Erum A. Hartung, MD, MTR

Erum A. Hartung, MD, MTR

Erum A. Hartung, MD, MTR, is the Co-Director of the Kidney/Liver Program and the Associate Director of the Pediatric Nephrology Fellowship Program at Children's Hospital of Philadelphia.

Areas of Expertise: Polycystic kidney diseases, Genetic kidney diseases, Kidney Transplantation
Locations: Main Campus; Specialty Care & Surgery Center, Brandywine Valley
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Jefferson Medical College, Philadelphia, PA

Internship

Internal Medicine and Pediatrics - Cedars-Sinai Medical Center, Los Angeles, CA

Residency

Internal Medicine and Pediatrics - Cedars-Sinai Medical Center, Los Angeles, CA
Pediatrics - Johns Hopkins University, Baltimore, MD

Fellowship

Pediatric Nephrology - Johns Hopkins University, Baltimore, MD

Additional Training

Certificate in Patient Oriented Research - University of Pennsylvania, Philadelphia, PA

Board Certification

Nephrology
Pediatrics

Graduate Degree

MS in Translational Research (MTR) - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Co-Director, Combined Kidney/Liver Program

Associate Director, Pediatric Nephrology Fellowship Program

Curriculum Director, Pediatric Nephrology Fellowship Program

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania 

Departments and Services

Research Interests

Autosomal recessive polycystic kidney disease

Kidney and liver imaging

Neurocognitive outcomes

Translational research

Publications

Papers

2018

Liu HS, Hartung EA, Jawad AF, Ware JB, Laney N, Port AM, Gur RC, Hooper SR, Radcliffe J, Furth SL, Detre JA: Regional Cerebral Blood Flow Changes in Children and Young Adults with Chronic Kidney Disease. Radiology February 2018 Notes: in press.

Hartung EA, Erus G, Jawad AF, Laney N, Doshi JJ, Hooper SR, Radcliffe J, Davatzikos C, Furth SL: Brain Magnetic Resonance Imaging Findings in Children and Young Adults With CKD. American Journal of Kidney Diseases February 2018 Notes: doi: 10.1053/j.ajkd.2017.11.024. [Epub ahead of print]

2017

Outeda P, Menezes L, Hartung EA, Bridges S, Zhu X, Xu H, Gao Q, Qian F, Germino GG, Watnick T: A Novel Model of Autosomal Recessive Polycystic Kidney Questions the Role of the FPC C-terminus in Disease Mechanism. Kidney International 92(5): 1130-44, Nov 2017 Notes: doi: 10.1016/j.kint.2017.04.027. [Epub ahead of print]

Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG: NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology. Scientific Reports 7(1): 7733, Aug 2017 Notes: doi: 10.1038/s41598-017-08284-4.

2016

Hartung EA, Dell KM, Matheson M, Warady BA, Furth SL: Growth in Children with Autosomal Recessive Polycystic Kidney Disease in the CKiD Cohort Study. Frontiers in Pediatrics August 2016 Notes: doi.org/10.3389/fped.2016.00082.

Dell KM, Matheson M, Hartung EA, Warady BA, Furth SL: Kidney disease progression in autosomal recessive polycystic kidney disease. The Journal of Pediatrics Jan 2016 Notes: [Epub ahead of print], doi: 10.1016/j.jpeds.2015.12.079.

2015

Hooper SR, Laney N, Radcliffe J, Moodalbail D, Hartung EA, Ruebner RL, Jawad AF, Furth SL: Executive functioning in children, adolescents, and young adults with chronic kidney disease. Journal of Developmental and Behavioral Pediatrics 36(9): 734-42, Nov-Dec 2015 Notes: doi: 10.1097/DBP.0000000000000221.

Hartung EA, Kim JY, Laney N, Hooper SR, Radcliffe J, Port AM, Gur RC, Furth SL.: Evaluation of neurocognition in youth with chronic kidney disease using a novel computerized neurocognitive battery. Clinical Journal of the American Society of Nephrology 11(1): 39-46, Jan 2016 Notes: doi: 10.2215/CJN.02110215. Epub 2015 Oct 23.

Ruebner RL, Laney N, Kim JY, Hartung EA, Hooper SR, Radcliffe J, Furth SL: Neurocognitive dysfunction in children and young adults with chronic kidney disease. American Journal of Kidney Disease Oct 2015 Notes: [Epub ahead of print]. doi: 10.1053/j.ajkd.2015.08.025.

Hartung EA, Laney N, Kim JY, Ruebner RL, Detre JA, Liu H, Davatzikos C, Erus G, Doshi JJ, Schultz RT, Herrington JD, Jawad AF, Moodalbail DG, Gur RC, Port AM, Radcliffe J, Hooper SR, Furth SL: Design and methods of the NiCK study: neurocognitive assessment and magnetic resonance imaging analysis of children and young adults with chronic kidney disease. BMC Nephrology 16(1): 66, Apr 2015 Notes: doi: 10.1186/s12882-015-0061-1. PMCID: PMC4419485

2014

Hartung EA, Matheson M, Lande MB, Dell KM, Guay-Woodford LM, Gerson AC, Warady BA, Hooper SR, Furth SL: Neurocognition in Children with Autosomal Recessive Polycystic Kidney Disease in the CKiD Cohort Study. Pediatric Nephrology. Springer, 29(10): 1957-1965, October 2014 Notes: DOI: 10.1007/s00467-014-2816-5.

2013

Scholl UI, Goh G, Stölting G, de Oliveira RC, Choi M, Overton JD, Fonseca AL, Korah R, Starker LF, Kunstman JW, Prasad M L, Hartung EA, Mauras N, Benson M, Brady T, Shapiro JR, Loring E, Nelson-Williams C, Libutti SK, Mane S, Hellman P, Westin G, Akerström G, Björklund P, Carling T, Fahlke C, Hidalgo P, Lifton RP: Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nature Genetics 45(9): 1050-1054, September 2013 Notes: doi: 10.1038/ng.2695. Epub 2013 Aug 4.

Abstracts

2018

Sharma S, Maya C, Carson RH, Darge K, Hartung EA: Quantification of liver disease severity in autosomal recessive polycystic kidney disease (ARPKD) using magnetic resonance elastography (MRE). Pediatric Academic Societies / American Society of Pediatric Nephrology Annual Meeting (PAS/ASPN), Toronto, ON, Canada May 2018.

Kogon AJ, Kim JY, Laney N, Radcliffe J, Hooper SR, Furth SL, Hartung EA: Depression Associates with Obesity and Worse Neurocognitive Performance in Youth with Chronic Kidney Disease. Pediatric Academic Societies / American Society of Pediatric Nephrology Annual Meeting (PAS/ASPN), Toronto, ON, Canada  May 2018.

2016

Hartung EA, Darge K: Quantification of Liver Disease Severity in Autosomal Recessive Polycystic Kidney Disease (ARPKD) Using Ultrasound Elastography with Acoustic Radiation Force Impulse (ARFI) [abstract] Journal of the American Society of Nephrology / ASN Kidney Week, Chicago, IL November 2016 Notes: Poster.

Books

Chapters

Hartung EA, Watnick T, Germino GG: Introduction to Genetic Renal Disease (Chapter 14). Schrier's Diseases of the Kidney and Urinary Tract, 9th Edition. Coffman TM, Falk RJ, Molitoris BA, Neilson EG, Schrier RW (eds.). Wolters Kluwer/ Lippincott Williams & Wilkins, Page: 458-500, 2012.

Posters and Presentations

2017

Maya C, Hartung EA, Carson RH, Rand EB, Rychik J, Goldberg DJ, Darge K, Anupindi S: Pediatric MR Elastography on Siemens scanners: Early experience. European Society of Paediatric Radiology Annual Meeting, Davos, Switzerland May 2017 Notes: Oral presentation (C. Maya).

Maya C, Hartung EA, Carson RH, Darge K, Anupindi S: Comparison between the standard gradient echo (GRE) sequence and echo planar imaging (EPI) sequences in MR Elastography in a pediatric population. European Society of Paediatric Radiology Annual Meeting, Davos, Switzerland May 2017 Notes: Oral presentation (C. Maya).

Laskin B, Fisher B, Henry L, Correale C, Kreher G, Seif A, Reilly A, Hartung EA, Rand E, Goldberg R, Keashen R, Palmer JA, Bober C, Mita L, Miller R, McCandless K, Lopez S, Goldfarb S: Improved screening for Epstein-Barr virus infection to prevent post-transplant lymphoproliferative disorder in pediatric solid organ transplant recipients. Children's Hospital of Philadelphia Quality and Safety Day, Philadelphia, PA April 2017 Notes: Poster.

Kreher G, Fisher B, Correale C, Henry L, Rand E, Seif A, Reilly A, Hartung EA, Goldfarb S, Laskin BL: A Quality Improvement Effort to Improve Screening for Epstein-Barr Virus Infection in Pediatric Solid Organ Transplant Recipients. United Network for Organ Sharing (UNOS) Transplant Management Forum, Orlando, FL April 2017 Notes: Poster.

2016

Hartung EA, Darge K: Ultrasound elastography with acoustic radiation force impulse (ARFI) to assess liver fibrosis and portal hypertension in children with autosomal recessive polycystic kidney disease [Abstract] Pediatric Radiology/International Pediatric Radiology Conjoint Meeting, Chicago, IL 46(Supplement 1), May 2016 Notes: Oral presentation.

Hartung EA, Darge K: Quantification of Liver Disease Severity in Autosomal Recessive Polycystic Kidney Disease (ARPKD) Using Ultrasound Elastography with Acoustic Radiation Force Impulse (ARFI) [abstract] Journal of the American Society of Nephrology / ASN Kidney Week, Chicago, IL November 2016 Notes: Poster.

Laskin BL, Fisher B, Henry L, Correale C, Kreher G, Mittelstadt C, Rand E, Seif A, Reilly A, Hartung EA, Goldfarb S: A Quality Improvement Effort to Improve Screening for Epstein-Barr Virus Infection in Solid Organ Transplant Recipients. Children's Hospital of Philadelphia Quality and Safety Day, Philadelphia, PA  April 2016 Notes: Poster.

Lectures by Invitation

2017

Hartung EA. "Imaging to measure renal function: How good are our estimates?" Pediatric Academic Societies / American Society of Pediatric Nephrology Annual Meeting, San Francisco, CA. May, 2017.

Hartung EA. "Imaging of the Kidneys and Urinary Tract," Salzburg CHOP Pediatric Nephrology & Endocrinology Seminar, Salzburg, Austria. Apr, 2017.

Hartung EA. "Faculty Case Presentation: Hypertension" Salzburg CHOP Pediatric Nephrology & Endocrinology Seminar, Salzburg, Austria. Apr, 2017.

Hartung EA. "Tubular Disorders of Electrolyte Regulation," Salzburg CHOP Pediatric Nephrology & Endocrinology Seminar, Salzburg, Austria. Apr, 2017.

Hartung EA. "Glomerulonephritis," Salzburg CHOP Pediatric Nephrology & Endocrinology Seminar, Salzburg, Austria. Apr, 2017.

Hartung EA. "Polycystic Kidney Disease and Ciliopathies," Salzburg CHOP Pediatric Nephrology & Endocrinology Seminar, Salzburg, Austria. Apr, 2017.

2016

Hartung EA. Ultrasound elastography with acoustic radiation force impulse to assess liver fibrosis and portal hypertension in children with autosomal recessive polycystic kidney disease. International Pediatric Radiology Conjoint Meeting and Exhibition; 2016 May; Chicago, IL.

Hartung EA, Darge K: Quantification of Liver Disease Severity in Autosomal Recessive Polycystic Kidney Disease (ARPKD) Using Ultrasound Elastography with Acoustic Radiation Force Impulse (ARFI) [abstract] Journal of the American Society of Nephrology November 2016.

Awards and Honors

2017, American Society of Pediatric Nephrology Member of the Month, February 2017 - recognized for service to the ASPN Research Committee

2013-15,  CTSA KL2 Mentored Clinical Research Scholar Award, National Center for Advancing Translational Sciences, National Institutes of Health

2011, Alport Syndrome Symposium Travel Award

2010-11, Charles T. Bauer Foundation Research Award - National Kidney Foundation of Maryland

2008-2009, National Kidney Foundation of Maryland Grant Award

2001, Doctor of Medicine awarded Magna cum laude, Jefferson Medical College

2001,  Annie Simpson Pulmonary Medicine Prize, Jefferson Medical College

2000, Alpha Omega Alpha Honor Medical Society (Junior Year), Jefferson Medical College

2000-2001, Vice President, Jefferson Chapter of Alpha Omega Alpha, Jefferson Medical College

2000-2001, Dr. James D. and Jennie M. Beach Memorial Scholarship

1999,  Bachelor of Science awarded with Highest Distinction, Pennsylvania State University

1999-2001,  Hobart Amory Hare Honor Medical Society for Internal Medicine, Jefferson Medical College

1997, Evan Pugh Scholar Award, Pennsylvania State University

1996, President's Freshman Award, Pennsylvania State University

1995-2001, Starr Foundation Academic Scholarship

Editorial and Academic Positions

Editorial Positions

2017, Ad-hoc reviewer, Journal of the American Society of Nephrology

2016-present, Guest Associate Editor for Pediatric Nephrology, Research Topic: "Challenges in the Diagnosis and Management of Pediatric Polycystic Kidney Diseases," Frontiers in Pediatrics

2016-present, Topic Editor, Research Topic: "Challenges in the Diagnosis and Management of Pediatric Polycystic Kidney Diseases," Frontiers in Pediatrics

2016, Ad-hoc reviewer, Transplantation

2016, Ad-hoc reviewer, American Journal of Kidney Diseases

2015-present, Ad-hoc reviewer, Advances in Chronic Kidney Disease

2015-2017, Ad-hoc reviewer, Pediatric Nephrology

2015-present, Ad-hoc reviewer, Pediatric Nephrology

2014-present,  Ad-hoc reviewer, Clinical Journal of the American Society of Nephrology

2014-present, Ad-hoc reviewer, Liver International

2014-present, Review Editor for pediatric nephrology, Frontiers in Pediatrics

2014-present, Ad-hoc reviewer, Transplant International

Academic and Institutional Committees

2017-present, Scientific Review Committee

2017, K Grant Advisory Committee, Invited Grant Reviewer

2016-2017, Graduate Education Committee, Pediatric Residency Program

2015-16, Clinical Competency Committee, Pediatric Nephrology Fellowship Program

- 2016-present, Chair

2015-present, Quality Improvement Committee, Children's Hospital of Philadelphia Transplant Center: Improving Recognition of EBV Infection in Organ Transplant Recipients - Member

Leadership and Memberships

Memberships in Professional Organizations

2018-present, Polycystic Kidney Disease Foundation: PKD in Children Council
 - 2018-present, Physician Advisor
 - 2018-present, Science Advisory Committee
2017-present, Society for Pediatric Research
2016-present, American Board of Pediatrics
 - 2016-present, Nephrology Content Development Team (item writer for Pediatric Nephrology in-training, certification, and MOC exams)
2007-present, American Society of Nephrology
2007-present, American Society of Pediatric Nephrology
 - 2015-present, Project Leader, ASPN Research Mentoring Quality Improvement Program
 - 2015-2017, Co-Chair, ASPN Research Committee
 - 2013-2015, Member, ASPN Research Committee
 - 2016-present, Member, ASPN Training Program Directors Committee
 - 2016-present, Member, ASPN Program Committee