Robert O. Heuckeroth, MD, PhD

Robert O. Heuckeroth, MD, PhD

Robert Heuckeroth, MD, PhD, is a Board Certified Pediatric Gastroenterologist in the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia. He is also Research Director and Norman and Irma Braman Endowed Chair of CHOP's Lustgarten Center for GI Motility.

Areas of Expertise: Hirschprung's Disease, Chronic intestinal pseudo-obstruction syndrome, Intestinal motility disorders, Malnutrition, Genetics of gastrointestinal disease
Locations: Main Campus
Phone: 215-590-3630

Education and Training

Medical School

MD - Washington University School of Medicine, St. Louis, MO

Residency

Pediatrics - St. Louis Children's Hospital, St. Louis, MO

Fellowship

Clinical Fellow, Pediatric Gastroenterology and Nutrition - St. Louis Children's Hospital, St. Louis, MO

Additional Training

Research Fellow - Washington University School of Medicine, St. Louis, MO

Board Certification

Pediatric Gastroenterology
Pediatrics

Graduate Degree

PhD - Washington University School of Medicine, St. Louis, MO

Titles and Academic Titles

Attending Physician

Irma and Norman Braman Endowed Chair for Research in GI Motility Disorders

Research Director,Suzi and Scott Lustgarten Center for GI Motility

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Professor of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2016

Schill EM, Lake JI, Tusheva OA, Nagy N, Bery SK, Foster L, Avetisyan M, Johnson SL, Stenson WF, Goldstein AM, Heuckeroth RO: Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse. Developmental Biology. Elsevier, 409(2): 473-88, January 2016 Notes: Our article was featured on the cover of the journal, January 15, 2016.

Lake JI, Avetisyan M, Zimmerman A, Heuckeroth RO: Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton. Developmental Biology. Elsevier, 409(1): 152-65, January 2016.

2015

Avetisyan M, Wang H, Schill EM, Bery S, Grider JR, Hassell JA, Stappenbeck T, Heuckeroth RO: Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury. The Journal of Neuroscience 35(33): 11543-11558, August 2015 Notes: Our article was featured on the cover of the Journal August 19, 2015.

Schrenk S, Schuster A, Klotz M, Schleser F, Lake J, Heuckeroth RO, Kim YJ, Laschke MW, Menger MD, Schafer KH: Vascular and neural stem cells in the gut: do they need each other? Histochem Cell Biol 143(5): 397-410, April 2015.

Books

Chapters

2013

Heuckeroth RO : Hirschsprung disease  Pediatric Neurogastroenterology. Faure C, DiLorenzo C, Thapar N (eds.). Humana Press, New York, Heidelberg, Dordrecht, London  Page: 271-283, 2013.

2009

Heuckeroth RO: Autonomic and enteric nervous system: apoptosis and trophic support during development  Handbook of the Neuroscience of Aging. Patrick R. Hof and Charles V. Mobbs (eds.). San Diego: Academic Press, Page: 147-154, 2009.

Heuckeroth RO: Autonomic and enteric nervous system: apoptosis and trophic support during development  New Encyclopedia of Neuroscience. Squire L (eds.). Page: 791-798, 2009.

1985

Greenspan N, Seiden M, Clevinger B, Nahm M, Lutz C, Bartholow T, Heuckeroth RO, Fine S, Davie J: Idiotypes and anti-idiotypes. Immunity to Cancer  Reif AE, Mitchell MS  (eds.). Academic Press, New York, Page: 253-265, 1985.

Posters and Presentations

Invited Lectures

2016

"Emerging insights into intestinal motility disorders in infancy", NEONATAL UPDATE 2016, Imperial College London at BMA House. November 2016.

Environmental Triggers in Neurogastroenterological Disorders, World Congress of Gastroenterology, Hepatology and Nutrition (WCPGHAN), Montreal, Canada, October 2016.

"The Role of the Enteric Nervous System in the Development of Inflammatory Bowel Disease", Fourth Annual Pediatric Inflammatory Bowel Disease (IBD) Research Day at Weill Cornell Medical Center, New York, NY, September 2016.

"Birth defect prevention and repair: Nerve, guts, and a great environment help us all succeed!", Department of Pediatrics, Grand Rounds, Washington University School of Medicine in St. Louis, St. Louis, MO, April 2016.

"Neuroimmunology, the enteric nervous system and bowel inflammation: Underexplored approaches to preventing inflammation", Immunology Research Affinity Group, The Children's Hospital of Philadelphia, April 2016.

"Life of a physician scientist--Moving a lab", Medical Scientist Training Program, Washington University School of Medicine in St. Louis, St. Louis, MO, April 2016.

2015

"Building A Second Brain: New Strategies to Prevent and Treat Bowel Motility", Children's Research Institute Research Conference, Medical College of Wisconsin, Milwaukee, WI, December 2015.

"Ibuprofen slows migration of enteric nervous system precursor cells increasing the risk of Hirschsprung-like disease in animal models", North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN), Washington D.C., October 2015.

"Lessons from Hirschsprung disease models: Beauty, complexity and many ways to fail", 4th International Symposium on Development of the Enteric Nervous System: Cells, Signals, Genes and Therapy, April 2015.

"Building a beautiful nervous system in the bowel, New ideas about preventing Hirschsprung disease, a serious human birth defect", University of Quebec at Montreal, Montreal Canada, January 2015.

Awards and Honors

2016, Harvey R. Colten Award, Washington University School of Medicine
2015, Neurogastroenterology and Motility Prize for Basic Science/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN)
2012-2013, Alumni Endowed Professor of Pediatrics, Washington University School of Medicine
2009, Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
2007-2014, Best Doctors in America
1999, Glaxo Wellcome Institute for Digestive Health, Basic Research Award
1998, Miles and Shirley Fiterman Foundation Basic Sciences Research Award
1995, North American Society of Pediatric Gastroenterology & Nutrition Young Investigator Award
1993, Lucille P. Markey Charitable Trust Fellowship Award, Washington University School of Medicine
1990, George F. Gill Prize in Pediatrics, Washington University School of Medicine
1990, Alpha Omega Alpha, Washington University School of Medicine
1989, Gerty T. Cori Fellowship Award, Washington University School of Medicine
1988, Olin Fellowship, Washington University School of Medicine
1984, Kebar S. Chouke Prize and George F. Gill Prize in Anatomy, Washington University School of Medicine
1982, Phi Beta Kappa, University of Maryland
1982, American Institute of Chemistry Student Award, University of Maryland
1982, General Honors Program Sklar Award for Scholarship and Service, University of Maryland
1981, Phi Kappa Phi, University of Maryland
1980, Phi Mu Epsilon, University of Maryland
1978, Chancellor's Scholarship, University of Maryland

Editorial and Academic Positions

Editorial Positions

2016-present, JCI Insight, Board of Consulting Editors
2016-present, Case Reports in Pediatrics, Ad hoc reviewer
2016-present, The Journal of Neuroscience, Ad hoc reviewer
2015, Tissue Engineering, Ad hoc reviewer
2015, Nature, Ad hoc reviewer
2015, Scientific Reports, Ad hoc reviewer
2015, Pediatric and Developmental Pathology, Ad hoc reviewer
2011-present, Neurogastroenterology and Motility, Editorial Board
2000-present, The American Journal of Physiology, Gastrointestinal and Liver Physiology, Ad hoc reviewer
2000-present, BMC Gastroenterology, Ad hoc reviewer
2000-present, Neuroscience Letters, Ad hoc reviewer
2000-present, Neurobiology of Aging, Neurogastroenterology and Motility, Ad hoc reviewer
2000-present, Journal of Cellular Biochemistry, Ad hoc reviewer
2000-present, Developmental Dynamics, Ad hoc reviewer
2000-present, FEBS Journal, Ad hoc reviewer
2000-present, International Journal of Cancer, Ad hoc reviewer
2000-present, Neuron, Ad hoc reviewer
2000-present, Cell, Ad hoc reviewer
2000-present, Proceedings of the National Academy of Sciences, U.S.A., Ad hoc reviewer
2000-present, Journal of Clinical Investigation, Ad hoc reviewer
2000-present, Journal of Neuroscience, Ad hoc reviewer
2000-present, Gastroenterology, Ad hoc reviewer
2000-present, Hepatology, Ad hoc reviewer
2000-present, PLoS Biology, Ad hoc reviewer
2000-present, Development, Ad hoc reviewer
2000-present, Developmental Neurobiology, Ad hoc reviewer
2000-present, Trends in Genetics, Ad hoc reviewer
2000-present, American Journal of Human Genetics, Ad hoc reviewer

Academic and Institutional Committees

2015-present, Medical Scientist Training Program
2014-present, T32 Training Program in the Genetic Basis of Pediatric Gastrointestinal Disorders, Associate Program Director
2014-present, Mentoring Committee CHOP Pediatric Gastroenterology, Hepatology and Nutrition

Leadership and Memberships

Memberships in Professional Organizations

2011-2017, March of Dimes Foundation
 - Grant Review Committee A
2008-present, American Society for Clinical Investigation
2008, American Association for the Advancement of Science (AAAS) Research Competitiveness Program (U.S.A)
 - Grant Reviewer
2007-present, American Pediatric Society
2002-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
 - 2012-present, Publications committee
2000-present, Society for Pediatric Research
2000-present, Society for Neuroscience
1997-present, American Gastroenterological Association
1986-present, American Association for the Advancement of Science