Robert O. Heuckeroth, MD, PhD

male silhouette icon
Robert Heuckeroth, MD, PhD, is a pediatric gastroenterologist in the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia. He is also Research Director and Norman and Irma Braman Endowed Chair of CHOP's Lustgarten Center for GI Motility.

Areas of Expertise: Hirschprung's Disease, Chronic intestinal pseudo-obstruction syndrome, Intestinal motility disorders, Malnutrition, Genetics of gastrointestinal disease
Locations: Main Hospital; Buerger Center for Advanced Pediatric Care

Education and Training

Medical School

MD - Washington University School of Medicine, St. Louis, MO


Pediatrics - St. Louis Children's Hospital, St. Louis, MO


Clinical Fellow, Pediatric Gastroenterology and Nutrition - St. Louis Children's Hospital, St. Louis, MO

Board Certification

Pediatric Gastroenterology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Graduate Degree

PhD - Washington University School of Medicine, St. Louis, MO

Additional Training

Research Fellow - Washington University School of Medicine, St. Louis, MO

Titles and Academic Titles

Attending Physician

Irma and Norman Braman Endowed Chair for Research in GI Motility Disorders

Research Director, Suzi and Scott Lustgarten Center for GI Motility

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Professor of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services




Wright CM, Schneider S, Smith-Edwards KM, Mafra F, Leembruggen AJL, Gonzalez MV, Kothakapa DR, Anderson JB, Maguire BA, Gao T, Missall TA, Howard MJ, Bornstein JC, Davis BM, Heuckeroth RO.: scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3. Cellular and Molecular Gastroenterology and Hepatology   11:S2352-345X(20)30213-7, January 2021 Notes: j.jcmgh.2020.12.014. Online ahead of print.

Tao Gao, Elizabeth C. Wright-Jin, Rajarshi Sengupta, Jessica B. Anderson, and Robert O. Heuckeroth: Cell-autonomous retinoic acid receptor signaling has stage-specific effects on mouse enteric nervous system. JCI Insight 6(10): e145854, May 2021 Notes: doi: 10.1172/jci.insight.145854.


Wright CM, Garifallou JP, Schneider S, Mentch HL, Kothakapa DR, Maguire BA, Heuckeroth RO : Dlx1/2 mice have abnormal enteric nervous system function. JCI Insight 5(4): pii: 131494, February 2020.

Baumgarten HD, Wright CM, Rossidis AC, Lawrence KM, Kim AG, Mejaddam AY, McGovern PE, Orr MN, Coons BE, Butt Z, Li H, Hwang G, Radu A, Brown LJ, Rubenstein RC, Peranteau WH, Davey M, Heuckeroth RO, Flake AW : The EXTra-uterine Environment for Neonatal Development supports normal intestinal maturation and development. Cellular and Molecular Gastroenterology and Hepatology May 2020 Notes: DOI:

Graham KD, López SH, Sengupta R, Shenoy A, Schneider S, Wright CM, Feldman M, Furth E, Valdivieso F, Lemke A, Wilkins BJ, Naji A, Doolin E, Howard MJ, Heuckeroth RO : Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning. Gastroenterology 158(8): 2221-2235.e5, June 2020 Notes: doi: 10.1053/j.gastro.2020.02.035.

Rodolphe Soret, Sabine Schneider, Guillaume Bernas, Briana Christophers, Ouliana Souchkova, Baptiste Charrier, Franziska Righini-Grunder, Ann Aspirot, Mathieu Landry, Steven W. Kembel, Christophe Faure, Robert O. Heuckeroth, Nicolas Pilon: Glial Cell Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease. Gastroenterology Page: S0016-5085(20)34944-1, July 2020 Notes: doi: 10.1053/j.gastro.2020.07.018.

Sohaib Khalid Hashmi, Vasia Barka, Changsong Yang, Sabine Schneider, Tatyana M. Svitkina, Robert O. Heuckeroth: Pseudo-obstruction inducing ACTG2 R257C alters actin organization and function. JCI Insight 5(16): e140604, August 2020 Notes: doi: 10.1172/jci.insight.140604.

Kristen M. Smith-Edwards, Brian S. Edwards, Christina M. Wright, Sabine Schneider, Kimberly A. Meerschaert, Lindsay L. Ejoh, Sarah A. Najjar, Marthe J. Howard, Kathryn M. Albers, Robert O. Heuckeroth and Brian M. Davis: Sympathetic input to multiple cell types in mouse and human colon produces region-specific responses. Gastroenterology Page: S0016-5085(20)35211-2, September 2020 Notes: doi: 10.1053/j.gastro.2020.09.030.


Ellen M. Schill, Christina M. Wright, Alisha Jamil, Jonathan M. LaCombe, Randall J. Roper, Robert O. Heuckeroth: Down Syndrome Mouse Models have an Abnormal Enteric Nervous System. JCI Insight. 2019 Apr 18;5. pii: 124510. doi: 10.1172/jci.insight.124510.


Silvia Huerta Lopez, Marina Avetisyan, Christina Wright, Karim Mesbah, Robert Kelly, Anne Moon, Robert Heuckeroth: Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit. Developmental Biology Accepted, 2018.

James P. White, Shanshan Xiong, Nicole P. Malvin, William Khoury-Hanold, Robert O. Heuckeroth, Thaddeus S. Stappenbeck and Michael S. Diamond: Intestinal Dysmotility Syndromes Following Systemic Infection by Flaviviruses. Cell. 2018 Nov 15;175(5):1198-1212.e12. doi: 10.1016/j.cell.2018.08.069. Epub 2018 Oct 4.

Marina Avetisyan, Julia E. Rood, Silvia Huerta Lopez, Rajarshi Sengupta, Elizabeth Wright-Jin, Joseph D. Dougherty, Edward M. Behrens, Robert O. Heuckeroth: Muscularis macrophage development in the absence of an enteric nervous system. Proceedings of the National Academy of Sciences Epub ahead of print, April 2018.


Abernathy DG, Kim WK, McCoy MJ, Lake AM, Ouwenga R, Lee SW, Xing X, Li D, Lee HJ, Heuckeroth RO, Dougherty JD, Wang T, Yoo AS: MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Cell Stem Cell 21(3): 332-348, September 2017.

Karaa A, Rahman S, Lombès A, Yu-Wai-Man P, Sheikh M, Alai-Hansen S, Cohen B, Dimmock D, Emrick L, Falk M, McCormack S, Mirsky D, Moore T, Parikh S, Shoffner J, Taivassalo T, Tarnopolsky M, Tein I, Odenkirchen J, Goldstein A; National Institute of Neurological Disorders and Stroke (NINDS) Mitochondrial Disease Common Data Element Working Group. (Heuckeroth R contributed as an author as part of the NINDS Mitochondrial Disease Common Data Element Working Group): Common Data Elements for Clinical Research in Mitochondrial Disease: a National Institute for Neurological Disorders and Stroke project.  J Inherit Metab Dis. Epub ahead of print: doi: 10.1007/s10545-017-0035-5, March 2017.


Schill EM, Lake JI, Tusheva OA, Nagy N, Bery SK, Foster L, Avetisyan M, Johnson SL, Stenson WF, Goldstein AM, Heuckeroth RO: Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse. Developmental Biology. Elsevier, 409(2): 473-88, January 2016 Notes: Our article was featured on the cover of the journal, January 15, 2016.

Lake JI, Avetisyan M, Zimmerman A, Heuckeroth RO: Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton. Developmental Biology. Elsevier, 409(1): 152-65, January 2016.


Avetisyan M, Wang H, Schill EM, Bery S, Grider JR, Hassell JA, Stappenbeck T, Heuckeroth RO: Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury. The Journal of Neuroscience 35(33): 11543-11558, August 2015 Notes: Our article was featured on the cover of the Journal August 19, 2015.

Schrenk S, Schuster A, Klotz M, Schleser F, Lake J, Heuckeroth RO, Kim YJ, Laschke MW, Menger MD, Schafer KH: Vascular and neural stem cells in the gut: do they need each other? Histochem Cell Biol 143(5): 397-410, April 2015.


Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO : Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. Journal for Clinical Investigation 123(12): 5152-64, Dec 2013.

Lake JI, Tusheva OA, Graham BL, Heuckeroth RO: Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis. Journal for Clinical Investigation 123(11): 4875-87, November 2013.

Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO: Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function. Developmental Biology 381(1): 28-37, Sep 2013.


Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW: Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection. American Journal of Physiology - Gastrointestinal & Liver Physiology 302(10): G1143-50, May 15 2012.

Bennett WE Jr., Heuckeroth RO: Hypothyroidism is a rare cause of isolated constipation. Journal of Pediatric Gastroenterology & Nutrition 54(2): 285-7, Feb 2012.


Viader A, Wright-Jin EC, Vohra BPS, Heuckeroth RO, Milbrandt J: Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction. PLoS ONE [Electronic Resource] 6(11): e27727, 2011.


Grider JR, Heuckeroth RO, Kuemmerle JF, Murthy KS: Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line-derived neurotrophic factor. Neurogastroenterology & Motility 22(7): 779-86, Jul 2010.

Wang H, Malone JP, Gilmore PE, Davis AE, Magee JC, Townsend R, Heuckeroth RO: Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis. Journal of Pediatric Gastroenterology & Nutrition 50(4): 411-6, Apr 2010.

Jain S, Knoten A, Hoshi M, Wang H, Vohra B, Heuckeroth RO, Milbrandt J: Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. Journal of Clinical Investigation 120(3): 778-90, Mar 2010.

Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO: Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation. Development 137(4): 631-40, Feb 2010.

Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BPS, Keller-Peck C, Heuckeroth RO: The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. Journal of Neuroscience 30(4): 1523-38, Jan 27 2010.


Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Kulkarni S, Deardorff MA, Uzielli MLG, Dorsett D, Beebe DC, Jay PY,  Heuckeroth RO, Krantz I, Milbrandt J: Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.[Erratum appears in PLoS One. 2009;4(5). doi: 10.1371/annotation/ea5b7eb5-5087-448a-8325-c8efff1f54d9 Note: Shashikant, Kulkarni [corrected to Kulkarni, Shashikant]] PLoS ONE [Electronic Resource] 4(5): e5232, 2009.


Sato Y, Heuckeroth RO: Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro. Developmental Biology 320(1): 185-98, Aug 1 2008.


Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY, Milbrandt J: Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development 134(17): 3191-201, Sep 2007.

Vohra BPS, Fu M, Heuckeroth RO: Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity. Journal of Neuroscience 27(35): 9458-68, Aug 29 2007.

Wang H, Zhang Y, Heuckeroth RO: PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA. FEBS Letters 581(16): 3098-104, Jun 26 2007.

Wang H, Zhang Y, Heuckeroth RO: Tissue-type plasminogen activator deficiency exacerbates cholestatic liver injury in mice. Hepatology 45(6): 1527-37, Jun 2007.

Vohra BPS, Planer W, Armon J, Fu M, Jain S, Heuckeroth RO: Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Developmental Dynamics 236(1): 106-17, Jan 2007.


Fu M, Vohra BPS, Wind D, Heuckeroth RO: BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition. Developmental Biology 299(1): 137-50, Nov 1 2006.

Vohra BPS, Tsuji K, Nagashimada M, Uesaka T, Wind D, Fu M, Armon J, Enomoto H, Heuckeroth, RO: Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis. Developmental Biology 298(1): 259-71, Oct 1 2006.


Wang H, Vohra BPS, Zhang Y, Heuckeroth RO: Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice. Hepatology 42(5): 1099-108, Nov 2005.

Srinivasan S, Anitha M, Mwangi S, Heuckeroth RO: Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival. Molecular & Cellular Neurosciences 29(1): 107-19, May 2005.

Skinner MA, Kalyanaraman S, Safford SD, Heuckeroth RO, Tourtellotte W,  Goyeau D, Goodfellow P, Milbrandt JD, Freemerman A: A human yeast artificial chromosome containing the multiple endocrine neoplasia type 2B Ret mutation does not induce medullary thyroid carcinoma but does support the growth of kidneys and partially rescues enteric nervous system development in Ret-deficient mice. American Journal of Pathology 166(1): 265-74, Jan 2005.


Jain S, Naughton CK, Yang M, Strickland A, Vij K, Encinas M, Golden J, Gupta A, Heuckeroth R, Johnson EM Jr., Milbrandt J: Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development 131(21): 5503-13, Nov 2004.

Enomoto H, Hughes I, Golden J, Baloh RH, Yonemura S, Heuckeroth RO, Johnson EM Jr., Milbrandt J: GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron 44(4): 623-36, Nov 18 2004.

Wanigasekara Y, Airaksinen MS, Heuckeroth RO, Milbrandt J, Keast JR: Neurturin signaling via GFRalpha2 is essential for innervation of glandular but not muscle targets of sacral parasympathetic ganglion neurons. Molecular & Cellular Neurosciences 25(2): 288-300, Feb 2004.


Song XJ, Li D-Q, Farley W, Luo LH, Heuckeroth RO, Milbrandt J. Pflugfelder SC: Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Investigative Ophthalmology & Visual Science 44(10): 4223-9, Oct 2003.

Gianino S, Grider JR, Cresswell J, Enomoto H, Heuckeroth RO: GDNF availability determines enteric neuron number by controlling precursor proliferation. Development 130(10): 2187-98, May 2003.


Honma Y, Araki T, Gianino S, Bruce A, Heuckeroth RO, Johnson EM Jr., Milbrandt J: Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron 35: 267-282, 2002.


Enomoto H, Crawford PA, Gorodinsky A, Heuckeroth RO, Johnson EM Jr., Milbrandt J: RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons. Development 128(20): 3963-74, Oct 2001.


Enomoto H, Heuckeroth RO, Golden JP, Johnson EM, Milbrandt J: Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin. Development 127(22): 4877-89, Nov 2000.


Mazziotti MV, Willis LK, Heuckeroth RO, LaRegina MC, Swanson PE, Overbeek PA, Perlmutter DH: Anomalous development of the hepatobiliary system in the Inv mouse. Hepatology 30(2): 372-8, Aug 1999.

Heuckeroth RO, Enomoto H, Grider JR, Golden JP, Hanke JA, Jackman A, Molliver DC, Bardgett ME, Snider WD, Johnson EM, Jr., Milbrandt J: Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron 22(2): 253-63, Feb 1999.


Heuckeroth RO, Lampe PA, Johnson EM, Milbrandt J: Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Developmental Biology 200(1): 116-29, Aug 1 1998.

Enomoto H, Araki T, Jackman A, Heuckeroth RO, Snider WD, Johnson EM, Jr., Milbrandt J: GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron 21(2): 317-24, Aug 1998.

Milbrandt J, de Sauvage FJ, Fahrner TJ, Baloh RH, Leitner ML, Tansey MG, Lampe PA, Heuckeroth RO, Kotzbauer PT, Simburger KS, Golden JP, Davies JA, Vejsada R, Kato AC, Hynes M, Sherman D, Nishimura M, Wang LC, Vandlen R, Moffat B, Klein RD, Poulsen K, Gray C, Garces A, Johnson EM, Jr.: Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron 20(2): 245-53, Feb 1998.


Heuckeroth RO, Kotzbauer P, Copeland NG, Gilbert DJ, Jenkins NA, Zimonjic DB, Popescu NC, Johnson EM, Jr., Milbrandt J: Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3. Genomics 44(1): 137-40, Aug 15 1997.

Creedon DJ, Tansey MG, Baloh RH, Osborne PA, Lampe PA, Fahrner TJ, Heuckeroth RO, Milbrandt J, Johnson EM,Jr.: Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proceedings of the National Academy of Sciences of the United States of America 94(13): 7018-23, Jun 24 1997.

Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL,  Zimonjic DB, Popescu NC, Johnson EM, Jr., Milbrandt J: TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron 18(5): 793-802, May 1997.


Kotzbauer PT, Lampe PA, Heuckeroth RO, Golden JP, Creedon DJ, Johnson EM, Jr., Milbrandt J: Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384(6608): 467-70, Dec 5 1996.


Mumby SM, Heuckeroth RO, Gordon JI, Gilman AG: G protein alpha subunit expression myristoylation and membrane association in COS cells. Proc Natl Acad Sci USA 1990 87: 728-732, 1990.

Johnson DR, Cox AD, Solski PA, Devadas B, Adams SP, Leimgruber RM,  Heuckeroth RO, Buss JE, Gordon JI: Functional analysis of protein N-myristoylation: metabolic labeling studies using three oxygen-substituted analogs of myristic acid and cultured mammalian cells provide evidence for protein-sequence-specific incorporation and analog-specific redistribution. Proceedings of the National Academy of Sciences of the United States of America 87(21): 8511-5, Nov 1990.

Heuckeroth RO, Jackson-Machelski E, Adams SP, Kishore NS, Huhn M, Katoh A, Lu T, Gokel GW, Gordon JI: Novel fatty acyl substrates for myristoyl-CoA:protein N-myristoyl-transferase. Journal of Lipid Research 31(6): 1121-9, Jun 1990.

Duronio RJ, Jackson-Machelski E, Heuckeroth RO, Olins PO, Devine CS, Yonemoto W, Slice LW, Taylor SS, Gordon JI: Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. Proceedings of the National Academy of Sciences of the United States of America 87(4): 1506-10, Feb 1990.


Bryant ML, Heuckeroth RO, Kimata JT, Ratner L, Gordon JI: Replication of human immunodeficiency virus 1 and Moloney murine leukemia virus is inhibited by different heteroatom-containing analogs of myristic acid. Proceedings of the National Academy of Sciences of the United States of America 86(22): 8655-9, Nov 1989.

Heuckeroth RO, Gordon JI: Altered membrane association of p60v-src and a murine 63-kDa N-myristoyl protein after incorporation of an oxygen-substituted analog of myristic acid. Proceedings of the National Academy of Sciences of the United States of America 86(14): 5262-6, Jul 1989.

Duronio RJ, Towler DA, Heuckeroth RO, Gordon JI: Disruption of the yeast N-myristoyl transferase gene causes recessive lethality. Science 243(4892): 796-800, Feb 10 1989.


Heuckeroth RO, Gordon JI: Protein acylation: The covalent attachment of lipid to protein. ISI Atlas of Science.  Biochemistry 1: 261-267, 1988.

Heuckeroth RO, Glaser L, Gordon JI: Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: an approach for studying both the enzymology and function of protein acylation. Proceedings of the National Academy of Sciences of the United States of America 85(23): 8795-9, Dec 1988.

Heuckeroth RO, Towler DA, Adams SP, Glaser L, Gordon JI: 11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase. Journal of Biological Chemistry 263(5): 2127-33, Feb 15 1988.


Sweetser DA, Heuckeroth RO, Gordon JI: The metabolic significance of mammalian fatty acid-binding proteins: Abundant proteins in search of a function. Ann Rev Nutr 7: 337-359, 1987.

Lan AJY, Heuckeroth RO, Mariano PS: Electron-transfer-induced photocyclization reactions of arene-iminium salt systems.  Effects of cation diradical deprotonation and desilylation on the nature and efficiencies of reaction pathways followed. J Am Chem Soc 109: 2738-2745, 1987.

Borg RM, Heuckeroth RO, Lan AJY, Quillen SL, Mariano PS: Arene-iminium salt electron-transfer photochemistry. Mechanistically interesting photoaddition processes. J Am Chem Soc 109: 2728-2737, 1987.

Heuckeroth RO, Birkenmeier EH, Levin MS, Gordon JI: Analysis of the tissue-specific expression, developmental regulation, and linkage relationships of a rodent gene encoding heart fatty acid binding protein. Journal of Biological Chemistry 262(20): 9709-17, Jul 15 1987.


Seiden MV, Heuckeroth RO, Clevinger B, McMillian S, Lerner R, Davie JM: Hypervariable region peptides variably induce specific anti-idiotypic antibodies: An approach to determining antigenic dominance. J Immunol 136: 582-587, 1986.


Lan AJY, Quillen SL, Heuckeroth RO, Mariano PS: Arene-iminium salt photochemistry.  Dramatic effects of sequential electron-transfer-desilylation pathways on the nature and efficiency of photoaddition and photocyclization processes. J Am Chem Soc 106: 6439-6440, 1984.




Heuckeroth RO: Congenital and Acquired Disorders of the Enteric Nervous System. Translational Gastroenterology: Organogenesis to Disease. Samuelson LC, Gumucio DL (eds.). Wiley-Blackwell, 2014.


Heuckeroth RO : Hirschsprung disease  Pediatric Neurogastroenterology. Faure C, DiLorenzo C, Thapar N (eds.). Humana Press, New York, Heidelberg, Dordrecht, London  Page: 271-283, 2013.


Heuckeroth RO: Autonomic and enteric nervous system: apoptosis and trophic support during development  Handbook of the Neuroscience of Aging. Patrick R. Hof and Charles V. Mobbs (eds.). San Diego: Academic Press, Page: 147-154, 2009.

Heuckeroth RO: Autonomic and enteric nervous system: apoptosis and trophic support during development  New Encyclopedia of Neuroscience. Squire L (eds.). Page: 791-798, 2009.


Greenspan N, Seiden M, Clevinger B, Nahm M, Lutz C, Bartholow T, Heuckeroth RO, Fine S, Davie J: Idiotypes and anti-idiotypes. Immunity to Cancer  Reif AE, Mitchell MS  (eds.). Academic Press, New York, Page: 253-265, 1985.

Posters and Presentations

Invited Lectures


Heuckeroth RO. "Mechanistic approaches to ACTG2 mutation-induced visceral myopathy" European Forum on Visceral Myopathy 2022, Camogli (Genova) Italy. Apr 2022.


Heuckeroth RO. Pediatric Research Grand Rounds, "Making sense of bowel motility: New ideas provide new hope", Columbia University, New York, NY, USA. Oct 2021.

Heuckeroth RO. "Recognizing and making sense of Hirschsprung disease", The Monterrey Pediatric Society International Virtual Conference, Mexico. Sept 2021.

Heuckeroth RO. "Cell-autonomous loss of retinoic acid receptor signaling caused diverse stage-specific enteric nervous system defects in mice", American Neurogastroenterology and Motility Society (ANMS), Boston, MA USA. Aug 2021.

Heuckeroth RO. "Hirschsprung Disease", Pediatric Surgery Grand Rounds presented jointly with Dr. Edward J. Doolin, The Children's Hospital of Philadelphia, Philadelphia, PA. June 2021.

Heuckeroth RO. A Moving Journey Through the Bowel- New Hope for Bowel Motility Disorders, Mayo Clinic, Rochester, MN. Feb 2021.


Heuckeroth RO. "The kidney is not the bowel . . . or is it? Shared mechanisms underlying bowel dysmotility and renal/urinary tract anomalies", American Society of Pediatric Nephrology, 2020 Summer Virtual Series. July 2020.

Heuckeroth RO. Pediatric Grand Rounds: "Broken bowel and the second brain: Mechanistic approaches to bowel motility disorders and the potential for novel therapy", Medical University of South Carolina. Feb 2020.

Heuckeroth RO. Pediatric Grand Rounds, "Making Sense of Bowel Motility: A moveable feast, University of California San Diego, San Diego California. Jan 2020.

Heuckeroth RO. "At the cutting edge of enteric nervous system biology: Repair, regeneration, disease prevention, and challenges in bowel dysmotility", University of California San Diego, San Diego California. Jan 2020.

Awards and Honors

2016, Harvey R. Colten Award, Washington University School of Medicine
2015, Neurogastroenterology and Motility Prize for Basic Science/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN)
2012-2013, Alumni Endowed Professor of Pediatrics, Washington University School of Medicine
2009, Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
2007-2014, Best Doctors in America
1999, Glaxo Wellcome Institute for Digestive Health, Basic Research Award
1998, Miles and Shirley Fiterman Foundation Basic Sciences Research Award
1995, North American Society of Pediatric Gastroenterology & Nutrition Young Investigator Award
1993, Lucille P. Markey Charitable Trust Fellowship Award, Washington University School of Medicine
1990, George F. Gill Prize in Pediatrics, Washington University School of Medicine
1990, Alpha Omega Alpha, Washington University School of Medicine
1989, Gerty T. Cori Fellowship Award, Washington University School of Medicine
1988, Olin Fellowship, Washington University School of Medicine
1984, Kebar S. Chouke Prize and George F. Gill Prize in Anatomy, Washington University School of Medicine
1982, Phi Beta Kappa, University of Maryland
1982, American Institute of Chemistry Student Award, University of Maryland
1982, General Honors Program Sklar Award for Scholarship and Service, University of Maryland
1981, Phi Kappa Phi, University of Maryland
1980, Phi Mu Epsilon, University of Maryland
1978, Chancellor's Scholarship, University of Maryland

Editorial and Academic Positions

Editorial Positions

2022, Ad hoc reviewer, Nature Communications
2022, Ad hoc reviewer, Cellular and Molecular Gastroenterology and Hepatology
2021, Ad hoc reviewer, eNEURO
2021, Ad hoc reviewer, Journal of Pediatric Gastroenterology and Nutrition
2021-present, Editorial Board, Gastroenterology
2021-present, Ad hoc reviewer, Gastroenterology
2020, Ad hoc reviewer, Cellular and Molecular Gastroenterology and Hepatology
2019, Ad hoc reviewer, Journal of Pediatric Gastroenterology and Nutrition
2019, Ad hoc reviewer, Gastroenterology
2018, Ad hoc reviewer, Nature Reviews Neuroscience
2018, Ad hoc reviewer, The Journal of Neuroscience
2018, Ad hoc reviewer, Developmental Biology
2018, Ad hoc reviewer, Gastroenterology
2018, Ad hoc reviewer, Pediatric and Developmental Pathology
2017, Ad hoc reviewer, Proceedings of the National Academy of Sciences
2017-2018, Ad hoc reviewer, JOVE
2017, Ad hoc review, The Journal of Clinical Investigation
2016-present, Board of Consulting Editors for JCI Insight
2016, Ad hoc reviewer, Case Reports in Pediatrics
2016, Ad hoc reviewer , Developmental Biology
2016, Ad hoc reviewer, The Journal of Neuroscience
2015-present, Ad hoc reviewer, Neurogastroenterology and Motility
2011-present, Editorial Board, Neurogastroenterology and Motility

Academic and Institutional Committees

2019-present, Member of the Faculty Search Committee for a Physician Scientist in the Children's Hospital of Philadelphia Cardiac Center
2017-present, Data Safety Monitoring Board member for the NIH supported Gastroparesis Clinical Research Consortium (GpCRC DSMB)
2017-present, Medical Scientist Training Program, Perelman school of Medicine at the University of Pennsylvania Steering Committee Member
2015-present, Medical Scientist Training Program, Perelman school of Medicine at the University of Pennsylvania Admissions Committee Member
2014-present, Member Mentoring Committee CHOP Pediatric Gastroenterology, Hepatology and Nutrition

Leadership and Memberships

Memberships in Professional Organizations

2008-present, American Society for Clinical Investigation
2007-present, American Pediatric Society
2002-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
 - 2016-present, Neurogastroenterology Committee
 - 2012-present, Publications committee
2000-present, Society for Pediatric Research
2000-present, Society for Neuroscience
1997-present, American Gastroenterological Association
1996-present, American Board of Pediatrics
1986-present, American Association for the Advancement of Science