![J. William Gaynor, MD](/sites/default/files/styles/crop_and_center_300x375/public/providers-new-gaynor-j-william.jpg?itok=ttff4T1u)
J. William Gaynor, MD
Areas of expertise: Congenital heart disease, Cardiothoracic Surgery, Impact of the maternal-fetal environment on outcomes in congenital heart disease, Genetic modifiers of outcomes in congenital heart disease, Impact of environmental exposures on outcomes in congenital heart disease, Cardiac transplantation, Cerebral protection during cardiac surgery, Neurodevelopment in congenital heart disease
About J. William Gaynor, MD
Dr. Gaynor is a Professor of Pediatric Cardiothoracic Surgery and holds the Daniel M. Tabas Endowed Chair in Pediatric Cardiothoracic Surgery at Children's Hospital of Philadelphia. He has a long interest in long-term outcomes assessment in children with congenital heart defects. His research has focused on understanding neurodevelopmental outcomes and risk factors associated with adverse outcomes in this area. He has special interests in the understanding the role of the maternal-fetal environment and genetic factors as mediators of long-term outcomes. He currently serves as Director of the Long-term Follow-up Program in the Cardiac Center at CHOP and as the Co-Principal Investigator of the Birth Defects Biorepository.
Titles
Attending Surgeon
Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania
Certifications
Congenital Cardiac Surgery – American Board of Thoracic Surgery
Thoracic and Cardiac Surgery – American Board of Thoracic Surgery
Awards and Honors
2022, William P. Potsic MD Mentor Award
2022, Newburger-Bellinger Cardiac Neurodevelopmental Award, Cardiac Neurodevelopmental Outcomes Collaborative
1981, Alpha Omega Alpha
1978, Phi Beta Kappa
Leadership and Memberships
Memberships in Professional Organizations
American Association for Thoracic Surgery
American College of Surgeons
The Society of Thoracic Surgeons
The European Association for Cardio-Thoracic Surgery
The Society of University Surgeons
Southern Thoracic Surgical Association
Congenital Heart Surgeons Society
European Congenital Heart Surgeons Association
American Academy of Pediatrics - Section on Cardiology and Cardiac Surgery
American Heart Association - Council on Cardio-Thoracic and Vascular Surgery
American Heart Association - Council on Cardiovascular Disease in the Young
American College of Cardiology
David C. Sabiston, Jr. Surgical Society
International Society for Heart & Lung Transplantation
World Society for Pediatric and Congenital Heart Surgery
American Society of Extracorporeal Technology
Society for Thoracic Surgical Education
Editorial and Academic Positions
Editorial positions
2013-2019, Editor, Operative Techniques in Thoracic and Cardiothoracic Surgery
2011-2013, Associate Editor for Congenital Heart Surgery, Operative Techniques in Thoracic and Cardiovascular Surgery
2001-2007; 2012-2021, Advisory Editorial Board, Journal of Thoracic and Cardiovascular Surgery
2003-present, Advisory Editorial Board, Cardiology in the Young
Manuscript Reviewer
- American Heart Journal
- American Journal of Cardiovascular Drugs
- American Journal of Medical Genetics , Part B
- Anesthesia and Analgesia
- Annals of Thoracic Surgery
- Cardiology in the Young
- Cerebral Cortex
- Clinical Physiology and Functional Imaging
- Circulation
- Critical Care Medicine
- Developmental Medicine and Child Neurology
- European Journal of Cardio-Thoracic Surgery
- Journal of Pediatric Psychology
- Journal of Pediatrics
- Journal of Thoracic and Cardiovascular Surgery
- New England Journal of Medicine
- Pediatrics
- Stroke
- Transplantation
- World Journal for Pediatric and Congenital Heart Surgery
Academic and institutional committees
2011-present, Pediatric Cardiac Critical Care Consortium (PC4), Executive Committee
2007-present, Chair, Cardiac Center Information System Committee, The Children's Hospital of Philadelphia
2006-present, University of Pennsylvania Department of Surgery Committee on Appointments and Promotions, The Children's Hospital of Philadelphia
2000-present, Chair, Cardiac Center Neurocardiac Research Program, The Children's Hospital of Philadelphia
1999-present, Hospital Information Systems Committee, The Children's Hospital of Philadelphia
1998-present, International Committee on Pediatric Cardiac Surgery Nomenclature (Board of Directors)
Education & training
Medical Degree
MD - Medical University of South Carolina, Charleston, SC
Internship
Medicine - Parkland Memorial Hospital, Dallas, TX
Residency
Medicine - Parkland Memorial Hospital, Dallas, TX
Surgery - Duke University Medical Center, Durham, NC
Fellowship
Research Fellow, Surgery - Duke University Medical Center, Durham, NC
Cardiac Surgery - The Hospital for Sick Children, Great Ormond Street, London, England
Publications
Publications
2024
Crowley TB, Campbell I, Arulselvan A, Friedman D, Zackai EH, Geoffrion TR, Witmer C, Gaynor JW, McDonald-McGinn DM, Lambert MP. A case-control study of bleeding risk in children with 22q11.2 deletion syndrome undergoing cardiac surgery. Platelets. 35(1):2290108, 2024 Dec
Gaynor JW, Graham EM, Bhandari D, Fenchel M, Bradman A, Klepczynski B, Collier H, Ittenbach RF, Reese CM, Blount BC. Perioperative exposure to volatile organic compounds in neonates undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2024; 167:1166-1176.
Keisling J, Bedoukian E, Burstein DS, Gaynor JW, Gray C, Krantz I, Izumi K, Leonard J, Lin KY, Medne L, Seymour C, Skraban C, Ritter A, Ahrens-Nicklas RC. Diagnostic Yield of Exome Sequencing in Pediatric Cardiomyopathy. J Pediatr. 2024; 265:113808.
Sadhwani A, Sood E, Van Bergen AH, Ilardi D, Sanz JH, Gaynor JW, Seed M, Ortinau CM, Marino BS, Miller TA, Gaies M, Cassidy AR, Donohue JE, Ardisana A, Wypij D, Goldberg CS. Development of the data registry for the Cardiac Neurodevelopmental Outcome Collaborative. Cardiology in the Young. 2024; 34:79-85.
Aronowitz DI, Geoffrion TR, Burstein D, White RM, McHugh-Grant S, Mavroudis CD, Nuri MAK, Maeda K, Chen JM, Mascio CE, Gaynor JW, Fuller SM. Reintervention for Superior Vena Cava Obstruction After Heart Transplant. Ann Thorac Surg 2024; 117:198-204.
2023
Nathan, M; Newburger, JW; Gurvitz, M; Nathan, Meena; Newburger, Jane W; Bell, Margaret; Tang, Alexander; Gongwer, Russell; Dunbar-Masterson, Carolyn; Atz, Andrew M; Bacha, Emile; Colan, Steven; Gaynor, J William; Kanter, Kirk; Levine, Jami C; Ohye, Richard; Pizarro, Christian; Schwartz, Steven; Shirali, Girish; Tani, Lloyd. Development of the Residual Lesion Score for congenital heart surgery: the RAND Delphi methodology. Cardiology in the Young 2023; 33:977-990.
Smith AH, Shin AY, Tabbutt S, Banerjee M, Zhang W, Borasino S, Elhoff JJ, Gaynor JW, Ghanayem NS, Pasquali SK, St Louis JD, Shashidharan S, Ruppe M, Schumacher KR, Gaies M, Costello JM. Age at Surgery and Outcomes Following Neonatal Cardiac Surgery: An Analysis from the Pediatric Cardiac Critical Care Consortium. J Thorac Cardiovasc Surg 2023; 165:1528-1538.
Geoffrion TR, Goldberg D, Crowley TB, Chen JM, McDonald-McGinn DM, Gaynor JW. Chromosome 22q11 copy number variants and single ventricle CHD. Cardiol Young 2023; 33:101-105.
Lawrence KM, Radaelli E, McGovern PE, Licht DJ, Davey MG, Flake AW, Gaynor JW, Vossough A. Radiographic and Histologic Characterisation of White Matter Injury in a Sheep Model of CHD. Cardiol Young 2023; 33:432-436.
Jacobwitz M, Favilla E, Patel A, Giglia TM, Taing K, Ravishankar C, Gaynor JW, Licht DJ, McGuire JL, Beslow LA. Neurologic Complications of Infective Endocarditis in Children. Jacobwitz M, Favilla E, Patel A, Giglia TM, Taing K, Ravishankar C, Gaynor JW, Licht DJ, McGuire JL, Beslow LA. Cardiol Young 2023; 33:463-472.
Lawrence KM, Burstein DS, Ahrens-Nicklas R, Gaynor JW, Nuri MA. Noonan Syndrome Associated with Hypoplastic Left Heart Syndrome. Jacobwitz M, Favilla E, Patel A, Giglia TM, Taing K, Ravishankar C, Gaynor JW, Licht DJ, McGuire JL, Beslow LA. Cardiol Young 2023; 33:652-654.
Marino BS, Cassedy A, Brown KL, Franklin R, Gaynor JW, Cvetkovic M, Laker S, Levinson K, MacGloin H, Mahony L, McQuillan A, Mussatto K, O'Shea D, Newburger J, Sykes M, Teele SA, Wernovsky G, Wray J. Long-Term Quality of Life in Congenital Heart Disease Surgical Survivors: Multicenter Retrospective Study of Surgical and ICU Explanatory Factors. Pediatric Critical Care Medicine. 2023; 24:391-398.
Licht DJ, Jacobwitz M, Lynch JM, Ko T, Boorady T, Devarajan M, Heye KN, Mensah-Brown K, Newland JJ, Schmidt A, Schwab P, Winters M, Nicolson SC, Montenegro LM, Fuller S, Mascio C, Gaynor JW, Yodh AG, Gebb J, Vossough A, Choi GH, Putt ME. Impaired Maternal-Fetal Environment and Risk for Preoperative Focal White Matter Injury in Neonates with Complex Congenital Heart Disease. JAHA 2023; 12(7):e025516.
Lewis MJ, Hsieh A, Qiao L, Tan R, Kazzi B, Channing A, Griffin EL, Jobanputra V, Su J, Shahryar C, Kochilas L, Gaynor JW, Lee T, Goldmuntz E, Russell M, Mital S, Tristani M, Brueckner M, Newburger J, Shen Y, Chung WK. Association of Predicted Damaging De Novo Variants on Ventricular Function in Individuals with Congenital Heart Disease. Circulation. Genomic and Precision Medicine. 2023; 16(2):e003900.
Gartenberg AJ, Okunowo O, Dori Y, Smith CL, Gaynor JW, Mascio CE, Rome JJ, Gillespie MJ, Glatz AC, O'Byrne ML Association of Interstage Monitoring Era and Likelihood of Hemodynamic Compromise at Intervention for Recoarctation Following the Norwood Operation. JAHA 2023; 12(14):e029112.
Schmithorst V, Ceschin R, Lee V, Wallace J, Sahel A, Chenevert TL, Parmar H, Berman JI, Vossough A, Qiu D, Kadom N, Grant PE, Gagoski B, LaViolette PS, Maheshwari M, Sleeper LA, Bellinger DC, Ilardi D, O'Neil S, Miller TA, Detterich J, Hill KD, Atz AM, Richmond ME, Cnota J, Mahle WT, Ghanayem NS, Gaynor JW, Goldberg CS, Newburger JW, Panigrahy A. Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study. Diagnostics. 2023; 13(9).
Edelson JB, Zhang X, Goldstone AB, Rossano JW, O'Connor MJ, Gaynor JW, Edwards JJ, Wittlieb-Weber C, Maeda K. Reduced incidence of cardiac rejection in multi-organ transplants: A propensity matched study. Clinical Transplantation. 2023; 37(9):e15019.
Kristensen R, Omann C, Gaynor JW, Rode L, Ekelund CK, Hjortdal VE. Increased nuchal translucency in children with congenital heart defects and normal karyotype-is there a correlation with mortality? Frontiers in Pediatrics. 2023; 11:1104179.
Omann C, Kristensen R, Tabor A, Gaynor JW, Hjortdal VE, Nyboe C. School performance is impaired in children with both simple and complex congenital heart disease. Frontiers in Pediatrics. 2023; 11:1073046.
Sadhwani A, Sood E, Van Bergen AH, Ilardi D, Sanz JH, Gaynor JW, Seed M, Ortinau CM, Marino BS, Miller TA, Gaies M, Cassidy AR, Donohue JE, Ardisana A, Wypij D, Goldberg CS. Development of the data registry for the Cardiac Neurodevelopmental Outcome Collaborative. Cardiology in the Young. 2023; 1-7, May 19.
Simpao AF, Randazzo IR, Chittams JL, Burnham N, Gerdes M, Bernbaum JC, Walker T, Imsdahl S, DeWitt AG, Zackai EH, Gaynor JW, Loepke AW. Anesthesia and sedation exposure and neurodevelopmental outcomes in infants undergoing congenital cardiac surgery: a retrospective cohort study. Anesthesiology. 2023 Jul 13.
Stack KO, Schluger C, Roberts AL, Lawrence K, Balsara S, Hunt M, Kaplinski M, Gardner MM, Ravishankar C, Rossano J, Goldberg DJ, Mahle M, O'Connor MJ, Mascio CE, Gaynor JW, Burstein D. Impact of Ventricular Dysfunction and Atrioventricular Valve Regurgitation on Pre-Fontan Attrition. Ann Thorac Surg. 2023 Jul 08.
de Jong IEM, Hunt ML, Chen D, Du Y, Llewellyn J, Gupta K, Li D, Erxleben D, Rivas F, Hall AR, Furth EE, Naji A, Liu C, Dhand A, Burdick JA, Davey MG, Flake AW, Porte RJ, Russo PA, Gaynor JW, Wells RG. . A fetal wound healing program after intrauterine bile duct injury may contribute to biliary atresia. J Hepatology. 2023 Aug 21.
O'Connor AM, Cassedy A, Wray J, Brown KL, Cohen M, Franklin RCG, Gaynor JW, MacGloin H, Mahony L, Mussatto K, Newburger JW, Rosenthal DN, Teitel D, Ernst MM, Wernovsky G, Marino BS. Differences in Quality of Life in Children Across the Spectrum of Congenital Heart Disease. J Ped. 113701, 2023 Aug 26.
Gaynor JW, Graham EM, Bhandari D, Fenchel M, Bradman A, Klepczynski B, Collier H, Ittenbach RF, Reese CM, Blount BC. Perioperative exposure to volatile organic compounds in neonates undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2023 Aug 07.
Rusin G, Acosta SI, Brady KM, Vu E, Scahill C, Fonseca B, Barrett C, Simsic, J, Yates AR; Klepczynski B, Gaynor JW, Penny DJ. Automated prediction of cardiorespiratory deterioration in patients with single-ventricle parallel circulation: A multicenter validation study.JTCVS Open 2023.
Laurent GH, Ko TS, Mensah-Brown KG, Mavroudis CD, Jacobwitz M, Ranieri N, Nicolson SC, Gaynor JW, Baker WB, Licht DJ, Massey SL, Lynch JM. Electroencephalography as a tool to predict cerebral oxygen metabolism during deep-hypothermic circulatory arrest in neonates with critical congenital heart disease. JTCVS Open 2023.
Nathan M, Gauvreau K, White O, Anderson BR, Bacha EA, Barron DJ, Cleveland J, Del Nido PJ, Eghtesady P, Galantowicz M, Kennedy A, Kohlsaat K, Ma M, Mattila C, Van Arsdell G, Gaynor JW. Comparing Apples to Apples: Exploring public reporting of congenital cardiac surgery outcomes based on common congenital heart operations. J Thorac Vardiovasc Surg 2023; Sep 7.
Freud LR, Galloway S, Crowley TB, Moldenhauer J, Swillen A, Breckpot J, Borrell A, Vora NL, Cuneo B, Hoffman H, Gilbert L, Nowakowska B, Geremek M, Kutkowska-Kazmierczak A, Vermeesch JR, Devriendt K, Busa T, Sigaudy S, Vigneswaran T, Simpson JM, Dungan J, Gotteiner N, Gloning KP, Digilio MC, Unolt M, Putotto C, Marino B, Repetto G, Fadic M, Garcia-Minaur S, Buil AA, Thomas MA, Fruitman D, Beecroft T, Hui PW, Oskarsdottir S, Bradshaw R, Criebaum A, Norton ME, Lee T, Geiger M, Dunnington L, Isaac J, Wilkins-Haug L, Hunter L, Izzi C, Toscano M, Ghi T, McGlynn J, Grati FR, Emanuel BS, Gaiser K, Gaynor JW, Goldmuntz E, McGinn DE, Schindewolf E, Tran O, Zackai EH, Yan Q, Bassett A, Wapner R, McDonald-McGinn DM. Prenatal versus Postnatal Diagnosis of 22q11.2 Deletion Syndrome: Cardiac and Non-Cardiac Outcomes through 1 Year of Age. Am J OB Gyn 2023; Sep15.
Miller TA, Hernandez EJ, Gaynor JW, Russell MW, Newburger JW, Chung W, Goldmuntz E, Cnota JF, Zyblewski SC, Mahle WT, Zak V, Ravishankar C, Kaltman JR, McCrindle BW, Clarke S, Votava-Smith JK, Graham EM, Seed M, Rudd N, Bernstein D, Lee TM, Yandell m, Tristani-Firouzi M. Genetic and clinical variables act synergistically to impact neurodevelopmental outcomes in children with single ventricle heart disease. Communications Medicine 2023; 3:127 | https://doi.org/10.1038/s43856-023-00361-2 www.nature.com/commsmed.
Geoffrion TR, Aronowitz DI, Mangeot C, Ittenbach RF, Lodge AJ, Fuller SM, Chen JM, Gaynor JW. Contemporary Outcomes for Functional Single Ventricle with Total Anomalous Pulmonary Venous Connection. J Thorac Cardiovasc Surg 2023; Sep 29.
Brunetti MA, Griffis HM, O’Byrne ML, Glatz AC, Huang J, Schunacher KR, Bailly DK, Domnina Y, Lasa JJ, Moga MA, Zaccagni H, Simsic JM, Gaynor JW. Racial and Ethnic Variation in ECMO Utilization and Outcomes in Pediatric Cardiac ICU Patients, JACC Adv 2023; 2:100634.
Grasty MA, Mavroudis CD, DeWitt AG, Kozyak BW, Mamula P, MacFarland SP, Nuri MAK, Rogers LS, Rome JJ, Gaynor JW, Goldberg DJ Hereditary haemorrhagic telangiectasia and SMAD4 mutation in a patient with complex single ventricle heart disease. Cardiology in the Young. 2023: 1-3 Oct 09
Ittenbach RF, Gaynor JW, Dorich JM, Burnham NB, Huang G, Harvey MT, Corsmo JJ. uConsent: Addressing the gap in measuring understanding of informed consent in clinical research. Clin Transl Sci. 2023;00:1–13.
Fogel MA, Donnelly E, Crandell I, Hanlon A, Whitehead KK, Harris M, Partington S, Biko D, Flynn T, Nicolson S, Gaynor JW, Licht D, Vossough A. Cerebral Blood Flow, Brain Injury, and Aortic-Pulmonary Collateral Flow After the Fontan Operation. Am J Cardiol 2023; 208:164-170.
Goldberg CS, Trachenberg F, Gaynor JW, Mahle WT, Ravishankar C, Schwartz SM, Cnota JF, Ohye RG, Gongwer R, Taylor M, Paridon S, Frommelt PC, Afton K, Atz AM, Burns KM, Detterich JA, Hill KD, Cagera AG, Lewis AB, Pizarro C, Shah A Sharma B, Newburger JW and the PHN Investigators. Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study. Circulation. 2023; 148: 1330–1339.
Hsia J, Abend NS, Gaynor JW, Chen JM, Fuller S, Maeda K, Mavroudis CD, Nuri M, Leonard J, Ampah SB, Licht DJ, Massey SL, Naim MY. Incidence of Postoperative Seizures in Neonates Following Cardiac Surgery with Regional Cerebral Perfusion and Deep Hypothermic Circulatory Arrest, JTCVS Open (2023), doi: https://doi.org/10.1016/j.xjon.2023.10.026.
Keisling J, Bedoukian E, Burstein DS, Gaynor JW, Gray C, Krantz I, Izumi K, Leonard J, Lin KY, Medne L, Seymour C, Skraban C, Ritter A, Ahrens-Nicklas RC. Diagnostic Yield of Exome Sequencing in Pediatric Cardiomyopathy. J Pediatr. 2023; 113808, Nov 01.
Stanley HM, White BR, LaRosa CJ, Cocalis MW, Gaynor JW, Strong A, Gangaram B. Patent ductus arteriosus and coarctation of the aorta in association with PRDM6 variants. American J Med Gene. Part A. 2023 Dec 09.
Hunt M, de Jong IEM, Wells RG, Shah AA, Russo P, Mahle M, Gardner MM, Fuller S, Chen J, Gaynor JW. Conjugated hyperbilirubinemia is associated with increased morbidity and mortality after neonatal heart surgery. Cardiol Young. 1-8, 2023 Dec 18.
2022
Pasquali SK, Thibault D, Hall M, Chiswell K, Romano JC, Gaynor JW, Shahian DM, Jacobs ML, Gaies MG, O’Brien SM, Norton EC, Hill KD, Cowper PA, Shah SS, Mayer JE, Jacobs JP. Evolving Cost-Quality Relationship in Pediatric Heart Surgery. Ann Thorac Surgery 2022; 113:866-873.
Mavroudis CD, Ko T, Volk LE, Smood B, Morgan RW, Lynch JM, Licht DJ, Gaynor JW, Mascio CE, Kilbaugh TJ. Does Supply Meet Demand? A Comparison of Perfusion Strategies on Cerebral Metabolism in a Neonatal Swine Model. J Thorac Cardiovasc Surg 2022; 163:e47-e58.
Savla JJ, Putt ME, Huang J, Parry S, Moldenhauer JS, Reilly S, Youman J, Rychik J, Mercer-Rosa L, Gaynor JW, Kawut SM. Impact of Maternal-Fetal Environment on Mortality in Children with Single Ventricle Heart Disease. J Am Heart Assoc 2022; 11:e020299.
Omann C, Lawrence KM, Hunt ML, Moon JK, Buchanan J, Licht DJ, Ittenbach RF, McGovern P, Chen JM, Davey M, Hjortdal VE, Flake AW, Gaynor JW. Chronic Foetal Hypoxaemia does not Cause Elevation of Serum Markers of Brain Injury. Cardiol Young. 2022; 32(5):732-737.
Gaynor JW, Burnham NB, Ittenbach RF, Gerdes M, Bernbaum JC, Zackai E, Licht DJ, Russell WW, Zullo EE, Miller T, Hakonarson H, Clarke KA, Jarvik GP, Calafat AM, Bradman A, Bellinger DC, Henretig FM, Coker ES. Childhood exposures to environmental chemicals and neurodevelopmental outcomes in congenital heart disease. PLoS ONE [Electronic Resource]. 17(11):e0277611, 2022. PMID: 36395323.
Ruiz VM, Goldsmith MP, Shi L, Simpao AF, Galvez JA, Naim MY, Nadkarni V, Gaynor JW, Tsui FR. Early Prediction of Clinical Deterioration Using Data-Driven Machine-Learning Modeling of Electronic Health Records. J Thorac Cardiovasc Surg 2022; 164(1):211-222.e3.
Normand ST, Zelevinsky K, Nathan M, Abing HK, Dearani JA, Galantowicz M, Gaynor JW, Habib RH, Hanley FL, Jacobs JP, Kumar SR, McDonald DE, Pasquali SK, Shahian DM, Tweddell JS, Vener DF, Mayer JE Jr. Reevaluating Congenital Heart Surgery Center Performance Using Operative Mortality. Ann Thorac Surg 2022; 114(3):776-784
Normand ST, Zelevinsky K, Nathan M, Abing HK, Dearani JA, Galantowicz M, Gaynor JW, Habib RH, Hanley FL, Jacobs JP, Kumar SR, McDonald DE, Pasquali SK, Shahian DM, Tweddell JS, Vener DF, Mayer JE Jr. Mortality Prediction After Cardiac Surgery in Children: An STS Congenital Heart Surgery Database Analysis. Ann Thorac Surg. 2022; 114(3):785-798.
Gardner, MM; Keim, G; Yehya, N; Gardner, Monique M; Keim, Garrett; Hsia, Jill; Mai, Anh D; William Gaynor, J; Glatz, Andrew C; Yehya, Nadir. Characterization of “ICU‐30”: A Binary Composite Outcome for Neonates with Critical Congenital Heart Disease. JAHA 2022; 11:12.
Moon JK, Lawrence KM, Hunt ML, Davey MG, Flake AW, Licht DJ, Chen JM, Kilbaugh TJ, Gaynor JW, Beiting DP. Chronic Hypoxemia Induces Mitochondrial Respiratory Complex Gene Expression in the Fetal Sheep Brain. JTCVS Open. 2022; 10:342-349.
Ron, HA; Crowley, TB; McDonald-McGinn, DM; Ron, Hayley A; Crowley, Terrence Blaine; Liu, Yichuan; Unolt, Marta; Schindewolf, Erica; Moldenhauer, Julie; Rychik, Jack; Goldmuntz, Elizabeth; Emanuel, Beverly S; Ryba, Douglas; Gaynor, James William; Zackai, Elaine H; Hakonarson, Hakon; McDonald-McGinn, Donna M. Improved Outcomes in Patients with 22q11.2 Deletion Syndrome and Diagnosis of Interrupted Aortic Arch Prior to Birth Hospital Discharge, a Retrospective Study Genes 2023; 14:62.
Ko TS, Mavroudis CD, Benson EJ, Forti RM, Melchior RW, Boorady TW, Morano VC, Mensah-Brown K, Lin Y, Aronowitz D, Starr JP, Rosenthal TM, Shade BC, Schiavo KL, White BR, Lynch JM, Gaynor JW, Licht DJ, Yodh AG, Baker WB, Kilbaugh TJ. Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass. Metabolites Metabolites 2022:12(8)
Lynch JM, Mavroudis CD, Ko TS, Jacobwitz M, Busch DR, Xiao R, Nicolson SC, Montenegro LM, Gaynor JW, Yodh AG, Licht DJ. Association of Ongoing Cerebral Oxygen Extraction During Deep Hypothermic Circulatory Arrest with Postoperative Brain Injury. Sem Thorac Cardiovasc Surg 2022; 34:1275-1284.
Sukhavasi A, McHugh-Grant S, Glatz AC, Mondal A, Griffis H, Burnham N, Chen JM, Mascio CE, Gaynor JW, Spray TL, Fuller SM. Pulmonary Atresia with Intact Ventricular Septum: Intended Strategies. J Thorac Cardiovasc Surg 2022; 164:1277-1288.
Steurer MA, Schuhmacher K, Savla JJ, Banerjee M, Chanani NK, Eckhauser A, Elhoff J, Jacobs JP, Mikesell K, Peyvandi S, Romano J, Zhang W, Gaynor JW, Tabbutt S. Fetal Growth and Gestational Age Improve Outcome Predictions in Neonatal Heart Surgery. J Thorac Cardiovasc Surg 2022; 164:2003-2012.
Goldberg CS, Gaynor JW, Mahle WT, Ravishankar C, Frommelt P, Ilardi D, Bellinger D, Paridon S, Taylor M, Hill KD, Minich LL, Schwartz S, Afton K, Lamberti M, Trachtenberg FL, Gongwer R, Atz A, Burns KM, Chowdhury S, Cnota J, Detterich J, Frommelt M, Jacobs JP, Miller TA, Ohye RG, Pizarro C, Shah A, Walters P, Newburger JW, Pediatric Heart Network Investigators. The Pediatric Heart Network's Study on Long-term Outcomes of Children with HLHS and the Impact of Norwood Shunt Type in the Single Ventricle Reconstruction Trial Cohort (SVRIII): Design and Adaptations. Am Heart J 2022; 254:216-227.
Aronowitz DI, Geoffrion TR, Burstein D, White RM, McHugh-Grant S, Mavroudis CD, Nuri MAK, Maeda K, Chen JM, Mascio CE, Gaynor JW, Fuller SM. Reintervention for Superior Vena Cava Obstruction After Heart Transplant. Ann Thorac Surg 2022 Aug 05
Jacobs JP, Kumar SR, St Louis JD, Al-Halees ZY, Habib RH, Parsons N, Hill KD, Pasquali SK, Gaynor JW, Mascio CE, Overman DM, Dearani JA, Mayer JE Jr, Shahian DM, Jacobs ML. Variation in Case-Mix Across Hospitals: Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database. Ann Thorac Surg 2022; 115:485-492.
2021
Sananes R, Goldberg CS, Newburger JW, Hu C, Trachtenberg C, Gaynor JW, Mahle WT, Miller T, Uzark K, Mussatto KA, Pizarro C, Jacobs JP, Cnota J, Atz AM, Lai WW, Burns K, Milazzo A, Votava-Smith J, Brosig CL on behalf of the PHN investigators. 6-Year Neurodevelopmental Outcomes for Children with Single Ventricle Physiology Pediatrics 2021; 147: e2020014589.
Volk LE, Mavroudis CD, Ko T, Hefti M, Morgan RW, Melchior RW, Rosenthal TM, Chappell A, Fisher D, Dreher M, Licht DJ, Chen J, Gaynor JW, Mascio CE, Kilbaugh TJ. Increased Cerebral Mitochondrial Dysfunction and Reactive Oxygen Species with Cardiopulmonary Bypass. Eur J Cardiothorac Surg 2021; 59: 1256-1264.
Favilla E, Faerber JA, Hampton LE, Tam V, DeCost G, Ravishankar C, Gaynor JW, Burnham A, Licht DJ, Mercer-Rosa L. Early Evaluation and the Effect of Socioeconomic Factors on Neurodevelopment in Infants with Tetralogy of Fallot. Ped Cardiol 2021; 42: 643-653.
Petko M, Myung RJ, Volk LE, Judkins AR, Ittenbach RF, Gaynor JW. Deep Hypothermic Circulatory Arrest in Cyanotic Piglets is Associated with Increased Neuronal Necrosis. Cardiology in the Young 2021; 31: 769-774.
Zanaboni D, Min J, Seshadri R, Gaynor JW, Dreher M, Blinder JJ. Higher Total Ultrafiltration Volume during Cardiopulmonary Bypass-Assisted Infant Cardiac Surgery is Associated with Acute Kidney Injury and Fluid Overload. Ped Nephrol 2021: https://doi.org/10.1007/s00467-021-04976-2.
Lawrence KM, Ittenbach RF, Hunt ML Kaplinski M, Ravishankar C, Rychik J, Steven JM, Fuller SM, Nicolson SC, Gaynor JW, Spray TL, Mascio CE. Attrition between the Superior Cavo-Pulmonary Connection and the Fontan Procedure in Hypoplastic Left Heart Syndrome. J Thorac Cardiovasc Surg 2021; 162:385-393.
Naim MY, Putt M, Abend NS, Mastropietro CW, Frank DU, Chen JM, Fuller S, Gangemi JJ, Gaynor JW, Heinan K, Licht DJ, Mascio CE, Massey S, Roeser ME, Smith CJ, Kimmel SE. Development and Validation of a Seizure Prediction Model in Neonates After Cardiac Surgery. Ann Thorac Surg 2021; 111: 2041-2048.
Lisanti AJ, Savoca M, Gaynor JW, Mascarenhas MR, Ravishankar C, Sullivan E, Pieciak K, Costarino A, Chen J, Kennedy A, Olsen R, Min J, Mondal A, Huang J, Irving SY. Standardized Feeding Approach Mitigates Weight Loss in Infants with Congenital Heart Disease. J Peds 2021; 231: 124-130.
Bartoli CR, Hennessy-Strahs S, Dowling RD, Gaynor JW, Glatz AC. Abnormalities in the Von Willebrand-Angiopoietin Axis Contribute to Dysregulated Angiogenesis and Angiodysplasia in Children with a Glenn Circulation. JACC-Basic to Translational Science 2021; 6: 222-235.
Nathan M, Levine JC, Van Rompay MI, Lambert LM, Trachtenberg FL, Colan SD, Adachi I, Anderson BR, Bacha EA, Eckhauser A, Gaynor JW, Graham EM, Goot B, Jacobs JP, John R, Kaltman JR, Kanter KR, Mery CM, Minich, LL,Ohye, R, Overman D, Pizarro C, Raghuveer G, Schamberger MS, Schwartz SM, Narasimhan SL, Taylor MD, Wang K, Newburger JW. Impact of Major Residual Lesions on Outcomes After Surgery for Congenital Heart Disease. JACC 2021; 77: 2382-2394.
Burstein DS, Gaynor JW, Griffis H, Ritter A, OʼConnor MJ , Rossano JW, Lin KY. Ahrens-Nicklas RC. Genetic Variant Burden and Adverse Outcomes in Pediatric Cardiomyopathy. Ped Res 2021; 89(6):1470-1476.
Jacobs JP, Franklin RCG, Béland MJ, Spicer DE, Colan SD, Walters III HL, Bailliard F, Houyel L, St. Louis JD, Lopez L, Aiello VD, Gaynor JW, Krogmann ON, Kurosawa H, Maruszewski BJ, Stellin G, Weinberg PM, Jacobs ML, Boris JR, Cohen MS, Everett AD, Giroud JM, Guleserian KJ, Hughes ML, Juraszek AL, Seslar SP, Shepard CW, Srivastava S, Cook AC, Crucean A, Hernandez LE, Loomba RS, Rogers LS, Sanders SP, Savla JJ, Tierney ESS, Tretter JT, Wang L, Elliott MJ, Mavroudis CD, Tchervenkov CI. Nomenclature for Pediatric and Congenital Cardiac Care: Unification of Clinical and Administrative Nomenclature – The 2021 International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Revision of the International Classification of Diseases (ICD-11). World J Ped Cong Heart Surg 2021; 12:E1-E8.
Jacobs JP, Franklin RCG, Béland MJ, Spicer DE, Colan SD, Walters III HL, Bailliard F, Houyel L, St. Louis JD, Lopez L, Aiello VD, Gaynor JW, Krogmann ON, Kurosawa H, Maruszewski BJ, Stellin G, Weinberg PM, Jacobs ML, Boris JR, Cohen MS, Everett AD, Giroud JM, Guleserian KJ, Hughes ML, Juraszek AL, Seslar SP, Shepard CW, Srivastava S, Cook AC, Crucean A, Hernandez LE, Loomba RS, Rogers LS, Sanders SP, Savla JJ, Tierney ESS, Tretter JT, Wang L, Elliott MJ, Mavroudis CD, Tchervenkov CI. Nomenclature for Pediatric and Congenital Cardiac Care: Unification of Clinical and Administrative Nomenclature – The 2021 International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Revision of the International Classification of Diseases (ICD-11). Cardiol Young 2021; 31:1057-1188.
2020
Lawrence KM, McGovern PE, Mejaddam A, Rossidis AC, Baumgarten H, Kim AG, Grinspan JB, Licht DJ, Radaelli E, Rychik J, Peranteau WH, Davey MG, Flake AW, Gaynor JW. Prenatal hypoxemia alters microglial morphology in fetal sheep. J Thorac Cardiovasc Surg 2020; 159:270-7.
Goldstone AB, Baiocchi M, Wypij D, Stopp C, Andropoulos DB, Atallah J, Atz AM, Beca J, Donofrio MT, Duncan K, Ghanayem NS, Goldberg CS, Hövels-Gürich H, Ichida F, Jacobs JP, Justo R, Latal B, Li JS, Mahle WT, McQuillen PS, Menon SC, Pike NA, Pizarro C, Shekerdemian LS, Synnes A, Williams IA, Bellinger DC, Newburger J, Gaynor JW. The Bayley-III Scale May Underestimate Neurodevelopmental Disability after Cardiac Surgery in Infants. Eur J Thorac Cardiovasc Surg 2020; 57: 63-71.
Ko TS, Mavroudis CD, Baker WB, Morano VC, Mensah-Brown, Boorady TW, Schmidt AL, Lynch JM, Busch DR, Gentile J, Bratinov G, Lin Y, Jeong S, Melchoir RW, Rosenthal TM, Shade BC, Schaivo KL, Xiao R, Gaynor JW, Yodh AG, Kilbaugh TJ, Licht DJ. Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine. J Cereb Blood Flow Metab 2020; 40:187-203.
Fogel MA, Trusty PM, Nicolson SC, Spray TL, Gaynor JW, Whitehead KK, Yoganathan AP. Cross-Sectional Magnetic Resonance and Modeling Comparison from Just After Fontan to the Teen Years. Ann Thorac Surg 2020; 109:574-82.
McGovern PE, Lawrence K, Baumgarten H, Rossidis AC, Mejaddam AY, Licht DJ, Grinspan J, Schupper A, Rychik J, Didier RA, Vossough A, Spray TL, Peranteau WH, Davey MG, Flake AW, Gaynor JW. Ex Utero Extracorporeal Support as a Model for Fetal Hypoxia and Brain Dysmaturity. Ann Thorac Surg 2020; 109:810-819.
Jegatheeswaran A, Cohen MS, Gaynor JW, Mascio CE, Spray TL, Fuller S. Extracorporeal membrane oxygenation as a novel management strategy for interventricular septal hematoma following ventricular septal defect repair. J Thorac Cardiovasc Surg 2020; 159:1936-1940.
Thibault C, Naim MY, Abend NS, Licht DJ, Gaynor JW, Xiao R, Massey SL. A retrospective comparison of phenobarbital and levetiracetam for the treatment of seizures following cardiac surgery in neonates. Epilepsia 2020; 61:627-635.
Boskovski MT, Homsy J, Nathan M, Sleeper LA, Morton S, Manheimer KB, Tai A, Gorham J, Lewis M, Swartz M, Alfieris GM, Bacha EA Karimi M, Meyer D, Nguyen K, Bernstein D, Romano-Adesman A, Porter GA, Goldmuntz E, Chung WK, Srivastava D, Kaltman JR, Tristani-Firouzi M, Lifton R, Roberts AE, Gaynor JW, Gelb BD, Kim R, Seidman JG, Brueckner M, Mayer JE, Newburger JW, Seidman CE. De novo Damaging Variants, Clinical Phenotypes and Post-Operative Outcomes in Congenital Heart Disease. Circulation: Genomic and Precision 2020; 4: https://doi.org/10.1161/CIRCGEN.119.002836
Hunt ML, Ittenbach RI, Kaplinski M, Ravishankar C, Rychik J, Steven JM, Fuller SM, Nicolson SC, Spray TL, Gaynor JW, Mascio CE. Outcomes for the superior cavopulmonary connection in children with hypoplastic left heart syndrome: a 30-year experience. Eur J Cardiothorac Surg 2020; 58: 809-816.
Ho DY, Josowitz R, Katcoff H, Griffis HM, Tian ZY, Gaynor JW, Rychik J. Mid-gestational fetal placental blood flow is diminished in the fetus with congenital heart disease. Prenatal Diagnosis. 2020; 40:1432-1438.
Pasquali SK, Chiswell K, Hall M, Thibault B, Romano JC, Gaynor JW, Shahian DM, Jacobs ML, Gaies MG, O’Brien SM, Norton EC, Hill KD, Cowper PA, Pinto NM, Shah, SS MD, Mayer JE, Jacobs JP. Estimating Resource Utilization in Congenital Heart Surgery. Ann Thorac Surg 2020; 110: 962-8.
Lisanti AJ, Helman S, Sorbello A, Fitzgerald J, D’Amato A, Zhang X, Gaynor JW. Holding and Mobility of Pediatric Patients with Transthoracic Intracardiac Catheters. Critical Care Nurse 2020; 40: 16-24.
Bucholz EM, Sleeper LA, Goldberg CS, Pasquali SK, Anderson BR, Gaynor JW, Cnota JF, Newburger JW. Socioeconomic Status and Long-term Outcomes in Single Ventricle Heart Disease. Pediatrics 2020; 146: e20201240.
Kaplinski M, Ittenbach RF, Hunt ML, Stephan D, Natarajan SS, Ravishankar C, Giglia TM, Rychik J, Rome JJ, Mahle M, Kennedy AT, Steven JM, Fuller SM, Nicolson SC, Spray TL, Gaynor JW, Mascio CE. Decreasing Interstage Mortality after the Norwood Procedure: A 30-Year Experience. J Am Heart Assoc. 2020; 9: e016889. DOI: 10.1161/JAHA.120.016889.
Miller TA, Sadhwani A, Sanz J, Sood E, Ilardi D, Newburger JW, Goldberg CS, Wypij D, Gaynor JW, Marino BS. Variations in Practice in Cardiac Neurodevelopmental Follow-up Programs. Cardiology in the Young 2020; doi: 10.1017/S1047951120003522.
Pasquali,SK, Thibault D, O’Brien SM, Jacobs JP, Gaynor JW, Romano JC, Maies M, Hill KD, Jacobs ML, Shahian DM, Backer CL, Mayer JE. National Variation in Congenital Surgery Outcomes. Circulation 2020; 142: 1351-1360.
Nathan M, Trachtenberg FL, Van Rompay MI, Gaynor JW, Kanter K, Ohye R, Bacha EA, Tweddell J, Schwartz SM, Minich ll, Mery CM, Colan SD, Levine J, Lambert LM, Newburger JW, The Pediatric Heart Network Residual Lesion Score Study: Design and Objectives. J Thorac Cardiovasc Surg 2020; 160 218-231.e1.
2019
Russell MW, Moldenhauer JS, Rychik J, Nancy B. Burnham NB, Erin Zullo E, Samuel I Parry S, Simmons RA, Elovitz MA, Nicolson SC, Linn RL, Johnson MP, Yu S, Matthew Sampson M, Hakonarson H, Gaynor JW. Damaging variants in proangiogenic genes impair growth in fetuses with cardiac defects. [Published online ahead of print June 18, 2019] J Pediatr.
Zielonka B, Snarr BS, Liu MY, Zhang X, Mascio CE, Fuller S, Gaynor JW, Spray TL, Rychik J. Resource utilization for prenatally diagnosed single-ventricle cardiac defects: A Philadelphia fetus-to-Fontan cohort study. J Am Heart Assoc. 2019;8(11):e011284.
Lawrence KM, McGovern PE, Mejaddam A, Rossidis AC, Baumgarten H, Kim A, Grinspan JB, Licht DJ, Didier RA, Vossough A, Radaelli E, Rychik J, Song L, Peranteau WH, Davey MG, Flake AW, Gaynor JW. Chronic intrauterine hypoxia alters neurodevelopment in fetal sheep. J Thorac Cardiovasc Surg. 2019;157(5):1982–1991.
2018
Lawrence KM, Hennessy-Strahs S, McGovern PE, Mejaddam AY, Rossidis AC, Baumgarten HD, Bansal E, Villeda M, Han J, Gou Z, Zhao S, Rychik J, Peranteau WH, Davey MG, Flake AW, Gaynor JW, Bartoli CR. Fetal hypoxemia causes abnormal myocardial development in a preterm ex utero fetal ovine model. JCI Insight. 2018;3(24).
Rychik J, Goff D, McKay E, Mott A, Tian Z, Licht DJ, Gaynor JW. Characterization of the placenta in the newborn with congenital heart disease: distinctions based on type of cardiac malformation. Pediatr Cardiol. 2018;39(6):1165–1171.
Campbell IM, Sheppard SE, Crowley TB, McGinn DE, Bailey A, McGinn MJ, Unolt M, Homans JF, Chen EY, Salmons HI, Gaynor JW, Goldmuntz E, Jackson OA2, Katz LE, Mascarenhas MR, Deeney VFX, Castelein RM, Zur KB, Elden L, Kallish S, Kolon TF, Hopkins SE, Chadehumbe MA, Lambert MP, Forbes BJ, Moldenhauer JS, Schindewolf EM1, Solot CB, Moss EM, Gur RE, Sullivan KE, Emanuel BS, Zackai EH, McDonald-McGinn DM. What is new with 22q? An update from the 22q and You Center at the Children's Hospital of Philadelphia. Am J Med Genet A. 2018 Oct;176(10):2058-2069. doi: 10.1002/ajmg.a.40637.
Liu MY, Zielonka B, Snarr BS, Zhang X, Gaynor JW, Rychik J. Longitudinal Assessment of Outcome From Prenatal Diagnosis Through Fontan Operation for Over 500 Fetuses With Single Ventricle‐Type Congenital Heart Disease: The Philadelphia Fetus‐to‐Fontan Cohort Study. J Am Heart Assoc. 2018 Sept. 29;7(19):e009145.
Rossidis AC, Baumgarten HD, Lawrence KM, McGovern PE, Mejaddam AY, Li H, Hwang G, Young K, Peranteau WH, Davey MG, Gaynor JW, Flake AW. Chronically Hypoxic Fetal Lambs Supported by an Extra-Uterine Device Exhibit Mitochondrial Dysfunction and Elevations of Hypoxia Inducible Factor 1-Alpha. Fetal Diagn Ther. 2018 Jun 28; 1-8. [Epub ahead of print]
Gaynor JW, Parry S, Moldenhauer JS, Simmons RA, Rychik J, Ittenbach RF, Russell WW, Zullo E, Ward JL, Nicolson SC, Spray TL, Johnson MP. The impact of the maternal-fetal environment on outcomes of surgery for congenital heart disease in neonates. Eur J Cardiothorac Surg. 2018 Feb 13. doi: 10.1093/ejcts/ezy015. [Epub ahead of print] PMID: 29447332 [PubMed - as supplied by publisher]
2016
Rychik J, Khalek N, Gaynor JW, Johnson MP, Adzick NS, Flake AM, Hedrick HL. Fetal intrapericardial teratoma: natural history and management including successful in utero surgery. Am J Obstet Gynecol. 2016 Dec;215(6):780.e1-780.e7.
2015
Naim MY, Gaynor JW, Chen J, Nicolson SC, Fuller S, Spray TL, Dlugos DJ, Clancy RR, Costa LV, Licht DJ, Xiao R, Meldrum H, Abend NS. Subclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2015;150(1):169-178.
2014
Atchley KD, Pappas J, Kennedy A, Coffin SE, Gerber JS, Fuller SF, Spray TL, McCardle K, and Gaynor JW. Use of administrative data for surgical site infection surveillance after congenital cardiac surgery results in inaccurate reporting of site infection rates. Ann Thorac Surg 2014;97:651-8.
Parnell AS, Shults J, Gaynor JW, Leonard MB, Dai D, and Feudtner C. Accuracy of all patient refined diagnosis related groups classification system in congenital heart surgery. Ann Thorac Surg 2014; 97:641-50. Kirsch RE, Glatz AC, Gaynor JW, Nicolson SC, Spray TL, Wernovsky G, Bird GL. Results of elective repair at 6 months or younger in 277 patients with Tetralogy of Fallot: a 14-year experience at a single center. J Thorac Cardiovasc Surg 2014; 147:713-7.
Pasquali SK, Jacobs ML, He X, Shah SS, Peterson ED, Hall M, Gaynor JW, Hill KD, Mayer JE, Jacobs JP, and Li JS. Variation in congenital heart surgery costs across hospitals. Pediatrics; 2014
Gaynor JW, Ittenbach RF, Gerdes M, Bernbaum J, Clancy RR, McDonald-McGinn DM, Zackai EH, Wernovsky G, Nicolson SC, and Spray. Neurodevelopmental outcomes in preschool survivors of the Fontan procedure. J Thorac Cardiovasc Surg 2014; 147:1276-83.
Goff DA, Shera DM, Tang S, Lavin NA, Durning SM, Nicolson SC, Montenegro LM, Rome JJ, Gaynor JW, Spray TL, Vossough A, and Licht D. Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. J Thorac Cardiovasc Surg 2014; 147: 1312-8.
Rossano JW, Goldberg DJ, Fuller S, Ravishankar C, Montenegro LM, and Gaynor JW. Successful use of total artificial heart in the failing Fontan circulation. Ann Thorac Surg 2014; 97: 1438-40.
Keeshan BC, Goldfarb SB, Lin KY, Kreindler JL, Kaufman BD, Gaynor JW, Shaddy RE, and Rossano JW. Impact of congenital heart disease on outcomes of pediatric heart-lung transplantation. Pediatr Transplantation 2014; 18: 204-210.
Murphy MO, Glatz AC, Goldberg DJ, Rogers LS, Ravishankar C, Nicolson SC, Steven JM, Fuller S, Spray TL, and Gaynor JW. Management of early Fontan failure: a single-institution experience. European Journal of Cardio-Thoracic Surgery 2014; 1-7.
2013
Pasquali SK, Peterson ED, Jacobs JP, He X, Li JS, Jacobs ML, Gaynor JW, Hirsch JC, Shah SS, and Mayer JE. Differential case ascertainment in clinical registry vs. administrative data and impact on outcomes assessment in pediatric heart surgery. Ann Thorac Surg 2013; 95:197-203.
Jacobs JP, Jacobs ML,Maruszewski B, Lacour-Gayet FG, Tchervenkov CI, Tobota Z, Stellin G, Kurasawa H, Murakami A, Gaynor JW, Pasquali SK, Clarke DR, Austin EH, and Mavroudis C. Initial application in the EACTS and STS congenital heart surgery databases of an empirically derived methodology of complexity adjustment to evaluate surgical case mix and results. Eur Jo Cardiothorac Surg 2012; 42: 775-779.
Gaynor JW, Jarvik GP, Gerdes M, Kim DS, Rajagopalan R, Bernbaum J, Wernovsky G, Nicolson SC, Spray TL, and Clancy RR. Postoperative electroencephalographic seizures are associated with deficits in executive function and social behaviors at 4 years of age following cardiac surgery in infancy. J Thorac Cardiovasc Surg 2013; 146; 132-139.
Di Maria MV, Glatz AC, Ravishankar C, Quartermain M, Rush CH, Nance M, Gaynor JW, and Goldberg DJ. Supplemental tube feeding does not mitigate weight loss in infants with shunt-dependent single ventricle physiology. Ped Cardiol 2013;34: 350-1356.
Pasquali SK, Gaies MG, Jacobs JP, Gaynor JW, and Jacobs ML. Centre variation in cost and outcomes for CHD. Cardiol Young 2013; 22:796-799.
Buckley EM, Lynch JM, Goff DA, Schwab PJ, Baker WB, Durduran T, Busch DR, Nicolson SC, Montenegro LM, Naim MY, Xiao R, Spray TL, Yodh AG, Gaynor JW, and Licht DJ. Early postoperative changes in cerebral oxygen metabolism following neonatal cardiac surgery: effects of surgical duration. J Thorac Cardiovasc Surg 2013; 145: 196.
Ravishankar C,Zak V, Williams IA, Bellinger DC, Gaynor JW, Ghanayem NS, Krawczeski CD, Licht DJ, Mahony L, Newburger JW, Pemberton VL, Williams RV, Sananes R, Cook AL, Atz T, Khaikin S, and Hsu DT. Association of impaired linear growth and worse neurodevelopmental outcome in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial. Pediatrics 2013; 162: 250.
Piper BJ, Yasen AL, Tayler AE, Ruiz JR, Gaynor JW, Dayger CA, Gonzalez-Gross M, Kwon OD, Nilsson LG, Day INM, Raber J, and Miller K. Non-replication of an association of apolipoprotein E2 with sinistrality. Laterality 2013; 18: 251-261.
Mahle, WT, Lu MM, Ohye RG, Gaynor JW, Goldberg CS, Sleeper LA, Pemberton VL, Massatto KA, Williams IA, Sood E, Krawczeski CD, Lewis A, Mirarchi N, Scheurer M, Pasquali SK, Pinto N, Jacobs JP, McCrindle BW, and Newburger JW. A predictive model for neurodevelopmental outcome after the Norwood procedure. Ped Cardiol 2013; 34:327-333.
Buckley EM, Naim MY, Lynch JM, Goff DA, Schwab PJ, Diaz LK, Nicolson SC, Montenegro LM, Lavin NA, Durduran T, Spray TL, Gaynor JW, Putt ME, Yodh AG, Fogel MA, and Licht D. Sodium Bicarbonate causes dose dependent increases in cerebral blood flow in infants and children with single ventricle physiology. Pediatric Research 2013; 73: 668-673.
Wellen SL, Glatz AC, Gaynor JW, Montenegro LM, and Cohen MS. Transesophageal echocardiography probe insertion failure in infants undergoing cardiac surgery. Congenital Heart Disease 2013; 8: 240-245.
Rossano JW, Woods RK, Berger S, Gaynor JW, Ghanayem N, Morales DLS, Ravishankar C, Mitchell ME, Shah TK, Mahr C, Tweddell JS, Adachi I, Zangwill S, Wearden PD, Icenogle TB, Jaquiss RD, and Rychik J. Mechanical support as failure intervention in patients with cavopulmonary shunts (MFICS): rationale and aims of a new registry of mechanical circulatory support in single ventricle patients. Congenital Heart Disease 2013; 8: 182-186.
Lefkowitz DS, Novosel RS, Mohamed Z, Scharko A, Lin KY, Shaddy RE, Paridon SM, Miller K, Kaufman BD, Gaynor JW, and Rossano J. Psychiatric diagnoses and the use of psychiatric medications in pediatric ventricular assist device recipients Pediatric Transplantation 2013; 85: 62.
Pasquali SK, He X, Jacobs ML, Hall M, Gaynor JW, Shah SS, Peterson ED, Hill KD, Li JS, and Jacobs and JP. Hospital Variation in postoperative infection and outcome after congenital heart surgery. Ann Thorac Surg 2013; 96: 657-63.
Yi JJ, Tang SX, McDonald DM, Calkins ME, Whinna DA, Souders MC, Zackai EL, Goldmuntz E, Gaynor JW, Gur RC, Emanuel BS, Gur RE Contribution of congenital heart disease in neuropsychiatric outcome in school-age children with 22q11.2 deletion syndrome. Am J Med Genet Part B 2013; 9999: 1-11.
Eckhauser AW, O’Byrne ML, Weinberg PM, Ravishankar C, Spray TL, and Gaynor JW. Hypoplastic left ventricle and scimitar syndrome. Ann Thorac Surg 2013; 96:2232-4.
2012
Pasquali SK, Li JS, He X, Jacobs ML, O’Brien SM, Hall M, Jaquiss RD, Welke KF, Peterson ED, Shah SS, Gaynor JW, Jacobs JP. Perioperative methylprednisolone and outcome in neonates undergoing heart surgery. Pediatrics 2012; 129: e385-391.
Pasquali SK, Li JS, Burstein DS, Sheng S, O’Brien, Jacobs ML, Jaquiss RD, Peterson ED, Gaynor JW, Jacobs JP. Association of center volume with mortality and complications in pediatric heart surgery. Pediatrics 2012; 129: e370-376.
Goff DA, Luan X, Gerdes M, Bernbaum J, D’Agostino J, Rychik J, Wernovsky G, Licht D, Nicolson SC, Clancy RR, Spray TL, and Gaynor JW. Younger gestational age is associated with worse neurodevelopmental outcomes after cardiac surgery in infancy. J Thorac Cardiovasc Surg 2012; 143: 535-542.
Elia J, Glessner JT, Wang K, Takahashi N, Hadley D, Sleiman PM, Zhang H, Kim CE, Robison R, Lyon G, Gaynor JW, et al. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nature Genetics 2012; 44: 78-84.
Newburger JW, Sleeper LA, Bellinger D, Goldberg CS, Tabbutt S, Lu M, Mussatto KA, Williams IA, Gustafson KE, Mital S, Pike N, Sood E, Mahle W, Cooper DS, Dunbar-Masterson C, Dent Krawczeski C, Lewis A, Menon SC, Pemberton VL, Ravishankar C, Atz TW, Ohye R, and Gaynor JW. Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle trial. Circulation 2012; 125: 2081-2091.
Pasquali SK, He X, Jacobs JP, Jacobs ML, O’Brien SM, and Gaynor JW. Evaluation of failure to rescue as a quality metric in pediatric heart surgery: an analysis of the STS congenital heart surgery database. Ann Thorac Surg 2012; 94: 573-580.
Hirsch JC, Jacobs M, Andropoulos D, Austin E, Jacobs JP, Licht D, Pigula F, Tweddell J, and Gaynor JW. Protecting the infant brain during cardiac surgery: a systematic review for the Society of Thoracic Surgeons’ evidence based task force and congenital heart surgery workforce. Ann Thorac Surg 2012; 94:1365-1373.
Rogers LS, Glatz A, Ravishankar C, Spray TL, Nicolson SC, Rush CH, Gaynor JW, and Goldberg DJ. 18 years of the Fontan operation at a single institution: results from 771 consecutive patients. J Am Coll Cardiol 2012: 60: 1018-1025.
Pasquali S, Ohye RG, Kaltman J, Calderone CA, Dunbar-Masterson C, Gaynor JW, Jacobs JP, Kaza AK, Newburger J, Rhodes JF, Scheurer M, Silver E, Sleeper LA, Tabbutt S, Tweddell J, Uzark K, Wells W, Mahle WT, Pearson GD and Pediatric Network Investigators. Variation in perioperative care for infants undergoing the Norwood procedure J Thorac Cardiovasc Surg 2012; 144: 915-921.
Padalino MA, Vida VKL, Boccuzzo G, Tonello M, Sarris GE, Berggren H, Comas JV, Di Donato RM, Ebels T, Hraska V, Jacobs J, Gaynor JW, Metras D, Pretre R, Pozzi M, Rubay J, Sairaen H, Schreiber C, Maruszewsky B, Basso C, and Stellin G. Surgery for primary cardiac tumors in children: early and late results in a multi-center European congenital heart surgeons association (ECHSA) study. Circulation 2012; 126: 22-30.
Wu G, Jaimes C, Gaynor JW, and Markowitz RI. Radiographic signs of open median sternotomy in neonates and infants. Pediatr Radiol 2012; 42: 674-678.
Patel AK, Farrell P, Harris M, Gaynor JW, and Gillespie MJ. Acquired ventricular septal aneurysm in a patient with pulmonary atresia with intact ventricular septum. Cardiol Young 2012; 22: 227-229.
Kim DS, Stenaway IB, Rajagopalan R, Bernbaum JC, Solot CB, Burnham N, Zackai EH, Clancy RR, Nicolson SC, Gerdes M, Nickerson D, Hakonarson H, and Gaynor JW. Results of genome-wide analyses on neurodevelopmental phenotypes at four-year follow-up following cardiac surgery in infancy. PLoS ONE 2012: 7: e45936.
Kaczorowski DJ, Sathanandam S, Ravishankar C, Gillespie MJ, Montenegro LM, Gruber PJ, Spray TL, Gaynor JW, and Lin KL. Coronary osteoplasty for congenital atresia of the left main coronary artery ostium. Ann Thorac Surg 2012; 94: 1307-10.
D’Alessandro LCA, Paridon S, and Gaynor JW. Successful repair of aortic valve perforation in pediatric Libman Sacks endocarditis. J Thorac Cardiovasc Surg 2012; 144: 151-153.
2011
Szwast Al, Marino BS, Rychik J, Gaynor JW, Spray TL, and Cohen MS. Usefulness of left ventricular inflow index to predict successful biventricular repair in right-dominant unbalanced atrioventricular canal. Am J Cardiol 2011; 107: 103-109.
Clancy RR, Dicker L, Cho S, Cook N, Nicolson SC, Wernovsky G, Spray TL, and Gaynor JW. Agreement between long-term neonatal background classification by conventional and amplitude-integrated EEG. J Clin Neurophysiology 2011; 28: 1-9.
O’Connor MJ, Ravishankar C, Ballweg JA, Gillespie MJ, Gaynor JW, Tabbutt S, Dominguez TE. Early systemic-to-pulmonary artery shunt intervention in neonates with congenital heart disease. J Thorac Cardiovasc Surg 2011; 142: 106-112.
Zelicourt DA, Haggerty CM, Sundareswaran KS, White BS, Rosina JR, Kanter KR, Gaynor JW, Spray TL, Stavropoulos F, Fogel MA, and Yoganathan’s AP. Individualized computer-based surgical planning to address pulmonary arteriovenous malformations in patients with a single ventricle with an interrupted inferior cava and azygous continuation. J Thorac Cardiovasc Surg 2011; 141:1170-7.
Rogers LS, Peterson AL, Gaynor JW, Rome JJ, Weinberg PM, and Rychik J. Mitral valve dysplasia syndrome: a unique form of left-sided heart disease. J Thorac Cardiovasc Surg 2011; 142: 1381-7.
2010
Goldfarb SB, Gaynor JW, Fuller S, Kreindler J, Montenegro LM, Fynn-Thompson F, Visner G. Induction therapy with antithymocyte globulin before reperfusion. Ann Thorac Surg. 2010 Oct;90(4):1110-4; discussion 1114-5.
Gaynor JW, Gerdes M, Nord AS, Bernbaum J, Zackai E, Wernovsky G, Clancy RR, Heagerty PJ, Solot CB, McDonald-McGinn D, Jarvik GP. Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy? J Thorac Cardiovasc Surg. 2010 Oct 14. [Epub ahead of print]
Ballweg JA, Dominguez TE, Tabbutt S, Rome JJ, Gaynor JW, Nicolson SC, Spray TL, Ravishankar C. Reintervention for arch obstruction after stage 1 reconstruction does not adversely affect survival or outcome at Fontan completion. J Thorac Cardiovasc Surg. 2010 Sep;140(3):545-9.
Quartermain MD, Ittenbach RF, Flynn TB, Gaynor JW, Zhang X, Licht DJ, Ichord RN, Nance ML, Wernovsky G. Neuropsychological status in children after repair of acyanotic congenital heart disease. Pediatrics. 2010 Aug;126(2):e351-9. Epub 2010 Jul 26.
Burnham N, Ittenbach RF, Stallings VA, Gerdes M, Zackai E, Bernbaum J, Clancy RR, Gaynor JW. Genetic factors are important determinants of impaired growth after infant cardiac surgery. J Thorac Cardiovasc Surg. 2010 Jul;140(1):144-9. Epub 2010 Apr 9.
Ades AM, Dominguez TE, Nicolson SC, Gaynor JW, Spray TL, Wernovsky G, Tabbutt S. Morbidity and mortality after surgery for congenital cardiac disease in the infant born with low weight. Cardiol Young.2010 Feb;20(1):8-17. Epub 2009 Dec 18.
O'Connor MJ, Menteer J, Chrisant MR, Monos D, Lind C, Levine S, Gaynor JW, Hanna BD, Paridon SM, Ravishankar C, Kaufman BD. Ventricular assist device-associated anti-human leukocyte antigen antibody sensitization in pediatric patients bridged to heart transplantation. J Heart Lung Transplant. 2010 Jan;29(1):109-16.
2009
Brothers J, Gaynor JW, Paridon S, Lorber R, Jacobs M. Anomalous Aortic Origin of a Coronary Artery with an Interarterial Course: Understanding Current Management Strategies in Children and Young Adults. Pediatr Cardiol. 2009 Jun 2.
Raffini L, Schwed A, Zheng XL, Tanzer M, Nicolson S, Gaynor JW, Jobes D. Thromboelastography of Patients After Fontan Compared with Healthy Children. Pediatr Cardiol. 2009 Apr 9.
Licht DJ, Shera DM, Clancy RR, Wernovsky G, Montenegro LM, Nicolson SC, Zimmerman RA, Spray TL, Gaynor JW, Vossough A. Brain maturation is delayed in infants with complex congenital heart defects. J Thorac Cardiovasc Surg. 2009 Mar;137(3):529-36; discussion 536-7.
2008
Hehir DA, Dominguez TE, Ballweg JA, Ravishankar C, Marino BS, Bird GL, Nicolson SC, Spray TL, Gaynor JW, Tabbutt S. Risk factors for interstage death after stage 1 reconstruction of hypoplastic left heart syndrome and variants. J Thorac Cardiovasc Surg. 2008 Jul;136(1):94-9, 99.e1-3. Epub 2008 May 22.
2007
Kaltman JR, Gaynor JW, Rhodes LA, Buck K, Shah MJ, Vetter VL, Madan N, Tanel RE. Subcutaneous array with active can implantable cardioverter defibrillator configuration: a follow-up study. Congenit Heart Dis. 2007 Mar;2(2):125-9.
Ballweg JA, Dominguez TE, Ravishankar C, Gaynor JW, Nicolson SC, Spray TL, Tabbutt S. A contemporary comparison of the effect of shunt type in hypoplastic left heart syndrome on the hemodynamics and outcome at Fontan completion. J Thorac Cardiovasc Surg. 2010 Sep;140(3):537-44.
2006
Mitchell, ME, Ittenbach RF, Gaynor JW, Wernovsky G, Nicolson S and Spray TL. Intermediate outcomes following the Fontan procedure in the current era. J Thorac Cardiovasc Surg 2006; 131: 172-180.
Jacobs JP, Maruszewski B, Lacour-Gayet FG, Jacobs ML, Clarke DR, Tchervenkov CI, Gaynor JW, Spray TL, Stellin G, Elliott MJ, Ebels T, Tobota Z, Dokholyan RS, Peterson ED, Mavroudis C. Current Status of the European Association for Cardio-Thoracic Surgery and the Society of Thoracic Surgeons Congenital Heart Surgery Database. Ann Thorac Surg 2005; 80: 2278-2284.
Davidson A, Whiteman V, and Gaynor JW. Images in Cardiovascular Medicine: Fetal Cardiac Diverticulum. Circulation 2006; 113: e56.
Seliem MA, Fedec A, Cohen MS, Ewing S, Farrell PE, Rychik J, Schultz AH, Gaynor JW, and Spray TL. Real-time 3-dimentional echocardiographic imaging of congenital heart disease using matrix-array technology: freehand real-time scanning adds instant morphologic details not well delineated by conventional 2-dimensional imaging. J Am Soc Echocardiogr 2006; 19: 121-129.
Gaynor JW, Jarvik GP, Bernbaum J, Gerdes M, Wernovsky G, Burnham NB, D’Agostino JD, Zackai E, McDonald-McGinn DM, Nicolson SC, Spray TL and Clancy RR. The relationship of postoperative electrographic seizures to neurodevelopmental outcome at one year of age following neonatal and infant cardiac surgery. J Thorac Cardiovasc Surg 2006; 131:181-189.
Tabbutt S, Ittenbach RF, Nicolson SC, Burnham N, Hittle S, Spray TL, Gaynor JW. Intracardiac temperature monitoring in infants following heart surgery. J Thorac Cardiovasc Surg 2006; 131: 614-620.
Kaltman JR, Jarvik GP, Bernbaum J, Wernovsky G, Gerdes M, Zackai E, Clancy RR, Nicholson SC, Spray TL, and Gaynor, J.W. Neurodevelopmental outcome following early repair of ventricular septal defect with or without aortic arch obstruction. J Thorac Cardiovasc Surg 2006; 131:792-798.
Zuppa AF, Nicolson SC, Adamson PC, Wernovsky G, Mondick JT, Burnham N, Hoffman TM, Gaynor JW, Davis LA, Greeley WJ, Spray TL and Barrett JS. Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage 1 reconstruction. Anesth Analg 2006; 102:1062-1069.
Kaltman J, Hanna, B., Gallagher, P, Gaynor, JW, Godinez, R., Tanel, R, Ahah, M, Vetter, V, and Rhodes, L. Heart rate variability following neonatal heart surgery for complex congenital heart disease. PACE 2006; 29: 1-8.
Gruber PJ, Fuller S, Cleaver KM, Abdullah I, Gruber SB, Nicolson SC, Gaynor JW, Wernovsky G, Spray TL. Early results of single-stage biventricular repair of severe aortic hypoplasia or atresia with ventricular septal defect and an adequate left ventricle. J Thorac Cardiovasc Surg 2006; 132: 260-263.
Tchervenkov CI, Jacobs JP, Weinberg PM, Aiello VD, Beland MJ, Colan SD, Franklin RCG, Gaynor JW, Krogmann ON, Kurosawa H, Maruszewski B and Stellin G. The nomenclature, definition and classification of hypoplastic left heart syndrome. Cardiol Young 2006; 16: 339-368.
Meyer D, Zamora G, Wernovsky G, Ittenbach RF, Gallagher PR, Tabbutt S, Gruber PJ, Nicolson SC, Gaynor JW and Spray TL. Outcomes of the Fontan procedure utilizing cardiopulmonary bypass with aortic crossclamping. Ann Thorac Surg 2006; 82: 1611-1620.
Ravishankar C, Dominguez T, Kreutzer J, Wernovsky G, Marino BS, Godinez R, Priestly MA, Gruber PJ, Gaynor JW, Nicolson SC, Spray TL and Tabbutt S. Extracorporeal membrane oxygenation after stage 1 reconstruction for hypoplastic left heart syndrome. Ped Crit Care Med 2006; 7: 319-323.
Cohen MS, Schultz AH, Tian ZY, Donaghue DD, Weinberg PM, Gaynor JW, and Rychik J. Heterotaxy syndrome with functional single ventricle: does prenatal diagnosis improve survival? Ann Thorac Surg 2006; 82: 1629-1636.
Mercer-Rosa L, Seliem MA, Fedec A, Rome J, Rychik J, and Gaynor JW. Illustration of the additional value of real-time 3-dimensional echocardiography to conventional transthoracic and transesophageal 2-dimensional echocardiography in imaging muscular ventricular septal defects: does this have any impact on individual patient treatment? Am Soc Echocardiogr 2006; 19: 1511-1519.
Marino BS, Wernovsky G, McElhinney DB, Jawad A, Kreb DL, Mantel SF, van der Woerd WL, Gaynor JW, Spray TL, and Cohen MS. Neo-aortic valvar function after the arterial switch. Cardiol in the Young 2006; 16: 481-489.
2005
Gaynor JW, Kuypers M, Rossem M, Wernovsky G, Marino B, Tabbutt S, Nicolson SC, Spray TL. Hemodynamic Changes during Modified Ultrafiltration Immediately Following Stage 1 Reconstruction in 99 Neonates. Cardiol Young 2005; 15:4-7.
Hoehn KS, Wernovsky G, Rychik J, Gaynor JW, Spray TL, Feudtner C and Nelson RM. What factors are important to parents making decisions in neonatal research? Arch Dis Child Fetal Neonatal ED 2005; 90: 267-269.
Clancy RR, Sharif U, Ichord R, Spray TL, Nicolson S, Tabbutt S, Wernovsky G, Gaynor JW. Electrographic neonatal seizures after infant heart surgery. Epilepsia 2005; 46:84-90.
Jacobs JP, Lacour-Gayet FG, Jacobs ML, Clarke DR, Tchervenkov CI, Gaynor JW, Spray TL, Maruszewski B, Stellin G, Gould J, Dokholyan RS, Peterson ED, Elliot MJ and Mavroudis CM. Initial application in the STS congenital database of complexity-adjustment to evaluate surgical case mix and results. Ann Thorac Surg 2005; 79: 1635-1649.
Dominquez TE, Mitchell M, Freiss SH, Ravishankar C, Huh JW, Cullen J, Gaynor JW, Manno C, and Tabbutt S. The use and recombinant factor V11a for refractory hemorrhage during extracorporeal membrane oxygenation. Ped Crit Care Med 2005; 6: 348-351.
Kirshbom PM, Flynn TB, Clancy RR, Ittenbach RF, Hartman DM, Paridon SM, Wernovsky G, Spray TL and Gaynor JW. Late neuro-developmental outcome following repair of total anomalous pulmonary venous connection. J Thorac Cardiovasc Surg 2005; 129: 1091-1097.
Long CB, Shah SS, Lautenbach E, Coffin SE, Tabbutt S, Gaynor JW and Bell LM. Postoperative mediastinitis in children: epidemiology, microbiology, and risk factors for gram-negative pathogens. Ped Inf Dis J 2005; 24: 315-319.
Zeltser I, Menteer JD, Gaynor JW, Clark BJ, Kreutzer J, Rome JJ. Impact of re-coarctation following the Norwood operation on survival in the balloon angioplasty era. J Am Coll Cardiol 2005; 45: 1844-1848.
Hoehn SK, Wernovsky G, Rychik J, Tian ZY, Donaghue D, Alderfer MA, Gaynor JW, Kazak AE, Spray TL, Nelson RM. Assessment of parental stress and decision making in congenital heart diseases: prenatal versus postnatal diagnosis. Cardiol Young 2005; 15: 1844-1848.
Pastuszko P, Rome JJ, Gleason MM, Bellah RD, Montenegro LM and Gaynor JW. Hemoptysis following CardioSEAL device embolization of a venous collateral after the Fontan operation J Thorac Cardiovasc Surg 2005; 129: 1447-1448.
Gusic RJ, Myung R. Petko M, Gaynor, JW and Gooch KJ. Shear stress and pressure modulation of saphenous vein remodeling ex-vivo. J Biomech 2005; 129:1447-1448.
Nichol JW, Petko M, Myung RI, Gaynor JW, and Gooch KJ. Hemodynamic conditions alter axial and circumferential remodeling of arteries engineered ex vivo. Ann Biomed Eng 2005; 33: 721-732.
Shah SS, Lautenbach E, Long CB, Tabbutt S, Gaynor JW, Bilker WB, and Bell LM. Staphylococcus aureus as a risk factor for bloodstream infection in children with post-operative mediastinitis. Ped Inf Dis J 2005; 24: 834-837.
Gusic RJ, Petko M, Myung R, Gaynor JW and Gooch KJ. Mechanical properties of native and ex-vivo remodeled porcine saphenous veins. Biomech 2005; 38: 1770-1779.
Piel DA, Khan A, Waibel R, Birbach M, Cohen M, Spray TL, Deutchman CS, Gaynor JW, and Levy RJ. Chronic hypoxemia increases myocardial cytochrome oxidase. J Thorac Cardiovasc Surg 2005; 130: 1101-1106.
Gaynor JW, Nicolson SC, Jarvik GP, Wernovsky G, Montenegro LM, Burnham NB, Hartman DM, Louie A, Spray TL, Clancy RR. Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures. J Thorac Cardiovasc Surg 2005; 130: 1278-1286.
Tabbutt S, Dominguez TE, Ravishankar C, Marino BS, Gruber PJ, Wernovsky G, Gaynor JW, Nicolson SC, Spray TL. Outcomes following the Stage I reconstruction comparing right ventricle to pulmonary artery conduit with the modified Blalock Taussig shunt. Ann Thorac Surg 2005; 80: 1582-1591.
Zeltser I, Gaynor JW, Petko M, Myung R, Birbach M, Waibel R, Ittenbach R, Tanel RE, Vetter VL, Rhodes LA. The roles of chronic pressure and volume overload states in induction of arrhythmias: an animal model of physiologic sequelae following repair of tetralogy of Fallot. J Thorac Cardiovasc Surg 2005; 130: 1542-1548.
Schultz AH, Jarvik GP, Wernovsky G, Bernbaum J, Clancy RR, D’Agostino JD, Gerdes M, McDonald-McGinn D, Nicolson S, Spray TL, Zackai E and Gaynor JW. Effect of congenital disease on neurodevelopmental outcomes within multiple gestation births. J Thorac Cardiovasc Surg 2005; 130: 1511-1516.
2004
Galli KK, Zimmerman RA, Jarvik GP, Wernovsky G, Kuypers MK, Clancy RR, Montenegro LM, Mahle WT, Newman MF, Saunders AM, Nicolson SC, Spray TL, and Gaynor JW. Periventricular Leukomalacia is common following Neonatal Cardiac Surgery. J Thorac Cardiovasc Surg 2004; 127: 692-704
Pastusko P, Gruber PJ, Wernovsky G, Tanel RE, Rhodes LA, Nicolson SC, Spray TL, Gaynor JW. Thoratec Left Ventricular Assist Device as a Bridge to Recovery in a 27 kg Child. J Thorac Cardiovasc Surg 2004; 127: 1203-1204
Morris MC, Rodolfo IG, Portnoy JD, Tabbutt S, Ittenbach, R, Hanna BD, Hoffman TM, Gaynor JW, Connelly JT, Helfaer MA, Spray TL, and Wernovsky G. Extracorporeal Membrane Oxygenation in 137 patients in a Pediatric Cardiac Intensive Care Unit. Crit Care Med 2004; 32:1061-1069.
Golant A, Lou JE, Erol B, Gaynor JW, Low DW, and Dormans JP. Pediatric Osteoblastoma of the Sternum: A New Surgical Technique for Reconstruction after Removal. Case Report and review of the literature. J Ped Orthoped 2004; 24: 319-322.
Guillamondegui OD, Nance ML, Gaynor JW Flynn JM, Stafford PW, Crumbleholme TM. Successful Management of Concomitant Blunt Injury to the Trachea, Esophagus and Cervical Spine in a 6-year old female. J Pediatr Surg 2004; 39: 1130-1132.
Cohen MI, Rhodes LA, Spray TL, and Gaynor JW. Efficacy of prophylactic epicardial pacing leads in children leads in children and young adults. Ann Thorac Surg 2004; 78: 197-203.
Lacour-Gayet F, Clarke D, Jacobs J, Pozzi M, Hamilton DL, Daebritz S, Gaynor JW, Maruszsewski B, Mavroudis C, Jacobs M. The Aristotle Score: A Complexity-Adjusted Method to Evaluate Surgical Results. Eur J Cardio-Thorac Surg 2004; 25: 911-924.
Jacobs JP, Mavroudis C, Jacobs ML, Lacour-Gayet FG, Tchervenkov CI, Gaynor JW, Dokholyan RS, Peterson ED. Lessons Learned from the Data Analysis of the Second Harvest (1998-2001) of the Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database. Eur J Cardiothorac Surg 2004; 26: 18-37.
Lodge AJ, Rychik J, Nicolson SC, Ittenbach RF, Spray TL, Gaynor JW. Improving outcomes in functional single ventricle and total anomalous pulmonary venous connection. Ann Thorac Surg 2004; 78:1688-1695.
Zeltzer I, Rhodes L, Tanel RE, Vetter VL, Gaynor JW, Spray TL, and Cohen M. Post-pericardiotomy syndrome following permanent pacemaker implantation in children and young adults. Ann Thorac Surg 2004; 78:1684-1687.
Fogel MA, Durning S, Wernovsky G, Pollack AN, Gaynor JW, Nicolson S. Brain verses lungs: Hierarchy of feedback loops in single ventricle patients with superior cavopulmonary connection. Circulation 2004; 110 (Supp Π): Π 147- Π 152.
Licht D, Wang J, Silvestre DW, Nicolson SC, Montenegro, LM, Tabbutt S, Durning SM, Shabbout M, Shera DM, Gaynor JW, Spray TL, Clancy R, Zimmerman A, Dittre JA. Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects. J Thorac Cardiovasc Surg, 2004. 128:841-849.
Hoehn KS, Wernovsky G, Rychik J, Tian ZY, Donaghue D, Alderfer MA, Gaynor JW, Kazak AE, Spray TL, Nelson RM. Parental decision making in congenital heart disease. Cardiol young 2004; 14: 309-314.
2003
Clancy RR, McGaurn SA, Wernovsky G, Gaynor JW, Spray TL, Norwood WI, Jacobs ML, and Goin JE. Risk of seizures in survivors of newborn heart surgery using deep hypothermic circulatory arrest. Pediatrics 2003; 111: 592-601.
Clerin V, Nichol JW, Petko M, Myung RJ, Gaynor JW, and Gooch KJ. Tissue engineering of arteries by directed remodeling of intact arterial segments. Tissue Engineering 2003; 9:461-472.
Petko M, Myung RJ, Cohen MI, Wernovsky G, Rychik J, Nicolson SC, Gaynor JW, and Spray TL. Surgical reinterventions following the Fontan procedure. Eur J Cardio-Thorac Surg 2003; 24:255-259.
Myung RJ, Kirshbom PK, Petko M, Golden JA, Judkins AR, Ittenbach RF, Spray TL, and Gaynor JW. Modified ultrafiltration may not improve neurologic outcome following deep hypothermic circulatory arrest. Eur J Cardio-Thorac Surg 2003; 24:243-248.
Cohen MS, Marino BS, McElhinney DB, Robbers-Visser D, van der Woerd W, Gaynor JW, Spray TL, and Wernovsky G. Neo-aortic root dilation and valve regurgitation up to 21 years after staged reconstruction for hypoplastic left heart syndrome. J Am Coll Cardiol 2003; 42: 533-540.
Madan N, Gaynor JW, Tanel R, Cohen M, Nicolson SC, Vetter VL, and Rhodes LA. Single-finger subcutaneous defibrillation lead and “active can”: A novel minimally invasive defibrillation configuration for implantable cardioverter-defibrillator implantation in a young child. J Thorac Cardiovasc Surg 2003; 126: 1657-1659.
Gaynor JW, Gerdes M, Zackai EH, Bernbaum J, Wernovsky G, Clancy RR, Newman MF, Saunders AM, Heagerty PJ, D’Agostino JD, McDonald-McGinn D, Nicolson SC, Spray TL, and Jarvik GP. Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery. J Thorac Cardiovasc Surg 2003; 126:1736-1745.
Gould DS, Montenegro LM, Gaynor JW, Lacy SP, Stephens P, Steven JM, Spray TL, and Nicolson SC. A comparison of on-site and off-site PDA ligation in premature infants. Pediatrics 2003; 112: 1298-1301.
2002
Jones PL, Chapados R, Raff GW, Vitvitsky EV, Spray TL, and Gaynor JW. Altered hemodynamics controls matrix metalloproteinase activity and tenascin-C expression in neonatal pig lung. Am J Physiol Lung Cell Mol Physiol 2002; 282:L26-L35.
Kirshbom PM, Bridges ND, Myung RJ, Gaynor JW, Clark BJ, and Spray TL. Use of extracorporeal membrane oxygenation in pediatric thoracic organ transplantation. J Thorac Cardiovasc Surg 2002; 123:130-136.
Gaynor JW, Bridges ND, Cohen MI, Mahle WT, DeCampli WM, Steven JM, Nicolson SC, and Spray TL. Predictors of outcome after the Fontan operation: Is hypoplastic left heart syndrome still a risk factor? J Thorac Cardiovasc Surg 2002; 123:237-245.
Ramamoorthy C, Tabbutt S, Kurth CD, Steven JM, Montenegro LM, Durning S, Wernovsky G, Gaynor JW, Spray TL, Nicolson SC. Effects of inspired hypoxic and hypercapnic gas mixtures on cerebral oxygen saturation in neonates with univentricular heart defects. Anesthesiology 2002; 96:283-288.
Gaynor JW, Mahle WT, Cohen MI, Ittenbach RF, DeCampli WM, Steven JM, Nicolson SC, and Spray TL. Risk factors for mortality after the Norwood procedure. Eur J Cardiothorac Surg 2002; 22:82-89.
Cohen MI, Bush DM, Gaynor JW, Vetter VL, Tanel RE, and Rhodes LA. Pediatric Pacemaker Infections: Twenty-Year Experience. J Thorac Cardiovasc Surg 2002; 124:821-827.
Kirshbom PM, Myung RJ, Gaynor JW, Ittenbach RF, Paridon SM, DeCampli WM, Karl TR, and Spray TL. Preoperative pulmonary venous obstruction affects long-term outcome for survivors of total anomalous pulmonary venous connection repair. Ann Thorac Surg 2002; 74:1616-1620.
Deptula J, Gaynor JW, Groneck J, Owens T, Rogers K, Griffin DA, and Spray TL. Alleviating heat loss associated with modified ultrafiltration. J Extra Corpor Technol 2002; 34(2): 88-91.
Hoffman TM, Bush DM, Wernovsky G, Cohen MI, Wieand TS, Gaynor JW, Spray TL, and Rhodes LA. Postoperative junctional ectopic tachycardia in children: Incidence, risk factors, and treatment. Ann Thorac Surg 2002; 74:1607-1611.
Mahle WT, Tavani F, Zimmerman RA, Nicolson SC, Galli K, Gaynor JW, Clancy RR, Montenegro LM, Spray TL, Chiavacci RM, Wernovsky G, and Kurth CD. An MRI study of neurological injury before and after congenital heart surgery. Circulation 2002; 106 (Suppl I): I-109-I-114.
Hoffman TM, Wernovsky G, Wieand TS, Cohen MI, Jennings AC, Vetter VL, Godinez RI, Gaynor JW, Spray TL, and Rhodes LA. The incidence of arrhythmias in a pediatric cardiac intensive care unit. Pediatr Cardiol 2002; 23:598-604
Clerin V, Gusic RJ, O’Brien J, Kirshbom PM, Myung RJ, Gaynor JW, Gooch KJ. Mechanical environment, donor age, and the presence of the endothelium interact to modulate porcine artery viability ex vivo. Ann Biomed Engineering 2002; 30:1117-1127.
2001
Mott AR, Spray TL, Gaynor JW, Godinez RI, Nicolson SC, Steven JM, DeCampli WM, Schears GJ, and Wernovsky G. Improved results with cavopulmonary connections for functional single ventricle. Cardiol Young 2001; 11:3-11.
Mahle WT, Spray TL, Gaynor JW, and Clark BJ. Unexpected death after reconstructive surgery for hypoplastic left heart syndrome. Ann Thorac Surg 2001; 71:61-65.
Cohen MI, Rhodes LA, Wernovsky G, Gaynor JW, Spray TL, and Rychik J. Atrial pacing: An alternative treatment for protein-losing enteropathy after the Fontan operation. J Thorac Cardiovasc Surg 2001; 121:582-583.
Hoffman TM, Gaynor JW, Bridges ND, Paridon SM, and Spray TL. Aortic homograft interposition for management of complete tracheal anastomotic disruption after heart-lung transplantation. J Thorac Cardiovasc Surg 2001; 121:587-588.
Cohen MI, Vetter VL, Wernovsky G, Bush DM, Gaynor JW, Iyer VR, Spray TL, Tanel RE, and Rhodes LA. Epicardial pacemaker implantation and follow-up in patients with single ventricle after the Fontan operation. J Thorac Cardiovasc Surg 2001; 121:804-811.
Gaynor JW, O’Brien JE, Rychik J, Sanchez GR, DeCampli WM, and Spray TL. Outcome following tricuspid valve detachment for VSD closure. Eur J Cardio Thorac Surg 2001; 19:279-282.
Coon PD, Rychik J, Novello RT, Ro P, Gaynor JW, and Spray TL. Thrombus formation after the Fontan operation. Ann Thorac Surg 2001; 71:1990-1994.
Kucharczuk JC, Cohen MI, Rhodes LA, Karl TR, Spray TL, and Gaynor JW. Epicardial atrial pacemaker lead placement after multiple cardiac operations. Ann Thorac Surg 2001; 71:2057-2058.
Cohen MI, Bush DM, Vetter VL, Tanel RE, Wieand TS, Gaynor JW, and Rhodes LA. Permanent epicardial pacing in pediatric patients: Seventeen years of experience and 1200 outpatient visits. Circulation 2001; 103:2585-2590.
Mahle WT, Gaynor JW, and Spray TL. Atrioventricular valve replacement in patients with single ventricle. Ann Thorac Surg 2001; 72:182-186.
Kurth CD, Steven JL, Montenegro LM, Watzman HM, Gaynor JW, Spray TL, and Nicolson SC. Cerebral oxygen saturation before congenital heart surgery. Ann Thorac Surg 2001; 72:187-192.
Clancy RR, McGaurn SA, Goin JE, Hirtz DG, Norwood WI, Gaynor JW, Jacobs ML, Wernovsky G, Mahle WT, Murphy JD, Nicolson SC, Steven JM, and Spray TL. Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest. Pediatrics 2001; 108:61-70.
McElhinney DB, Hoydu AK, Gaynor JW, Spray TL, Goldmuntz E, and Weinberg PM. Patterns of right aortic arch and mirror-image branching of the brachiocephalic vessels without associated anomalies. Ped Cardiol 2001; 22:285-291.
Cohen MS, Weinberg P, Coon PD, Gaynor JW, and Rychik J. Deviation of atrial septum primum in association with normal left atrioventricular valve size. J Am Soc Echocardiogr 2001; 14:732-737.
McElhinney DB, Carpentieri DF, Bridges ND, Clark BJ, Gaynor JW, and Spray TL. Mitral valve sarcoma causing coronary artery occlusion in children. Cardiology in the Young 2001; 11:539-542.
McElhinney DB, Yang SG, Hogarty AN, Rychik J, Gleason MM, Zachary CH, Rome JJ, Karl TR, DeCampli WM, Spray TL, and Gaynor JW. Recurrent arch obstruction after repair of isolated coarctation of the aorta in neonates and young infants: Is low weight a risk factor? J Thorac Cardiovasc Surg 2001; 122:883-890.
Mahle WT, Rychik J, Gaynor JW, Spray TL, and Rome JJ. Restrictive interatrial communication after reconstructive surgery for hypoplastic left heart syndrome. Am J Cardiol 2001; 88:1454-1457.
2000
Raff GW, Gaynor JW, Weinberg P, Spray TL, and Gleason M. Membranous subpulmonic stenosis associated with ventricular septal defect and aortic insufficiency. J Am Soc Echocardiogr 2000; 13:58-60.
Clancy RR, McGaurn SA, Wernovsky G, Spray TL, Norwood WI, Jacobs ML, Murphy JD, Gaynor JW, and Goin JE. Pre-surgical risk-of-death prediction model in neonatal repair of congenital heart disease. J Thorac Cardiovasc Surg 2000; 119:347-357.
Di Russo GB, Clark BJ, Bridges ND, Godinez RI, Paridon SM, Spray TL, and Gaynor JW. Prolonged extracorporeal membrane oxygenation as bridge to cardiac transplantation in a neonate with Ebstein’s anomaly. Ann Thorac Surg 2000; 69:925-927.
Hoffman TM, Spray TL, Gaynor JW, Clark BJ, and Bridges ND. Survival after acute graft failure in pediatric thoracic organ transplant recipients. Ped Transplantation 2000; 4:112-117.
Gaynor JW, Wernovsky G, Rychik J, Rome JJ, DeCampli WM, and Spray TL. Outcome following single-stage repair of coarctation with ventricular septal defect. Eur J Cardio Thorac Surg 2000; 18:62-67.
Rychik J, Spray TL, Gaynor JW, and Wernovsky G. Assessment of pulmonary-to-systemic flow ratio after first stage palliation for hypoplastic left heart syndrome: Development of a new index using Doppler echocardiography. J Thorac Cardiovasc Surg 2000; 120:81-87.
Smythe WR, Bridges ND, Gaynor JW, Nicolson SC, Clark BJ, and Spray TL. Bilateral sequential lung transplant for ectodermal dysplasia. Ann Thorac Surg 2000; 70:654-656.
Yang SG, Novello R, Nicolson SC, Steven J, Gaynor JW, Spray TL, and Rychik J. Evaluation of ventricular septal defect repair using intraoperative transesophageal echocardiography: Frequency and significance of residual defects in infants and children. Echocardiography 2000; 17:681-684.
McElhinney DB, Hedrick HL, Bush DM, Pereira GR, Stafford PW, Gaynor JW, Spray TL, and Wernovsky G. Necrotizing enterocolitis in neonates with congenital heart disease: Risk factors and outcomes. Pediatrics 2000; 106:1080-1087.
Cohen MI, Bridges ND, Gaynor JW, Hoffman TM, Wernovsky G, Vetter VL, Spray TL, and Rhodes LA. Modifications to the cavopulmonary anastomosis do not eliminate sinus node dysfunction. J Thorac Cardiovasc Surg 2000; 120:891-901.
Mahle WT, Spray TL, Wernovsky G, Gaynor JW, and Clark BJ. Survival after reconstructive surgery for hypoplastic left heart syndrome: A 15-year experience from a single institution. Circulation 2000; 102 (Suppl III): 136-141.
Posner JC, Osterhoudt KC, Mollen CJ, Jacobstein CR, Nicolson SC, and Gaynor JW. Extracorporeal oxygenation as a resuscitative measure in the pediatric emergency department. Ped Emerg Care 2000; 16:413-415.
1999
Gaynor JW, Collins MH, Rychik J, and Spray TL. Long-term outcome of infants with single ventricle and total anomalous pulmonary venous connection. J Thorac Cardiovasc Surg 1999; 117:506-514.
Lee HR, Montenegro LM, Nicolson SC, Gaynor JW, Spray TL, and Rychik J. Usefulness of intra-operative transeseophageal echocardiography in predicting the degree of post-operative mitral regurgitation secondary to atrioventricular defect in children. Am J Cardiol 1999; 83:750-753.
McDonnell BE, Gaynor JW, Rychik J, Godinez RI, DeCampli WM, and Spray TL. Outcome following repair of tetralogy of Fallot with absent pulmonary valve. Ann Thorac Surg 1999; 67:1391-1396.
Palmer SM, Miralles AP, Lawrence CM, Gaynor JW, Davis RD, and Tapson VF. RATG induction decreases acute rejection after lung transplantation: Results of a randomized prospective study. Chest 1999; 116:127-133.
Cohen MI, Gaynor JW, Ramesh V, Karl TR, Steven JM, Clark BJ, and Rhodes LA. ECMO for patients with refractory ventricular arrhythmias. J Thorac Cardiovasc Surg 1999; 118:961-963.
Weinstein S, Gaynor JW, Bridges ND, Wernovsky G, Montenegro LM, Godinez RI, and Spray TL. Early survival of infants weighing 2.5 kilograms or less undergoing first stage reconstruction for hypoplastic left heart syndrome. Circulation 1999; 100 (Suppl II): 167-170.
Ramesh V, Gaynor JW, Shah M, Wieand TS, Spray TL, Vetter VL, and Rhodes LA. Comparison of left and right atrial epicardial pacing in patients with congenital heart disease. Ann Thorac Surg 1999; 68:2314-2319.
1998
Davies MJ, Khan N, Gaynor JW, and Elliott MJ. Modified ultrafiltration improves left ventricular systolic function in infants after cardiopulmonary bypass. J Thorac Cardiovasc Surg 1998; 115:361-370.
DiBernardo LR, Kirshbom PM, Skaryak LA, Quarterman RL, Johnson RL, Davies MJ, Gaynor JW, and Ungerleider RM. Acute functional consequences of left ventriculotomy. Ann Thorac Surg 1998; 66:159-165.
Vitvitsky EV, Griffin J, Collin MH, Spray TL, and Gaynor JW. Increased pulmonary blood flow produces endothelial cell dysfunction in neonatal swine. Ann Thorac Surg 1998; 66:1372-1377.
Cohen MI, Wernovsky G, Vetter VL, Wieand TS, Gaynor JW, Jacobs ML, Spray TL, and Rhodes LA. Sinus node function after a systematically staged Fontan. Circulation 1998; 98 (Suppl II): 352-359.
Low DW, Carman-Dillon CA, Gaynor JW, and Acker MA. Management of sternal and abdominal wounds in a pediatric heart transplant patient: A case report. Plastic Reconstructive Surg 1998; 102:2100-2210.
Rychik J, Levy H, Gaynor JW, DeCampli WM, and Spray TL. Outcomes after operations for pulmonary atresia with intact ventricular septum. J Thorac Cardiovasc Surg 1998; 116:924-931.
McLaughlin RB, Wetmore RF, Tavill MA, Gaynor JW, and Spray TL. Vascular anomalies causing symptomatic tracheobronchial compression. Laryngoscope 1998; 109:312-319.
1997
Gaynor JW, Feneley MP, Gall SA, Jr., Savitt MA, Silvestry SC, Davis JW, Rankin JS, and Glower DD. Left ventricular adaptation to aortic regurgitation in conscious dogs. J Thorac Cardiovasc Surg 1997; 113:149-158.
Koutlas TC, Wernovsky G, Bridges ND, Suh EJ, Godinez RI, Nicolson SC, Spray TL, and Gaynor JW. Orthotopic heart transplant for Kawasaki disease after rupture of a giant coronary artery aneurysm. J Thorac Cardiovasc Surg 1997; 113:217-218.
Koutlas TC, Bridges ND, Gaynor JW, and Spray TL. Pediatric Lung Transplantation - Are there surgical contraindications? Transplantation 1997; 63:269-274.
Markert ML, McLaughlin TM, Watson TJ, Ward FE, Kostyu DD, Buckley RH, Schiff SE, Ungerleider RM, Gaynor JW, Oldham KT, Mahaffey SM, Ballow M, Driscoll DA, Hale LP, and Haynes BF. Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus. J Immunol 1997; 158:998-1005.
Kirshbom PM, Page SO, Jacobs MT, Tsui SSL, Bello E, Ungerleider RM, Schwinn DA, and Gaynor, JW. Cardiopulmonary bypass and circulatory arrest increase endothelin-1 production and receptor expression in the lung. J Thorac Cardiovasc Surg 1997; 113:777-783.
Koutlas TC, Gaynor JW, Nicolson SC, Steven JM, Wernovsky G, and Spray TL. Modified ultrafiltration reduces postoperative morbidity after cavopulmonary connection. Ann Thorac Surg 1997; 64:37-43.
Tsui SSL, Kirshbom PM, Davies MJ, Jacobs MT, Kern FH, Gaynor JW, Greeley WJ, and Ungerleider RM. Thromboxane A (2)-receptor blockade improves cerebral protection for deep hypothermic circulatory arrest. Eur J Cardiothorac Surg 1997; 12:228-235.
Davies MJ, Quarterman RL, Tsui SSL, Jacobs MT, Davis JW, Elliott MJ, Ungerleider RM, and Gaynor JW. Comparison of three indexes of contractility in the neonatal left ventricle. Cardiovascular Engineering 1997; 2:180-190.
1996
Kirshbom PM, Skaryak LA, DiBernardo LR, Kern FH, Greeley WJ, Gaynor JW, and Ungerleider RM. pH-stat cooling improves cerebral metabolic recovery after circulatory arrest in infants with aorto-pulmonary collaterals. J Thorac Cardiovasc Surg 1996; 111:147-157.
Kirshbom PM, Tapson VF, Harrison JK, Davis RD, and Gaynor JW. Delayed right heart failure following lung transplantation. Chest 1996; 109:575-577.
Tsui SSL, Kirshbom PM, Davies MJ, Jacobs MT, Greeley WJ, Kern FH, Gaynor JW, and Ungerleider RM. Nitric oxide production affects cerebral perfusion and metabolism after deep hypothermic circulatory arrest. Ann Thorac Surg 1996; 61:1699-1707.
Kirshbom PM, Jacobs TM, Steven SL, Tsui SSL, DiBernardo LR, Schwinn DA, Ungerleider RM, and Gaynor JW. Effects of cardiopulmonary bypass and circulatory arrest on endothelium dependent vasodilation in the lung. J Thorac Cardiovasc Surg 1996; 111:1248-1256.
Koutlas TC, Harrison JK, Bashore TM, O'Laughlin MP, Tripp ME, and Gaynor JW. Late conduit occlusion after modified Fontan procedure with classic Glenn shunt. Ann Thorac Surg 1996; 62:258-262.Van Trigt P, Davis RD, Shaeffer GS, Gaynor JW, Landolfo KP, Higginbotham MB, Tapson VF, and Ungerleider RM. Survival benefits of heart and lung transplantation. Ann Surg 1996; 223:576-584.
Cheifetz IM, Meliones JN, Wilson BG, Gaynor JW, and Schulman SR. Severe cardiorespiratory dysfunction following cold water submersion: The successful use of extracorporeal membrane oxygenation. Respiratory Care 1996; 141:226-231.
Skaryak LA, Kirshbom PM, DiBernardo LR, Wilson BG, Meliones JN, Ungerleider RM, and Gaynor JW. Low-flow cardiopulmonary bypass produces greater pulmonary dysfunction than circulatory arrest. Ann Thorac Surg 1996; 62:1284-1288.
Bridges ND, Gaynor JW, and Spray TL. Outcome of children with pulmonary hypertension referred for lung or heart and lung transplantation. Transplantation 1996; 62:1824-1828.
1995
Skaryak LA, Kirshbom PM, DiBernardo LR, Kern FH, Greeley WJ, Ungerleider RM, and Gaynor JW. Modified ultrafiltration improves cerebral metabolic recovery after circulatory arrest. J Thorac Cardiovasc Surg 1995; 109:744-752.
Gaynor JW, Burke M, Dollery C, Sullivan I, Deanfield J, and Elliott MJ. Repair of anomalous pulmonary venous connection to the superior vena cava. Ann Thorac Surg 1995; 59:1471-1475.
Gaynor JW, Bull C, Sullivan ID, Armstrong BE, Deanfield JE, Taylor JFN, Rees PG, Ungerleider RM, de Leval MR, Stark J, and Elliott MJ. Late outcome of survivors of intervention for neonatal aortic valve stenosis. Ann Thorac Surg 1995; 60:122-126.
Kirshbom PM, Tsui SSL, DiBernardo LR, Meliones JN, Schwinn DA, Ungerleider RM, and Gaynor JW. Blockade of endothelin converting enzyme reduces pulmonary hypertension after cardiopulmonary bypass and circulatory arrest. Surgery 1995; 118:440-445.
DiMaio JM, Van Trigt P, Gaynor JW, Davis RD, Coveney E, Clary BM, and Lyerly HK. Generation of tumor-specific T lymphocytes for treatment of post-transplant lymphoma. Circulation 1995; 92 (Suppl II): 202-205.
Kirshbom PM, Skaryak LA, DiBernardo LR, Kern FH, Greeley WJ, Gaynor JW, and Ungerleider RM. Effects of aorto-pulmonary collaterals on cerebral cooling and cerebral metabolic recovery following circulatory arrest. Circulation 1995; 92 (Suppl II): 490-494.
Ungerleider RM, Kisslo J, Bengur AR, Li J, Kern FH, Gaynor JW, and Greeley WJ. Intraoperative echocardiography during congenital heart surgery: Experience from 1000 cases. Ann Thorac Surg 1995; 60:S539-S542.
1994
Gaynor JW, Feneley MP, Gall SA Jr, Maier GW, Kisslo JA, Davis JW, Rankin JS, and Glower DD Jr. Measurement of left ventricular volume in normal and volume-overloaded canine hearts. Am J Physiol 1994; 266:H329-H340.
Darling EM, Shearer IR, Nanry K, Kern FH, Greeley WJ, Ungerleider RM, and Gaynor JW. Modified ultrafiltration in pediatric cardiopulmonary bypass. J Extra-Corpor Technol 1994; 26:205-209.
1993
Gall SA Jr, Maier GW, Glower DD, Gaynor JW, Cobb FR, Sabiston DC Jr, and Rankin JS. Recovery of myocardial function after repetitive episodes of reversible ischemia. Am J Physiol 1993; 264:H1130-H1138.
Miller OI, Gaynor JW, Macrae DJ, and Tasker RC. Inhaled nitric oxide for pulmonary hypertension after repair of exomphalos. Arch Dis Child 1993; 69:518-520.
1990
Glower DD, Douglas JM Jr, Gaynor JW, Jones RN, and Oldham HN Jr. Candida mediastinitis after a cardiac operation. Ann Thorac Surg 1990; 49:157-163.
Feneley MP, Elbeery JR, Gaynor JW, Gall SA Jr, Davis JW, and Rankin JS. Ellipsoidal shell subtraction model of right ventricular volume: comparison with regional free wall dimensions as indexes of right ventricular function. Circ Res 1990; 67:1427-1436.
1988
Feneley MP, Maier GW, Kern KB, Gaynor JW, Gall SA Jr, Sanders AB, Raessler K, Muhlbaier LH, Rankin JS, and Ewy GA. Influence of compression rate on initial success of resuscitation and 24 hour survival after prolonged manual cardiopulmonary resuscitation in dogs. Circulation 1988; 77:240-250.
Feneley MP, Gaynor JW, Maier GW, Gall SA Jr, Kisslo JA, and Rankin JS. In vivo estimation of left ventricular wall volume in volume-overloaded canine hearts. Am J Physiol 1988; 255:H1399-H1404.
1987
Feneley MP, Maier GW, Gaynor JW, Gall SA, Kisslo JA, Davis JW, and Rankin JS. Sequence of mitral valve motion and transmitral blood flow during manual cardiopulmonary resuscitation in dogs. Circulation 1987; 76:363-375.
Lectures by Invitation
2023
Gaynor JW. "The Role of Exposomes in Neurodevelopment and CNS Disease". Neurodevelopment Special Interest Group. American Neurological Association. Philadelphia, PA. Sept 2023.
Gaynor JW. “Fetal Surgery for Intrapericardial Teratoma”. 8th World Congress of Pediatric Cardiology and Cardiac Surgery. Washington, DC. Aug 2023.
Gaynor JW. “Connecting the Research Laboratory to the Operating Theater”. 8th World Congress of Pediatric Cardiology and Cardiac Surgery. Washington, DC. Aug 2023.
Gaynor JW. “Debate: Neurodevelopmental Disorders in CHD Cannot be Modified by Interventions”. Cardiac Neurodevelopmental Consortium Symposium. 8th World Congress of Pediatric Cardiology and Cardiac Surgery. Washington, DC. Aug 2023.
Gaynor JW. “The Placenta when the Fetus has CHD”. Visiting Professor. University of Copenhagen. Copenhagen, Denmark. Apr 2023.
Gaynor JW. “Peri-operative Exposure to Volatile Organic Compounds in Neonates Undergoing Cardiac Surgery”. Society for Thoracic Surgery Education. Park City, Utah. Mar 2023.
2022
Gaynor JW. “The Neurodevelopmental Exposome in Congenital Heart Disease”. The Newburger-Bellinger Neurodevelopmental Award Lecture. Cardiac Neurodevelopmental Consortium Symposium Annual Meeting. Montreal, Canada. Oct 2022.
Gaynor JW. “The Neurodevelopmental Exposome in Congenital Heart Disease”. Visiting Professor. University of Copenhagen. Copenhagen, Denmark. June 2022.
Gaynor JW. “The Ridiculous Risk Hypoplast and Equivalent: Is Risk Modifiable in TAPVC, Mitral Dysplasia, Severe TR, Intact Atrial Septum, and Low Birth Weight?”. American Association for Thoracic Surgery Congenital Heart Surgery Course. Boston, MA. May 2022.
Gaynor JW. “The Artificial Womb and Impact on the Fetal Heart”. American College of Cardiology Scientific Sessions. Washington, DC (Virtual). Apr 2022.
2021
Gaynor JW. “Neurodevelopmental Outcomes in Children with Congenital Heart Disease: The Impact of Fetal Life”. Copenhagen Baby Heart Symposium. Copenhagen, Denmark (Virtual). Nov 2021.
Gaynor JW. “Unexplained Variation in Outcomes for CHD”. Betty Irene Moore Children’s Heart Center Research Day. Lucile Packard Children’s Hospital Stanford. Stanford University School of Medicine - Palo Alto, CA (Virtual). Apr 2021.
Gaynor JW. “Life Before Birth: The Maternal Fetal Environment and Outcomes for Congenital Heart Disease”. 13th Pediatric and Darby Children’s Research Institute Symposium. Medical University of South Carolina - Charleston, SC (Virtual). Apr 2021.
Books
Lyerly HK and Gaynor JW (eds). The Handbook of Surgical Intensive Care: Practices of the Surgical Residents at the Duke University Medical Center, 3rd Edition. Chicago: Mosby Year Book, 1992.
- Spanish Translation-Lyerly HK and Gaynor JW (eds). The Handbook of Surgical Intensive Care, 3rd Edition. Chicago: Mosby Year Book, 1992.
- German Translation-Lyerly HK, Gaynor JW, and Foitzik T (eds). The Handbook of Surgical Intensive Care, 3rd Edition. Heidelberg: Springer-Verlag GmbH & Co. KG, 1994.
Editorials, Reviews, Chapters
2021
Brothers JA, Gaynor JW. Surgery for Congenital Anomalies of the Coronary Arteries. In: Sabiston and Spencer Surgery of the Chest, 10th Edition. Selke, Del Nido, Swanson (Eds). Elsevier 2021 (In Press).
Jegatheeswaran A, Gaynor JW, Brothers JA: Surgery for Congenital Coronary Artery Anomalies. Johns Hopkins Textbook of Cardiothoracic Surgery, third edition 2021 (In Press).
2018
Brothers JA, Gaynor JW: Coronary anomalies. Operative Cardiac Surgery, 6th ed. Thomas Spray, Michael Acker (eds.). NPM Ltd, 2018, 687-97, August 2018.
2015
Brothers JA, Gaynor JW. Surgery for Congenital Anomalies of the Coronary Arteries. In: Sabiston and Spencer Surgery of the Chest, 9th Edition. Selke, Del Nido, Swanson (Eds). Elsevier, Page: 2222-42, Sep 2015.
2014
Brothers JA, Gaynor JW. Coronary artery anomalies in children. Chap. 98 in: Mastery of Cardiothoracic Surgery. Kaiser LR, Kron IL, Spray TL (Eds). Philadelphia: Lippincott Williams & Wilkins, 2014, 1055-1073.
Brothers JA, Gaynor JW. Surgery for congenital coronary artery anomalies. Chap. 83 in: The Johns Hopkins Manual of Cardiothoracic Surgery, 2nd Edition. Yuh D, Vricella L (Eds). Philadelphia: Elsevier, 2014, 1277-1294.
2013
Brothers JA, Gaynor JW: Coronary Artery Anomalies in Children. In: Mastery of Cardiothoracic Surgery. Kaiser LR, Kron IL, Spray TL (eds). Lippincott Williams and Wilkins 2013.
Brothers JA, Gaynor JW. Congenital Anomalies of the Coronary Arteries. In: The John Hopkins Manual of Cardiothoracic Surgery, 2nd Edition
2011
Ravishankar C, Dominquez TE, Rosenthal TM, and Gaynor JW. Mechanical Circulatory Support in the Patient with Congenital Heart Disease. In: Heart Failure in Congenital Heart Disease: From Fetus to Adult. Shaddy RE (Eds). 2011. 123-153.
Berkowitz DH and Gaynor JW. Management of Pediatric Cardiopulmonary Bypass. In: Pediatric Cardiac Surgery, Fourth Edition. Mavroudis C, and Backer CL (eds) Wiley- Blackwell.
Fuller S, and Gaynor JW. Aortopulmonary Window and Aortic Origin of a Pulmonary Window. In: Pediatric Cardiac Surgery, Fourth Edition. Mavroudis C, and Backer CL (eds) Wiley- Blackwell.
2010
Brothers JA and Gaynor JW. Surgery for Congenital Anomalies of the Coronary Arteries. John Hopkins Manual of Cardiothoracic Surgery, 2nd Edition. Yan S, Doty J, and Versula L (eds.) McGraw-Hill.
Brothers JA, Gaynor JW. Surgery for Congenital Anomalies of the Coronary Arteries. In: Sabiston and Spencer Surgery of the Chest, 8th Edition. Selke, Del Nido, Swanson (eds). Elsevier 2010, 1963-1980.
2005
Wernovsky G and Gaynor JW. Long-term neurological outcomes in children with congenital heart disease. In: Avery’s Diseases of the Newborn, 8th Edition. Taeusch HW, Ballard RA, and Gleason CA (eds). Elsevier Saunders, 2005, 896 –901.
Gaynor JW. Coarctation, Aortopulmonary Collaterals, and Aortopulmonary Shunts. In: Sabiston & Spencer Surgery of the Chest, 7th Edition. del Nido P, Swanson SJ (eds). Elsevier 2005, 1913-1931.
2004
Gaynor JW. Coronary Artery Anomalies. In: Operative Cardiac Surgery, 5th Edition. Gardner TJ and Spray TL (eds). London: Arnold Publishers, 2004, 879-892.
2003
Gaynor JW. Reconstructive surgery: The Fontan operation and modifications. In: The Hypoplastic Left Heart Syndrome. Wernovsky G and Rychik J (eds). Kluwer Academic Publishing, 2003, 149-166.
Gaynor JW. Aortopulmonary Window and Aortic Origin of a Pulmonary Artery. In: Pediatric Cardiac Surgery, 3rd Edition. Mavroudis C and Backer CL (eds). Mosby, 2003, 353-360.
1998
Shah MJ, Rome JJ, Rychik J, Gaynor JW, and Spray TL. Outcome of primary repair of tetralogy of Fallot in the newborn period. In: Proceedings of the Second World Congress of Pediatric Cardiology and Cardiac Surgery. Imai Y and Momma K (eds). New York: Futura Publishing Company, 1998, 446.
Gaynor JW. Modified ultrafiltration following cardiopulmonary bypass. In: Proceedings of the Second World Congress of Pediatric Cardiology and Cardiac Surgery. Imai Y and Momma K (eds). New York: Futura Publishing Company, 1998, 626.
Gaynor JW. Coronary artery anomalies. Chap. 88 in: Mastery of Cardiothoracic Surgery. Kaiser LR, Kron IL, and Spray TL (eds). Boston: Lippincott-Raven, 1998, 880-893.
Gaynor JW and Spray TL. Congenital heart disease and anomalies of the great vessels. Vol. 2, Part IX in: Pediatric Surgery, 5th Edition. O'Neill JA, Rowe MI, Grosfeld JL, Fonkalsrud EW, and Coran AG (eds). St. Louis: Mosby, 1998, 1835-1848.
Gaynor JW and Spray TL. Heart and Lung Transplantation. Chap. 61 in: Pediatric Surgery and Urology: Long-Term Outcomes. Stringer MD, Oldham KT, Mouriquand PDE, and Howard ER (eds). London: W.B. Saunders, 1998, 765-776.
1997
Shah MJ, Rome JJ, Rychik J, Gaynor JW, and Spray TL. Outcome of primary repair of tetralogy of Fallot in the newborn period. In: Proceedings of the Second World Congress of Pediatric Cardiology and Cardiac Surgery. Imai Y and Momma K (eds). New York: Futura Publishing Company, 1998, 446.
Gaynor JW. Modified ultrafiltration following cardiopulmonary bypass. In: Proceedings of the Second World Congress of Pediatric Cardiology and Cardiac Surgery. Imai Y and Momma K (eds). New York: Futura Publishing Company, 1998, 626.
1996
Gaynor JW and Sabiston DC Jr. Patent ductus arteriosus, coarctation of the aorta, aortopulmonary window, and anomalies of the aortic arch. Chap. III in: Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 15th Edition. Sabiston DC Jr (ed). Philadelphia: W.B. Saunders Company, 1996, 1961-1975.
1995
Gaynor JW, Kern FH, Greeley WJ, and Ungerleider RM. Management of cardiopulmonary bypass in infants and children: Deep hypothermia and total circulatory arrest. Vol. II, Chap. 60 in: Glenn’s Thoracic and Cardiovascular Surgery, 6th Edition. Baue AE, et al (eds). Stamford: Appleton and Lange, 1995, 1023-1034.
Gaynor JW and Sabiston DC Jr. Patent ductus arteriosus, coarctation of the aorta, aortopulmonary window, and anomalies of the aortic arch. Vol. II, Chap. 33 in: Surgery of the Chest, 6th Edition. Sabiston DC Jr and Spencer FC (eds). Philadelphia: W.B. Saunders Company, 1995, 1275-1315.
Ungerleider RM and Gaynor JW. Pulmonary atresia or stenosis with intact ventricular septum. Vol. II, Chap. 39 in: Surgery of the Chest, 6th Edition. Sabiston DC Jr and Spencer FC (eds). Philadelphia: W.B. Saunders Company, 1995, 1492-1508.
1994
Gaynor JW. Congenital cardiac disorders: Patent ductus arteriosus, coarctation of the aorta, interruption of the aortic arch, aortopulmonary window, anomalies of the aortic arch, pulmonary artery sling, atrial septal defects, and ventricular septal defects. Chap. 49, Sec. I in: Sabiston Essentials of Surgery, 2nd Edition. Sabiston DC Jr and Lyerly HK (eds). Philadelphia: W.B. Saunders Company, 1994, 666-675.
Gaynor JW and Ungerleider RM. Aortopulmonary window. Chap. 19 in: Pediatric Cardiac Surgery, 2nd Edition. Mavroudis C and Backer CL (eds). Chicago: Mosby-Year Book, Inc., 1994, 247-252.
1992
Elbeery JR and Gaynor JW. Hemodynamic management. Chap. 2 in: The Handbook of Surgical Intensive Care: Practices of the Surgical Residents at the Duke University Medical Center, 3rd Edition. Lyerly HK and Gaynor JW (eds). Chicago: Mosby Year Book Medical Publishers, 1992, 17-61.
Gaynor JW. Shock. Chap. 3 in: The Handbook of Surgical Intensive Care: Practices of the Surgical Residents at the Duke University Medical Center, 3rd Edition. Lyerly HK and Gaynor JW (eds). Chicago: Mosby Year Book Medical Publishers, 1992, 62-79.
Gaynor JW. Congestive Heart Failure. Chap. 5, Sec. III-B in: The Handbook of Surgical Intensive Care: Practices of the Surgical Residents at the Duke University Medical Center, 3rd Edition. Lyerly HK and Gaynor JW (eds). Chicago: Mosby Year Book Medical Publishers, 1992, 134-137.
Gaynor JW. Patent ductus arteriosus, coarctation of the aorta, and anomalies of the aortic arch. Chap. IV in: Textbook of Surgery, Pocket Companion. Sabiston DC Jr and Lyerly HK (eds). Philadelphia: W.B. Saunders Company, 1992, 856-864.
1991
Gaynor JW and Sabiston DC Jr. Patent ductus arteriosus, coarctation of the aorta, aortopulmonary window, and anomalies of the aortic arch. Chap. IV in: Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 14th Edition. Sabiston DC Jr (ed). Philadelphia: W.B. Saunders Company, 1991, 1855-1872.
1990
Gaynor JW and Sabiston DC Jr. Patent ductus arteriosus, coarctation of the aorta, aortopulmonary window, and anomalies of the aortic arch. Vol. II, Chap. II in: Surgery of the Chest, 5th Edition. Sabiston DC Jr and Spencer FC (eds). Philadelphia: W.B. Saunders Company, 1990, 1128-1172.
1989
Gaynor JW. Cardiac Monitoring. Chap. 20 in: The Handbook of Surgical Intensive Care: Practices of the Surgery Residents at the Duke University Medical Center, 2nd Edition. Lyerly HK (ed). Chicago: Year Book Medical Publishers, 1989, 531-560.
Rankin JS, Elbeery JR, Lucke JC, Gaynor JW, Harpole DH, Feneley MP, Nikolic S, and Glower DD. On the law of the heart and related topics. In: Critical Care: State of the Art, Volume 10. Fullerton, CA: Society of Critical Care Medicine, 1989.
Rankin JS, Elbeery JR, Lucke JC, Gaynor JW, Harpole DH, Feneley MP, Nikolic S, Maier GS, Tyson GS, Olsen CO, and Glower DD. An energetic analysis of myocardial performance. Chap. C, Sect. III in: Cardiac Mechanics and Function in the Normal and Diseased Heart. Hori M, Suga H, Baan J, Yellin EL (eds). Tokyo: Springer Verlag, 1989, 165-188.
1987
Gaynor JW and Sabiston DC Jr. Patent ductus arteriosus, coarctation of the aorta, aortopulmonary window, and anomalies of the aortic arch. Chap. 47, Sect. II in: Essentials of Surgery. Sabiston DC Jr (ed). Philadelphia: W.B. Saunders Company, 1987, 1061-1076.
Rankin JS, Gaynor JW, Feneley MP, Glower DD, Spratt JA, Tyson GS, Maier GW, Olsen CO, Skelton TW, and Bashore TM. Diastolic myocardial mechanics and the regulation of cardiac performance. In: Diastole. Grossman W and Lorell B, (eds). Massachusetts: Martinus Nijhoff Publishers, 1987.