Stephen P. Hunger, MD

Stephen P. Hunger, MD

Stephen P. Hunger, MD, is a nationally prominent specialist in children’s cancer. He is Chief of the Division of Oncology, Director of the Center for Childhood Cancer Research, and holder of the Jeffrey E. Perelman Distinguished Chair in the Department of Pediatrics at Children's Hospital of Philadelphia, PA.

Areas of Expertise: Acute lymphoblastic leukemia, Relapsed acute lymphoblastic leukemia (ALL), Chronic myeloid leukemia (CML), Hematologic malignancies, Precision medicine, Cancer predisposition, Adolescent and young adult care
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Connecticut School of Medicine, Farmington, CT

Internship

Pediatrics - The Johns Hopkins Hospital, Baltimore, MD

Residency

Pediatrics - The Johns Hopkins Hospital, Baltimore, MD

Fellowship

Pediatric Hematology/Oncology - Stanford University School of Medicine, Stanford, CA
Postdoctoral Scholar (Research) - Department of Pathology, Stanford University School of Medicine, Stanford, CA

Board Certification

Diplomate, National Board of Medical Examiners
Pediatric Hematology/Oncology
Pediatrics

Undergraduate Degree

BS - Massachusetts Institute of Technology, Cambridge, MA

Titles and Academic Titles

Chief, Division of Oncology

Director, Center for Childhood Cancer Research

Jeffrey E. Perelman Distinguished Chair in the Department of Pediatrics

Professor, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Acute lymphoblastic leukemia (ALL)

Publications

Papers

2018

Ma X, Liu Y, Liu Y, Alexandrov LB, Edmonson MN, Gawad C, Zhou X, Li Y, Rusch MC, Easton J, Huether R, Gonzalez-Pena V, Wilkinson MR, Hermida LC, Davis S, Sioson E, Pounds S, Cao X, Ries RE, Wang Z, Chen X, Dong L, Diskin SJ, Smith MA1, Guidry Auvil JM, Meltzer PS, Lau CC, Perlman EJ, Maris JM, Meshinchi S, Hunger SP, Gerhard DS, Zhang J. Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. Nature. 2018 Feb 28. doi: 10.1038/nature25795. [Epub ahead of print]

2017

Tasian SK, Teachey DT, Li Y, Shen F, Harvey RC, Chen I-M, Ryan T, Vincent TL, Willman CL, Perl AE, Hunger SP, Loh ML, Carroll M, Grupp SA. Potent Efficacy of Combined PI3K/mTOR and JAK or ABL Inhibition in Murine Xenograft Models of Ph-like Acute Lymphoblastic Leukemia.  Blood, 129: 177-187, 2017. PMID: 27777238.  PMCID 5234216

Karol SE, Larsen E, Cheng C, Cao X, Yang W, Ramsey LB, Fernandez CA, McCorkle JR, Paugh SW, Autry RJ, Lopez-Lopez E, Diouf B, Jeha S, Pui C-H, Raetz EA, Winick NJ, Carroll WL, Hunger SP, Loh ML, Devidas M, Evans WE, YangJJ.  Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia.  Leukemia, 31: 1325-1332, 2017 [Epub 2017 Jan 18].  PMID: 28096535.  PMCID 5462853

Liu Y, Fernandez CA, Smith C, Yang W, Cheng C, Panetta C, Kornegay N, Liu C, Ramsey LB, Karol SE, Janke LJ, Larsen EC, Winick N, Carroll WL, Loh ML, Raetz EA, Hunger SP, Devidas M, Yang JJ, Mullighan CG, Zhang J, Evans WE, Jeha S, Pui C-H, Relling MV.  Genome-wide Study Links PNPLA3 Variant with Elevated Hepatic Transaminase after Acute Lymphoblastic Leukemia Therapy.  Clinical Pharmacology & Therapeutics, 2017 Jan 16 [Epub ahead of print].  PMID: 28090653.  PMCID 5511775

Winick N, Devidas M, Chen S, Maloney K, Larsen E, Mattano L, Borowitz MJ, Carroll A, Gastier-Foster JM, Heerema NA, Willman C, Wood B, Loh M, Raetz E, Hunger* SP, Carroll* WL.  The Impact of initial cerebrospinal fluid findings on outcome among patients with NCI standard and high-risk B-lymphoblastic leukemia: A report from the Children’s Oncology Group. Journal of Clinical Oncology, 35: 2527-2534, 2017 [Epub 2017 May 23].  PMID: 28535084.   PMCID 5536164 *SPH and WLC contributed equally. 

Hunger SP.  CML in blast crisis: More common than we think?  Blood, 129: 2713-2714, 2017.  PMID: 28522462

Reshmi* SC, Harvey* RC, Roberts* KG, Stonerock E, Smith A, Jenkins H, Chen I-M, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh** ML, Mullighan** CG, Willman** CL, Gastier-Foster** JM, Hunger** SP. Targetable Kinase Gene Fusions in Children, Adolescents, and Young Adults with High Risk B-ALL: A Study from the Children’s Oncology Group. Blood, 129: 3352-3361, 2017 [Epub 2017 Apr 13].  PMID: 28408464.  PMCID 5482101  *contributed equally as 1st authors; **contributed equally as senior authors.

Hardy KK, Embry LM, Kairalla JA, Helian S, Devidas M, Armstrong D, Hunger SP, Carroll WL, Larsen E, Raetz EA, Loh ML, Yang W, Relling MV, Noll RB, Winick N.  Neurocognitive Functioning of Children Treated for High Risk B-acute Lymphoblastic Leukemia Randomized to Different Methotrexate and Corticosteroid Treatment Strategies: A Report from the Children’s Oncology Group.  Journal of Clinical Oncology, 35: 2700-2707, 2017 [Epub 2017 Jul 3].  PMID: 28671857

Liu Y, Easton J, Shao Y, Wang Z, Wilkinson MR, Maciaszek J, McCastlain K, Edmonson M, Zhou X, Ma X, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Guidry Auvil J, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino B, Downing JR, Loh ML, Hunger SP*, Zhang J*, Mullighan CG*.  The Genomic Landscape of Pediatric and Young Adult T-lineage Acute Lymphoblastic Leukemia. Nature Genetics, 49:1211-1218, 2017 [Epub 2017 Jul 3].  PMID: 28671688.  PMCID 5535770.   *corresponding authors.

Roberts KG, Yang Y-L, Payne-Turner D, Lin W, Files JK, Dickerson K, Gu Z, Taunton J, Janke L, Chen T, Loh ML, Hunger SP, Mullighan CG.  Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like acute ALL.  Blood Advances 2017 1:1657-1671.

DiNofia A, Seif AE, Devidas M, Li Y, Hall M, Huang YSV, Cahen V, Hunger SP, Winick NJ, Carroll WL, Fisher BT, Larsen EC, Aplenc R.  Cost Comparison by Treatment Arm and Center-Level Variations in Cost and Inpatient Days on the Phase III High-Risk B Acute Lymphoblastic Leukemia Trial AALL0232.  Cancer Medicine, 2017 Dec 23 [Epub ahead of print].  PMID: 29274118.

Salzer WL, Burke MJ, Devidas M, Chen S, Gore L, Larsen EC, Borowitz MJ Wood B, Heerema NA, Carroll AJ, Hilden JM, Loh ML, Raetz EA, Winick NJ, Carroll WL, Hunger SP.  Feasibility of Intensive Post-Induction Therapy Incorporating Clofarabine in the Very High Risk Stratum of Patients with Newly Diagnosed High Risk B-Lymphoblastic Leukemia: a Report from the Children’s Oncology Group Study AALL1131.  Cancer, 2017 Dec 19 [Epub ahead of print].  PMID: 29266189

Tasian SK, Loh ML, Hunger SP.  Philadelphia Chromosome-like Acute Lymphoblastic Leukemia.  Blood, 130: 2064-2072, 2017.  [Epub 2017 Oct 2].  PMID:  28972016.

Hunger SP.  Integrated Risk Stratification using Minimal Residual Disease and Sentinel Genetic Alterations in Pediatric Acute Lymphoblastic Leukemia.  Journal of Clinical Oncology,  2017 Nov 13 [Epub ahead of print].  PMID: 29131700.

Zheng DJ, Lu X, Schore RJ, Balsamo L, Devidas M, Winick NJ, Raetz EA, Loh ML, Carroll WL, Sung L, Hunge SP, Angiolillo A, Kadan-Lottick NS.  Longitudinal analysis of quality of life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children’s Oncology Group (COG) AALL0932.  Cancer, 2017 Nov 7 [Epub ahead of print].  PMID:  29112230

Rau RE, Dreyer Z, Choi MR, Liang W, Skowronski R, Devidas M, Raetz EA, Adamson PC, Blaney SM, Loh ML, Hunger SP.  Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children’s Oncology Group.  Pediatric Blood and Cancer, 2017 Nov 1 [Epub ahead of print].  PMID: 29090524.

Teachey DT, Hunger SP.  Acute Lymphoblastic Leukaemia In 2017: Immunotherapy for ALL Takes the World by Storm.  Nature Reviews Clinical Oncology, 2017 Dec 19 [Epub ahead of print].  PMID: 29255238

Burke MJ, Devidas M, Maloney K, Angiolillo A, Schore R, Dunsmore K, Larsen E, Mattano Jr. LA, Salzer W, Winter SS, Carroll W, Winick NJ, Loh ML, Raetz E, Hunger SP, Bleyer A. Severe Pegaspargase Hypersensitivity Reaction Rates (Grade 3) with Intravenous Infusion versus Intramuscular Injection: Analysis of 54,280 Doses Administered to 16,534 Patients on Children’s Oncology Group (COG) Clinical Trials. Leukemia and Lymphoma, 2017 Nov 8:1-10 [Epub ahead of print].  PMID:  29115886

Gupta* S, Devidas* M, Loh ML, Raetz EA, Chen S, Wang C, Brown P, Carroll AJ, Heerema NA, Gastier-Foster JM, Dunsmore KP, Larsen EC, Maloney KW, Mattano Jr. LA, Winter SS, Winick NJ, Carroll WL, Hunger SP, Borowitz** MJ, Wood** BL (*Co-first authors; **Co-senior authors).  Minimal Residual Disease Assessment of Remission after Induction Therapy is Superior to Morphologic Assessment for Risk Stratification in Childhood Acute Lymphoblastic Leukemia: A Report from the Children’s Oncology Group.  Leukemia, 2017 Dec 18 [Epub ahead of print].  PMID: 29249823

Barredo* JC, Hastings* C, Lu X, Devidas M, Chen Y, Armstrong FD, Winick N, Wood BL, Yanofsky R, Loh M, Gastier-Foster JM, Jorstad DT, Marcus Jr. R, Ritchey K, Carroll** WL, Hunger** SP (*Co-first authors; **Co-senior authors). Isolated Late Testicular Relapse of B-cell Acute Lymphoblastic Leukemia Treated with Intensive Systemic Chemotherapy and Response-based Testicular Radiation: A Children’s Oncology Group Study.  Pediatric Blood and Cancer, 2017 Dec 29 [Epub ahead of print].  PMID: 29286562

Wood B, David Wu D, Crossley B, Dai Y, Williamson D, Gawad C, Borowitz M, Devidas M, Maloney KW, Larsen E, Winick N, Raetz E, Carroll WL, Hunger SP, Loh ML, Robins H, Kirsch I.  Measurable Residual Disease Detection by High Throughput Sequencing Improves Risk Stratification for Pediatric B-ALL.  Blood, 2017 Dec 28 [Epub ahead of print].  PMID: 29284596

2016

Matloub Y, Stork L, Asselin B, Hunger SP, Borowitz M, Jones T, Bostrom B, Gastier-Foster JM, Heerema NA, Carroll A, Winick N, Carroll WL, Camitta B, Devidas M, Gaynon PS.  Outcome of children with T-lineage acute lymphoblastic leukemia and standard-risk features – comparison among Children Cancer Group protocols 1952 and 1991 and Pediatric Oncology Group protocol 9404.  Pediatric Blood and Cancer, 63: 255-261, 2016 [Epub 2015 Oct 20].  PMID: 26485054. PMCID 4715507

Carroll WL, Hunger SP.  Therapies on the Horizon for Childhood acute Lymphoblastic Leukemia.  Current Opinion in Pediatrics, 28:12-18, 2016.  PMID: 26576011.  PMCID 4755474

Vora A, Andreano A, Pui C-H, Hunger SP, Schrappe M, Zimmerman M, Biondi A, Conter V, Escherich G, Silverman L, Goulden N, Taskinen M, Pieters R, Horibe K, Devidas M, Valsecchi MG.  Influence Of Cranial Radiotherapy On Outcome In Children With Acute Lymphoblastic Leukaemia Treated With Contemporary Therapy.  Journal of Clinical Oncology, 34: 919-926, 2016 [Epub 2016 Jan 11].  PMID: 26755523.  PMCID 4871998

Karol SE, Yang W, Mattano Jr LA, Maloney KW, Smith C, Liu C, Ramsey LB, Fernandez CA, Chang TY, Neale G, Cheng C, Mardis E, Fulton R, Scheet P, Larsen EC, Loh ML, Raetz EA, Hunger SP, Devidas M, Relling MV.  Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia. Blood, 127: 558-564, 2016 [Epub 2015 Nov 20].  PMID: 26590194.  PMCID 4742546

Iacobucci I*, Li Y*, Roberts KG, Dobson SM, Kim JC, Payne-Turner D, Harvey RC, Valentine M, McCastlain K, Easton J, Yergeau D, Janke LJ, Shao Y, Chen I-ML, Rusch M, Zandi S, Kornblau SM, Konopleva M, Jabbour E, Paietta EM, Rowe JM, Pui C-H, Gastier-Foster J, Gu Z, Reshmi S, Loh M, Racevskis J, Tallman MS, Wiernik PH, Litzow MR, Willman CL, McPherson JD, Downing JR, Zhang J, Dick JE, Hunger SP, Mullighan CG.  Truncating rearrangements of the erythropoietin receptor in acute lymphoblastic leukemia.  Cancer Cell, 8: 186-200, 2016.  PMID: 26859458.  PMCID 4750652

Dizon DS, Krilov L, Cohen EEW, Gangadhar TC, Ganz PA, Hensing T, Hunger SP, Krishnamurthi SS, Lassman AB, Markham MJ, Mayer EL, Neuss MN Pal SK, Richardson LC, Schilsky RL, Schwartz GK, Spriggs DR, Villalona-Calero MA, Villani G, Masters GA.  Clinical Cancer Advances 2016: Annual Report On Progress Against Cancer From The American Society Of Clinical Oncology.  Journal of Clinical Oncology, 34: 987-1011, 2016 [Epub 2016 Feb 4]. PMID: 26846975.  PMCID 5075244

Tricoli JV, Blair DG, Anders C, Bleyer A, Boardman L, Khan J, Kummar S, Hayes-Lattin B, Hunger S, Merchant M, Siebel NL, Thurin M, Willman C.  Biological and Clinical Characteristics of Adolescent and Young Adult Cancers: Acute Lymphocytic Leukemia, Colon Cancer, Breast Cancer, Melanoma and Sarcoma.  Cancer, 122: 1017-1028, 2016 [Epub 2016 Feb 5].  PMID: 26849082.  PMCID 4803597

Dupuis LL, Lu X, Mitchell H-R, Sung L, Mattano L, Carroll W, Winick N, Hunger SP, Maloney K, Kadan-Lottick N.  Anxiety, Pain, and Nausea during Treatment of Childhood Acute Lymphoblastic Leukemia: A Prospective, Longitudinal Study from the Children’s Oncology Group.  Cancer, 122: 1116-1125, 2016 [Epub 2016 Jan 15].  PMID: 26773735.  PMCID 5138861

Larsen EC, Devidas M, Chen S, Salzer WL, Nachman JB, Raetz EA, Loh ML, Mattano LA Jr., Cole C, Eicher A, Haugan M, Sorenson M, Heerema NA, Carroll AJ, Gastier-Foster JM, Borowitz MJ, Wood BL, Willman CL, Winick* NJ, Hunger* SP, Carroll* WL.  Dexamethasone and High Dose Methotrexate Improve Outcome for Children and Young Adults with High-Risk B-Acute Lymphoblastic Leukemia:  A Report From Children’s Oncology Group Study AALL0232.  *NJW, SPH and WLC contributed equally.  Journal of Clinical Oncology, 34: 2380-2388, 2016 [Epub 2016 Apr 25].  PMID: 27114587.  PMCID 4981974

Kunin-Batson AS, Lu X, Balsamo L, Graber K, Devidas M, Hunger SP, Carroll WL, Winick NJ, Mattano LA, Maloney KW, Kadan-Lottick KS.  Prevalence and predictors of anxiety and depression after completion of chemotherapy in childhood acute lymphoblastic leukemia: A prospective longitudinal study.  Cancer, 122: 1608-1617, 2016 [Epub 2016 Mar 29].  PMID: 27028090.  PMCID 4860039

Kolenova A, Maloney KW, MD, Hunger SP.  Philadelphia Chromosome Positive Acute Lymphoblastic Leuklemia or Chronic Myeloid Leukemia in Lymphoid Blast Crisis?  Journal of Pediatric Hematology/Oncology, 38: e193-195, 2016 [Epub 2016 May 9].  PMID: 27164534

Liu C, Yang W, Devidas M, Cheng C, Pei D, Smith C, Carroll WL, Raetz EA, Bowman WP, Larsen, EC, Maloney KW, Martin PL, Mattano LA, Winick NJ, Mardis ER, Fulton RS, Bhojwani D, Howard SC, Jeha S, Pui C-H, Hunger SP, Evans WE, Loh ML, Relling MV.  Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients with Acute Lymphoblastic Leukemia.  Journal of Clinical Oncology, 34: 2133-2140, 2016 [Epub 2016 Apr 25].  PMID: 27114598.  PMCID 4962704

Matlawska K, Kang H, Devidas M, Wen J, Harvey RC, Nickl C, Ness SA, Rush M, Li Y, Onozawa M, Martinez C, Wood BL, Asselin B, Chen I-M, Roberts KG, Baruchel A, Soulier J, Dombret H, Zhang J, Larson RS, Raetz E, Carroll W, Winick N, Aplan PD, Loh M, Mullighan CG, Hunger SP, MD, Heerema NA, Carroll AJ, Dunsmore KP, Winter SS.  MLL Rearrangements Impact Outcome in HOXA-deregulated T-lineage Acute Lymphoblastic Leukemia:  A Children's Oncology Group Study.  Leukemia, 30: 1909-1912, 2016 [Epub 2016 Mar 8].  PMID: 26952838.  PMCID 5014577

Rodriguez V, Kairalla J, Salzer W, Raetz E, Loh M, Carroll A, Heerema NA, Wood B, Borowtiz MJ, Burke M, Asselin BL, Devidas M, Winick NW, Carroll WL, Hunger SP, Dreyer Z.  A Pilot Study of Intensified PEG-Asparaginase in High Risk Acute Lymphoblastic Leukemia:  Children’s Oncology Group Study AALL08P1.  Journal of Pediatric Hematology/Oncology, 38: 409-417, 2016. PMID: 27299599

Hunger SP.  Glucocorticoid Selection for Pediatric ALL. Blood, 127: 2049-2051, 2016.  PMID: 2712729.  PMCID 4955695

Bernt K, Hunger SP, Neff T.  The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities.  Frontiers in Pediatrics, 4:49 2016. PMID: 27242978.  PMCID 4870860

Zaliova M, Moorman AV, Cazzaniga G, Stanulla M, Harvey RC, Roberts KG, Heatley SL, Loh ML, Konopleva M, Chen IM, Zimmermannova O, Schwab C, Smith O, Mozziconacci MJ, Chabannon C, Kim M, Falkenburg JH, Norton A, Marshall K, Haas OA, Starkova J, Stuchly J, Hunger SP, White D, Mullighan CG, Willman CL, Stary J, Trka J, Zuna J.  Characterization of leukemias with ETV6-ABL1 fusion.  Hematologica, 101: 1082-1093, 2016 [Epub 2016 May 26].  PMID: 27229714.  PMCID 5060025

Rau R, Carroll AJ, Heerema NA, Arland A, Carroll WL, Winick NJ, Raetz EA, Loh ML, Yang W, Relling MV, Dai Y, Devidas M, Hunger SP.  Klinefelter Syndrome and 47,XYY Syndrome in Children With B Cell Acute Lymphoblastic Leukemia.  British Journal of Haematology, 2016 Jul 19 [Epub ahead of print].  PMID: 27434379

Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi I, Weinholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui C-H, Jeha S, Harvey RC, Chen I-ML, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrozek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis EA, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JD, Mullighan CG.  Deregulation of DUX4 and ERG in Acute Lymphoblastic Leukemia.  Nature Genetics, 48: 1481-1489, 2016 [Epub 2016 Oct 24].  PMID: 27776115.  PMCID 5144107

Gu Z, Li Y, Liu Y, Reshmi S, Roberts K, Harvey RC, McCastlain K, Payne-Turner D, Churchman M, Iacobucci I, Shao Y, Easton J, Chen I-M, Valentine M, Mungall K, Mungall A, Ma Y, Moore R, Marra M, Stonerock E, Gastier-Foster J, Devidas M, Dai Y, Wood B, Borowitz M, Larsen E, Maloney K, Mattano LA Jr, Angiolillo A, Salzer W, Burke M, Rambaldi L, Spinelli O, Radich JP, Minden MD, Moorman AV, Patel BP, Fielding AK, Rowe JM, Luger S, Bhatia R, Aldoss I, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S,  Kantarjian HM, Konopleva M, Paietta E, Willman CL, Gerhard DS, Loh M, Hunger SP, Mullighan C.  Recurrent MEF2D Fusions In Acute Lymphoblastic Leukemia.  Nature Communications, 7:13331, 2016.  PMID: 27824051.  PMCID 5105166

Niewerth D, Kaspers GJL, Jansen G, van Meerloo J, Zweegman S, Jenkins G, Whitlock JA, Hunger SP, Lu X, van de Ven PM, Horton TM, Cloos J.  Proteasome subunit expression analysis and chemosensitivity in relapsed paediatric acute leukemia patients receiving bortezomib-containing chemotherapy.  Journal of Hematology Oncology, 9: 82, 2016. PMID: 27599459.  PMCID 5011854

Tasian SK, Hunger SP.  Genomic Characterization of Pediatric Acute Lymphoblastic Leukaemia: an Opportunity for Precision Medicine Therapeutics.  British Journal of Haematology, 176: 867-882, 2017 [Epub 2016 Dec 16].  PMID: 27984637

2015

Perez-Andreu V, Roberts KG, Xu H, Smith C, Zhang H, Yang W, Harvey RC, Payne-Turner D, Devidas M, Chen I-M, Carroll WL, Heerema NA, Carroll AJ, Raetz EA, Gastier-Foster JM, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Rowe JM, Luger SM, Tallman MS, Dean M, Burchard EG, Yue F, Wang Y, Pui C-H, Jeha S, Relling MV, Evans WE, Gerhard DS, Loh ML, Willman CL, Hunger SP, Mullighan CG, Yang JJ.  A Genome-wide Association Study of Susceptibility to Acute Lymphoblastic Leukemia in Adolescent and Young Adults.  Blood, 125: 680-686, 2015 [Epub 2014 Dec 2].  PMID: 25468567.  PMCID 4304112

Suryani S, Bracken LS, Harvey RC, Sia KCS, Carol H, Chen I-M, Evans K, Dietrich P, Roberts KG, Kurmasheva RT, Billups C, Mullighan CG, Willman CL, Hunger SP, Houghton PJ, Smith MA, Lock RB.  Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia.  Molecular Cancer Therapeutics, 14:364-374, 2015 [Epub 2014 Dec 10].  PMID: 25504635.  PMCID 4326541

Pui C-H, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang D-C, Downing JR, Evans WE, Relling MV, Mullighan CG.  Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.  Journal of Clinical Oncology, 33: 2938-2948, 2015 [Epub 2015 Aug 24].  PMID: 26304874.  PMCID 4567699

Ma X, Edmonson M, Yergeau D, Muzny DM, Vardhan Doddapaneni D, Rusch M, Song G, Easton J, Harvey RC, Wheeler DA, Ma J, Hampton OA, Vadodaria B, Wu G, Nagahawatte P, Carroll WL, Chen I-M, Gastier-Foster JM, Relling MV, Smith MA, Devidas M, Guidry Auvil JM, Downing JR, Loh ML, Willman CL, Gerhard DS, Mullighan* CG, Hunger* SP, Zhang* J.  The Rise and Fall of Subclones from Diagnosis to Relapse in Pediatric B-Acute Lymphoblastic Leukemia (B-ALL).  Nature Communications, 6: 6604, 2015.  PMID: 25790293.  PMCID 4377644 *corresponding authors. 

Raetz EA, Cairo MS, Borowitz MJ, Lu X, Devidas M, Reid JM, Goldenberg DM, Wegener WA, Zeng H, Whitlock JA, Adamson PC, Hunger SP, Carroll WL.  Re-induction Chemoimmunotherapy with Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL) in Children, Adolescents and Young Adults:  Phase II Results from Children’s Oncology Group (COG) Study ADVL04P2.  Pediatric Blood and Cancer, 62: 1171-1175, 2015 [Epub 2015 Mar 2].  PMID: 25732247.  PMCID 4701208

Maude SL, Dolai S, Delgado-Martin C, Vincent TL, Robbins A, Selvanathan A, Ryan T, Hall J, Wood AC, Tasian SK, Hunger SP, Loh ML, Mullighan CG, Wood BL, Hermiston ML, Grupp SA, Lock RB, Teachey DT.  Efficacy of JAK/STAT Pathway Inhibition in Murine Xenograft Models of Early T-cell Precursor (ETP) Acute Lymphoblastic Leukemia.  Blood, 125: 1759-1767, 2015 [Epub 2015 Feb 2].  PMID: 25645356.  PMCID 4357583

Winter# SS, Dunsmore# KP, Devidas M, Eisenberg N, Asselin BL, Wood BL, Leonard MS, Murphy J, Gastier-Foster JM, Carroll AJ, Heerema NA, Loh ML, Raetz EA, Winick* NJ, Carroll* WL, Hunger* SP.  Safe Integration of Nelarabine into Intensive Chemotherapy in Newly Diagnosed T-cell Acute Lymphoblastic Leukemia: Children’s Oncology Group Study AALL0434.  Pediatric Blood and Cancer, 62: 1176-1183, 2015 [Epub 2015 Mar 8].  PMID: 25755211. #Equal contributors as first authors; *Equal contributors as senior authors.  PMCID 4565502

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Tiz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger S, Willman CL, Melnick A, Loh M, Jung J, Coligan J, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Muschen M.  Signalling thresholds and negative B cell selection in acute lymphoblastic leukemia.  Nature, 521: 357-361, 2015 [Epub 2015 Mar 23].  PMID: 25799995.  PMCID 4441554

Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini C, Pecci A, Gnan C, De Rocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Gutierrez Hartman A, Liang X, Pluthero FG, Rowley JW, Weyrich AS, Kahr WHA, Porter CP, Di Paola J.  Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia.  Nature Genetics, 47: 535-538 2015 [Epub 2015 Mar 25].  PMID: 2580728.  PMCID 4631613

Bi W, Kang G, Zhao Y, Cui Y, Yan S, Li Y, Cheng C, Pounds SB, Borowitz MJ, Relling MV, Yang JJ, Pui C-H, Hunger SP, Hartford CM, Leung W, Zhang JF.  SVSI: Fast and Powerful Set-Valued System Identification Approach to Identifying Rare Variants in Sequencing Studies for Ordered Categorical Traits.  Annals of Human Genetics, 79: 294-309, 2015 [Epub 2015 May 11].  PMID: 25959545.  PMCID 4474746

Diouf B, Crews KR, Lew G, Pei D, Cheng C, Bao J, Zheng J, Yang W, Fan Y, Paugh S, McCorkle JR, Lu X, Winick NJ, Carroll WL, Loh ML, Hunger SP, Devidas M, Pui CH, Relling MV, Evans WE.  Genome-wide analyses identify a susceptibility locus for vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia.  Journal of the American Medical Association, 313: 815-823, 2015. PMID: 25710658.  PMCID 4377066

Lindemulder SJ, Stork LC, Bostrom B, Lu X, Devidas M, Hunger S, Neglia JP, Kadan-Lottick NS.  Survivors of Standard Risk Acute Lymphoblastic Leukemia do not have Increased Risk for Overweight and Obesity Compared to Non-Cancer Peers: A Report From the Children’s Oncology Group.  Pediatric Blood and Cancer, 62:1035-1041, 2015 [Epub 2015 Feb 7].  PMID: 25663378.  PMCID 4405430

Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina N, Chen W-Y, Huan J, LaTocha D, Ballabio E, Xiao G, Lee J-W, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon S-M, Shojaee S, Chan LN, Yu J, Kornblau SM, Burger JA, Bijl JJ, Ye BH, Ansel M, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Milne TA, Chang BH, Müschen M.  Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.  Cancer Cell, 27: 409-425, 2015.  PMID: 25759025.  PMCID 4618684

Hunger SP, Mullighan CG.  Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine. Blood, 125: 3977-3987, 2015 [Epub 2015 May 21].  PMID: 25999453.  PMCID 4481590

Fernandez CA, Smith C, Yang W, Mullighan CG, Qu C, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Karol SE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Jeha S, Pui C-H, Evans WE, Devidas M, Relling MV.  Genome-wide analysis links NFATC2 with asparaginase allergy.  Blood, 126: 69-75, 2015 [Epub 2015 May 18].  PMID: 25987655.  PMCID 4492197

Xu H, Zhang H, Yang W, Yadav R, Morrison AC, Qian M, Devidas M, Liu Y, Perez-Andreu V, Zhao X, Gastier-Foster JM, Lupo PJ, Neale J, Raetz E, Larsen E, Bowman WP, Carroll WL, Winick N, Williams R, Hansen T, Holm J-C, Mardis E, Fulton R, Pui C-H, Zhang J, Mullighan CG, Evans WE, Hunger SP, Gupta R, Schmiegelow K, Loh ML, Relling MV, Yang JJ.  Inherited Coding Variants at the CDKN2A Locus Influence Susceptibility to Acute Lymphoblastic Leukaemia in Children.  Nature Communications, 6:7553, 2015.  PMID: 26104880.  PMCID 4544058

Kolenová A, Kaiserová E, Makohusová M, Šubová Z, Bubanská E, Oravkinová I, Svec P, Fabri O, Hunger SP, Sufliasrska S, Horáková S, Mrázová V, Stary J.  Improved outcome for children and adolescent with acute lymphoblastic leukemia in the first decade of the 21st century: A Report from the Slovak Republic. Neoplasma, 62: 812-820, 2015 [Epub 2015 Aug 17].  PMID: 26278138

Hunger SP, Mullighan CGM.  Acute lymphoblastic leukemia in children.  New England Journal of Medicine, 373: 1551-1562, 2015.  PMID: 26465987

Borowitz MJ, Wood BL, Devidas M, Loh ML, Raetz EA, Salzer WL, Nachman JB, Carroll AJ, Heerema NA, Gastier-Foster JM, Willman CL, Dai Y, Winick NJ, Hunger SP, Carroll WL, Larsen E.  Minimal Residual Disease In High Risk Pediatric ALL Retains Prognostic Significance Even With More Effective Therapy.  A Report From Children’s Oncology Group Study AALL0232.  Blood,126: 964-971, 2015 [Epub 2015 Jun 29].  PMID: 26124497.  PMCID 4543229

Tasian SK, Loh ML, Hunger SP.  Childhood Acute Lymphoblastic Leukemia: Integrating Genomics into Therapy.  Cancer, 121: 3577-3590, 2015 [Epub 2015 Jul 20]. PMID: 26194091.  PMCID 4592406

Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, Koeffler HP, Willman CL, Hunger SP, Melnick A, Kornblau SM, Müschen M. Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell, 28: 114-128, 2015 [Epub 2015 Jun 9].  PMID: 26073130.  PMCID 4565502

Karol SE, Yang W, Van Driest SL, Chang TY, Kaste S, Bowton E, Basford M, Bastarache L, Roden DM, Denny JS, Larsen E, Winick N, Carroll WL, Cheng C, Pei D, Fernandez CA, Liu C, Smith C, Loh ML, Raetz EA, Hunger SP, Scheet P, Jeha S, Pui C-H, Evans WE, Devidas M, Mattano Jr LA, Relling MV.  Genetics of Glucocorticoid-Associated Osteonecrosis in Children with Acute Lymphoblastic Leukemia.  Blood, 126: 1770-1776, 2015 [Epub 2015 Aug 11].  PMID: 26265699.  PMCID 4600016

Jones CL, Gearheart CM, Fosmire S, Delgado-Martin C, Evensen NA, Bride K, Waanders AJ, Pais F, Wang J, Bhatla T, Bitterman DS, de Rijk SR, Bourgeois W, Dandekar S, Park E, Teachey DT, Raetz EA, Hermiston ML, Müschen M, Loh ML, Hunger SP, Zhang J, Garabedian MJ, Porter CC*, Carroll WL*.  MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric B-precursor Acute Lymphoblastic Leukemia.  Blood, 126: 2202-2212, 2015 [Epub 2015 Aug 31].  PMID: 26324703.  PMCID 4635116

Moriyama T, Metzger ML, Wu G, Nishii R, Qian M, Devidas M, Yang W, Cheng C, Cao X, Quinn E, Raimondi S, Gastier-Foster J, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Komada K, Wang S, Edmondson M, Xu H, Mardis E, Fulton R, Pui C-H, Mullighan CG, Evans WE, Zhang J, Hunger SP, Relling MV, Nichols KE, Loh ML, Yang JJ.  Germline Genetic Variation in ETV6 and Predisposition to Childhood Acute Lymphoblastic Leukemia.  Lancet Oncology, 16: 1659-1666, 2015 [Epub 2015 Oct 28].  PMID: 26522332.  PMCID 4684709

Gupta S, Howard SC, Hunger SP, Antillon FG, Metzger ML, Israels T, Harif M, Rodriguez-Galindo C.  Treating Childhood Cancer in Low- and Middle-Income Countries.  In: Gelband H, Jha P, Sankaranarayanan R, Horton S, editors. Cancer: Disease Control Priorities, Third Edition (Volume 3). Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2015 Nov 01. Chapter 7.  PMID: 26913338

Mitchell H-R, Lu X, Myers R, Sung L, Balsamo L, Carroll WL, Raetz E, MD, Loh ML, Mattano LM, Winick NJ, Devidas M, Hunger SP, Maloney K, Kadan-Lottick, MD.  Prospective, Longitudinal Assessment of Quality of Life in Children from Diagnosis to Three Months off Treatment for Standard Risk (SR) Acute Lymphoblastic Leukemia (ALL): Results of Children’s Oncology Group Study AALL0331.  International Journal of Cancer, 138: 332-339, 2016 [Epub 2015 Sep 3].  PMID: 26235006. PMCID 5138856

2014

Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Müschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD.  VPREB1 Deletions Occur Independent of Lambda-Light Chain Rearrangement in Childhood Acute Lymphoblastic Leukemia.  Leukemia, 28: 216-220, 2014 [Epub 2013 Jul 24].  PMID: 23881307.  PMCID 40434507

De Lorenzo P, Moorman AV, Pieters R, Dreyer ZE, Heerema NA, Carroll AJ, Hunger SP, Harvey R, Willman CL, Devidas M, Valsecchi MG, Harrison CJ.  Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements.  Leukemia, 28: 428-430, 2014 [Epub 2013 Sep 27].  PMID: 24072099.  PMCID 4285361 

Hunger SP.  Introduction and overview to issue on new developments in pediatric hematology/oncology.  Current Opinion in Pediatrics, 26: 1-2, 2014.  PMID: 24299912.

Harrison CJ, Moorman AV, Schwab C, Carroll AJ, Raetz EA, Devidas M, Strehl S, Nebral K, Harbott J, Teigler-Schlegel A, Zimmermann M, Dastuge N, Baruchel A, Soulier J, Auclerc M-F, Attarbaschi A, Mann G, Stark B, Cazzaniga G, Chilton L, Vandenberghe P, Forestier E, Haltrich I, Raimondi SC, Parihar M, Bourquin J-P, Tchinda J, Haferlach C, Vora A, Hunger SP, Heerema NA, Haas OA.  An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome.  Leukemia, 28:1015-1021, 2014 [Epub 2013 Oct 29].  PMID: 24166298.  PMCID 4283797

Buitenkamp TD, Izraeli S, Zimmermann M, Forestier E, Heerema NA, van den Heuvel-Eibrink MM, Pieters R, Korbijn CM, Silverman LB, Schmiegelow K, Liang DC, Horibe K, Arico M, Biondi A, Basso G, Rabin KR, Schrappe M, Cario G, Mann G, Morak M, Panzer R, Mondelaers V, Lammens T, Cave H, Stark B, Ganmore I, Moorman AV, Vora A, Hunger SP, Pui CH, Mullighan CG, Manabe A, Escherich G, Kowalczyk JR, Whitlock JA, Zwaan CM.  Acute lymphoblastic leukemia in children with Down syndrome: A retrospective analysis from the Ponte di Legno study group.  Blood, 123:70-77, 2014 [Epub 2013 Nov 12].  PMID: 24222333.  PMCID 3879907

Myers RM, Balsamo L, Lu X, Devidas M, Hunger SP, Carroll WL, Winick NJ, Maloney KW, Kadan-Lottick NS.  A Prospective Study of Anxiety, Depression, and Behavioral Changes in the First Year after Diagnosis of Childhood Acute Lymphoblastic Leukemia: A Report from the Children’s Oncology Group.  Cancer, 120:1417-1425, 2014 [Epub 2014 Jan 28].  PMID: 24473774.  PMCID 4319360

Hunger SP.  Expanding Clinical Trial Networks in Pediatric Acute Lymphoblastic Leukemia.  Journal of Clinical Oncology, 32: 169-70, 2014 [Epub 2013 Dec 16]. PMID: 24344213

Schultz KR, Devidas M, Bowman WP, Aledo A, Slayton WB, Sather H, Zheng HZ, Davies SM, Gaynon PS, Trigg M, Rutledge R, Jorstad D, Carroll AJ, Heerema N, Winick N, Borowitz MJ, Hunger SP, Carroll WL, Camitta B.  Philadelphia Chromosome Negative Very High Risk Acute Lymphoblastic Leukemia in Children and Adolescents: Results from Children's Oncology Group (COG) Study AALL0031. Leukemia, 28: 964-967, 2014 [Epub 2014 Jan 17].  PMID: 24434862.  PMCID 4283793

Schultz KR, Carroll A, Heerema NA, Bowman WP, Aledo A, Slayton WB, Sather H, Devidas M, Zheng HZ, Davies SM, Gaynon PS, Trigg M, Rutledge R, Jorstad D, Winick N, Borowitz MJ, Hunger SP, Carroll WL, Camitta B.  Long Term Follow-up of Imatinib in Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Children's Oncology Group Study AALL0031.  Leukemia, 28:1467-71, 2014 [Epub 2014 Jan 20].  PMID: 24441288.  PMCID 4282929

Bernt KM, Hunger SP. Current Concepts in Pediatric Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL).  Frontiers in Oncology, 4:54, 2014 [Epub 2014 March 25].  PMID: 24724051.  PMCID 3971203

Kang G, Bi W, Zhao Y, Zhang J-F, Yang JJ, Xu H, Loh ML, Hunger SP, Relling MV, Pounds S, Cheng C.  A New System Identification Approach to Identifying Genetic Variants in Sequencing Studies for a Binary Phenotype.  Human Heredity, 78:104-116, 2014.  PMCID 4270367

Dandekar S, Romanos-Sirakis E, Pais F, Bhatla T, Jones C, Bourgeois W, Hunger SP, Raetz EA, Hermiston ML, Dasgupta R, Morrison DJ, Carroll WL.  Wnt Inhibition Leads to Improved Chemosensitivity in Pediatric Acute Lymphoblastic Leukemia.  British Journal of Hematology, 167:87-99, 2014 [Epub 2014 Jul 4].  PMID: 24995804.  PMCID 4207443

Roberts* KG, Li* Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen S-C, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen I-M, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock J, Raetz EA, White D, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui C-H, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing^ JR, Hunger^ SP, Willman^ C, Zhang^ J, Mullighan^ CG.  Targetable kinase activating lesions in Ph-like acute lymphoblastic leukemia.  New England Journal of Medicine; 371:1005-1015, 2014. PMID: 25207766.  PMCID 4191900. *contributed equally; ^contributed equally and corresponding authors.

Fernandez CA, Smith C, Yang W, Date M, Bashford D, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Turner V, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV.  HLA-DRB1*07:01 is Associated with a Higher Risk of Asparaginase allergies.  Blood, 124:1266-1276, 2014 [Epub 2014 Jun 26].  PMID: 24970932

Lau S, Lu X, Balsamo L, Devidas M, Winick NJ, Hunger SP, Carroll WL, Stork L, Maloney KW, Kadan-Lottick NS.  Family Life Events in the First Year of Acute Lymphoblastic Leukemia Therapy.  Pediatric Blood and Cancer, 61:2277-2284, 2014 [Epub 2014 Aug 30]. PMID: 25175168.  PMCID 4282930

Chonghaile TN, Roderick JE, Glenfield C, Ryan J, Sallan SE, Silverman LB, Loh ML, Hunger SP, Wood B, DeAngelo D, Stone R, Harris M, Gutierrez A, Kelliher MA, Letai A.  Maturation stage of T-ALL determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.  Cancer Discovery, 4:1074-1087, 2014 [Epub 2014 Jul 3].  PMID: 24994123.  PMCID 4154982

Angiolillo AL, Schore RJ, Devidas M, Borowitz MJ, Carroll AJ, Gastier-Foster JM, Heerema NA, Keilani T, Lane AR, Loh ML, Reaman GH, Adamson PC, Wood B, Wood C, Zheng HW, Raetz EA, Winick NJ, Carroll WL, Hunger SP.  Pharmacokinetic and Pharmacodynamic Properties of Calaspargase Pegol E. coli L-asparaginase in the Treatment of Patients with Acute Lymphoblastic Leukemia: Results from Children's Oncology Group Study AALL07P4. Journal of Clinical Oncology, 32:3874-3882, 2014 [Epub 2014 Oct 27].  PMID: 25348002.  PMCID  4239306

Dreyer ZE, Hilden JM, Jones T, Devidas M, Winick NJ, Willman CL, Harvey RC, Chen I-M, Behm FG, Pullen DJ, Wood BL, Carroll AJ, Heerema NA, Felix CA, Robinson B, Reaman GH, Salzer WL, Hunger SP, Carroll WL, Camitta BM.  Intensified Chemotherapy Without SCT In Infant All: Results from COG P9407 (cohort 3). Pediatric Blood and Cancer, 62: 419-426, 2015 [Epub 2014 Nov 14].  PMID: 25399948.  PMCID 5145261

Salzer WL, Asselin BL, Plourde PV, Corn T, Hunger SP.  Development of Asparaginase Erwinia chrysanthemi for the Treatment of Acute Lymphoblastic Leukemia.  Annals of the New York Academy of Sciences, 1329:81-92, 2014 [Epub 2014 Aug 5].  PMID: 25098829

Bleyer A, Asselin B, Koontz SE, Hunger SP.  Clinical Application of Asparaginase Activity Levels.  Pediatric Blood and Cancer, 62:1102-1105 2015 [Epub 2014 Nov 12].  PMID: 25393506

Salzer WL, Jones TL, Devidas M, Dreyer ZE, Gore L, Winick NJ, Sung L, Raetz E, Loh ML, Wang CY, De Lorenzo P, Valsecchi MG, Pieters R, Carroll WL, Hunger SP, Hilden JM, Brown P.  Decreased Induction Morbidity and Mortality Following Modification to Induction Therapy in Infants with Acute Lymphoblastic Leukemia Enrolled on AALL0631: A Report from the Children’s Oncology Group.  Pediatric Blood and Cancer, 62: 414-418, 2015 [Epub 2014 Nov 18].  PMID: 25407157.  PMCID 4480675

Mansour MR, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Lawton L, Jenkinson S, Gale RE, Linch DC, Sallan SE, Silverman LB, Loh ML, Hunger SP, Sanda T, Young RA, Look AT.  An Oncogenic Super-Enhancer Formed through Somatic Mutation of a Non-Coding Intergenic Element.  Science, 346:1373-1377, 2014 [Epub 2014 Nov 13].  PMID: 25394790.  PMCID 4720521

2013

Xu H, Yang W, Perez‐Andreu V, Devidas M, Fan Y, Cheng C, Pei D, Scheet P, Burchard EG, Eng C, Huntsman S, Torgerson DG, Dean M, Winick NJ, Martin PL, Camitta BM, Bowman WP, Willman CL, Carroll WL, Mullighan CG, Bhojwani D, Hunger SP, Pui C-H, Evans WE, Relling MV, Loh ML, Yang JJ.  Genome-wide Association Study Identifies a Novel Susceptibility Locus at 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethnically Diverse Populations.  Journal of the National Cancer Institute, 105: 733-742, 2013 [Epub 2013 Mar 19].  PMID: 23512250.  PMCID 3691938

Macy ME, Duncan T, Whitlock J, Hunger SP, Boklan J, Narendaren A, Herzog C, Arceci RJ, Bagatell R, Trippett T, Christians U, Rolla K, Ivy SP, Gore L.  A Multi-Center Phase Ib Study of Oxaliplatin (NSC#266046) in Combination with Fluorouracil and Leucovorin in Pediatric Patients with Advanced Solid Tumors.  Pediatric Blood and Cancer, 60: 230-236, 2013 [Epub 2012 Sep 28].  PMID: 23024067.  PMCID 3522763

Hunger SP, Baruchel A, Biondi A, Evans WE, Jeha S, Loh M, Moericke A, Pieters R, Relling MV, Schmiegelow K, Schrappe M, Silverman LB, Stanulla M, Valsecchi MG, Vora A, Pui C-H.  The Thirteenth International Childhood Acute Lymphoblastic Leukemia Workshop Report: La Jolla, CA USA, December 7-9, 2011.  Pediatric Blood and Cancer, 60: 344-348, 2013 [Epub 2012 Sep 28]. PMID: 23024117

Hunger SP.  Introduction and overview to issue on new developments in pediatric hematology/oncology.  Current Opinion in Pediatrics, 25:1-2, 2013 [Epub 2012 Dec 27].  PMID: 23274431

Loh* ML, Zhang* J, Harvey RC, Roberts K, Payne-Turner D, Kang H, Wu G, Chen X, Becksfort J, Edmonson M, Buetow KH, Carroll WL, Chen I-M, Wood B, Borowitz MJ, Devidas M, Gerhard DS, Bowman WP, Larsen E, Winick, N, Raetz E, Smith M, Downing JR, Willman CL#, Mullighan# CG, Hunger# SP.  Tyrosine Kinome Sequencing of Pediatric Acute Lymphoblastic Leukemia:  A Report from The Children’s Oncology Group TARGET Project. MLL and JZ contributed equally.  CLW, CGM and SPH are corresponding authors. Blood, 121: 485-488, 2013 [Epub 2012 Dec 4].  PMID: 23212523.  PMCID 3548168

Ramsey LB, Panetta JC, Smith C, Yang W, Fan Y, Winick NJ, Martin PL, Cheng C, Devidas M, Pui C-H, Evans WE, Hunger SP, Loh M, Relling MV. Genome-wide Study of Methotrexate Clearance Replicates SLCO1B1Blood, 121: 898-904, 2013 [Epub 2012 Dec 11].  PMID: 23233662.  PMCID 3567337

Hunger SP, Loh ML, Whitlock JA, Winick NJ, Carroll WL, Devidas M, Raetz EA.  Children’s Oncology Group’s 2013 Blueprint for Research: Acute Lymphoblastic Leukemia.  Pediatr Blood Cancer, 60: 957-963, 2013 [Epub 2012 Dec 19].  PMID: 23255467.  PMCID 4045498.

Horton TM and Hunger SP.  Children are not large mice: Response to editorial Bortezomib and bone health in adults: can we extend these findings to childrenEuropean Journal of Haematolgy, 90:535, 2013 [Epub 2013 Apr 23]. PMID: 23534840

Holmfeldt L, Wei L, Diaz-Flores E, Zhang J, Ding L, Payne-Turner D, Churchman M, Andersson A, Chen S-C, McCastlain K, Becksfort J, Ma J, Wu G, Patel SN, Heatley SL, Song G, Easton J, Parker M, Chen X, Rusch M, Boggs K, Vadodaria B, Hedlund E, Drenberg C, Baker S, Pei D, Cheng C, Lu C, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Minden M, Lewis ID, To LB, Marlton P, Raca G, Stock W, Neale G, Drexler HG, Dickins RA, Shurtleff SA, Pui C-H, Ribeiro RC, Devidas M, Carroll AJ, Heerema NA, Wood B, Borowitz MJ, Gastier-Foster JM, Raimondi SC, Mardis ER, Wilson RK, Downing JR, Hunger SP, Loh ML, Mullighan CG.  The Genomic Landscape Of Hypodiploid Acute Lymphoblastic Leukemia.  Nature Genetics 45: 242-252, 2013 [Epub 2013 Jan 20]. PMID: 23334668.  PMCID 3919793

Levy AS, Pyke-Grimm KA, Lee DA, Palla SL, Naranjo A, Saulnier Sholler G, Gratias E, Maloney K, Parshankar F, Lee-Scott M, Beierle EA, Gow K, Kim GE, Hunger S, Smith FO, Horton TM.  Mentoring in Pediatric Oncology: A Report from the Children’s Oncology Group Young Investigator Committee.  Journal of Pediatric Hematology/Oncology, 35: 456-461, 2013.  PMID: 23892351.  PMCID 38639621

Urtishak KA, Edwards AYZ, Wang L-S, Hudome A, Robinson BW, Barrett JS, Cao K, Cory L, Moore JS, Bantly AD, Yu Q-C, Chen I-ML, Atlas SL, Willman CL, Kundu M, Carroll AJ, Heerema NA, Devidas M, Hilden JM, Dreyer ZE, Hunger SP, Reaman GH, Felix CA.  Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia (ALL). Blood, 121: 2689-2703, 2013 [Epub 2013 Feb 7].  PMID: 23393050.  PMCID 3617634

Meyer JA, Wang J, Hogan LE, Dandekar S, Patel JP, Tang Z, Zumbo P, Li S, Zavadil J, Levine RL, Cardozo T, Hunger SP, Raetz EA, Morrison DJ, Mason C, Carroll WL.  Relapse Specific Mutations in NT5C2 in Childhood Acute Lymphoblastic Leukemia. Nature Genetics, 45: 290-294, 2013 [Epub 2013 Feb 3].  PMID: 23377183.  PMCID 3681285

Heerema NA, Carroll AJ, Devidas M, Loh ML, Borowitz MJ, Gastier-Foster JM, Larsen EC, Mattano LA Jr, Maloney KW, Willman CL, Wood BL, Winick NJ, Carroll WL, Hunger SP, Raetz EA.  Intrachromosomal Amplification of Chromosome 21 Is Associated with Inferior Outcomes in Children with Acute Lymphoblastic Leukemia Treated in Contemporary Standard-Risk Children’s Oncology Group Studies: A Report from the Children’s Oncology Group. Journal of Clinical Oncology, 31: 3397-3402, 2013 [Epub 2013 Aug 12].  PMID: 23940221.  PMCID 3770866

Teachey DT, Hunger SP.  Improving the Prediction of Relapse in Childhood Acute Lymphoblastic Leukaemia.  British Journal of Haematology, 162: 606-620, 2013 [Epub 2013 Jun 29].  PMID: 23808872

Salzer WL, Asselin B, Supko JG, Devidas M, Kaiser NA, Plourde P, Winick NJ, Reaman GH, Raetz E, Carroll WL, Hunger SP.  Erwinia Asparaginase Achieves Therapeutic Activity after PEG-asparaginase allergy:  A Report from the Children’s Oncology Group.  Blood, 122: 507-514, 2013 [Epub 2013 Jun 5].  PMID: 23741010.  PMCID 3724190

Mulcahy Levy JM, Hunger SP.  Brain Size and Neuropsychological Functioning in Long-Term Survivors of Pediatric Acute Lymphoblastic Leukemia.  Translational Pediatrics, 2: 140-142, 2013. PMID: 26835308.  PMCID 4729082

Mullighan CG, Hunger SP.  Therapy of Pediatric ALL: From Bowie to Obama.  Blood, 122:2531-2532, 2013.  PMID: 24113793

Perez‐Andreu V, Roberts KR, Harvey RC, Yang W, Cheng C, Pei D, Xu H, Gastier‐Foster J, Xu H, Shuyu E, Lim JYS, Chen I-M, Fan Y, Devidas M, Borowitz MJ, Smith C, Neale G, Burchard EG, Torgerson DG, Antillon Klussman F, Villagran CRN, Winick NJ, Camitta BM, Raetz E, Wood B, Yue F, Carroll WL, Larsen E, Bowman WP, Loh ML, Dean M, Bhojwani D, Pui C-H, Evans WE, Relling MV, Hunger SP, Willman CL, Mullighan CG, Yang JJ.  Inherited GATA3 Genetic Variants are Associated with Ph‐like Childhood Acute Lymphoblastic Leukemia and Risk of Relapse.  Nature Genetics, 45:1494-1498, 2013 [Epub 2013 Oct 20].  PMID: 24141364.  PMCID 4039076

2012

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen S-C, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick D, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti El Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore SP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenaur JC, Evans WE, Pui C-H, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG.  The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature, 481:157-163, 2012 [Epub 2012 Jan 12]. PMID: 22237106. PMCID 3267575

Xu H, Cheng C, Devidas M, Pei D, Fan Y, Yang W, Neale G, Scheet P, Burchard EG, Torgerson DG, Eng C, Dean M, Antillon F, Winick NJ, Martin PL, Willman CL, Camitta BM, Reaman GH, Carroll WL, Loh ML, Evans WE, Pui C-H, Hunger SP, Relling MV, Yang JJ.  ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia. Journal of Clinical Oncology, 30: 751-757, 2012 [Epub 2012 Jan 30]. PMID: 22291082.  PMCID 3295551

Caniza MA, Hunger SP, Schrauder A, Valsecchi MG, Pui C-H, Masera G, and members of the International Study Group of Childhood ALL (the “Ponte di Legno Working Group”). The controversy of varicella vaccination in children with acute lymphoblastic leukemia. Pediatric Blood and Cancer, 58: 12-16, 2012 [Epub 2010 Sep 16].  PMID: 20848637.  PMCID 3004985

Kang H, Wilson CS, Harvey RC, Chen I-M, Murphy MH, Atlas SR, Bedrick EJ, Devidas M, Carroll AJ, Robinson BW, Stam RW Valsecchi MG, PhD7, Pieters R, Heerema NA, Hilden JA, Dreyer ZE, Camitta B, Winick N, Carroll WL, Felix CA, Reaman GH, Hunger SP, Willman CL.  Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children’s Oncology Group Study.  Blood, 119: 1872-1881, 2012 [Epub 2011 Dec 30].  PMID: 22210879.  PMCID 3293641

Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, Reaman GH, Carroll WL.  Improved survival for children and adolescents with acute lymphoblastic leukemia from 1990-2005: A report from the Children’s Oncology Group. Journal of Clinical Oncology, 30:1663-1669, 2012 [Epub 2012 Mar 12].  PMID: 22412151.  PMCID 3383113  This was the 35th most frequently cited manuscript published in JCO in 2012 and the only pediatric cancer manuscript among the 50 most commonly cited manuscripts.

Meshinchi S, Hunger SP, Aplenc R, Adamson P, Jessup JM.  Lessons Learned From The Investigational Device Exemption (IDE) Review of Children’s Oncology Group Trial AAML1031. Clinical Cancer Research, 18:1547-1554, 2012.  PMID: 22422407.  PMCID 3310885

Chang BH, Willi SG, Stork L, Hunger SP, Carroll WL, Camitta BM, Winick NJ, Druker BJ, Schultz KR. Imatinib resistant BCR-Abl mutations at relapse in children with Ph+ ALL: a Children's Oncology Group (COG) study. British Journal of Haematology, 157: 507-510, 2012 [Epub 2012 Feb 2].  PMID: 22299775.  PMCID 4290865

Schrappe M, Hunger S, Pui C-H, Saha V, Gaynon P, Baruchel A, Masera G, Otten J, Tsuchida M, Versluys AB, Escherich G, Heymans M, Silverman L, Horibe K, Mann G, Camitta B, Harbott J, Riehm H, Richards S, Devidas M, Zimmermann M. Outcome after induction failure in childhood acute lymphoblastic leukemia.  New England Journal of Medicine, 366: 1371-1381, 2012. PMID: 22494120.  PMCID 3374496

Chen I-M, Harvey RC, Mullighan CG, Gastier-Foster J, Wharton W, Kang H, Borowitz MJ, Camitta BM, Carroll AJ, Devidas M, Pullen DJ, Payne-Turner D, Tasian SK, Reshmi S, Cottrell CE, Reaman GH, Bowman WP, Carroll WL, Loh M, Winick NJ, Hunger SP, Willman CL.  Outcome Modeling with CRLF2, IKZF1, JAK and Minimal Residual Disease in Pediatric Acute Lymphoblastic Leukemia: A Children’s Oncology Group Study. Blood, 119: 3512-3522, 2012 [Epub 2012 Feb 24].  PMID: 22368272.  PMCID 3325039

Nakano TA, Hunger SP.  Blood Consult: Therapeutic strategy and complications in the adolescent and young adult with acute lymphoblastic leukemia.  Blood, 119:4372-4374, 2012 [Epub 2012 Mar 21]. PMID: 22438250.  PMCID 4123436

Salzer WL, Jones TJ, Devidas M, Hilden JM, Winick N, Hunger S, Carroll WL, Camitta B, Dreyer ZD.  Modifications to induction therapy decrease risk of early death in infants with acute lymphoblastic leukemia treated on Children’s Oncology Group P9407.  Pediatric Blood and Cancer, 59: 834-839, 2012 [Epub 2012 Apr 5]. PMID: 22488662.  PMCID 4008315

Dunsmore KP, Devidas M, Linda SB, Borowitz MJ, Winick N, Hunger SP, Carroll WL, Camitta B.  Pilot Study of Nelarabine in Combination with Intensive Chemotherapy in High-Risk T-cell Acute Lymphoblastic Leukemia. A report from the Children’s Oncology Group. Journal of Clinical Oncology, 30: 2753-2759, 2012 [Epub 2012 Jun 25].  PMID: 22734022.  PMCID 3402886

Roberts KG*, Morin RD*, Zhang J, Hirst M, Zhao Y, Su X, Chen SC, Payne-Turner D, Churchman ML, Harvey RC, Chen X, Kasap C, Yan C, Becksfort J, Finney RP, Teachey DT, Maude SL, Tse K, Moore R, Jones S, Mungall K, Birol I, Edmonson MN, Hu Y, Buetow KE, Chen IM, Carroll WL, Wei L, Ma J, Kleppe M, Levine RL, Garcia-Manero G, Larsen E, Shah NP, Devidas M, Reaman G, Smith M, Paugh SW, Evans WE, Grupp SA, Jeha S, Pui CH, Gerhard DS, Downing JR, Willman CL, Loh M, Hunger SP#, Marra M#, Mullighan CG#. Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.  RD and KGR contributed equally.  SPH, MM and CGM are corresponding authors. Cancer Cell, 22: 153-166, 2012.  PMID: 22897847.  PMCID 3422513

Tasian SK, Doral, MY, Borowitz MJ, Wood BL, Chen I-M, Harvey RC, Gastier-Foster JM, Willman CL, Hunger SP, Mullighan CG, Loh ML. Aberrant STAT5 and PI3K/mTOR Pathway Signaling Occurs in Human CRLF2-Rearranged B-Precursor Acute Lymphoblastic Leukemia. Blood, 120: 833-842, 2012 [Epub 2012 Jun 8].  PMID: 22685175.  PMCID 3412346

Mattano LA Jr, Devidas M, Nachman JB, La MK, Sather HN, Hunger SP, Steinherz PG, Gaynon PS, Seibel NL.  Effect of alternate-week versus continuous week dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia:  Results from the CCG-1961 randomised cohort trial. Lancet Oncology, 13: 906-915, 2012 [Epub 2012 Aug 15].  PMID: 22901620.  PMCID 3448283

Messinger YH, Higgins RR, Devidas M, Hunger SP, Carroll AJ, Heerema NA.  Pediatric acute Lymphoblastic Leukemia with a t(8;14)(q11.2;q32): B-cell disease with high proportion of Down Syndrome: A Children’s Oncology Group (COG) Study. Cancer Genetics, 205: 453-458, 2012.  PMID: 22939398.  PMCID 3432955

Araten DJ, Sanders KJ, Anscher D, Zamechek L, Hunger SP, Ibrahim S.  Leukemic Blasts with the PNH Phenotype in Children with Acute Lymphoblastic Leukemia. American Journal of Pathology, 181:1862-1869, 2012 [Epub 2012 Aug 30].  PMID: 22940070.  PMCID 3483812

Maloney KW, Giller R, Hunger SP.  Recent advances in the understanding and treatment of pediatric leukemias.  Adv Pediatr. 59: 329-358, 2012. PMID: 22789585

Maude SL, Tasian SK, Vincent T, Hall JW, Sheen C, Roberts KG, Seif AE, Barrett DM, Chen I-M, Collins JR, Mullighan CG, Hunger SP, Harvey RC, Willman CL, Fridman JS, Loh ML, Grupp SA, Teachey DT. Targeting JAK1/2 and mTOR in Murine Xenograft Models of Ph-like Acute Lymphoblastic Leukemia (ALL). Blood, 120: 3510-3518, 2012 [Epub 2012 Sep 6].  PMID: 22955920.  PMCID 3482861

Rao S, Lee SY, Gutierrez A, Perrigoue J, Thapa RJ, Tu Z, Jeffers JR, Rhodes M, Anderson S, Oravecz T, Hunger SP, Timakhov RA, Zhang R, Balachandran S, Zambetti GP, Testa JR, Look AT, Wiest DL. Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.  Blood, 120: 3764-3773, 2012 [Epub 2012 Sep 13].  PMID: 22976955.  PMCID 3488889

Yang JJ, Cheng C, Devidas M, Cao X, Campana D, Yang W, Fan Y, Neale G, Cox N, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Bowman WP, Camitta BM, Reaman GH, Carroll WL, Willman CL, Hunger SP, Evans WE, Pui C-H, Loh M, Relling MV. Genome-wide Association Study Identifies Germline Polymorphisms Associated with Relapse of Childhood Acute Lymphoblastic Leukemia.  Blood, 120:4197-4204, 2012 [Epub 2012 Sep 24].  PMID: 23007406.  PMCID 3501717

2011

Pieters R, Hunger SP, Boos J, Rizzari C, Silverman L, Baruchel A, Göekbuget N, Schrappe M, Pui C-H.  L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase.  Cancer, 117: 238-249, 2011 [Epub 2010 Sep 7].  PMID: 20824725.  PMCID 3000881

Bowman WP, Larsen EL, Devidas M, Linda SB, Blach L, Carroll AJ, Carroll WL, Pullen DJ, Shuster J, Willman CL, Winick N, Camitta BM, Hunger SP, Borowitz MJ.  Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia:  Results of Children’s Oncology Group trial P9906. Pediatric Blood and Cancer, 57: 569-577, 2011 [Epub 2011 Feb 25].  PMID: PMID: 21360654.  PMCID 3136564

Hobernicht SL, Schweiger B, Zeitler P, Wang M, Hunger SP.  Acquired growth hormone deficiency in a girl with chronic myelogenous leukemia treated with tyrosine kinase inhibitor therapy. Pediatric Blood and Cancer, 56: 671-673, 2011.  [Epub 2010 Dec 22].  PMID: 2118203

Hunger SP, Raetz E, Loh M, Mullighan CG.  Improving outcomes for high-risk ALL: Translating new discoveries into clinical care. Pediatric Blood and Cancer, 56: 984-993, 2011  [Epub 2011 Feb 15].  PMID: 21370430

Freyer DR, Devidas M, La M, Carroll WL, Gaynon PS, Hunger SP, Seibel NL.  Post-relapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: A report from the Children’s Oncology Group. Blood, 117: 3010-15, 2011 [Epub 2010 Dec 30].  PMID: 21193696. PMCID 3062307

Yang JJ, Cheng C, Devidas M, Cao X, Fan Y, Campana D, Yang W, Neale G, Cox N, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Camitta BM, Carroll A, Reaman GH, Carroll WL, Loh M, Hunger SP, Pui C-H, Evans WE, Relling MV. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.  Nature Genetics, 43: 237-241, 2011  [Epub 2011 Feb 6].  PMID: 21297632.  PMCID 3104508

Yu L, Slovak, ML, Mannoor K, Chen C, Hunger SP, Carroll AJ, Schultz RA, Shaffer LG, Ballif BC, Ning Y.  Microarray detection of multiple recurring submicroscopic chromosomal aberrations in pediatric T-cell acute lymphoblastic leukemia.  Leukemia, 25: 1042-1046, 2011 [Epub 2011 Mar 8].  PMID: 21383747

Teuffel O, Kuster SP, Hunger SP, Conter V, Hitzler J, Ethier M-C, Shah PS, Beyene J, Sung L.  Dexamethasone versus prednisone for induction therapy in childhood acute lymphoblastic leukemia: A systematic review and meta-analysis. Leukemia 25: 1232-1238, 2011 [Epub 2011 Apr 29].  PMID: 21527934

Schafer ES, Hunger SP. Optimal therapy for acute lymphoblastic leukemia in adolescents and young adults.  Nature Reviews Clinical Oncology, 8: 417-424, 2011 [Epub 2011 May 31].  PMID: 21629213.

Meng X, Matlawska-Wasowska K, Girodon F, Mazel T, Willman CL, Atlas S, Chen I-M, Harvey RC, Hunger SP, Ness SA, Winter SS, Wilson BS.  GSI-I (Z-LLNle-CHO) inhibits gamma-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.  Leukemia, 25:1135-46, 2011 [Epub 2011 Apr 15].  PMID: 21494254.  PMCID 3170956

Loudin MG, Wang J, Eastwood Leung HC, Gurusiddappa S, Meyer J, Condos G, Morrison D, Tsimelzon A, Devidas M, Heerema NA, Carroll AJ, Plon SE, Hunger SP, Basso G, Pession A, Bhojwani D, Carroll WL, Rabin KR.  Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles. Leukemia 25:1555-63, 2011 [Epub 2011 Jun 7].  PMID: 21647151.  PMCID 4107887

Matloub Y, Bostrom BC, Hunger SP, Stork LC, Angiolillo A, Sather H, La M, Gastier-Foster JM, Heerema NA, Sailer S, Buckley PJ, Thomson B, Cole C, Nachman JB, Reaman G, Winick NJ, Carroll WL, Devidas M, Gaynon PS.  Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: A report from the Children’s Oncology Group. Blood, 118: 243-251, 2011 [Epub 2011 May 11]. PMID: 21562038.  PMCID 3138679

Zhang J*, Mullighan CG*, Harvey RC, Wu G, Chen X, Edmonson M, Buetow KE, Carroll WL, Chen I-M, Devidas M, Gerhard DS, Loh ML, Reaman GH, Relling MV, Camitta BM, Bowman WP, Smith M, Willman CL#, Downing JR#, Hunger SP#.  Key pathways are frequently mutated in high risk childhood acute lymphoblastic leukemia: A report from the Children’s Oncology Group TARGET Project.  JZ and CGM contributed equally.  CLW, JRD and SPH contributed equally and are corresponding authors. Blood 118: 3080-3087, 2011 [Epub 2011 Jun 16].  PMID: 21680795.  PMCID 3175785

Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT.  The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.  Blood, 118: 4169-4173, 2011 [Epub 2011 Aug 30]. PMID: 21878675

Hogan LE, Meyer JA, Yang J, Wang J, Wong N, Yang W, Condos N, Hunger SP, Raetz E, Saffery R, Relling M, Bhojwani D, Morrison DJ, Carroll WL.  Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies. Blood 118: 5218-5226, 2011 [Epub 2011 Sep 14]. PMID: 21921043.  PMCID 3204734

Hunger SP. Tyrosine Kinase Inhibitor Use in Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Hematology Am Soc Hematol Educ Program, 2011: 361-355.  PMID: 22160058

2010

Schrappe M, Nachman J, Hunger S, Schmiegeloew K, Conter V, Masera G, Pieters R, Pui CH.  Educational symposium on long-term results of large prospective clinical trials for childhood acute lymphoblastic leukemia (1985-2000).  Leukemia, 24: 253-254, 2010. PMID: 20145664

Bercovitz RS, Greffe BS, Hunger SP.  Acute tumor lysis syndrome in a 7-month-old with hepatoblastoma.  Current Opinion Pediatrics 22: 113-116, 2010.  Epub 2009 Nov 18. PMID: 19926992 

Horton TM, Sposto R, Brown P, Reynolds CP, Hunger SP, Winick N, Raetz E, Carroll W, Arceci R, Borowitz M, Gaynon P, Gore L, Jeha S, Maurer B, Siegel SE, Biondi A, Kearns P, Narendran A, Silverman L, Smith M, Zwaan M, Whitlock J.  Toxicity assessment of molecularly targeted drugs incorporated into multiagent chemotherapy regimens for pediatric acute lymphocytic leukemia (ALL): Review from an international consensus conference. Pediatric Blood and Cancer 54: 872-878, 2010. Epub 2010 Feb 1. PMID: 20127846.  PMCID 2857540

Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RL, Borowitz MH, Silverman R, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT. Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood 115: 2845-2851, 2010.  [Epub 2010 Feb 1]. PMID: 20124220.  PMCID 2854430

Harvey* RC, Mullighan*# CG, Chen I-M, Wharton W, Mikhail FM, Carroll AJ, Kang H, Liu W, Dobbin KK, Smith MA, Carroll WL, Devidas M, Bowman WP, Camitta B, Reaman GH, Hunger SP#, Downing JR, Willman CL#.  Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, hispanic/latino ethnicity and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. * RCH and CGM contributed equally; #CGM, SPH and CLW are corresponding authors. Blood, 115: 5312-5321, 2010. [Epub 2010 Feb 4]. PMID: 20139093.  PMCID 2902132

Pulsipher MA, Hunger SP, Gamis AS, Wall DA, Grupp SA. Allogeneic marrow transplantation in children with acute leukemia:  Careful comparison to chemotherapy alternatives required.  Leukemia, 24:1212-6, 2010. [Epub 2010 Apr 29].  PMID: 20428198

Jones AE, Albano EA, Lovell MP, Hunger SP.  Metastatic alveolar rhabdomyosarcoma in multiple endocrine neoplasia type 2a.  Pediatric Blood and Cancer, 55:1213-1216, 2010.  [Epub 2010 Jun 8]. PMID: 20533522

Eden T, Pieters R, Richards S, Childhood Acute Lymphoblastic Leukaemia Collaborative Group (CALLCG).  Systematic review of the addition of vincristine plus steroid pulses in maintenance treatment for childhood acute lymphoblastic leukaemia – an individual patient data meta-analysis involving 5659 children. British Journal of Haematology, 149:722-33, 2010. [Epub 2010 Mar 16]. PMID: 20331462

Maloney KW, Carroll WL, Carroll AJ, Devidas M, Borowitz MJ, Martin PL, Pullen J, Whitlock JA, Willman CL, Winick NJ, Camitta BM, Hunger SP.  Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: A report from the Children’s Oncology Group.  Blood 116:1045-50, 2010. [Epub 2010 May 4]. PMID: 20442364.  PMCID 2938126

Cleaver AL, Beesley AH, Firth MJ, Sturges NC, O’Leary RA, Hunger SP, Baker DL, Kees UR.  Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: A Children’s Oncology Group study. Molecular Cancer, 9: 105, 2010. [Epub 2010 May 12]. PMID: 20459861.  PMCID 2879253

Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Tosello V, Kutok J, Larson RS, Borowitz MJ, Loh ML, Ferrando AA, Winter SS, Mullighan CG, Silverman LB, Chin L, Hunger SP, Sallan SE, Look AT.  Absence of biallelic TCRg deletions predicts early treatment failure in pediatric T-Cell acute lymphoblastic leukemia.  Journal of Clinical Oncology, 28:3816-23, 2010. [Epub 2010 Jul 19].  PMID: 20644084.  PMCID 2940399

Leclerc GJ, Sanderson C, Hunger S, Devidas M, Barredo JC.  Folylpolyglutamate synthetase gene transcription is regulated by a multiprotein complex that binds the TEL-AML1 fusion in acute lymphoblastic leukemia. Leukemia Research 34: 1601-1609, 2010.  [Epub 2010 Jun 8]. PMID: 20538338.  PMCID 2946984

Aricò M, Schrappe M, Hunger SP, Carroll WL, Conter V, Galimberti S, Manabe A, Saha V, Baruchel A, Vettenranta K, Horibe K, Benoit Y, Pieters R, Escherich G, Silverman LB, Pui CH, Valsecchi MG. Clinical outcome of 610 children with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia treated between 1995 and 2005. Journal of Clinical Oncology 28:4755-4761, 2010. [Epub 2010 Sep 27].  PMID: 20876426.  PMCID 3020705

Harvey RC, Mullighan CG, Wang X, Dobbin KK, Davidson GS, Bedrick EJ, Chen I-M, Atlas SR, Kang H, Ar K, Wilson CS, Wharton W, Murphy M, Devidas M, Carroll AJ, Borowitz MJ, Bowman WP, Downing JR, Relling M, Yang J, Bhojwani D, Carroll WL, Camitta B, Reaman GH, Smith M, Hunger SP, Willman CL.  Identification of novel cluster groups in pediatric higher risk B-precursor acute lymphoblastic leukemia with gene expression profiling: Correlation with genome-wide DNA copy number alterations, clinical characteristics and outcome.  Blood, 116: 4874-4884, 2010.  [Epub 2010 Aug 10]. PMID: 20699438.  PMCID 3321747

2009

Yang JJ, Cheng C, Yang W, Pei D, Cao X, Fan Y, Pounds SB, Neale G, Treviño LR, French D, Campana D, Downing JR, Evans WE, Pui C-H, Devidas M, Bowman WP, Camitta BM, Willman CL, Davies SM, Borowitz MJ, Carroll WL, Hunger SP, Relling MV.  Genome-wide interrogations of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.  Journal of the American Medical Association, 301: 393-403, 2009. PMID: 19176441.  PMCID 2664534

Garner R, Li Y, Gray BA, Zori R, Braylan R, Wall J, Hunger SP.  Long-term disease control of refractory anaplastic large cell lymphoma with vinblastine. Journal of Pediatric Hematology/Oncology, 31:145-147, 2009. PMID: 19194204

Hunger SP, Sung L, Howard SC. Treatment strategies and regimens of graduated intensity for childhood acute lymphoblastic leukemia in low-income countries: A proposal.  Pediatric Blood and Cancer, 52: 559-565, 2009.  Epub 2009 Jan 6. PMID: 19127567

Mullighan CG, Su X, Zhang J, Radtke I, Phillips LAA, Miller CB, Ma J, Liu W, Cheng C, Schulman B, Harvey R, Chen I-M, Clifford R, Carroll WL, Reaman G, Bowman WP, Devidas M, Gerhard DS, Yang W, Relling MV, Shurtleff SA, Campana D, Borowitz MJ, Pui C-H, Smith M, Hunger SP, Willman C, Downing JR.  Deletion of IKZF1 (Ikaros) is associated with poor prognosis in acute lymphoblastic leukemia. New England Journal of Medicine, 360: 470-480, 2009.  Epub 2009 Jan 7. PMID: 19129520.  PMCID 2674612

Hunger SP, Loh KM, Baker KS, Schultz KR.  Controversies of and unique Issues in hematopoietic cell transplantation for infant leukemia.  Biol Blood Marrow Transplant 15(1 Suppl): 79-83, 2009. PMID: 19147083

Saxonhouse MA, Tarquino D, Carney PR, Bennett J, Smith A, Hunger SP, Geyer J.  Low molecular weight heparin use in a case of non-cardiogenic multifocal perinatal thromboembolic stroke. Advances in Hematology, Epub 2009 Feb 16. PMID: 19946420.  PMCID 2778868

Nachman J, La M, Hunger SP, Heerema N, Gaynon PS, Hastings C, Mattano LA, Sather H, Devidas M, Fryer D, Steinherz P, Seibel NL.  Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive post induction treatment: A report from the Children’s Oncology Group. Journal of Clinical Oncology, 27: 5189-5194, 2009. Epub 2009 Oct 5. PMID: 19805689.  PMCID 3053149

Schultz KR, Bowman WP, Aledo A, Slayton WB, Sather H, Devidas M, Villaluna D, Wang C, Pasut B, Davies SM, Eslinger T, Gaynon PS, Trigg M, Rutledge R, Burden L, Jorstad D, Carroll A, Heerema N, Winick N, Borowitz MJ, Hunger SP, Carroll WL, Camitta C.  Improved early event free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukaemia: A Children's Oncology Group study. Journal of Clinical Oncology, 27: 5175-5181, 2009. Epub 2009 Oct 5. PMID: 19805687.  PMCID 2773475

Mullighan* CG, Zhang* J, Harvey* RC, Collins-Underwood JR, Schulman BA, Phillips LA, Tasian SK, Loh ML, Su X, Liu W, Devidas M, Atlas SR, Chen I-M, Clifford RJ, Gerhard DS, Carroll WL, Reaman GH, Smith M, Downing# JR, Hunger# SP, Willman# CL.  JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc. Natl Acad Sci USA, 106: 9414-9418, 2009.  Epub 2009 May 20. *CGM, JZ and RCH contributed equally; #JRD, SPH and CLW contributed equally. PMID: 19470474.  PMCID 2695045

Trippett TM, Herzog C, Whitlock JA, Wolff J, Kuttesch J, Bagatell R, Hunger S, Boklan J, Smith AA, Arceci RJ, Katzenstein HM, Harbison C, Zhou X, Lu H, Langer C, Weber M, Gore L.  Phase I and pharmacokinetic study of cetuximab and irinotecan in children with refractory solid tumors: A study of the Pediatric Oncology Experimental Therapeutic Investigators’ Consortium. Journal of Clinical Oncology, 27: 5102-5209, 2009.  Epub 2009 Sept 21. PMID: 19770383.  PMCID 2818074

Gutierrez A, Sanda T, Grebliunaite R, Cariacedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau L, Winter SS, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman L, Hunger SP, Sallan S, Look AT.  High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood 114: 647-650, 2009.  Epub 2009 May 20. PMID: 19458356.  PMCID 2713461

Advani AS, Hunger SP, Burnett AK.  Acute leukaemia in adolescents and young adults. Semin Oncol 36: 213-26, 2009. PMID: 19460579

Treviño LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M, Willman C, Neale G, Downing J, Raimondi SC, Pui C-H, Evans WE, Relling MV.  Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nature Genetics, 41: 1001-1005, 2009.  Epub 2009 Aug 16. PMID: 19684603.  PMCID 2762391

Biondi A, Baruchel A, Hunger S, Masera G, Schmiegelow K, Schrappe M, Pui CH.  The eleventh international childhood acute lymphoblasic leukemia workshop report: Ponte di Legno, Italy, 6-7 May 2009.  Leukemia, 23:2318-2324, 2009. Epub 2009 Nov 5. PMID: 19890375.  PMCID 2818074

Mullighan CG, Collins-Underwood JR, Phillips LAA, Loudin ML, Liu W, Zhang J, Ma J, Coustan-Smith E, Harvey RC, Willman CL, Mikhail FM, Meyer J, Carroll AJ, Williams RT, Cheng J, Heerema NA, Basso G, Pession A, Pui CH, Raimondi SC, Hunger SP, Downing JR, Carroll WL, Rabin KR.  Rearrangement of CRLF2 in B-progenitor and Down syndrome associated acute lymphoblastic leukemia. Nature Genetics 41: 1243-1246, 2009.  Epub 2009 Oct 18. PMID: 19838194.  PMCID 2783810

Brown P, Hunger SP, Smith FO, Carroll WL, Reaman GH.  Novel targeted drug therapies for the treatment of childhood acute leukemia.  Expert Review of Hematology, 2: 145-158, 2009. PMID: 20126514.  PMCID 2794143

Kang H, Chen I-M, Wilson CS, Bedrick EJ, Harvey RC, Atlas SR, Devidas M, Mullighan CG, Wang X, Murphy M, Ar K, Wharton W, Borowitz MJ, Bowman WP, Bhojwani D, Carroll WL, Camitta B, Reaman GH, Smith MA, Downing JR, Hunger SP, Willman CL.  Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia.  Blood 115: 1394-1405, 2010.  Epub 2009 Oct 30. PMID: 19880498.  PMCID 2826761

Gaynon PS, Angiolillo AL, Carroll WL, Nachman JB, Trigg ME, Sather HN, Hunger SP, Devidas M.  Long term results of the Children’s Cancer Group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children’s Oncology Group report. Leukemia, 24: 285-297, 2010.  Epub 2009 Dec 17. PMID: 20016531.  PMCID 2906139

Salzer WL, Devidas M, Carroll WL, Winick N, Pullen J, Hunger SP, Camitta BM.  Long-term results of the Pediatric Oncology Group studies for childhood acute lymphoblastic leukemia 1984-2001: A report from the Children’s Oncology Group. Leukemia, 24: 355-370, 2010.  Epub 2009 Dec 17. PMID: 20016527.  PMCID 4300959

2008

Jackman KM, Hunger SP. Flavopiridol displays preclinical activity in acute lymphoblastic leukemia. Pediatr Blood Cancer 50: 772-778, 2008. Epub 2007 Nov 13. PMID: 18000861

Bhojwani D, Kang H, Menezes RX, Yang W, Sather H, Moskowitz NP, Min D-J, Potter JW, Harvey R, Hunger SP, Seibel N, Raetz EA, Pieters R, Relling MV, den Boer ML, Willman CL, Carroll, WL.  Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children’s Oncology Group study. Journal of Clinical Oncology 26: 4376-4384, 2008. PMID: 18802149.  PMCID 2736991

Rubnitz J, Wichlan D, Devidas M, Shuster J, Linda SB, Kurtzberg J, Bell B, Hunger SP, Chauvent A, Pui C-H, Camitta B, Pullen J.  Prospective Analysis of TEL Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia: A Children’s Oncology Group Study. Journal of Clinical Oncology 26: 2186-2191, 2008. PMID: 18445843. PMCID 4485397

Graham DK and Hunger SP:  BAC to the Future?  Comparative genomic hybridization and genotyping pediatric leukemia cytogenetic abnormalities. Pediatr Blood Cancer 51: 153-154, 2008. PMID: 18300321

Khan NI, Cisterne A, Devidas M, Shuster J, Hunger SP, Shaw P, Bradstock KF, Bendall LJ.  Expression of CD44, but not CD44v6, predicts relapse in children with B cell progenitor ALL lacking adverse or favorable genetics. Leukemia and Lymphoma 49: 710-718, 2008. PMID: 18398738

Zhong C-h, Prima V, Liang X, Frye C, McGavran L, Meltesen L, Wei Q, Boomer T, Varella-Garcia M, Gump J, Hunger SP.  E2A-NMP4 and P120-E2A fusion created by a cryptic t(12;19) in acute leukemia. Leukemia 22: 723-729, 2008.  Epub 2008 Jan 10. PMID: 18185522

Borowitz MJ, Devidas M, Hunger SP, Bowman WP, Carroll AJ, Carroll WL, Linda S, Martin PL, Pullen DJ, Viswanatha D, Willman CL, Winick N, Camitta BM.  Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors.  A Children’s Oncology Group study. Blood, 111: 5477-5485, 2008.  Epub 2008 April 3. PMID: 18388178.  PMCID 2424148

Henry DD, Hunger SP, Braylan RC, Dharnidharka VR.  Low viral load post-transplant lymphoproliferative disease (PTLD) localized within the tongue. Transpl Infect Dis. 10: 426-430, 2008.  Epub 2008 Jul 22. PMID: 18657087

Raetz EA, Borowitz MJ, Devidas M, Linda SB, Hunger SP, Winick NJ, Camitta BM, Gaynon PS, Carroll WL.  A re-induction platform for children with first marrow relapse:  Results from Children’s Oncology Group (COG) study AALL01P2. Journal of Clinical Oncology 26: 3971-3978, 2008. PMID: 18711187.  PMCID 2654313

Abbatiello SE, Pan Y-Z, Zhou M, Wayne AS, Veenstra TD, Hunger SP, Kilberg MS, Eyler JR, Richards NGJ, Conrads TP.  Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients. Journal of Proteomics 71: 61-70, 2008. Epub 2007 Dec 5. PMID: 18541474

Nguyen K, Devidas M, Cheng SC, La M, Raetz EA, Carroll WL, Winick NJ, Hunger SP, Gaynon PS, Loh ML.  Factors influencing survival after relapse from acute lymphoblastic leukemia: A Children’s Oncology Group study. Leukemia 22: 2142-2150, 2008.  Epub 2008 Sep 25. PMID: 18818707.  PMCID 2872117

Yang YJ, Bhojwani D, Yang W, Cai X, Stocco G, Crews K, Wang J, Morrison D, Devidas M, Hunger SP, Willman CL, Raetz EA, Pui C-h, Evans WE, Relling MV, Carroll WL.  Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.  Blood 112: 4178-4183, 2008.  Epub 2008 Sep 2. PMID: 18768390.  PMCID 2581992

Araya CE, Mehta MB, Gonzalez-Peralta RP, Hunger SP, Dharnidharka VR.  Native kidney post-transplant lymphoproliferative disorder (PTLD) in a non-renal transplant patient. Pediatric Transplantation, 13: 495-498, 2009. Epub 2008 Jul 30.  PMID: 18673359

2006

Yang F, Li Y, Braylan R, Hunger SP, Yang L-J. Pediatric T-Cell Post-Transplant Lymphoproliferative Disorder after Solid Organ Transplantation. Pediatr Blood Cancer 50: 415-418, 2008.  Epub 2006 Oct 18. PMID: 17051534.  PMCID 3419753

2007

Schultz KR, Pullen JK, Sather HN, Shuster JJ, Devidas M, Borowitz MJ, Carroll AJ, Heerema NA, Rubnitz JE, Loh ML, Raetz ER, Winick NJ, Hunger SP, Carroll WL, Gaynon PS, Camitta BM.  Risk and response-based classification of childhood B-precursor acute lymphoblastic leukemia: A combined analysis of prognostic markers from the pediatric oncology group (POG) and Children’s Cancer Group (CCG).  Blood 109(3):926-35, 2007.  Epub 2006 Sep 26. PMID: 17003380.  PMCID 1785141

Bagatell R, Gore L, Egorin MJ, Ho R, Heller G, Boucher N, Zuhowski EG, Whitlock JA, Hunger SP, Narendran A, Katzenstein HM, Arceci RJ, Boklan JL, Herzog CE, Whitesell LJ, Ivy SP, Trippett TM.  Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) in pediatric patients with recurrent or refractory solid tumors:  A Pediatric Oncology Experimental Therapeutics Investigators Consortium study.  Clinical Cancer Research 13: 1783-1788, 2007. PMID: 17363533

Prima V, Hunger SP.  Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia. Leukemia 21: 2470-2475, 2007.  Epub 2007 Sept 27. PMID: 17898785

Su N, Pan Y-X, Zhou M, Harvey RC, Hunger SP, Kilberg MS. Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines. Pediatr Blood Cancer 50: 274-279, 2008.  Epub 2007 May 18. PMID: 17514734

2006

Bhojwani D, Kang H, Moskowitz N, Min D-J, Lee K, Potter J, Davidson G, Borowitz M, Belitskaya-Levy I, Hunger SP, Willman C, Raetz E, Carroll WL.  Biological pathways associated with relapse in childhood acute lymphoblastic leukemia.  Blood 108: 711-717, 2006. PMID: 16822902.  PMCID 1895482

Chen I-M, Chakerian A, Devidas M, Borowitz MJ, Hunger SP, Willman CL, Viswanatha DS.  Resolution of ambiguous low-level positive quantitative polymerase chain reaction results in TEL-AML1 positive ALL using a post-PCR fluorescent oligoligation method. Br. J. Haematol 135: 358-361, 2006.  Epub 2006 Sept 19. PMID: 16984387

2005

Trobaugh-Lotrario AD, Kletzel M, Quinones RR, McGavran L, Hunger SP, Malcolm J, Schissel D, Hild E, Giller RH. Monosomy 7 associated with pediatric acute myeloid leukemia and myelodysplastic syndrome: successful management by allogeneic hematopoietic stem cell transplantation.  Bone Marrow Transplant 35: 143-149, 2005. PMID: 15558042

Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP.  Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia.  Leukemia 19: 806-813, 2005. PMID: 15744350

Hollander MC, Patterson AD, Salvador JM, Anver MR, Perotti D, Hunger SP, Fornace AJ Jr.  Gadd45a acts as a modifier locus for lymphoblastic lymphoma. Leukemia 19: 847-850, 2005. PMID: 15744335

Aricó M, Baruchel A, Bertrand Y, Biondi A, Conter V, Eden OB, Gadner H, Gaynon P, Horibe K, Hunger SP, Janka-Schaub G, Masera G, Nachman J, Pieters R, Schrappe M, Schmiegelow K, Grazia Valsecchi M, Pui CH.  The seventh international childhood acute lymphoblastic leukemia workshop report: Palermo, Italy, January 29 to 30, 2005. Leukemia 19: 1145-1152, 2005. PMID: 15902295

Hunger SP, Winick NJ, Sather HN, Carroll WL.  Therapy of low risk subsets of childhood acute lymphoblastic leukemia: when do we say enough?  Pediatr Blood Cancer 45: 876-880, 2005. PMID: 16007585

Baudis M, Prima V, Tung YH, Hunger SP.  ABCB1 over-expression and drug-efflux in acute lymphoblastic leukemia cell lines with t(17;19) and E2A-HLF expression. Pediatr Blood Cancer, 47: 757-764, 2006.  Epub 2005 Oct 3. PMID: 16206189

2004

Dharnidharka V, Douglas VK, Hunger SP, Fennell RS.  Hodgkin’s disease after post transplant lymphoproliferative disease in a renal transplant recipient.  Pediatric Transplantation 8: 87-90, 2004. PMID: 15009846

Liang X, Odom LF, Meech SJ, Bitter MA, Ryder JW, Hunger SP, Lovell MA, Wei Q, Meltesen R, McGavran.  Assessment of t(2;5)(p23;q35) translocation and variants in ALK positive anaplastic large cell lymphoma. American Journal of Clinical Pathology 121: 496-506, 2004. PMID: 15080301

van der Burg M, Poulsen TS, Hunger SP, Beverloo HB, Smit EME, Vang-Nielsen K, Langerak AW, van Dongen JM.  Split-signal FISH for detection of chromosome aberrations n acute lymphoblastic leukemia.  Leukemia 18: 895-908, 2004. PMID: 15042105

Sutherland N, Gonzalez-Peralta R, Douglas-Nikitin V, Hunger SP. Polycythermia vera in a child following treatment for acute lymphoblastic leukemia. Journal of Pediatric Hematology/Oncology 26: 315-319, 2004. PMID: 15111786

Winick NJ, Carroll WL, Hunger SP: Childhood Leukemia: New Advances and New Challenges.  New England Journal of Medicine 351: 601-603, 2004. PMID: 15295054

2003

Foa R, Vitale A, Mancini M, Cuneo A, Mecucci C, EliA C, Lombardo R, Saglio G, Torelli G, Annino L, Specchia G, Damasio E, RecchiA A, Di Raimondo F, Tafuri A, FazI P, Hunger SP, MandellI F.  The E2A-PBX1 fusion characterizes a subset of adult acute lymphoblastic leukemia with distinct biologic and clinical features.  British Journal of Haematology 120: 484-487, 2003. PMID: 12580965

Toretsky JA, Jenson J, Sun C-C, Eskenazi AE, Campbell A, Hunger SP, Caires A, Frantz C, Hill JL, Stamberg J.  Translocation (11;15;19): a highly specific chromosome rearrangement associated with poorly differentiated thymic carcinoma in young patients.  American Journal of Clinical Oncology 26: 300-306, 2003. PMID: 12796605

Casillas JN, Woods WG, Hunger SP, McGavran L, Alonzo TA, Feig SA.  Prognostic implications of t(10;11) translocations in childhood acute myelogenous leukemia (AML): A Report from the Children’s Cancer Group.  Journal of Pediatric Hematology/Oncology 25: 594-600, 2003. PMID: 12902910

2002

Drabkin HA, Parsy C, Ferguson K, Guilhot F, Lacotte L, Roy L, Zeng C, Baron A, Hunger SP, Varella-Garcia M, Gemmill R, Brizard F, Brizard A, Roche J. Quantitative Hox expression In chromosomally defined  subsets of acute myelogenous leukemia.  Leukemia 16:186-195, 2002. PMID: 11840284

Moos PJ, Raetz EA, Carlson MA, Szabo A, Smith FE, Willman C, Wei Q, Hunger SP, Carroll WL.  Identification of gene expression profiles that segregate patients with childhood leukemia.  Clinical Cancer Research 8: 3118-30, 2002. PMID: 12374679

Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR.  Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc. Natl Acad Sci USA 99: 15101-15106, 2002. PMID: 12415113.  PMCID 137550

2001

Boomer T, Varella-Garcia M, McGavran L, Metelsen L, Olsen AS, Hunger SP.  Detection of E2A translocations via fluorescence in situ hybridization.  Leukemia 15: 95-102, 2001. PMID: 11243406

Li S, Hunger SP.  The DBP transcriptional activation domain is highly homologous to that of HLF and TEF and is not responsible for the tissue type-specific transcriptional activity of DBP. Gene 263: 239-245, 2001. PMID: 11223263

Meech SJ, McGavran L, Odom LF, Liang X, Meltesen L, Gump J, Wei Q, Carlsen S, Hunger SP.  An unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4-anaplastic lymphoma kinase gene fusion. Blood 98: 1209-1216, 2001. PMID: 11493472

Gump J, McGavran L, Wei Q, Hunger SP.  Analysis of TP53 mutations in relapsed childhood acute lymphoblastic leukemia.  Journal of Pediatric Hematology/Oncology 23: 416-419, 2001. PMID: 11878574

2000

Kadan-Lottick NS, Stork L, Ruyle SZ, Koyle M, Hunger SP, McGavran L.  Cytogenetic abnormalities in a case of botryoid rhabdomyosarcoma.  Medical and Pediatric Oncology 34: 293-295, 2000. PMID: 10742076

Gore L, Ess J, Bitter M, McGavran L, Meltesen L, Wei Q, Hunger SP.  Protean clinical manifestations in children with leukemias containing MLL-AF10 fusion.  Leukemia 14: 2070-2075, 2000. PMID: 11187895

1999

Maloney KW, McGavran L, Odom LF, Hunger SP.  Acquisition of p16INK4A and p15INK4B gene abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia. Blood 93: 2380-2385, 1999. PMID: 10090949

Iiboshi Y, Papst PJ, Hunger SP, Terada N. L-Asparaginase inhibits the rapamycin-targeted signaling pathway.  Biochemical & Biophysical Research Communications 260: 534-539, 1999. PMID: 10403802

Maloney KW, McGavran L, Murphy JM, Odom LF, Stork L, Wei Q, Hunger SP.  TEL-AML1 fusion identifies a subset of children with standard risk acute lymphoblastic leukemia who have an excellent prognosis when treated with therapy that includes a single delayed intensification.  Leukemia 13: 1708-1712, 1999. PMID: 10557042

1998

Hunger SP, Fall MZ, Camitta BM, Carroll AJ, Link MP, Lauer SJ, Mahoney DH, Pullen DJ, Shuster JJ, Steuber CP, Cleary ML:  E2A-PBX1 chimeric transcript status at end of consolidation does not predict treatment outcome in childhood acute lymphoblastic leukemias with a t(1;19)(q23;p13):  A Pediatric Oncology Group study.  Blood 91: 1021-1028, 1998. PMID: 9446665

Hunger SP, Cleary ML.  What significance should we attribute to the detection of MLL fusion transcripts?  Blood 92: 709-711, 1998. PMID: 9680337

Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-21) suggests a potential role for truncated AF10 polypeptides. Leukemia 12:1404-1410, 1998. PMID: 9737689

Maloney, KW, McGavran L, Odom LF, Hunger SP. Different patterns of homozygous p16INK4A and p15INK4B deletions in childhood acute lymphoblastic leukemias containing distinct E2A translocations. Leukemia 12: 1417-1421, 1998. PMID: 9737691

Hunger SP, McGavran L, Meltesen L, Parker NB, Kassenbrock K, Bitter M:  Oncogenesis in utero:  Fetal demise due to acute myelogenous leukemia with an MLL translocation. Br. J. Haematol 103: 539-542, 1998. PMID: 9827932

Leon RP, Hedlund T, Meech s, Li S, Schaack J, Hunger SP, Duke RC, DeGregori J.  Adenoviral-mediated gene transfer in lymphocytes. Proc. Natl Acad Sci USA 95: 13159-13164, 1998. PMID: 9789058

Sifontes MT, Nuss R, Hunger SP, Waters JL, Jacobson LJ, Manco-Johnson MJ:  Activated protein C resistance and the factor V Leiden mutation in children with thrombosis.  Amer. J Hematol 57: 29-32, 1998. PMID: 9423813

1997

Sifontes MT, Nuss R, Hunger SP, Wilimas J, Jacobson LJ, Manco-Johnson MJ:  The factor V Leiden mutation in children with cancer and thrombosis.  British Journal of Haematology 96: 484-489, 1997. PMID: 9054652

Maloney KW, Rubnitz JE, Cleary ML, Frankel LS, Hakami N, Link MP, Pullen DJ, Hunger SP:  Lack of ETV6 (TEL) gene rearrangements or p16INK4A/p15INK4B homozygous gene deletions in infant acute lymphoblastic leukemia.  Leukemia 11: 979-983, 1997. PMID: 9204978

Hunger SP, Sun T, Boswell AF, Carroll AJ, McGavran L:  Hyperdiploidy and E2A-PBX1 fusion in an adult with t(1;19)+ acute lymphoblastic leukemia:  Case report and review of the literature.  Genes, Chromosomes and Cancer 20: 392-398, 1997. PMID: 9408756

Sifontes MT, Nuss R, Hunger SP, Jacobson LJ, Waters JL, Manco-Johnson MJ:  Correlation between the functional assay for activated protein C resistance and Factor V Leiden in the neonate.  Ped Res 42: 776-778, 1997. PMID: 9396556

1996

Hunger SP:  Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia:  Clinical features and molecular pathogenesis.  Blood 87:1211-1224, 1996. PMID: 8608207

Hunger SP, Li S, Fall MZ, Naumovski L, Cleary ML:  The proto-oncogene HLF and the related bZIP protein TEF display highly similar DNA-binding and transcriptional regulatory properties.  Blood 87:4607-4617, 1996. PMID: 8639829

1994

Saltman DL, Hunger SP, and Turner GE:  Molecular analysis of chromosome aberrations.  Methods in Molecular Biology 29: 437-448, 1994. PMID: 8032421

Hunger SP, Devaraj PE, Foroni L, Secker-Walker LM, and Cleary ML:  Two types of genomic rearrangements create alternative E2A-HLF fusion proteins in t(17;19)-ALL.  Blood 83: 2970-2977, 1994. PMID: 8180393

Hunger SP, Brown R, and Cleary ML:  DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF.  Molecular and Cellular Biology 14: 5986-5996, 1994. PMID: 8065331.  PMCID 359124

Hunger SP, Link MP, and Donaldson SS:  ABVD/MOPP and low dose involved field radiotherapy in Pediatric Hodgkin's disease:  The Stanford experience.  Journal of Clinical Oncology 12: 2160-2166, 1994. PMID: 7523608

1993

Hunger SP, Tkachuk DC, Amylon MD, Link MP, Carroll AJ, Welborn JL, Willman CL, and Cleary ML:  Consistent HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.  Blood 81: 3197-3203, 1993. PMID: 8389614

Borowitz MJ, Hunger SP, Carroll AJ,. Shuster JJ, Pullen DJ, Steuber PJ, and Cleary ML:  Predictability of the t(1;19)(q23;p13) from surface antigen phenotype.  Implications for screening cases of childhood ALL for molecular analysis.  A Pediatric Oncology Group study.  Blood 82: 1086-1091, 1993. PMID: 8353275

Hunger SP and Cleary ML:  Chimaeric oncoproteins resulting from chromosomal translocations in acute lymphoblastic leukaemia.  seminars in CANCER BIOLOGY 4: 387-399, 1993. PMID: 8142624

1992

Hunger SP, Sklar J, and Link MP:  Acute lymphoblastic leukemia occurring as a second malignant neoplasm in childhood:  Report of three cases and review of the literature.  Journal of Clinical Oncology 10: 156-163, 1992. PMID: 1309379

Hunger SP, Ohyashiki K, Toyama K, and Cleary ML:  HLF, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.  Genes and Development 6: 1608-1620, 1992. PMID: 1516826

1991

Suryanarayan K, Hunger SP, Kohler S, Carroll AJ, Crist WM, Link MP, and Cleary ML:  Consistent involvement of the BCR gene by 9;22 breakpoints in pediatric acute leukemias.  Blood 77: 324-330, 1991. PMID: 1985699

Hunger SP, Galili N, Carroll AJ, Crist WM, Link M, and Cleary ML:  The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias.  Blood 77: 687-693, 1991. PMID: 1671560

1990

Mellentin JD, Nourse J, Hunger SP, Smith SD, and Cleary ML:  Molecular analysis of the t(1;19) breakpoint cluster region in pre-B cell ALL.  Genes, Chromosomes and Cancer 2: 239-247, 1990. PMID: 2078515

Abstracts

2014

Iacobucci I, Roberts K, Li Y, Zhang J, Harvey RC, Payne-Turner D, Valentine M, McCastlain K, Easton J, Chen I-M, Rusch R, Kornblau SM, Konopleva M, Paietta E, Rowe JM, Pui C-H, Gastier-Foster JM, Loh ML, Willman C, Downing JR, Hunger SP, Mullighan CG.  Rearrangements of the erythropoietin receptor are recurrent in Ph-like acute lymphoblastic leukemia and are sensitive to Jak2 inhibition [abstract] In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; 2015. Abstract nr 4369.

Maloney KW, Larsen E, Devidas M, Mattano L, Friedmann A, Gastier-Foster JM, Carroll AJ, Heerema NA, Borowitz MJ, Wood B, Whitlock JA, Loh M, Raetz E, Winick N, Hunger SP, Carroll WL.  Event Free (EFS) and Overall Survival (OS) for Children with Down Syndrome (DS) and B-Lymphoblastic Leukemia (B-ALL) in Children’s Oncology Group (COG) Clinical Trials AALL0232 and AALL0331.  Pediatric Blood and Cancer, 61(S1), S3: 4009, 2014 (Selected for plenary presentation at ASPHO 2014).

Books

Hunger SP, Conter V, Raetz EA, Valsecchi MG, Henze G.  Classification And Treatment Of Acute Lymphoblastic Leukemia.  In Childhood Leukemia.  Reaman GH and Smith FO, eds.  Springer, 2010.

Gore L and Hunger SP.  Molecular oncology and translational therapy.  In Cancer in Children and Adolescents.  Carroll WL and Findlay JL, eds.  Jones and Bartlett Publishers (Sudbury Mass), 2010.

Brown P and Hunger SP:  Acute leukemia in children.  In: Conn’s Current Therapy 2010. Bope ET Rakel RE and Kellerman RD, eds. Elsevier, 2009.

Carroll WC, Raetz E, Loh M, Hunger S, Schultz K.  Current biological basis for risk stratification in Children’s Oncology Group (COG) acute lymphoblastic leukemia trials. Educational Book, International Society of Paediatric Oncology, 2006.

Hunger SP: Why do some childhood ALLs relapse?  Blood, 101: 3343, 2003.

Hunger SP: Abnormal transcription factors produced by chromosome translocations in human cancer.  In: Transcription Factors.  Locker J, ed.  BIOS Scientific Publishers Limited (Oxford), 2001.

Hunger SP:  Cytogenetic and molecular abnormalities in lymphoid malignancies.  In: Textbook of Malignant Haematology.  Degos L, Linch DC, and Lowenberg B, eds.  Martin Dunitz Ltd (London), 1999.

Hunger SP and Cleary, ML:  PCR assessment of the efficacy of therapy in Philadelphia chromosome-positive leukemias.  In: The Polymerase Chain Reaction.  Mullis KB, Ferré F, and Gibbs RA, eds.  Birkhäuser (Boston, MA), 1994.

Chapters

2014

Hunger SP.  Introduction and overview to issue on new developments in pediatric hematology/oncology.  Current Opinions in Pediatrics, 26: 1-2, 2014.  PMID: 24299912.

2012

Hunger SP.  Development and refinement of augmented treatment regimens for pediatric high-risk acute lymphoblastic leukemia. In: Govindan R, ed. 2012 ASCO Educational Book. Alexandria, VA: American Society of Clinical Oncology; 2012; 611-615.

2010

Hunger SP. SIOP state-of-the-art acute lymphoblastic leukemia symposium: Philadelphia chromosome positive ALL: Use of tyrosine kinase inhibitors. Educational Book, International Society of Paediatric Oncology, 2010, page 67-71.

Mullighan CG, Pui, C-H, Hunger SP.  Advances in understanding the genetics and improvements in treatment for adolescents and young adults with acute lymphoblastic leukemia. ASCO Educational Book 2010, pages 383-389.

Prima V, Glushakova LG, Hunger SP. MEF2D (myocyte enhancer factor 2D). Atlas Genet Cytogenet Oncol Haematol, 14: 772-775, 2010.

Schrappe M, Nachman J, Hunger S, Schmiegeloew K, Conter V, Masera G, Pieters R, Pui CH.  Educational symposium on long-term results of large prospective clinical trials for childhood acute lymphoblastic leukemia (1985-2000).  Leukemia, 24: 253-254, 2010. PMID: 20145664

2008

Graham DK and Hunger SP:  BAC to the Future?  Comparative genomic hybridization and genotyping pediatric leukemia cytogenetic abnormalities. Pediatr Blood Cancer 51: 153-154.  Epub 2008 Feb 25. PMID: 18300321

2005

Hunger SP, Biondi A.  Early response and minimal residual disease testing in childhood ALL: Methodologies and clinical application.  Educational Book, International Society of Paediatric Oncology, 2005, page 70-73.

Hunger SP, Voss SD, Borowitz M.  Detection of minimal residual disease in childhood cancers: technology and applications.  ASCO Educational Book page 771-785, 2005.

Slayton WB and Hunger SP:  Cytogenetic and molecular abnormalities in lymphoid malignancies.  In: Textbook of Malignant Hematology.  Degos L, Linch DC, and Lowenberg B, eds. (pages 234-242)  Taylor & Francis (London), 2005.

2004

Winick NJ, Carroll WL, Hunger SP: Childhood Leukemia: New Advances and New Challenges.  New England Journal of Medicine 351: 601-603, 2004. PMID: 15295054

1994

Saltman DL, Hunger SP, and Turner GE:  Molecular analysis of chromosome aberrations.  Methods in Molecular Biology 29: 437-448, 1994. PMID: 8032421

1993

Hunger SP and Cleary ML:  Chimaeric oncoproteins resulting from chromosomal translocations in acute lymphoblastic leukaemia.  seminars in CANCER BIOLOGY 4: 387-399, 1993. PMID: 8142624

Posters and Presentations

2017

Ma X, Liu Y, Liu Y, Edmonson M, Gawad C, Zhou Z, Li Y, Rusch M, Easton J, Wilkinson M, Hermida LC, Davis S, Smith M, Guidry-Auvil J, Meltzer P, Lau CC, Perlman E, Maris JM, Meshinchi S, Hunger SP, Gerhard DS, Zhang J.  Comparison of somatic alterations in the genome and transcriptome of 1,705 pediatric leukemia and solid tumors: A Report from the Children’s Oncology Group (COG) – NCI TARGET Project.  Selected for oral presentation at AACR 2017.

Gupta S, Devidas M, Chen S, Wang C, Loh ML, Raetz EA, Brown P, Carroll AJ, Heerema NA, Gastier-Foster JM, Dunsmore KP, Larsen EC, Maloney KW, Mattano LA Jr, Winter SS, Winick NJ, Carroll WL, Hunger SP, Borowitz M, Wood B.  Minimal Residual Disease Assessment of Remission after Induction Therapy is Superior to Morphologic Assessment for Risk Stratification in Childhood Acute Lymphoblastic Leukemia: A Report from the Children’s Oncology Group (COG).  Pediatric Blood and Cancer, S103(S5): 4007, 2017 (Selected for oral presentation at ASPHO 2017).

Loh M, Raetz E, Devidas M, Dai Y, Borowitz M, Carroll A, Chen I-M, Gastier-Foster J, Friedmann A, Harvey R, Heerema N, Larsen E, Maloney K, Mattano L, Mullighan C, Rabin K, Reshmi S, Roberts K, Willman C, Wood B, Zweidler-McKay P, Zhang J, Winick N, Hunger S, Carroll W.  Outcomes of Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia based on Blast Genotype at Diagnosis: A Report from the Children’s Oncology Group.  Pediatric Blood and Cancer, 64(S1), S103(S5): 4017, 2017 (Selected for oral presentation at ASPHO 2017).

Gozde A, Gallo D; Surrey L; Aplenc R, Bagatell-Berg R; Bhatti T; Brodeur G; Hunger SP, Luo M, Maris JMM, Mosse Y, Santi M, Tasian SK, Waanders AJ, Chang F, Zelley K, Li MM.  Cancer Predisposition Identified in Tumor-Only Next Generation Sequencing: Experience from the Children's Hospital of Philadelphia.  Accepted for oral presentation at ACMG 2017.

Burke M, Salzer W, Chen S, Devidas M, Gore L, Hilden J, Larsen E, Raetz E, Winick N, Carroll W, Hunger S, Loh.  Intensification with Cyclophosphamide and Etoposide Does Not Improve Outcome for Children and Young Adults with Very High Risk B-Lymphoblastic Leukemia: Children’s Oncology Group Study AALL1131.  Pediatr Blood Cancer 64: S73 (P-016), 2017 (Poster Presentation at SIOP Annual Congress, Washington DC, October 2017).

DiNofia A, Wilkes J, Flaherty English TR, Sullivan J, Oranges K, Dwyer E, Powell S, Rheingold S, Hunger SP, Reilly A.  Reducing Hospital Length of Stay for Patients Newly Diagnosed with Acute Lymphoblastic Leukemia.  Pediatr Blood Cancer 64: S16 (O-019), 2017 (Oral Presentation at SIOP Annual Congress, Washington DC, October 2017).

Mattano L, Devidas M, Chen S, Raetz E, Loh M, Winick N, Hunger SP, Carroll WL, Larsen E.  Osteonecrosis (ON) Is Associated With Improved Event Free Survival (EFS) In High-Risk Acute Lymphoblastic Leukemia (HR-ALL): Results Of Children’s Oncology Group (COG) Study AALL0232.  Pediatr Blood Cancer 64: S17 (O-021), 2017 (Oral Presentation at SIOP Annual Congress, Washington DC, October 2017).

Slayton W, Schultz K, Kairalla J, Meenakshi D, Pulsipher M, Silverman L, Borowitz M, Carroll A, Heerema N, Gastier-Foster J, Mizrahy S, Wood B, Merchant T, Brown V, Raetz E, Winick N, Loh M, Carroll W, Hunger S.  Dasatinib Maintains Outstanding 5-Year Survival Outcomes in Children With Ph+ ALL, But Does Not Prevent CNS Relapses: Children’s Oncology Group (COG) AALL0622 Trial.  Pediatr Blood Cancer 64: S16 (O-020), 2017 (Oral Presentation at SIOP Annual Congress, Washington DC, October 2017).

Winick N, Martin P, Devidas M, Shuster J, Borowitz MJ, Bowman P, Larsen E, Pullen J, Hunger SP, Carroll WL, Camitta B.  Delayed Intensification (DI) Enhances Continuous Complete Remission (CCR) Rates For Patients With B-ALL When Combined with Intravenous Methotrexate: Children’s Oncology Group Study (COG) POG 9904/9905.  Pediatr Blood Cancer 64: S15 (O-018), 2017 (Oral Presentation at SIOP Annual Congress, Washington DC, October 2017).

Angiolillo A, Schore R, Devidas M, Lu X, Rabin KR, Zweidler-McKay P, Borowitz M, Wood BL, Carroll AJ, Heerema N, Wang C, Maloney K, Winick N, Carroll WL, Raetz E, Loh ML, Hunger SP.  Intensification of Oral Methotrexate is Not Superior to Standard Methotrexate Dosing during Maintenance in Children with National Cancer Institute (NCI) Standard-Risk B Acute Lymphoblastic Leukemia (SR B-ALL): A Report from Children’s Oncology Group (COG) Study AALL0932.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 140a (Oral Session Presentation at ASH 2017).

Burns MA, Liao ZW, Pouliot GP, Stevenson KE, Neuberg DS, Thorner AR, Ducar M, Silverman EA, Hunger SP, Loh ML, Winter SS, Dunsmore KP, Wood B, Devidas M, Harris MH, Silverman LB, Sallan SE, Gutierrez A.  Hedgehog Pathway Mutations Drive Oncogenic Transformation in High-Risk T-cell Acute Lymphoblastic Leukemia.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 367a (Oral Session Presentation at ASH 2017).

Chang Y, Woessner D, Lin W, Chen T, Xu B, Fan Y, Tan H, Peng J, Kasper L, Churchman M, Gerhard D, Loh M, Hunger S, Seth A, Gascoigne KE, Mullighan C.  CREBBP histone acetyltransferase domain mutations result in dexamethasone resistance in B-progenitor ALL.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 560a (Oral Session Presentation at ASH 2017).

Hunger SP, Saha V, Devidas M, Valsecchi MG, Gastier Foster J, Cazzaniga G, C. Reshmi S, Borowitz M, Moorman A, Heerema NA, Carroll AJ, Barnette P, Gramatges MM, Maloney K, Sun W, Swanink R, Termuhlen A, Loh ML, Raetz EA, Silverman LB, Schrappe M, Schultz KR, Slayton W, Healey D, Biondi A.  CA180-372: An International Collaborative Phase 2 Trial of Dasatinib and Chemotherapy in Pediatric Patients with Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL).  Selected for oral presentation at ASH 2017.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 98a (Oral Session Presentation at ASH 2017).

Orgel E, Alexander TB, Wood BL, Kahwash S, Devidas M, Dai Y, Alonzo TA, Mullighan C, Inaba H, Hunger SP, Gamis AS, MD, Carroll AJ, Heerema NA, Berman J, Woods WG, Loh ML, Zweidler-McKay P, Horan JT.  Efficacy of ALL Therapy for WHO2016-Defined Mixed Phenotype Acute Leukemia: A Report from the Children’s Oncology Group.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 883a (Oral Session Presentation at ASH 2017).

Pouliot GP, Burns MA, Degar J, Vo C, Moreau L, Roderick JE, Kochupurakkal B, Peirs S, Menten B, Loh ML, Hunger SP, MD8, Silverman LB, Sallan SE, Harris MH, Stevenson KE, Neuberg DS, Weinstock DM, Weng AP, Kelliher M, Van Vlierberghe P, D'Andrea AD, Gutierrez A.  The Fanconi Pathway in Pediatric T-Cell Acute Lymphoblastic Leukemia.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 2722a (Poster Session Presentation at ASH 2017).

Qian M, Cao X, Devidas M, Yang W, Cheng C, Carroll A, Heerema NA, Zhang H, Moriyama T, Gastier-Foster JM, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui C-H, Mullighan C, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ.  TP53 Germline Variations Influence the Predisposition and Prognosis of Acute Lymphoblastic Leukemia in Children.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 31a (Oral Session Presentation at ASH 2017).

Reshmi SC, Harvey RC, Roberts KG, Smith A, Dai Y, Chen I-M, Valentine M, Liu Y, Li Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Angiolillo A, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Mattano L, Maloney KW, Carroll WL, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP.  Genomic and outcome analyses of Philadelphia chromosome-like (Ph-like) NCI Standard Risk B-Acute Lymphoblastic Leukemia (SR B-ALL) patients treated on Children’s Oncology Group (COG) AALL0331.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 477a (Oral Session Presentation at ASH 2017).

Schwab C, Kjeldsen E, Heerema NA, Carroll A, Bashton M, Ryan S, Moorman AV, Hunger SP, Loh ML, Hasle H, Harrison CJ.  Constitutional ring chromosome 21 predisposes to acute lymphoblastic leukaemia (ALL) with iAMP21.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 3978a (Poster Session Presentation at ASH 2017).

Zhang H, Yang H, Liu T, Qian M-X, Roberts KG, Yang W, Perez-Andreu V, Xu H, Gastier-Foster J, Smith C, Pui C-H, Evans WE, Relling MV, Hunger SP, Mullighan CG, Loh ML, Yue F, Yang JJ.  Characterization of causal variants at the GATA3 loci associated with susceptibility to Ph-like acute lymphoblastic leukemia.  Blood (ASH Annual Meeting Abstracts), Nov 2017; 130: 475a (Oral Session Presentation at ASH 2017).

2016

Bride KL, Freedman JL, Bunin NJ, Hunger SP, Rheingold SR, Seif AE.  Hematopoietic Stem Cell Transplantation (HSCT) for Acute Lymphoblastic Leukemia (ALL) in First Remission (CR1): A Single-Institution Retrospective Cohort Study Demonstrating Excellent Event-Free (EFS) and Overall Survival (OS).  Oral Presentation at ASBMT 2016.

Horton T, Lu X, O’Brien M, Borowtiz B, Devidas M, Raetz E, Brown B, Zeng H, Whitlock J, Hunger S.  Minimal Residual Disease Strongly Predicts Clinical Outcome in a Regimen Combining Bortezomib with Reinduction Chemotherapy for First Relapse Acute Lymphoblastic Leukemia: A Children’s Oncology Group Study.  Pediatric Blood and Cancer, 63(S1), S16: 508, 2016 (Selected for poster presentation at ASPHO 2016).

Lew G, Lu X, Yanofsky RA, Rheingold SR, Whitlock JA, Wang C, Devidas M, Hastings CA, Winick NJ, Carroll WL, Borowitz MJ, Pulsipher MA, Hunger SP.  Race And Ethnicity do not Impact Outcomes After Relapse Of Childhood B-Lymphoblastic Leukemia: A Report From Children’s Oncology Group (COG) Study AALL0433.  Pediatric Blood and Cancer, 63(S1), S17: 512, 2016 (Selected for poster presentation at ASPHO 2016).

Schore RJ, Devidas M, Bleyer A, Reaman GH, Winick N, Loh M, Raetz E, Carroll W, Hunger SP, Angiolillo AL.  Plasma asparaginase activity and asparagine depletion in patients with acute lymphoblastic leukemia (ALL) treated with pegaspargase (SS-PEG E. coli L-asparaginase): Results from Children’s Oncology Group (COG) Study AALL07P4.  Journal of Clinical Oncology, 34, 2016 (suppl; abstr 10508)  (Selected for oral presentation at ASCO 2016). 

Kirsch I, Crossley B, Williamson D, Gawad C, Wood B, Borowitz M, Devidas M, Maloney K, Larsen E, Winick N, Martin P, Hunger SP, Loh M, Robins H.  High Throughput Sequencing as a Measure of Early Response to Therapy in Childhood ALL. Abstract selected for oral presentation at the European Hematology Annual Congress, Copenhagen, Denmark June 11, 2016.

Albers C, Kuo F, Roberts KG, Stonerock E, Li M, Harvey R, Chang F, Aster J, Boykin R, Gerlach J, Willman CL, Mullighan CG, Hunger S, Loh M, Gastier-Foster J, Reshmi SC.   Assessment of New Methodologies to Identify Actionable Gene Fusions in Philadelphia chromosome-like (Ph-like) High-Risk (HR) B-Acute Lymphoblastic Leukemia (ALL). Submitted to the Association for Molecular Pathology Annual Meeting 2016.

Bhatla T, Wand J, Fleur SS, Brown P, Hunger S, Loh M, Carroll WL.  Epigenetic landscape of relapsed childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 63: S26 (O-085), 2016 (Oral Presentation at SIOP Annual Congress, Dublin, October 2016).

Brown P, Kairalla J, Wang C, Dreyer Z, Salzer W, Sorenson M, Borowitz M, Carroll A, Heerema N, Gore L, Devidas M, Carroll W, Winick N, Raetz E, Loh M, Hunger S, Hilden J.  Addition of Flt3 Inhibitor Lestaurtinib To Post-Induction Chemotherapy Does Not Improve Outcomes In MLL-Rearranged Infant Acute Lymphoblastic Leukemia (ALL): AALL0631, A Children’s Oncology Group Study.  Pediatr Blood Cancer 63: S7 (O-001), 2016 (Oral Presentation at SIOP Award Session, Dublin, October 2016).

Gu Z, Liu Y, Roberts K, Shao Y, Harvey RC, Chen I-M, Valentine M, Pei D, Marra M, Larsen E, Spinelli O, Minden MD, Fielding AK, Stock W, Konopleva M, Willman CL, Loh M, Hunger S, Mullighan C. Recurrent MEF2D Fusions Define a New Subtype of Acute Lymphoblastic Leukemia Associated with Older Age at Diagnosis and Poor Outcome.  Pediatr Blood Cancer 63: S14 (O-034), 2016 (Oral Presentation at SIOP Annual Congress, Dublin, October 2016).

Kirsch I, Crossley B, Williamson D, Gawad C, Wood B, Borowitz M, Devidas M, Maloney K, Larsen E, Winick N, Raetz E, Carroll C, Hunger S, Loh M, Robins H.  High Throughput Sequencing As A Measure Of Early Response To Therapy In Childhood ALL.  Pediatr Blood Cancer 63: S14 (O-031), 2016 (Oral Presentation at SIOP Annual Congress, Dublin, October 2016).

Liu Y, Easton J, Shao Y, Wilkinson M, Edmonson M, Ma X, Guidry Auvil J, Gerhard D, Winick N, Raetz E, Willman C, Carroll W, Dunsmore K, Winter S, Wood B, Downing Jm Loh M, Hunger S, Zhang J, Mullighan C.  The Genomic Landscape of Pediatric T-Lineage Acute Lymphoblastic Leukemia.  Pediatr Blood Cancer 63: S15 (O-035), 2016 (Oral Presentation at SIOP Annual Congress, Dublin, October 2016).

Maloney KW, Friedmann A, Devidas M, Mattano L, Buckley P, Borowitz MJ, Carroll AJ, Gastier-Foster JM, Heerema NA, Kadan-Lottick N, Loh ML, Matloub YH, Marshall DT, Stork L, Raetz EA, Wood B, Winick NJ, Hunger SP, Carroll WL.  Very Favorable Complete Continuous Remission (CCR) and Overall Survival (OS) for Standard-Risk High (SRH) Acute Lymphoblastic Leukemia (ALL) Patients Treated on COG AALL0331.  Pediatr Blood Cancer 63: S31 (O-103), 2016 (Oral Presentation at SIOP Annual Congress, Dublin, October 2016).

Slayton W, Schultz K, Chang W, Kairalla J, Devidas M, Gastier-Foster J, Raetz W, Loh M, Silverman L, Winick N, Carroll W, Hunger S.  BCR/ABL1 Point Mutations are Uncommon in Children With Ph+ Acute Lymphoblastic Leukemia Receiving Dasatinib Plus Multiagent Chemotherapy: A Report From Children’s Oncology Group Trial AALL0622.  Pediatr Blood Cancer 63: S14 (O-033), 2016 (Oral Presentation at SIOP Annual Congress, Dublin, October 2016).

Alexander TB, Gu Z, Choi JK, Loh M, Horan J, Buldini B, Basso G, Elitzur S, de Haas V, Zwaan CM, Yeoh A, Reinhardt D, Tomizawa D, Lammens T, De Moerloose B, Zho L, Hori H, Moorman A, Moore A, Hrusak O, Hunger SP, Guidry Auvil JM, Smith MA, Davidsen TM, Hermida L, Gesuwan P, Gerhard DS, Inaba H, Mullighan CG.  Genomic Landscape Of Pediatric Mixed Phenotype Acute Leukemia.  Blood 2016 128: 454 (Oral Presentation at ASH 2016).

Ariës IM, Chonghaile TN, Karim SA, Jacob M, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, Teachey DT, Rabin K, Silverman LB, Sallan SE, Knoechel B, Van Vlierberghe P, Letai AG, Gutierrez A.  PRC2 Mutations Induce Resistance to Combination Chemotherapy by Blocking Mitochondrial Apoptosis in T-cell Acute Lymphoblastic Leukemia.  Blood 2016 128: 604 (Oral Presentation at ASH 2016).

Gupta S, Devidas M, Chen S, Wang C, Loh ML, Raetz EA, Brown P, Carroll AJ, Heerema NA, Gastier-Foster JM, Dunsmore KP, Larsen EC, Maloney KW, Mattano LA Jr, Winter SS, Winick NJ, Carroll WL, Hunger SP, Borowitz M, Wood B.  Minimal Residual Disease Assessment of Remission after Induction Therapy is Superior to Morphologic Assessment for Risk Stratification in Childhood Acute Lymphoblastic Leukemia: A Report from the Children’s Oncology Group (COG).  Blood 2016 128: 758 (Oral Presentation at ASH 2016).

Hampton OA, Ramos E, Kakkar N, Junco JJ, Reuther J, Angiolillo A, Schore R, Burke MJ, Salzer WL, Devidas M, Carroll AC, Heerema NA, Raetz EA, Loh ML, Hunger SP, Jain J, Doddapaneni H, Muzny DM, Wheeler D, Fisher KE, Lopez-Terrada D, Roy A, D Parsons DW, Rabin KR.  Integrated Genomic Analysis of Down Syndrome Acute Lymphoblastic Leukemia Reveals Recurrent Cancer Gene Alterations and Evidence of Frequent Subclonal Driver Events.  Blood 2016 128: 4083 (Poster Presentation at ASH 2016).

Kang H, Sharma N, Nickl CK, Ness SA, Devidas M, Wood BL, Asselin BL, Raetz EA, Carroll WL, Winick NJ, Loh ML, Hunger SP, Heerema NA, Carroll AJ, Dunsmore KP, Larson R, Winter SS, Matlawska-Wasowska K.  New insights into deregulated gene expression pathways in MLL- and AF10-rearranged T-lineage acute lymphoblastic leukemia.  Blood 2016 128: 2906 (Poster Presentation at ASH 2016).

Loh M, Zhang J, Ma, Pei, Dai Y, Devidas M, Edmonson M, Rusch, Carroll A, Chen I-M, Gastier-Foster J, Harvey R, Heerema N, Iacobucci I, Payne-Turner D, Maloney K, Larsen E, Raetz E, Willman C, Winick N, Carroll W, Mullighan C, Hunger SP.  Whole Exome Sequencing of Pediatric Acute Lymphoblastic Leukemia Patients Identify Mutations in 11 Pathways: A Report from the Children’s Oncology Group.  Blood 2016 128: 455 (Oral Presentation at ASH 2016).

Loh M, Raetz E, Devidas M, Dai Y, Borowitz M, Carroll A, Chen I-M, Gastier-Foster J, Harvey R, Heerema N, Larsen E, Li Y-J, Maloney K, Mattano L, Mullighan C, Rabin K, Reshmi S, Roberts K, Willman C, Wood B, Zweidler-McKay P, Zhang J, Winick N, Hunger S, Carroll W.  Outcomes of Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia based on Blast Genotype at Diagnosis: A Report from the Children’s Oncology Group.  Blood 2016 128: 451 (Oral Presentation at ASH 2016).

Nishii R, Baskin R, Moriyama T, Hoshitsukid K, Metzger ML, Wu G, Devidas M, Yang W, Quinn E, Gastier-Foster JM, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Takagi M, Pui C-H, Evans WE, Zhang J, Relling MV, Hunger SP, Mullighan C, Loh ML, Nichols KE, Yang JJ.  Comprehensive Functional Characterization of Germline ETV6 Variants Associated with Inherited Predisposition to Acute Lymphoblastic Leukemia in children.  Blood 2016 128: 1085 (Oral Presentation at ASH 2016).

Schore RJ, Devidas M, Bleyer A, Reaman G, Lebedinsky C, Zhang H, Koppensteiner H, Loh ML, Raetz E, Winick N, Carroll WL, Hunger SP, Angiolillo A.  Anti-Pegaspargase, Anti-Calaspargase Pegol and Anti-Polyethelene Glycol Antibody Incidence in High Risk Acute Lymphoblastic Leukemia Patients Receiving Pegaspargase or Calaspargase Pegol and Associated Anaphylactic or Hypersensitivity Reaction Rates: Results from Children’s Oncology Group (COG) Study AALL07P4.  Blood 2016 128: 3965 (Poster Presentation at ASH 2016).

Schwab C, Sinclair P, Moorman AV, Hunger S, Loh ML, Carroll AJ, Heerema NA, Harrison C.  Improved Diagnosis of Intrachromosomal Amplification of Chromosome 21 (iAMP21) by Copy Number Profiling. Blood 2016 128: 1733 (Poster Presentation at ASH 2016). 

Valsecchi MG, Devidas M, Lucenti A, Schrappe M, Cazzaniga G, Möricke A, Bartram CR, Mann G, Carroll W, Larsen E, Winick N, Basso G, Conter V, Zimmermann M, Suciu S, Biondi A, Hunger S, Galimberti S.  Evaluation of Minimal Residual Disease as a Surrogate Endpoint for Event Free Survival in Childhood B-Lineage Acute Lymphoblastic Leukemia.  Blood 2016 128: 759 (Oral Presentation at ASH 2016).

Wood BL, Wu D, Kirsch IM, Crossley B, Williamson D, Gawad C, Borowitz MJ, Devidas M, Maloney KW, Larsen E, Winick N, Raetz E, Carroll WL, Hunger SP, Loh ML, Robins H.  Residual Disease Monitoring By High Throughput Sequencing Provides Risk Stratification in Childhood B-ALL and Identifies a Novel Subset of Patients Having Poor Outcome. Blood 2016 128: 1086 (Oral Presentation at ASH 2016).

2015

Iacobucci I, Roberts K, Li Y, Zhang J, Harvey RC, Payne-Turner D, Valentine M, McCastlain K, Easton J, Chen I-M, Rusch R, Kornblau SM, Konopleva M, Paietta E, Rowe JM, Pui C-H, Gastier-Foster JM, Loh ML, Willman C, Downing JR, Hunger SP, Mullighan CG.  Rearrangements of the erythropoietin receptor are recurrent in Ph-like acute lymphoblastic leukemia and are sensitive to Jak2 inhibition. Cancer Research (Proceedings: AACR 106th Annual Meeting 2015); 75: Abstract  #4369 (Oral Session Presentation at AACR 2015).

Reshmi SC, Harvey RC, Smith A, Chen I-M, Valentine M, Liu Y, Li Y, Zhang J, Roberts KG, Shao Y, Easton J, Payne-Turner D, Devidas M, Heerema N, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Angiolillo A, Burke MM, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Loh ML, Hunger SP, Mullighan CG, Willman CL, Gastier-Foster JM.  Frequency of Actionable Gene Fusions in Patients with Philadelphia Chromosome-like (Ph-like) B-Acute Lymphoblastic Leukemia (ALL): A Study from the Children’s Oncology Group (COG).  Cancer Research (Proceedings: AACR 106th Annual Meeting 2015); 75: Abstract  #4729 (Oral Session Presentation at AACR 2015).

Burke MJ, Devidas M, Chen S, Gore L, Larsen E, Hilden J, Loh ML, Winick N, Carroll WL, Raetz E, Hunger SP, Salzer WL.  Feasibility of intensive post-Induction therapy incorporating clofarabine (CLOF) in the very high risk (VHR) stratum of patients with newly diagnosed high risk B-lymphoblastic leukemia (HR B-ALL): Children’s Oncology Group AALL1131.  Journal of Clinical Oncology, 33: No 15_suppl (May 20 Supplement), 2015: 10007a (Oral presentation at ASCO 2015).

Esiashvili N, Lu X, Hunger S, Merchant TE, Brown PA, Wall DA, Grupp SA, Pulsipher M.  Higher Lung Dose Received during Total Body Irradiation for Allogeneic Hematopoetic Stem Cell Transplantation in Children with Acute Lymphoblastic Leukemia is Associated with Inferior Progression-free and Overall Survival: A Report from the Children’s Oncology Group.  Journal of Clinical Oncology, 33: No 15_suppl (May 20 Supplement), 2015: 10030a (Poster presentation at ASCO 2015).

Maloney KW, Angiolillo A, Schore RJ, Devidas M, Lu X, Wang C, Friedmann A, Mattano LA, Loh M, Raetz E, Stork L, Winick N, Hunger SP, Carroll WL.  Intravenous (IV) and intramuscular (IM) Pegaspargase (PEG) administration are associated with a low rate of adverse events (AE) in Standard risk (SR) Acute Lymphoblastic Leukemia (ALL) Children’s Oncology Group (COG) trials.  Journal of Clinical Oncology, 33: No 15_suppl (May 20 Supplement), 2015: 10035a (Poster presentation at ASCO 2015).

Slayton WB, Kairalla JA, Schultz KR, Devidas M, Helian S, Pulsipher M, Chang BH, Carroll WL, Borowitz MJ, Brown VI, Winick NJ, Carroll AJ, Heerema NA, Gastier-Foster JM, Wood BL, Mizrahy S, Hunger S.  Outcomes of Dasatinib Plus Intensive Chemotherapy or Stem Cell Transplant (SCT) for Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) on Children’s Oncology Group AALL0622.  Journal of Clinical Oncology, 33: No 15_suppl (May 20 Supplement), 2015: 10006a (Oral presentation at ASCO 2015).

Winick NJ, Embry LM, Hardy KK, Kairalla JA, Devidas M, Armstrong D, Hunger S, Carroll WL, Larsen E, Raetz EA, Loh ML, Noll R.  Neurocognitive function of children treated for High-Risk B-Acute Lymphoblastic Leukemia (HR-ALL) randomized to Capizzi (CMTX) versus High-Dose methotrexate (HDMTX): A report from the Children’s Oncology Group (COG).  Journal of Clinical Oncology, 33: No 15_suppl (May 20 Supplement), 2015: 10002a (Oral presentation at ASCO 2015).

Pulsipher M, Esiashvili N, Lu X, Hunger S, Merchant TE, Brown PA, Wall DA, Grupp SA.  Inadequate Lung Shielding in Children with ALL Undergoing Allo-HSCT is Associated with Inferior Survival: Report from the Children’s Oncology Group/Pediatric Blood and Marrow Transplant Consortium.  Pediatr Blood Cancer 62: S154, 2015 (oral presentation at SIOP, Capetown, October 2015).

Chen Z, Geng H, Lowell CA, Weiss A, Hunger SP, Melnick A, Muschen M.  Targeted Activation of B-cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia.  Blood 2015 126: 3716 (Poster Presentation at ASH 2015).

Liu Y, Easton J, Shao Y, Wilkinson M, Edmonson M, Ma X, Smith MA, Rusch M, Guidry Auvil J, Gerhard DS, Relling MV, Winick NJ, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Downing JR, Loh ML, Hunger SP, Zhang J, Mullighan CG.  The Genomic Landscape of Childhood T-Lineage Acute Lymphoblastic Leukemia.  Blood 2015 126: 691 (Oral Presentation at ASH 2015).

Karol SE, Yang W, Mattano LA, Maloney KW, Smith C, Liu CC, Ramsey LB, Fernandez CA, Chang TY, Neale G, Cheng C, Mardis E, Fulton R, Scheet P, Larsen EC, Loh ML, Raetz EA, Hunger SP, Devidas M, Relling MV.  Genetic Risk Factors for the Development of Osteonecrosis in Children Under Age 10.  Blood 2015 126: 250 (Oral Presentation at ASH 2015).

Matlawska KS, Kang H, Devidas M, Wen J, Harvey RC, Nickl CK, Ness SA, Rusch M, Li Y, Onozawa M, Martinez C, Wood BL, Asselin BL, Chen I-M, Roberts KG, Baruchel A, Soulier J, Dombret H, Zhang J, Larson RS, Raetz EA, Carroll WL, Winick NJ, Aplan PD, Loh ML, Mullighan CG, Hunger SP, Heerema NA, Carroll AJ, Dunsmore KP, Winter SS.  Mixed Lineage Leukemia Rearrangements (MLL-R) are Determinants of High Risk Disease in Homeobox A (HOXA)-deregulated T-lineage Acute Lymphoblastic Leukemia:  A Children's Oncology Group Study.  Blood 2015 126: 694 (Oral Presentation at ASH 2015).

Moriyama T, Metzger M, Wu G, Nishii R, Qian M, Devidas M, Yang W, Quinn E, Gastier-Foster J, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Komada K, Mardis, E, Fulton R, Pui C-H, Evans WE, Zhang J, Hunger SP, Relling MV, Nichols K, Loh ML, Yang JJ.  Germline Genetic Variation in ETV6 and Predisposition to Childhood Acute Lymphoblastic Leukemia.  Blood 2015 126: 695 (Oral Presentation at ASH 2015).

Rabin KR, Hitzler J, Rodriguez V, Schore RJ, Angiolillo AL, Burke ML, Salzer WL, Maloney KW, Lu X, Devidas M, Loh ML, Raetz EA, Hunger SP.  Treatment-Related Mortality (TRM) in Children with Down Syndrome (DS) and B-Lymphoblastic Leukemia (B-ALL): An Interim Report from the Children’s Oncology Group Trials AALL0932 and AALL1131.  Blood 2015 126: 2502 (Poster Presentation at ASH 2015).

Raetz E, Loh M, Devidas M, Maloney K, Larsen E, Mattano L, Borowitz M, Wood B, Carroll A, Heerema N, Chen I-M, Friedmann A, Schultz K, Relling M, Harvey R, Gastier-Foster J, Willman C, Winick N, Hunger SP, Carroll W.  Genetic and response-based risk classification identifies a subgroup of NCI high risk childhood B-lymphoblastic leukemia (HR B-ALL) with outstanding outcomes:  A report from the Children’s Oncology Group (COG).  Blood 2015 126: 807 (Oral Presentation at ASH 2015).

Reshmi SC, Stonerock ES, Borowitz M, Geese WJ, Healey D, Gastier-Foster J, Hunger SP, Biondi A, Cazzaniga G.  International Laboratory Comparison of Methodologies for Determining Minimal Residual Disease (MRD) in Childhood Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL).  Blood 2015 126: 2612 (Poster Presentation at ASH 2015).

Salzer WL, Burke M, Larsen E, Chen S, Gore L, Hilden J, Loh ML, Raetz E, Winick N, Carroll WL, Devidas M, Hunger SP.  Incidence of Allergic Reactions to Pegaspargase (PEG) Administered Intramuscularly Versus Intravenously (IM vs. IV) in Children and Young Adults with High Risk B- Lymphoblastic Leukemia (HR B-ALL): Results of Children’s Oncology Group (COG) Studies AALL0232/AALL1131.  Blood 2015 126: 1303 (Poster Presentation at ASH 2015).

Tasian SK, Li Y, Shen F, Ryan T, Vincent TL, Teachey DT, Maude SL, Harvey RC, Chen I-M, Willman CL, Perl AE, Hunger SP, Loh ML, Carroll M, Grupp SA.  Potent Efficacy of Combined PI3K/mTOR and JAK or SRC/ABL Inhibition in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia.  Blood 2015 126: 798 (Oral Presentation at ASH 2015).

Winter SS, Devidas M, Chen S, Asselin BA, Carroll WL, Wood B, Esiashvili N, Nikki BJ, Hayashi RJ, Loh ML, Carroll AJ, Heerema NA, Raetz E, Winick NJ, Hunger SP, Dunsmore KP.  Capizzi-Style Methotrexate with Pegasparagase (C-MTX) Is Superior to High-Dose Methotrexate (HDMTX) in T-Lineage Acute Lymphoblastic Leukemia (T-ALL): Results from Children's Oncology Group (COG) AALL0434.  Blood 2015 126: 794 (Oral Presentation at ASH 2015).

Zaliova M, Moorman AV, Cazzaniga G, Stanulla M, Harvey RC, Roberts KG, Heatley SL, Loh ML, Konopleva M, Chen I, Zimmermannova O, Schwab C, Smith O, Mozziconacci MJ, Chabannon C, Kim M, Falkenburg JHF, Norton A, Marshall K, Haas OA, Starkova J, Stuchly J, Hunger SP, White D, Mullighan CG, Willman CL, Stary J, Trka J, Zuna J.  Characterization of leukemias with ETV6-ABL1 fusion.  Blood 2015 126: 84 (Oral Presentation at ASH 2015).

Zhang J, McCastlain K, Qu C, Wu G, Edmonson M, Li Y, Wei L, Payne-Turner D, Yoshihara H, Churchman ML, Waanders E, Ntziachristos P, Aifantis I, Roberts KG, Ma J, Song G, Easton, J Mulder HL, Chen X, Rusch M, Boggs K, Vadodaria B, Dalton J, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Evans WE, Pui C-H, Jeha S, Harvey RC, Chen I-M L, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrozek K, Paietta E, Tallman MS, Stock W, Voorhees PM, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Hunger SP, Loh ML, Downing JR, Mullighan CG.  Expression of an Oncogenic ERG Isoform Characterizes a Distinct Subtype of B-Progenitor Acute Lymphoblastic Leukemia.  Blood 2015 126: 693 (Oral Presentation at ASH 2015).

Awards and Honors

2015-present, Jeffrey E. Perelman Distinguished Chair in the Department of Pediatrics, Children's Hospital of Philadelphia
2015, Elected to the John Morgan Society of the University of Pennsylvania
2014, Ann T. Bass Endowed Visiting Professor, Stanford University, Stanford CA
2013, Visiting Professor, McMaster University, Hamilton, Ontario, Canada
2012, First Annual Sam Gross Visiting Professor in Pediatric Oncology, University of Florida College of Medicine, Gainesville FL
2011, Visiting Professor, University of Chicago, Chicago, IL
2011-present, Cambridge Who’s Who Executive and Professional Registry
2009, SIOP Award for Basic Science Abstract
2009-present, Guide to America’s Top Oncologists
2007-present, Ergen Family Chair in Pediatric Cancer
2004-present, Guide to America’s Top Physicians
2002-present, The Best Doctors In America
2001-2007, STOP! Children’s Cancer Endowed Chair in Pediatric Oncology
1998-2001, Leukemia Society of America Translational Research Awardee
1997-1999, Professional Development Award, The Children’s Hospital Research Institute, Denver, CO
1995-1997, 1995-1997 BLOOD/American Society of Hematology (ASH) Scholar Award
1992-1994, Individual National Research Service Award, National Cancer Institute
1991-1992, American Cancer Society Physician's Research Training Award
1982, Linda Ives Memorial Fund Award for Research in Pediatrics, University of Connecticut School of Medicine
1978, Undergraduate Research Opportunities Award, Massachusetts Institute of Technology
1977-1981, National Merit Scholar

Editorial and Academic Positions

Editorial positions

2013-2015, Editorial Board, Journal of Clinical Oncology
2013-2014, Guest Editor, Current Opinion in Pediatrics issue on New Developments in Pediatric Hematology/Oncology
2013, Reviewer, Hematology 2013, American Society of Hematology Annual Meeting Education Program Book
2013-present, Member, Editorial Committee, Romanian Journal of Oncology and Hematology
2011-present, Editorial Board, Frontiers Oncology
2010-present, Editorial Advisory Board, PDQ Pediatric Treatment
2009-present, Editorial Board, Leukemia Research
2009-present, Editorial Board, Pediatric Blood and Cancer

Ad Hoc Reviewer

1994-present, Blood
1994-present, Leukemia
1994-present, Genes
1994-present, Chromosomes & Cancer
1994-present, Molecular and Cellular Biology
1994-present, Proc Natl Acad Sci USA
1994-present, Journal of Pediatric Hematology/Oncology
1994-present, Hematologica
1994-present, Bone Marrow Transplantation
1994-present, Journal of Clinical Oncology
1994-present, Pediatric Blood and Cancer

Academic and institutional committees

2009-2013, St. Baldrick’s Foundation Grant Review Committee
2006-2013, Alex’s Lemonade Stand Grant Review Committee
2000-present, Children’s Oncology Group grant and research proposal reviews

Leadership and Memberships

Memberships in professional organizations

International

International Society of Paediatric Oncology

National

American Association for the Advancement of Science
American Society of Clinical Oncology
American Society of Hematology
American Society of Microbiology
American Society of Pediatric Hematology-Oncology
Children’s Oncology Group
Society for Pediatric Research