Misun Hwang, MD, MS

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Misun Hwang, MD, MS, is the Director of the Section of Neonatal Imaging and an attending radiologist with the Department of Radiology at Children's Hospital of Philadelphia.

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Vanderbilt School of Medicine, Nashville, TN

Internship

Preliminary Medicine - New York Hospital Queens, New York, NY

Residency

Radiology - University of Pittsburgh Medical Center, Pittsburgh, PA

Fellowship

Pediatric Radiology - Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification

Diagnostic Radiology

Graduate Degree

MS in Translational Research - Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Radiologist

Director, Section of Neonatal Imaging

Assistant Professor of Pediatric Radiology, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2022

Hwang M*, Zhang Z*, Kilbaugh TJ, Sridharan A, Katz J. *Equal contribution: Cerebral microcirculation mapped by echo particle tracking velocimetry quantifies the intracranial pressure and detects ischemia. Nature Communications 2022 Notes: Accepted.

Hwang M, Tierradentro-Garcia LO, Haddad S, Poznick L, Kilbaugh T, Chiotos K.: Feasibility of Contrast-Enhanced Ultrasound for Assessing Cardiac and Renal Microvascular Flow in Patients with Multisystem Inflammatory Syndrome in Children  Clinical Radiology 2022 Notes: Accepted.

2021

Hwang M, Khaw K, Sridharan A, Poznick L, Hallowell T, Delso N, Roberts A, Kilbaugh TJ: Brain Contrast-Enhanced Ultrasound Evaluation of a Pediatric Swine Model. Ultrasound Quarterly December 2020 Notes: doi: 10.1097/RUQ.0000000000000544. Online ahead of print as of February 2021.

Zheng Q, Viaene AN, Freeman CW, Hwang M: Radiologic-pathologic evidence of brain injury: Hypoperfusion in the Papez circuit results in poor neurodevelopmental outcomes in neonatal hypoxic ischemic encephalopathy. Child's Nervous System 37(1): 63-68, January 2021 Notes: doi: 10.1007/s00381-020-04795-0.

Zheng Q, Freeman CW, Hwang M: Sex-related differences in arterial spin-labelled perfusion of metabolically active brain structures in neonatal hypoxic-ischaemic encephalopathy. Clinical Radiology S0009-9260(21): 00029-5, February 2021 Notes: https://doi.org/10/1016/j.crad.2020.12.026, Online ahead of print as of April 2021.

Sridharan A, Riggs B, Darge K, Huisman TAGM, Hwang M: The Wash-Out of Contrast-Enhanced Ultrasound for Evaluation of Hypoxic Ischemic Injury in Neonates and Infants: Preliminary Findings. Ultrasound quarterly March 2021 Notes: DOI: 10.1097/RUQ.0000000000000560, Advance online publication. Online ahead of print as of May 2021.

Misun Hwang, Luis Octavio Tierradentro-García, Brandi L Kozak, Kassa Darge: Cerebrospinal Fluid Flow Detection in Post-hemorrhagic Hydrocephalus With Novel Microvascular Imaging Modality. Journal of Ultrasound in Medicine Jul 2021 Notes: doi: 10.1002/jum.15781.

Piskunowicz N, Sridharan A, Poznick L, Silvestro E, Hwang M: Optimization of Mechanical Indices for Clinical Contrast Enhanced Ultrasound. Journal of Ultrasound in Medicine 40(9): 1963-1970, September 2021 Notes: doi:10.1002/jum.15578.

Shin SS, Sridharan A, Khaw K, Hallowell T, Morgan RW, Kilbaugh TJ, Hwang M: Intracranial Pressure and Cerebral Hemodynamic Monitoring After Cardiac Arrest in Pediatric Pigs Using Contrast Ultrasound-Derived Parameters. Journal of Ultrasound in Medicine September 2021 Notes: doi: 10.1002/jum.15825.

Hwang M, Tierradentro-Garcia LO, Hussaini SH, Cajigas-Loyola SC, Kaplan SL, Otero HJ, Bellah RD: Ultrasound imaging of preterm brain injury: fundamentals and updates. Pediatric Radiology Oct 2021 Notes: doi: 10.1007/s00247-021-05191-9. Online ahead of print as of February 2022.

Ntoulia A, Anupindi SA, Back SJ, Didier RA, Hwang M, Johnson AM, McCarville MB, Papdopoulou F, Piskunowicz M, Sellars ME, Darge K: Contrast-enhanced ultrasound: a comprehensive review of safety in children. Pediatric Radiology 51(12): 2161-2180, November 2021 Notes: doi: 10.1007/s00247-021-05223-4.

Huisman TA, Hwang M, Orman G: Possible additional MRI markers for critical brain swelling with increased intracranial pressure in children? Neuroradiology Journal 34(6): 642-645, December 2021 Notes: doi: 10.1177/19714009211019381.

2020

Liu J, Kurepa D, Feletti F, Alonso-Ojembarrena A, Lovrenski J, Copetti R, Sorantin E, Rodriguez-Fanjul J, Katti K, Zhang H, Hwang M, Yeh TF, Hu CB, Feng X, Qiu RX, Chi JH, Shang LL, Lyu GR, He SZ, Chai YF, Qiu Zj, Cao HY, Gao YQ, Ren XL, Guo G, Zhang L, Liu Y: International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure. Journal of Visualized Experiments 12(157), March 2020 Notes: Doi: 10.3791/60836 Video-Audio Media.

Khaw KL, Sridharan A, Poznick L, Kilbaugh TJ, Hwang M: Probe position sensor to track image location in 2D ultrasound. Ultrasonics 103: 106084, April 2020 Notes: DOI: 10.1016/j.ultras.2020.106084. PMCID: PMC7474525

Benjamin J, Dennis R, White S, Muson D, Anupinid SA, Piskunowicz M, Darge K, Gokli A, Hwang M: Improved Diagnostic Sensitivity of Bowel Disease of Prematurity on Contrast-Enhanced Ultrasound. Journal of Ultrasound in Medicine 39(5): 1031-1036, May 2020 Notes: doi: 10.1002/jum.15168.

Chattaraj R, Hwang M, Semerov SD, Dmochowski IJ, Hammer DA, Lee D, Sehgal CM: Ultrasound Responsive Noble Gas Microbubbles for Applications in Image-Guided Gas Delivery. Advanced Healthcare Materials 9(9): 31901721, May 2020.

Zheng Q, Shellikeri S, Hwang H, Hwang M, Sze RW: Deep Learning Measurement of Leg Length Discrepancy in Children Based on Radiographs. Radiology 296(1): 152-158, July 2020 Notes: doi: 10.1148/radiol.2020192003.

2019

Hwang M, Piskunowicz M, Darge K. Advanced Ultrasound Techniques for Pediatric Imaging. Pediatrics. 2019 Mar;143(3). pii: e20182609. doi: 10.1542/peds.2018-2609.

Liu J, Copetti R, Sorantin E, Lovrenski J, Rodriguez-Fanjul J5, Kurepa D6, Feng X7, Cattaross L8, Zhang H, Hwang M, Yeh TF, Lipener Y, Lodha A, Wang JQ, Cao HY, Hu CB, Lyu GR, Qiu XR, Jia LQ, Wang XM, Ren XL, Guo JY, Gao YQ, Li JJ, Liu Y, Fu W, Wang Y, Lu ZL, Wang HW, Shang LL (2019 Mar 6). Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus. J Vis Exp. 2019 Mar 6;(145). doi: 10.3791/58990.

2018

Al-Hamad S, Hackam DJ, Goldstein SD, Huisman TAGM, Darge K, Hwang M. Contrast-Enhanced Ultrasound and Near-Infrared Spectroscopy of the Neonatal Bowel: Novel, Bedside, Noninvasive, and Radiation-Free Imaging for Early Detection of Necrotizing Enterocolitis. Am J Perinatol. 2018 Dec;35(14):1358-1365. doi: 10.1055/s-0038-1655768. Epub 2018 May 31.

Hwang M, Riggs B,  Saade-Lemus S, Huisman T. Bedside Contrast-Enhanced Ultrasound Diagnosing Cessation of Cerebral Circulation in a Neonate: A Novel Bedside Diagnostic Tool. Neuroradiol J. 2018 Dec;31(6):578-580. doi: 10.1177/1971400918795866. Epub 2018 Sep 7. 

Thimm MA, Rhee D, Takemoto CM, Karnsakul W, Cuffari C, Guerrerio AL, Garcia A, Gearhart J, Huisman TAGM, Hwang M (2018 Oct). Diagnosis of Congenital and Acquired Focal Lesions in the Neck, Abdomen, and Pelvis with Contrast-Enhanced Ultrasound: A Pictorial Essay. European Journal of Pediatrics, 177(10): 1459-1470. Doi: 10.1007/s00431-018-3197-8. PMID: 29971555. Electronically published: 2018 Jul 3.

Hwang M. Introduction to contrast-enhanced ultrasound of the brain in neonates and infants: current understanding and future potential. Pediatric Radiology 2018. Pediatr Radiol. 2018 Oct 23. doi: 10.1007/s00247-018-4270-1. [Epub ahead of print]

Hwang M, Riggs BJ, Saade-Lemus S, Huisman TAGM. Bedside contrast-enhanced ultrasound diagnosing cessation of cerebral circulation in a neonate: A novel bedside diagnostic tool. Neuroradiol J. 2018 Dec;31(6):578-580. doi: 10.1177/1971400918795866. Epub 2018 Sep 7.

Hwang M, Thimm MA, Guerrerio AL. Detection of cavernous transformation of the portal vein by contrast-enhanced ultrasound. J Ultrasound 2018 [Epub ahead of print]

Thimm M, Cuffari C, Garcia A, Hwang M. Contrast-Enhanced Ultrasound and Shear Wave Elastography Evaluation of Crohn’s Disease Activity in Three Adolescent Patients. Pediatric Gastroenterology, Hepatology & Nutrition 2018 [In press]

Back SJ, Maya C, Darge K, Acharya PT, Barnewolt CE, Coleman JL, Dillman JR, Fordham LA, Hwang M, Lim A, McCarville MB, Munden MM, Paltiel HJ, Volberg FM. Pediatric contrast-enhanced ultrasound in the United States: a survey by the Contrast-Enhanced Ultrasound Task Force of the Society of Pediatric Radiology. Pediatr Radiol 2018 [Epub ahead of print]

Shin SS, Huisman TAGM, Hwang M. Ultrasound Imaging for Traumatic Brain Injury. J Ultrasound Med 2018. [Epub ahead of print]

Shrot S, Hwang M, Stafstrom CE, Huisman TAGM, Soares BP. Dysplasia and overgrowth: magnetic resonance imaging of pediatric brain abnormalities secondary to alterations in the mechanistic target of rapamycin pathway. Neuroradiology. 2018;60(2):137-150.

2017

Hwang M, Riggs BJ, Katz J, Seyfert D, Northington F, Shenandoah R, Burd I, McArthur J, Darge K, Thimm MA, Huisman TAGM. Advanced Pediatric Neurosonography Techniques: Contrast-Enhanced Ultrasonography, Elastography, and Beyond. J Neuroimaging 2017;28:150-157.

Hwang M, de Jong RM, Herman RT, Boss R, Riggs B, Tekes A, Spevak M, Poretti A, Soares BP, Baily CR, Dunn E, Shin SS, Shrot S, Huisman TAGM. Novel Contrast Ultrasound Evaluation in Neonatal Hypoxic Ischemic Injury: Clinical Applications and Future Directions. J of Ultrasound Med 2017; 36:2379-2386.

Bailey C, Huisman TAGM, de Jong RM, Hwang M. Contrast-Enhanced Ultrasound and Elastography Imaging of the Neonatal Brain: A Review. J Neuroimaging 2017;27(5):437-441 PMID: 28419634

Hwang M, Tudorascu DL, Nunley K, Karim H, Aizenstein HJ, Orchard TJ, Rosano C. Corrigendum to “Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease. J Diabetes Res 2017:4295645.

Hwang M, Shin SS, Thimm MA, Ghodadra A, Sylvester CL, Nischal K, Panigrahy A, Zuccoli G. Apparent Diffusion Coefficient (ADC) of the vitreous humor and Susceptibility Weighted Imaging (SWI) of the retina in abused children with retinal hemorrhages. Clinical Imaging 2017;44:38-41.

Shin SS, Bales JW, Dixon E, Hwang M. Structural imaging of mild traumatic brain injury may not be enough: overview of functional and metabolic imaging of mild traumatic brain injury. Brain Imaging Behav 2017;11:591-610.

2016

Hwang M, Tudorascu D, Nunley K, Karim H, Aizenstein H, Orchard T, Ryan C, Rosano C. Brain activation and psychomotor speed in middle-aged patients with type I diabetes: relationships with hyperglycemia and brain small vessel disease. J. Diabetes Res 2016;1-11. PMID 26998494

Hwang M, Zuccoli G, Panigrahy A, Rodriguez D, Poe M, Escolar M. Thickening of the cauda equine roots: A common finding in Krabbe disease. Eur Radiol. 2016 Oct;26(10):3377-82. doi: 10.1007/s00330-016-4233-6. Epub 2016 May 2.

2015

Hwang M, Marovich R, Shin S, Chi D, and Branstetter B. Optimizing CT for the evaluation of vestibular aqueduct enlargement: Inter-rater reproducibility and predictive value of reformatted CT measurements. Journal of Otology 2015;10:13-17.

Hwang M and Zuccoli G. Autoimmune Labyrinthitis Associated with Ulcerative Colitis. Pediatric Neurology 2015;53:375-6.

2014

Rafay A, Matthew O, Hwang M, Lieberman F, Mountz J. Malignant Gliomas: Current Perspectives. Cancer Manag Res. 2014 Mar 24;6:149-70. doi: 10.2147/CMAR.S54726. eCollection 2014.

2012

Hwang M, Joyce J, Klein H, and Hou JZ. Unsuspected Pneumonia Detected by Increased Lung Uptake on In-111 Ibritumomab Tiuxetan Scan. Clinical Nuclear Medicine 2012;37:1003-5. PMID: 22955077.

2011

Kan H, Hwang M, Lowas SR, Hernanz-Schulman M. Impact of Pelvic CT on Staging, Surveillance, and Survival of Pediatric Patients with Wilms Tumor and Hepatoblastoma. American Journal of Roentgenology, 2011 May;196(5):W515-8. PMID: 21512039.

Speirs C, Hwang M, Kim S, Chang S, Varki V, Mitchell L, Schleicher S, Lu B. Harnessing the cell death pathway for targeted cancer treatment. Am J Cancer Res. 2011;1(1):43-61. PMID: 21969218.

Jaboin JJ, Hwang M, Perez C, Cooper C, Chen H, Ye C, Cai Q, Wills M, Lu B. No Evidence for Association of the MDM2-309 T/G Promoter Polymorphism with Prostate Cancer Outcomes. Urology Oncology, 2011 Jun;29(3):319-23. PMID 19523862.

Jaboin JJ, Hwang M, Lopater Z, Chen H, Ray GL, Perez C, Cai Q, Wills M, Lu B. The Matrix Metalloproteinase-7 polymorphism Rs10895304 is associated with increased recurrence risk in patients with clinically localized prostate cancer. International Journal of Radiation Oncology, Biology, Physics (IJROBP), 2011 Apr 1;79(5):1330-5. PMID 20605361.

Farrell M, Trivedi N, Romine L, Hwang M, Schrimmer D, Wan J, Do P, LaCoursiere Y, Hartney C, Benirschke K, Pretorius D. Prenatal Diagnosis of an Abnormal Placental Cord Insertion Site and Correlation With Neonatal Outcomes in Twins, J Ultrasound Med 30:S31, April 2011.

2010

Hwang M, Hariri G, Lyshchik A, Hallahan D, and Fleischer AC. Correlation of Quantified Contrast-Enhanced Sonography to In Vivo Tumor Response. Journal of Ultrasound in Medicine (JUM) 2010;29:597-607. PMID: 20375378

Hwang M, Lyshchik A, Fleischer AC. Molecular Sonography Using Targeted Microbubbles. Ultrasound Quarterly 2010;26:75-82. PMID: 20498563

Perez C, Chen H, Shyr Y, Courtney R, Zheng W, Cai Q, Hwang M, Jaboin J, Wills M, Smith J, Lu B. The EGFR Polymorphism rs884419 is Associated with Freedom from Recurrence in Patients with Resected Prostate Cancer. Journal of Urology 2010;183:2062-2069. PMID: 20303520

2009

Hwang M, Niermann K, Lyshchik A, and Fleischer AC. Sonographic Assessment of Tumor Vasculature from In Vivo Models to Clinical Applications. Ultrasound Quarterly 2009;25:175-83. PMID: 19956050

Hwang M, Moretti L and Lu B. HSP90 Inhibitors: Multi-Targeted Antitumor Effects and Novel Combinatorial Therapeutic Approaches in Cancer Therapy. Curr Med Chem 2009;16-24:3081-3092. PMID: 19689285 

Sasi N, Hwang M, Jaboin JJ, Csiki L, Lu B. Regulated Cell Death Pathways: New Twists in Modulation of BCL2 Family Function. Mol Cancer Therapeutics. 2009;8(6):1421-9. PMID: 19509269

Fleischer A, Lyshchik A, Andreotti R, Hwang M, Jones H, Fishman D. Advances in Sonographic Detection of Ovarian Cancer: Depiction of Tumor Neovascularity with Microbubbles. American Journal of Roentgenology (AJR) 2009;194:343-8. PMID: 20093594

2008

Hwang M, Perez CA, Moretti L, Lu B: The mTOR signaling network: insights from its role during embryonic development. Curr Med Chem 2008;15:1192-1208.

Hwang M*, Kim KW*, Moretti L, Jaboin JJ, Cha YI, Lu B: Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 2008;4:659-668. *Equal contribution PMID: 18424912

2007

Hwang M, Yong C, Moretti L, Lu B. Zebrafish as a Model System to Screen Radiation Modifiers. Curr Genomics, 2007;vol 8, no 6:360-369. PMID: 19412436

Abstracts

2022

Haddad S, Alves CA, Tierradentro-Garcia LO, Vossough A, Hwang M: Normative measurements of the choroid plexus in neonates-preliminary study. ASPNR, 2022.

2021

Angela Viaene and Misun Hwang: Post-cardiac arrest cerebral microthrombi in infants. American Association of Neuropathologists January 2021.

Kristina Khaw, Anush Sridharan, Todd Kilbaugh, Misun Hwang: Evaluating contrast-enhanced ultrasound derived cerebral blood flow and elastography correlations in a pediatric porcine model of asphyxia associated cardiac arrest. American Institute of Ultrasound in Medicine April 2021.

Shauna Dougherty, Elizabeth Brennan, Trudy Morgan, Brandi Kozak, Misun Hwang: Microflow and lenticulostriate vessels of the neonatal brain. American Institute of Ultrasound in Medicine April 2021.

Colbey W. Freeman, Sunil Unnikrishnan, Anush Sridharan, Danielle Aronowitz, Julia C. Slovis, Todd Kilbaugh, Misun Hwang: Contrast-enhanced ultrasound in a porcine model of pediatric extracorporeal membrane oxygenation. Pendergrass Symposium, Department of Radiology at University of Pennsylvania  June 2021.

Zeng Zhang, Misun Hwang, Todd Kilbaugh, Anush Sridharan, Joseph Katz: Visualization and Quantification of the Cerebral Microcirculation using Contrast-enhanced Ultrasound Particle Tracking Velocimetry. 14th International Symposium on Particle Image Velocimetry August 2021.

Kristina Khaw, Anush Sridharan, Todd Kilbaugh, Misun Hwang: Evaluating brain elastography correlations in a pediatric porcine model of asphyxia associated cardiac arrest. International Pediatric Radiology Congress October 2021.

Luis Octavio Tierrandentro-Garcia, Rebecca Dennis, Asef Khwaja, Makhethe Vuma, Alireza Zandifar, Kassa Darge, Sudha Anupindi, Thane A. Blinman, Misun Hwang: Diagnosing midgut volvulus in infants. International Pediatric Radiology Congress October 2021.

Makhethe Vuma, Luis O. Tierradentro-García, Rebecca Dennis, Asef Khwaja1, Alireza Zandifar, Kassa Darge, Rebecca Dennis, Asef Khwaja, Sudha Anupindi, Thane A. Blinman, Misun Hwang: Diagnostic efficiency of ultrasound for intestinal malrotation in infants: experience from a tertiary children's hospital. International Pediatric Radiology Congress October 2021.

Misun Hwang, Luis Octavio Tierrandentro-Garcia, Laura Poznick, Todd Kilbaugh, Kathleen Chiotos: Contrast-enhanced ultrasound (CEUS) in three patients with Multisystem Inflammatory Syndrome in Children (MIS-C). International Pediatric Radiology Congress October 2021.

Shawn Lyo, Luis Octavio Tierradentro Garcia, Angela Viaene, Misun Hwang: High-Resolution Neurosonographic Examination of the Lenticulostriate Vessels in Neonates with Hypoxic-Ischemic Encephalopathy. International Pediatric Radiology Congress October  2021.

Luis O. Tierradentro-Garcia, Rebecca Dennis, Asef Khwaja, Makhethe Vuma, Zandifar Alireza, Kassa Darge, Sudha Anupindi, Thane A. Blinman: Diagnosing midgut volvulus in infants. Pendergrass Symposium 2021.

Shawn Lyo, Luis O. Tierradentro-Garcia, Cesar Alves, Misun Hwang: Neurosonographic Vascular Anatomy As Depicted With Microflow Imaging. Radiological Society of North America 2021.

2020

Rajarshi Chattaraj, Serge D. Zemerov, Ivan J. Dmochowski, Misun Hwang, Daniel A. Hammer, Chandra M. Sehgal, Daeyeon Lee: Ultrasound Responsive Noble Gas Microbubbles. Biomedical Engineering Society annual meeting October 2020.

2019

Zheng Q, Ouyang M, Marin-Saavedra JS, Saade-Lemus S, Yu Q, Sze RW, Flibotte J, Detre J, Huang H, Hwang M. Increased brain perfusion in neonatal hypoxic ischemic injury with negative reading of DWI, T1/T2-weighted images: Implications of perfusion MRI for reperfusion response monitoring and prognostication. ISMRM. Montreal, May 2019.

Cort K, Edgar C, Otero H, Nguyen J, Johnson A, Victoria T, White A, Hwang M. Towards implementing brain contrast enhanced ultrasound in the clinical setting: the impact of didactic session on normal brain perfusion. Society of Pediatric Radiology. San Francisco, May 2019.

Cort K, Piskunowicz M, Hwang M. Contrast-enhanced ultrasound for the evaluation of neonatal brain injury: Techniques and protocols. Society of Pediatric Radiology. San Francisco, May 2019.

White SA, Dennis R, Back S, Hwang M. Beyond liver lesions and vesicoureteral reflux: contrast-enhanced ultrasound as an emerging problem-solving tool for pediatric radiologists. Society of Pediatric Radiology. San Francisco, May 2019.

Sridharan A, Darge K, Huisman T, Hwang M. The importance of “wash-out” kinetics of contrast-enhanced ultrasound for diagnosis of diffuse hypoxic ischemic injury in neonates and infants: preliminary impressions. Society of Pediatric Radiology. San Francisco, May 2019.

Dennis B, Andronikous S, Hill L, Hwang M. Development of a 3D ultrasound phantom for trainee education. Society of Pediatric Radiology. San Francisco, May 2019.

Zheng Q, Marin-Saavedra JS, Ouyang M, Saade-Lemus S,Yu Q, Huang H, Sze RW, Hwang M. Region specific perfusion alterations in neonatal hypoxic ischemic injury evaluated with arterial spin labeling (ASL) MRI. Society of Pediatric Radiology. San Francisco, May 2019.

Zheng Q, Ouyang M, Marin-Saavedra JS, Saade-Lemus S,Yu Q, Huang H, Sze RW, Hwang M. Altered brain perfusion in neonatal hypoxic ischemic injury in the setting of normal DWI, T1, and T2 sequences: Implications of perfusion-based imaging for reperfusion response monitoring and prognostication. Society of Pediatric Radiology. San Francisco, May 2019.

Zheng Q, Ouyang M, Marin-Saavedra JS, Saade-Lemus S,Yu Q, Huang H, Sze RW, Hwang M. Quantitative ASL perfusion method for Detection of Neonatal Hypoxic Ischemic Injury as Reference Standard for Developing Contrast-Enhanced Ultrasound. Society of Pediatric Radiology. San Francisco, May 2019.

 

Books

Chapters

2021

Hwang M: Recent Advances in Neonatal CEUS. Contrast-Enhanced Ultrasound in Pediatric Imaging. Sidhu PS, Sellars ME, Deganello A (eds.). Springer, Page: 265-275, 2021.

2014

Hwang M, Oborski M, Laymon C, Imani F, Mountz J. Quantitative Brain Imaging: Assessing Therapy Responses. Biomedical Imaging: Applications and Advances. Elsevier Science, Philadelphia, PA. Ed 2014.

Raay A, Matthew O, Hwang M, Lieberman F, Mountz J. Malignant Gliomas: Current Perspectives. Cancer Management and Research. Ed 2014.

2012

Hwang M, Imani F, Mountz J. Brain Imaging: Role of Quantitative Image Biomarkers for the Assessment of Therapy Response in Brain Tumor. Biomedical Imaging: Applications and Advances, Woodhead Publishing, 2012.

2011

Csiki I, Hwang M, Kirby W, Crass J, Ding G, Coffey C, Lu B. Chapter 17D: Use of the Breath-Hold Cone Beam CT in the Stereotactic Radiosurgical Treatment of Stage I Non-Small Cell Lung Cancer Patient. Image-Guided Radiation Therapy (IGRT): A Clinical Perspective. Ed 2011.

2010

Moretti L, Sebahat O, Hwang M, Lu B, Hallahan D. Chapter 14: Cell Cycle and Vascular Targets for Radiotherapy. Lung Cancer: Principles and Practice. Ed 2010.

2009

Jaboin JJ, Hwang M, Lu B. Autophagy in Lung Cancer. Methods in Enzymology. Elsevier Inc, 2009, vol 453, 287-304. PMID: 19216912

Posters and Presentations

2022

Haddad S, Foran A, Tierradentro-Garcia L, Ho Fung V, Hwang M: Brain ultrasound using microvascular imaging documents reperfusion injury in hypoxic ischemic encephalopathy. The Society for Pediatric Radiology, Annual Meeting & Postgraduate Course, Denver, CO April - May 2022 Notes: Case Report Poster (accepted December 2022).

Haddad S, Linn R, Hwang M: Feasibility of Contrast-enhanced Ultrasound for Assessing the Fetal Placental Microvascular Architecture in an Ex-Vivo Placenta  The Society for Pediatric Radiology, Annual Meeting & Postgraduate Course, Denver, CO April - May 2022 Notes: Oral Present (accepted December 2021).

Foran A, Tierradentro-Garcia L, Haddad S, Clough E, Hwang M: Brain Ultrasound Using Microvascular Imaging to Assess Cerebral Blood Flow in Neonatal Hydrocephalus. The Society for Pediatric Radiology, Annual Meeting & Postgraduate Course, Denver, CO 2022 Notes: Oral scientific presentation (accepted December 2021).

2021

Kristina Khaw, Anush Sridharan, Sunil Unnikrishnan, Todd Kilbaugh, Misun Hwang: Evaluating contrast-enhanced ultrasound derived cerebral blood flow and elastography correlations in a pediatric porcine model of asphyxia associated cardiac arrest. American Institute of Ultrasound in Medicine Annual Meeting, Virtual Meeting April 2021 Notes: Accepted for presentation February, 2021.

Tierradentro-Garica LO, Dennis R, Khwaja A, Vuma M, Zandifar A, Darge K, Anupindi S, Blinman TA, Hwang M: Diagnosing midgut volvulus in infants. University of Pennsylvania Symposium, Philadelphia, PA June 2021 Notes: Oral presentation - received summa cum laude designation.

Hwang M,  Tierradentro-García LO, Poznick L, Kilbaugh T, Chiotos K: Contrast-enhanced ultrasound (CEUS) in three patients with multisystem inflammatory syndrome in children (MIS-C). International Pediatric Radiology Congress (IPR), Rome, Italy October 2021 Notes: Poster presentation.

Lyo S, Tierradentro-Garcia L, Alves C, Hwang M: A Pictorial Review Of Neurosonographic Vascular Anatomy As Depicted With Microflow Imaging. Radiological Society of North America, Chicago, IL November-December 2021 Notes: Educational Exhibit (electronic poster).

2020

Khaw K, Sridharan A, Delso N, Roberts AL, Landis WP, Poznick L, Kilbaugh TJ, Hwang M: Comparing invasive and non-invasive hemodynamic monitoring and contrast-enhanced ultrasound methods of measuring vascular changes in a pediatric porcine model of asphyxia-associated cardiac arrest. American Institute of Ultrasound in Medicine (AIUM) Annual Meeting, New York, NY March 2020 Notes: Oral presentation.

Goncalves FG, Zheng Q, Hwang M: Quantitative evaluation of the brain echogenicity in hypoxic-ischemic encephalopathy compared with controls. Society for Pediatric Radiology Annual Meeting & Postgraduate Course, Miami, FL May 2020 Notes: Oral presentation canceled due to COVID-19.

Khaw, K., Sridharan, A., Poznick, L., Hwang, M.: Evaluating the correlation between bolus perfusion kinetics using contrast-enhanced ultrasound and intracranial pressure in a pediatric porcine model of asphyxia-associated cardiac arrest. Society for Pediatric Radiology Annual Meeting & Postgraduate Course, Miami, FL May 2020 Notes: Oral presentation (cancel due to COVID-19).

Khaw, K., Sridharan, A., Poznick, L., Kilbaugh, T., Hwang, M.: Evaluating the correlation between doppler ultrasound parameters and invasive hemodynamic measurements in a pediatric porcine model of asphyxia-associated cardiac arrest. Society for Pediatric Radiology Annual Meeting & Postgraduate Course, Miami, FL May 2020 Notes: Oral presentation (canceled due to COVID-19).

Zheng Q, Viaene AN, Freeman CW, Hwang M: Radiologic-pathologic evidence of brain injury: Hypoperfusion in the Papez circuit results in poor neurodevelopmental outcomes in neonatal hypoxic ischemic encephalopathy. Society for Pediatric Radiology Annual Meeting & Postgraduate Course, Miami, FL May 2020 Notes: Oral presentation - canceled due to COVID-19.

Choi J, Sridharan A, Poznick L, Kilbaugh T, Hwang M: Contrast-Enhanced ultrasound evaluation of intracranial pressure in porcine model of hydrocephalus. Pendergrass Day Symposium, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (Virtual Meeting) June 2020 Notes: Virtual oral presentation.

Zheng Q, Zhao C, Ouyang M, Vossough A, Zuccoli J, Sze RW, Huang H, Hwang M: Decreased fractional anisotropy in the diffusion tensor imaging of neonatal hypoxic ischemic encephalopathy with normal conventional MRI. International Society for Magnetic Resonance in Medicine (ISMRM) & SMRT Conference & Exhibition (Virtual Meeting) August 2020 Notes: Virtual oral presentation.

Chattaraj R, Zemerov SD, Dmochowski IJ, Hwang M, Hammer DA, Sehgal C, Lee D: Ultrasound responsive noble gases. Biomedical Engineering Society Annual Meeting (Virtual Meeting) October 2020 Notes: Virtual oral presentation.

Zhang Z, Katz J, Hwang M, Kilbaugh T: Cerebral Vascular Super Resolution Imaging and Blood Flow Measurement Using Ultrasound Enhanced Particle Tracking Velocimetry. Annual Meeting of the American Physical Society (APS), Seattle, WA (Virtual Meeting) November 2020 Notes: Virtual oral presentation.

Choi J, Sridharan A, Poznick L, Kilbaugh T, Hwang M: Contrast-Enhanced Ultrasound Evaluation of Intracranial Pressure in Porcine Model of Hydrocephalus. Radiological Society of North America Annual Meeting, Chicago, IL (Virtual Meeting) December 2020 Notes: Virtual oral presentation.

Viane, A, Hwang, M: Microthrombi and decreased cerebral microvascular blood flow in infants with cardiac arrest. Annual Meeting of the American Association of Neuropathologists (Virtual Meeting) December 2020 Notes: Virtual oral presentation.

Invited Lectures

2022

Hwang M. Academic career in translational imaging research, University of Pennsylvania Radiology Residency Research Track Invited Lecture Series. 2022

Hwang M. Fetal and Neonatal Brain US, Society of Pediatric Radiology Annual Meeting, Virtual. Jan 2022.

2021

Hwang M. "Head US cerebral perfusion with microbubbles", Pediatric Neurocritical Care Research Group (PNCRG) Multimodality Neuromonitoring Minisymposium, virtual conference. Nov 2021.

Hwang M. Brain CEUS in Neonatal Hydrocephalus, ICUS, Chicago IL. Oct 2021.

Hwang M. Distinguished Invited Guest, "Neonatal Brain Swelling", Advanced Neuro Ultrasonography in Neonates, The 52nd Annual Congress of Korean Society of Ultrasound in Medicine (KSUM 2021), Coex, Seoul, Korea (virtual). May 2021.

Hwang M. Distinguished Invited Guest, "Neonatal brain contrast-enhanced ultrasound and elastography", Advanced Neuro Ultrasonography in Neonates, The 52nd Annual Congress of Korean Society of Ultrasound in Medicine (KSUM 2021), Coex, Seoul, Korea (virtual). May 2021.

Hwang M. "Preterm Brain Ultrasound", Society for Pediatric Radiology, Neonatal Imaging Online Course. Jan 2021.

2020

Hwang M. "Brain CEUS and elastography", American Institute of Ultrasound in Medicine (AIUM), Miami, FL. May 2020.

2019

Hwang M. "Updates on Neonatal CEUS", International Bubble Conference, Chicago, IL. Sept 2019.

Hwang M. "Neonatal Updates", 34th Annual Advances in Contrast Ultrasound International Bubble Conference, Chicago, IL. Sept 2019.

Hwang M. "Introduction to Contrast-Enhanced Ultrasound", Texas Children's Hospital, Pediatric Radiology, Houston, TX. Aug 2019.

Hwang M. "CEUS in neonatal brain", 5th International Pediatric CEUS Course, London, UK. Jun 2019.

Hwang M. "Contrast US of the brain", Society for Pediatric Radiology Annual Meeting, San Francisco, CA. May 2019.

Hwang M. "Contrast US of the Brain", Society for Pediatric Radiology annual meeting, San Francisco, CA. May 2019.

Hwang M. "Neonatal Applications of Contrast-Enhanced Ultrasound", Session: How to Develop a Pediatric Ultrasound Contrast Service, American Institute of Ultrasound in Medicine (AIUM), Orlando, FL. Apr 2019.

Hwang M. "Quantitative Detection of Brain Injury with Contrast-Enhanced Ultrasound in Neonates and Infants", American Institute of Ultrasound in Medicine (AIUM), Orlando, FL. Apr 2019.

Hwang M. "Quantitative CEUS techniques for detection and prognostication of neonatal brain injury", Ultrasound Contrast Research, Dallas, TX. Feb 2019.

Hwang M. "CEUS in neonatal brain: quantitative techniques for diagnosis and prognostication", 24th European Symposium on Ultrasound Contrast Imaging, Rotterdam, Netherlands. Jan 2019.

Awards and Honors

2019, First Place Winner, New Investigator Competition at American Institute of Ultrasound in Medicine (AIUM)
2018-2020, NIH CTSI KL2 Awardee, University of Pennsylvania
2017-2018, Research Scholar, Radiologic Society of North America
2010, Roentgen Award, Vanderbilt Medical School, Nashville, TN
2010, Finalist, AIUM New Investigator Award Competition, San Diego, CA

Editorial and Academic Positions

Editorial Positions

2016-present, Reviewer, American Journal of Neuroradiology
2016-present, Reviewer, Radiology
2016-present, Reviewer, Pediatric Radiology
2016-present, Reviewer, Journal of Ultrasound in Medicine

Academic and Institutional Committees

2021-present, Radiology Research Committee
2021-present, Selection Committee, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania

Leadership and Memberships

Memberships in Professional Organizations

International

2021-present, European Society of Paediatric Radiology
2018-present, International Contrast Ultrasound Society
2017-present, Radiological Society of North America

National

2018-present, American Institute of Ultrasound in Medicine
2017-present, Society of Pediatric Radiology
 - 2018-present, Neonatal Imaging Committee
 - 2017-present, Contrast Enhanced Ultrasound Task Force
2016-present, American College of Radiology
2013-present, American Roentgen Ray Society
 - 2021, Categorical Course Faculty