Misun Hwang, MD

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Misun Hwang, MD, is an attending radiologist with the Department of Radiology at Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Vanderbilt School of Medicine, Nashville, TN

Internship

Preliminary Medicine - New York Hospital Queens, New York, NY

Residency

Radiology - University of Pittsburgh Medical Center, Pittsburgh, PA

Fellowship

Pediatric Radiology - Children’s Hospital of Philadelphia, Philadelphia, PA

Titles and Academic Titles

Attending Radiologist

Assistant Professor of Pediatric Radiology, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2018

Hwang M. Introduction to contrast-enhanced ultrasound of the brain in neonates and infants: current understanding and future potential. Pediatric Radiology 2018. Pediatr Radiol. 2018 Oct 23. doi: 10.1007/s00247-018-4270-1. [Epub ahead of print]

Hwang M, Riggs BJ, Saade-Lemus S, Huisman TAGM. Bedside contrast-enhanced ultrasound diagnosing cessation of cerebral circulation in a neonate: A novel bedside diagnostic tool. Neuroradiol J. 2018 Dec;31(6):578-580. doi: 10.1177/1971400918795866. Epub 2018 Sep 7.

Hwang M, Thimm MA, Guerrerio AL. Detection of cavernous transformation of the portal vein by contrast-enhanced ultrasound. J Ultrasound 2018 [Epub ahead of print]

Thimm M, Cuffari C, Garcia A, Hwang M. Contrast-Enhanced Ultrasound and Shear Wave Elastography Evaluation of Crohn’s Disease Activity in Three Adolescent Patients. Pediatric Gastroenterology, Hepatology & Nutrition 2018 [In press]

Back SJ, Maya C, Darge K, Acharya PT, Barnewolt CE, Coleman JL, Dillman JR, Fordham LA, Hwang M, Lim A, McCarville MB, Munden MM, Paltiel HJ, Volberg FM. Pediatric contrast-enhanced ultrasound in the United States: a survey by the Contrast-Enhanced Ultrasound Task Force of the Society of Pediatric Radiology. Pediatr Radiol 2018 [Epub ahead of print]

Shin SS, Huisman TAGM, Hwang M. Ultrasound Imaging for Traumatic Brain Injury. J Ultrasound Med 2018. [Epub ahead of print]

Shrot S, Hwang M, Stafstrom CE, Huisman TAGM, Soares BP. Dysplasia and overgrowth: magnetic resonance imaging of pediatric brain abnormalities secondary to alterations in the mechanistic target of rapamycin pathway. Neuroradiology. 2018;60(2):137-150.

2017

Hwang M, Riggs BJ, Katz J, Seyfert D, Northington F, Shenandoah R, Burd I, McArthur J, Darge K, Thimm MA, Huisman TAGM. Advanced Pediatric Neurosonography Techniques: Contrast-Enhanced Ultrasonography, Elastography, and Beyond. J Neuroimaging 2017;28:150-157.

Hwang M, de Jong RM, Herman RT, Boss R, Riggs B, Tekes A, Spevak M, Poretti A, Soares BP, Baily CR, Dunn E, Shin SS, Shrot S, Huisman TAGM. Novel Contrast Ultrasound Evaluation in Neonatal Hypoxic Ischemic Injury: Clinical Applications and Future Directions. J of Ultrasound Med 2017; 36:2379-2386.

Bailey C, Huisman TAGM, de Jong RM, Hwang M. Contrast-Enhanced Ultrasound and Elastography Imaging of the Neonatal Brain: A Review. J Neuroimaging 2017;27(5):437-441 PMID: 28419634

Hwang M, Tudorascu DL, Nunley K, Karim H, Aizenstein HJ, Orchard TJ, Rosano C. Corrigendum to “Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease. J Diabetes Res 2017:4295645.

Hwang M, Shin SS, Thimm MA, Ghodadra A, Sylvester CL, Nischal K, Panigrahy A, Zuccoli G. Apparent Diffusion Coefficient (ADC) of the vitreous humor and Susceptibility Weighted Imaging (SWI) of the retina in abused children with retinal hemorrhages. Clinical Imaging 2017;44:38-41.

Shin SS, Bales JW, Dixon E, Hwang M. Structural imaging of mild traumatic brain injury may not be enough: overview of functional and metabolic imaging of mild traumatic brain injury. Brain Imaging Behav 2017;11:591-610.

2016

Hwang M, Tudorascu D, Nunley K, Karim H, Aizenstein H, Orchard T, Ryan C, Rosano C. Brain activation and psychomotor speed in middle-aged patients with type I diabetes: relationships with hyperglycemia and brain small vessel disease. J. Diabetes Res 2016;1-11. PMID 26998494

Hwang M, Zuccoli G, Panigrahy A, Rodriguez D, Poe M, Escolar M. Thickening of the cauda equine roots: A common finding in Krabbe disease. Eur Radiol. 2016 Oct;26(10):3377-82. doi: 10.1007/s00330-016-4233-6. Epub 2016 May 2.

2015

Hwang M, Marovich R, Shin S, Chi D, and Branstetter B. Optimizing CT for the evaluation of vestibular aqueduct enlargement: Inter-rater reproducibility and predictive value of reformatted CT measurements. Journal of Otology 2015;10:13-17.

Hwang M and Zuccoli G. Autoimmune Labyrinthitis Associated with Ulcerative Colitis. Pediatric Neurology 2015;53:375-6.

2014

Rafay A, Matthew O, Hwang M, Lieberman F, Mountz J. Malignant Gliomas: Current Perspectives. Cancer Manag Res. 2014 Mar 24;6:149-70. doi: 10.2147/CMAR.S54726. eCollection 2014.

2012

Hwang M, Joyce J, Klein H, and Hou JZ. Unsuspected Pneumonia Detected by Increased Lung Uptake on In-111 Ibritumomab Tiuxetan Scan. Clinical Nuclear Medicine 2012;37:1003-5. PMID: 22955077.

2011

Kan H, Hwang M, Lowas SR, Hernanz-Schulman M. Impact of Pelvic CT on Staging, Surveillance, and Survival of Pediatric Patients with Wilms Tumor and Hepatoblastoma. American Journal of Roentgenology, 2011 May;196(5):W515-8. PMID: 21512039.

Speirs C, Hwang M, Kim S, Chang S, Varki V, Mitchell L, Schleicher S, Lu B. Harnessing the cell death pathway for targeted cancer treatment. Am J Cancer Res. 2011;1(1):43-61. PMID: 21969218.

Jaboin JJ, Hwang M, Perez C, Cooper C, Chen H, Ye C, Cai Q, Wills M, Lu B. No Evidence for Association of the MDM2-309 T/G Promoter Polymorphism with Prostate Cancer Outcomes. Urology Oncology, 2011 Jun;29(3):319-23. PMID 19523862.

Jaboin JJ, Hwang M, Lopater Z, Chen H, Ray GL, Perez C, Cai Q, Wills M, Lu B. The Matrix Metalloproteinase-7 polymorphism Rs10895304 is associated with increased recurrence risk in patients with clinically localized prostate cancer. International Journal of Radiation Oncology, Biology, Physics (IJROBP), 2011 Apr 1;79(5):1330-5. PMID 20605361.

Farrell M, Trivedi N, Romine L, Hwang M, Schrimmer D, Wan J, Do P, LaCoursiere Y, Hartney C, Benirschke K, Pretorius D. Prenatal Diagnosis of an Abnormal Placental Cord Insertion Site and Correlation With Neonatal Outcomes in Twins, J Ultrasound Med 30:S31, April 2011.

2010

Hwang M, Hariri G, Lyshchik A, Hallahan D, and Fleischer AC. Correlation of Quantified Contrast-Enhanced Sonography to In Vivo Tumor Response. Journal of Ultrasound in Medicine (JUM) 2010;29:597-607. PMID: 20375378

Hwang M, Lyshchik A, Fleischer AC. Molecular Sonography Using Targeted Microbubbles. Ultrasound Quarterly 2010;26:75-82. PMID: 20498563

Perez C, Chen H, Shyr Y, Courtney R, Zheng W, Cai Q, Hwang M, Jaboin J, Wills M, Smith J, Lu B. The EGFR Polymorphism rs884419 is Associated with Freedom from Recurrence in Patients with Resected Prostate Cancer. Journal of Urology 2010;183:2062-2069. PMID: 20303520

2009

Hwang M, Niermann K, Lyshchik A, and Fleischer AC. Sonographic Assessment of Tumor Vasculature from In Vivo Models to Clinical Applications. Ultrasound Quarterly 2009;25:175-83. PMID: 19956050

Hwang M, Moretti L and Lu B. HSP90 Inhibitors: Multi-Targeted Antitumor Effects and Novel Combinatorial Therapeutic Approaches in Cancer Therapy. Curr Med Chem 2009;16-24:3081-3092. PMID: 19689285 

Sasi N, Hwang M, Jaboin JJ, Csiki L, Lu B. Regulated Cell Death Pathways: New Twists in Modulation of BCL2 Family Function. Mol Cancer Therapeutics. 2009;8(6):1421-9. PMID: 19509269

Fleischer A, Lyshchik A, Andreotti R, Hwang M, Jones H, Fishman D. Advances in Sonographic Detection of Ovarian Cancer: Depiction of Tumor Neovascularity with Microbubbles. American Journal of Roentgenology (AJR) 2009;194:343-8. PMID: 20093594

2008

Hwang M, Perez CA, Moretti L, Lu B: The mTOR signaling network: insights from its role during embryonic development. Curr Med Chem 2008;15:1192-1208.

Hwang M*, Kim KW*, Moretti L, Jaboin JJ, Cha YI, Lu B: Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 2008;4:659-668. *Equal contribution PMID: 18424912

2007

Hwang M, Yong C, Moretti L, Lu B. Zebrafish as a Model System to Screen Radiation Modifiers. Curr Genomics, 2007;vol 8, no 6:360-369. PMID: 19412436

Abstracts

2019

Zheng Q, Ouyang M, Marin-Saavedra JS, Saade-Lemus S, Yu Q, Sze RW, Flibotte J, Detre J, Huang H, Hwang M. Increased brain perfusion in neonatal hypoxic ischemic injury with negative reading of DWI, T1/T2-weighted images: Implications of perfusion MRI for reperfusion response monitoring and prognostication. ISMRM. Montreal, May 2019.

Cort K, Edgar C, Otero H, Nguyen J, Johnson A, Victoria T, White A, Hwang M. Towards implementing brain contrast enhanced ultrasound in the clinical setting: the impact of didactic session on normal brain perfusion. Society of Pediatric Radiology. San Francisco, May 2019.

Cort K, Piskunowicz M, Hwang M. Contrast-enhanced ultrasound for the evaluation of neonatal brain injury: Techniques and protocols. Society of Pediatric Radiology. San Francisco, May 2019.

White SA, Dennis R, Back S, Hwang M. Beyond liver lesions and vesicoureteral reflux: contrast-enhanced ultrasound as an emerging problem-solving tool for pediatric radiologists. Society of Pediatric Radiology. San Francisco, May 2019.

Sridharan A, Darge K, Huisman T, Hwang M. The importance of “wash-out” kinetics of contrast-enhanced ultrasound for diagnosis of diffuse hypoxic ischemic injury in neonates and infants: preliminary impressions. Society of Pediatric Radiology. San Francisco, May 2019.

Dennis B, Andronikous S, Hill L, Hwang M. Development of a 3D ultrasound phantom for trainee education. Society of Pediatric Radiology. San Francisco, May 2019.

Zheng Q, Marin-Saavedra JS, Ouyang M, Saade-Lemus S,Yu Q, Huang H, Sze RW, Hwang M. Region specific perfusion alterations in neonatal hypoxic ischemic injury evaluated with arterial spin labeling (ASL) MRI. Society of Pediatric Radiology. San Francisco, May 2019.

Zheng Q, Ouyang M, Marin-Saavedra JS, Saade-Lemus S,Yu Q, Huang H, Sze RW, Hwang M. Altered brain perfusion in neonatal hypoxic ischemic injury in the setting of normal DWI, T1, and T2 sequences: Implications of perfusion-based imaging for reperfusion response monitoring and prognostication. Society of Pediatric Radiology. San Francisco, May 2019.

Zheng Q, Ouyang M, Marin-Saavedra JS, Saade-Lemus S,Yu Q, Huang H, Sze RW, Hwang M. Quantitative ASL perfusion ethod for Detection of Neonatal Hypoxic Ischemic Injury as Reference Standard for Developing Contrast-Enhanced Ultrasound. Society of Pediatric Radiology. San Francisco, May 2019.

2017

Bailey C, Hwang M. The Use of Contrast Enhanced Ultrasound in Pediatric Radiology: Advantages, Clinical and Research Applications, and Future Directions. Society of Pediatric Radiology. Vancouver, May 2017. 

Books

Chapters

2014

Hwang M, Oborski M, Laymon C, Imani F, Mountz J. Quantitative Brain Imaging: Assessing Therapy Responses. Biomedical Imaging: Applications and Advances. Elsevier Science, Philadelphia, PA. Ed 2014.

Raay A, Matthew O, Hwang M, Lieberman F, Mountz J. Malignant Gliomas: Current Perspectives. Cancer Management and Research. Ed 2014.

2012

Hwang M, Imani F, Mountz J. Brain Imaging: Role of Quantitative Image Biomarkers for the Assessment of Therapy Response in Brain Tumor. Biomedical Imaging: Applications and Advances, Woodhead Publishing, 2012.

2011

Csiki I, Hwang M, Kirby W, Crass J, Ding G, Coffey C, Lu B. Chapter 17D: Use of the Breath-Hold Cone Beam CT in the Stereotactic Radiosurgical Treatment of Stage I Non-Small Cell Lung Cancer Patient. Image-Guided Radiation Therapy (IGRT): A Clinical Perspective. Ed 2011.

2010

Moretti L, Sebahat O, Hwang M, Lu B, Hallahan D. Chapter 14: Cell Cycle and Vascular Targets for Radiotherapy. Lung Cancer: Principles and Practice. Ed 2010.

2009

Jaboin JJ, Hwang M, Lu B. Autophagy in Lung Cancer. Methods in Enzymology. Elsevier Inc, 2009, vol 453, 287-304. PMID: 19216912

Posters and Presentations

2018

Hwang M, Sridharan A, Darge K, Sehgal C, Huisman TAGM. Quantitative Detection of Neonatal Brain Injury with Contrast Enhanced Ultrasound. Radiological Society of North America. Chicago, Nov 2018.

2017

Hwang M, Back S, Darge K, Zderic S. Ultrasound Estimated Bladder Weight Correlates with Videourodynamic Studies in Neurogenic Bladder Dysfunction. Society of Pediatric Radiology. Vancouver, May 2017. Oral Presentation.

2016

Hwang M, Blaskey L, Owen J, Roberts T, Berman J. Autism Patients Show Reversed Hemispheric Dominance in Language Function: New Insights Gained from Diffusor MR Tractography of the Superior Longitudinal Fasciculus (SLF). American Society of Neuroradiology. DC, May 2016. Oral Presentation.

Hwang M,  Blaskey L, Owen J, Roberts T, Berman J. Autism Patients Show Reversed Hemispheric Dominance in Language Function: New Insights Gained from Diffusor MR Tractography of the Superior Longitudinal Fasciculus (SLF). American Society of Neuroradiology. DC, May 2016.

Hwang M and Servaes S. How to differentiate between child abuse and normal variants on skeletal survey. Society of Pediatric Radiology. Chicago, April 2016. 

Invited Lectures

2018

Hwang M. Neonatology and Critical Care Bedside Ultrasound Course, Children’s Hospital of Philadelphia. November 2018.

Hwang M. European Society of Neuroradiology, Rotterdam, Netherlands, “CEUS and elastography  of the brain”. September 2018.

Hwang M. International Bubble Conference, Chicago, “Neonatal applications of CEUS”. September 2018.

Hwang M. Children’s National Hospital, District of Columbia,  “Introduction to CEUS”. June 2018.

Hwang M. European Society of Neuroradiology, “Neonatal emerging applications of CEUS”. June 2018.

Awards and Honors

2018-2020, NIH CTSI KL2 Awardee, University of Pennsylvania
2017-2018, Research Scholar, Radiologic Society of North America
2010, Roentgen Award, Vanderbilt Medical School, Nashville, TN
2010, Finalist, AIUM New Investigator Award Competition, San Diego, CA

Leadership and Memberships

Memberships in Professional Organizations

International

2017-present, Radiological Society of North America

National

2018-present, American Institute of Ultrasound in Medicine
2017-present, Society of Pediatric Radiology
 - 2018-present, Neonatal Imaging Committee
 - 2017-present, Contrast Enhanced Ultrasound Task Force