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Soma Jyonouchi, MD
Soma Jyonouchi, MD

Soma Jyonouchi, MD

Soma Jyonouchi, MD, is an attending physician with the Division of Allergy and Immunology and the Center for Cornelia de Lange Syndrome and Related Diagnoses at Children's Hospital of Philadelphia.

Areas of expertise: Immunodeficiency in Cornelia de Lange syndrome and other genetic syndromes, Asthma

Locations: Buerger Center for Advanced Pediatric Care

Make an appointment

215-590-2549

About Soma Jyonouchi, MD

Titles

Attending Physician

Assistant Professor of Pediatrics Perelman School of Medicine University of Pennsylvania

Certifications

Allergy and Immunology – American Board of Allergy and Immunology

Pediatrics – American Board of Pediatrics

Education & training

Medical Degree

MD - Medical College of Wisconsin, Milwaukee, WI

Residency

Pediatrics - Children's Hospital and Research Center at Oakland, Oakland, CA

Fellowship

Allergy and Immunology - The Children's Hospital of Philadelphia, Philadelphia, PA

Team affiliations

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Publications

Publications

2019

Primary immunodeficiency considerations in assisted reproductive technology. Sun D. Capucilli P, Jyonouchi S. J Allergy Clinical Immunol Pract 2020 Feb;8(2) 747-747-749. DOI: 10.1016/j.jaip.2019.07.008. Pub 2019 Jul 18.

2017

Immunodeficiencies Associated with Abnormal Newborn Screening for T Cell and B Cell Lymphopenia. Jyonouchi S, Jongco AM, Puck J, Sullivan KE. J Clin Immunol. 2017 May;37(4):363-374. DOI: 10.1007/s10875-017-0388-4 Epub 2017 Mar 28

Phase 1 trial of low-dose interleukin 2 therapy in patients with Wiskott-Aldrich syndrome. Jyonouchi S, Gwafila B, Gwalani LA, Ahmad, M, Moertel C, Holbert C, Kim JY, Kobrinsky N, Roy-Ghanta S, Orange JS. Clin Immunol. 2017 Jun;179:47-53. DOI: 10.1016/j.clim.2017.02.001. Pub 2017 Feb 14. PMID: 2823030. Clinical Trial. 

2011

Pedroza LA, Kumar V, Sanborn KB, Mace EM, Niinkoski H, Nadeau K, et al. Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1. J Allergy Clin Immunol. Epub 2011 Sep 28. Cited in PubMed; PMID 21962774.

Jyonouchi S, Abraham V, Orange JS, Spergel JM, Gober L, Dudek E, et al. Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin. J Allergy Clin Immunol. 2011 Jul;128(1):102-109.e13. Epub 2011 Apr 1. Cited in PubMed; PMID 21458849.

Jyonouchi S, Forbes L, Ruchelli E, Sullivan KE. Dyskeratosis congenita: a combined immunodeficiency with broad clinical spectrum--a single-center pediatric experience. Pediatr Allergy Immunol. 2011 may;22(3):313-9. doi: 10.1111/j.1399-3038.2010.01136.x. Epub 2011 Feb 1. Cited in PubMed; PMID 21284747.

2009

Jyonouchi S, McDonald-McGinn DM, Bale S, Zackai EH, Sullivan KE. CHARGE (colomba, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chromosome 22q11.2 deletion syndrome: a comparison of immunologic and nonimmunologic phenotypic features. Pediatrics. 2009 May;123(5):3871-7. Cited in PubMed; PMID 19403480.

Jyonouchi S, Brown-Whitehorn TA, Spergel JM. Association of eosinophilic gastrointestinal disorders with other atopic disorders. Immunol Allergy Clin North Am. 2009 Feb;29(1):85-97, x. Cited in PubMed; PMID 19141344.

Patient experience rating

(based on 131 submissions)
  • Provider listened carefully
    4.6 of 5
  • Trust provider with care
    4.6 of 5
  • Provider gave enough info about child's health
    4.6 of 5
  • Would recommend the provider
    4.7 of 5
Learn about the patient experience rating system

Comments

  • Dr.Soma, is amazing. Very educated doctor and kind. The visit was quicker than I thought it would be.
    5 of 5
    Aug 28, 2026

  • Soma DR is great , I am appreciate
    5 of 5
    Aug 13, 2026

  • The doctor was smart, very kind, explained things well, and answered all of my questions. He was one of the best doctors at CHOPS.
    5 of 5
    Aug 06, 2026

  • The provider was a great doctor who gave my son very attentive and caring attention. The doctor was very informative the whole visit. The nurses and staff were also excellent as well. Overall, my son had a great experience at CHOP as always, and we were able to resolve his issues at that current visit. And I look forward to his next future appointments with the same doctor, and I look forward to seeing the nurses and staff again. Thank you.
    5 of 5
    Jul 15, 2026

  • He listened to everything I had to say and responded to each concern with respect and understanding. I left the appointment feeling like I had a plan for my daughter.
    5 of 5
    Jul 01, 2026

  • Very friendly. Made us feel comfortable. My son was anxious and nervous.
    5 of 5
    Jun 29, 2026
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About the Patient Experience Rating System

The patient experience rating is an average of all responses to the care provider-related questions from surveys submitted by patient families and verified by our survey partner National Research Corporation (NRC Health), an independent company that specializes in patient experience. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question. Responses are measured using percent positive scoring. Percent positive is the percentage of respondents who answered with the most desirable response. We are committed to transparency and sharing the voices of our patients and families. Comments are reviewed before posting to ensure accuracy, privacy, and relevance. To provide meaningful feedback, comments are displayed on provider profiles once a sufficient number have been received. All feedback is also shared internally to support learning, recognition, and continuous improvement. The comments reflect the experiences and perspectives of the patients and families who submitted them. The comments are not endorsed by and do not reflect the views of Children’s Hospital of Philadelphia.