia, PA May 2019.

Josh Pankin, MinQi Lu, Michael Morley, Apoorva Babu, David B Frank: Spatiotemporal lineage mapping to define molecular crossroads of heart versus lung mesodermal fate. Podium-Gordon Research Conference on Lung Development, Injury and Repair, Bates College, Lewiston, ME  August 2019.

Vanderver A, Adang L, Gavazzi F, Ulrick N, Koh J, McDonald K, Peer K, Besnier C, Cross Z, Frank D, Helman G, Jaffe N, Kramer-Golinkoff J, Pizzino A, Rand E, Rhee J, Waldman A, Woidill S, Yum S,  Takanohashi A, Armangue T, Goldbach Mansky R, Shults J: Open label use of the Janus kinase inhibitor baricitinib in a genetic interferonopathy, Aicardi Goutières Syndrome. Podium-48th Annual Meeting of the Child Neurology Society, Charlotte, NC October 2019.

Michael L O'Byrne, Jennifer A Faerber,  Hannah Katcoff, , David B Frank, Alex Davidson, Therese M Giglia, Catherine M Avitabile: Variation in utilization of pulmonary vasodilators in children and adolescents with pulmonary hypertension:  An analysis of data from the Marketscan® Commercial and Medicaid Claims Databases Poster-American Heart Association Scientific Sessions, Philadelphia, PA November 2019.

Invited Lectures

2020

Frank David B. Re-Initiation of Developmental Paradigms for Regeneration After Neonatal Lung Injury,  2020 American Thoracic Society International Conference, D97 STEM CELLS, LUNG REPAIR, AND DISEASE / Mini Symposium. May 2020.

Frank David B. Spatiotemporal Lineage Mapping to Define Molecular Crossroads of Heart Versus Lung Mesodermal Fate,  2020 American Thoracic Society International Conference, C97 REGULATION OF LUNG PROGENITOR CELLS AND DIFFERENTIATION / Mini Symposium. May 2020.

Frank David B. "Pulmonary vascular development", 13th International Conference on Neonatal and Childhood Pulmonary Vascular Disease, San Francisco, CA. Mar 2020.

2019

Frank David B. "Spatiotemporal lineage mapping to define molecular crossroads of heart versus lung mesodermal fate", Gordon Research Conference on Lung Development, Injury and Repair, Bates College, Lewiston, ME. Aug 2019.

Frank David B. "The failing myocardium in pulmonary hypertension". Invited speaker at 22nd Annual Update in Pediatric & Congenital Cardiovascular Disease Conference, Huntington Beach, CA. Feb 2019.

Frank David B. "Lung disease and pulmonary hypertension in the premature infant". Invited speaker at 22nd Annual Update in Pediatric & Congenital Cardiovascular Disease Conference, Huntington Beach, CA. Feb 2019.

Awards and Honors

2020-2023, Doris Duke Charitable Foundation Clinician Scientist Development Award
2017, Smart Heart Award, Children's Heart Foundation (Pennsylvania Chapter)
2016-2019, Parker B. Francis Fellowship Program Awardee
2015, Poster Award Winner, Gordon Conference on Lung Development, Injury, and Repair
2015, Fellow Research Award, Pediatric Academic Society/Society for Pediatric Research
2014, Finalist Presenter, The Neonatal Cardiopulmonary Biology Young Investigator's Forum
2014, Research Day Poster Award Winner, Children's Hospital of Philadelphia
2013, Fellow's Award, 6th International Conference Neonatal and Childhood Pulmonary Vascular Disease
2011, Research Day Poster Award Winner, Children's Hospital of Philadelphia
2009, Richard B. Johnston Jr. Award in Pediatrics, Vanderbilt University School of Medicine
2005, Genzyme Keystone Conference Scholarship, Keystone Conference on TGF-beta and disease
2001-2009, Microbes and Defense Academic Society, Vanderbilt University School of Medicine
1998-2000, Predoctoral Cancer Research Training Award, National Cancer Institute
1997, Howard Hughes Undergraduate Summer Research Award, University of Nebraska-Lincoln

Editorial and Academic Positions

Editorial Positions

2021-present, Reviewer, Elife
2019-present, Reviewer, European Respiratory Journal
2019-present, Reviewer, Journal of Medical Genetics
2018-present, Reviewer, American Journal of Respiratory and Critical Care Medicine
2017-present, Reviewer, Development

Academic and Institutional Committees

2019-present, Drug and Safety Monitoring Board, Baricitinib in Aicardi Goutieres Syndrome
2016-present, Cardiac Center Strategic Planning (Research Workgroup)
2016-present, Cardiac Center Strategic Planning (Maintaining Talent in the Cardiac Center Workgroup)

Leadership and Memberships

Memberships in Professional Organizations

2018-present, American Thoracic Society
2018-present, American Heart Association
 - 2018-present, Dev Basic Science Fellowship Review Committee
2011-present, American College of Cardiology