Soma Jyonouchi, MD

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Soma Jyonouchi, MD, is an attending physician with the Division of Allergy and Immunology and the Center for Cornelia de Lange Syndrome and Related Diagnoses at Children's Hospital of Philadelphia.

Areas of Expertise: Immunodeficiency in Cornelia de Lange syndrome and other genetic syndromes, Asthma
Locations: Buerger Center for Advanced Pediatric Care

Education and Training

Medical School

MD - Medical College of Wisconsin, Milwaukee, WI


Pediatrics - Children's Hospital and Research Center at Oakland, Oakland, CA


Allergy and Immunology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Allergy and Immunology – American Board of Allergy and Immunology
Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics Perelman School of Medicine University of Pennsylvania

Conditions Treated

Departments and Services




Primary immunodeficiency considerations in assisted reproductive technology. Sun D. Capucilli P, Jyonouchi S. J Allergy Clinical Immunol Pract 2020 Feb;8(2) 747-747-749. DOI: 10.1016/j.jaip.2019.07.008. Pub 2019 Jul 18.


Immunodeficiencies Associated with Abnormal Newborn Screening for T Cell and B Cell Lymphopenia. Jyonouchi S, Jongco AM, Puck J, Sullivan KE. J Clin Immunol. 2017 May;37(4):363-374. DOI: 10.1007/s10875-017-0388-4 Epub 2017 Mar 28

Phase 1 trial of low-dose interleukin 2 therapy in patients with Wiskott-Aldrich syndrome. Jyonouchi S, Gwafila B, Gwalani LA, Ahmad, M, Moertel C, Holbert C, Kim JY, Kobrinsky N, Roy-Ghanta S, Orange JS. Clin Immunol. 2017 Jun;179:47-53. DOI: 10.1016/j.clim.2017.02.001. Pub 2017 Feb 14. PMID: 2823030. Clinical Trial. 


Pedroza LA, Kumar V, Sanborn KB, Mace EM, Niinkoski H, Nadeau K, et al. Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1. J Allergy Clin Immunol. Epub 2011 Sep 28. Cited in PubMed; PMID 21962774.

Jyonouchi S, Abraham V, Orange JS, Spergel JM, Gober L, Dudek E, et al. Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin. J Allergy Clin Immunol. 2011 Jul;128(1):102-109.e13. Epub 2011 Apr 1. Cited in PubMed; PMID 21458849.

Jyonouchi S, Forbes L, Ruchelli E, Sullivan KE. Dyskeratosis congenita: a combined immunodeficiency with broad clinical spectrum--a single-center pediatric experience. Pediatr Allergy Immunol. 2011 may;22(3):313-9. doi: 10.1111/j.1399-3038.2010.01136.x. Epub 2011 Feb 1. Cited in PubMed; PMID 21284747.


Jyonouchi S, McDonald-McGinn DM, Bale S, Zackai EH, Sullivan KE. CHARGE (colomba, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chromosome 22q11.2 deletion syndrome: a comparison of immunologic and nonimmunologic phenotypic features. Pediatrics. 2009 May;123(5):3871-7. Cited in PubMed; PMID 19403480.

Jyonouchi S, Brown-Whitehorn TA, Spergel JM. Association of eosinophilic gastrointestinal disorders with other atopic disorders. Immunol Allergy Clin North Am. 2009 Feb;29(1):85-97, x. Cited in PubMed; PMID 19141344.

Posters and Presentations


Jyonouchi S. Primary immunodeficiency and genetics [presentation]. Arcadia University Genetic Counseling Masters Program; 2011 Apr 14; Glenside, PA.