Judith R. Kelsen, MD

Papers

2020

Liang G, Conrad MA, Kelsen JR, Kessler LR, Breton J, Albenberg LG, Marakos S, Galgano A, Devas N, Erlichman J, Zhang H, Mattei L, Bittinger K, Baldassano RN, Bushman FD: The dynamics of the stool virome in very early onset inflammatory bowel disease. J Crohns Colitis May 2020

Kerur B, Benchimol EI, Fiedler K, Stahl M, Hyams J, Stephens M, Lu Y, Pfefferkorn M, Alkhouri R, Strople J, Kelsen J, Siebold L, Goyal A, Rosh JR, LeLeiko N, Van Limbergen J, Guerrerio AL, Maltz R, Karam L, Crowley E, Griffiths A, Heyman MB, Deneau M, Benkov K, Noe J, Mouton D, Pappa H, Galanko JA, Snapper S, Muise AM, Kappelman MD: Natural History of  Very Early Onset Inflammatory Bowel Disease in North America: A Retrospective Cohort Study. Inflamm Bowel Dis May 2020

2019

Breton J, Kastl A, Hoffmann N, Rogers R, Grossman AB, Mamula P, Kelsen JR, Baldassano RN, Albenberg L.: Efficacy of Combination Antibiotic Therapy for Refractory Pediatric Inflammatory Bowel Disease. IBD Feb 2019.

Taylor DM, Aronow BJ, Tan K, Bernt K, Salomonis N, Greene CS, Frolova A, Henrickson SE, Wells A, Pei L, Jaiswal JK, Whitsett J, Hamilton KE, MacParland SA, Kelsen J, Heuckeroth RO, Potter SS, Vella LA, Terry NA, Ghanem LR, Kennedy BC, Helbig I, Sullivan KE, Castelo-Soccio L, Kreigstein A, Herse F, Nawijn MC, Koppelman GH, Haendel M, Harris NL, Rokita JL, Zhang Y, Regev A, Rozenblatt-Rosen O, Rood JE, Tickle TL, Vento-Tormo R, Alimohamed S, Lek M, Mar JC, Loomes KM, Barrett DM, Uapinyoying P, Beggs AH, Agrawal PB, Chen YW, Muir AB, Garmire LX, Snapper SB, Nazarian J, Seeholzer SH, Fazelinia H, Singh LN, Faryabi RB, Raman P, Dawany N, Xie HM, Devkota B, Diskin SJ, Anderson SA, Rappaport EF, Peranteau W, Wikenheiser-Brokamp KA, Teichmann S, Wallace D, Peng T, Ding YY, Kim MS, Xing Y, Kong SW, Bönnemann CG, Mandl KD, White PS: The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Dev Cell March 2019.

Conrad MA, Carreon CK, Dawany N, Russo P, Kelsen JR: Distinct histopathological features at diagnosis of very early onset inflammatory bowel disease. J Crohns and Colitis April 2019.

Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY.: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med April 2019.

Nicholson MR, Mitchell PD, Alexander E, Ballal S, Bartlett M, Becker P, Davidovics Z, Docktor M, Dole M, Felix G, Gisser J, Hourigan SK, Jensen MK, Kaplan JL, Kelsen J, Kennedy M, Khanna S, Knackstedt E, Leier M, Lewis J, Lodarek A, Michail S, Oliva-Hemker M, Patton T, Queliza K, Russell GH, Singh N, Solomon A, Suskind DL, Werlin S, Kellermayer R, Kahn SA: Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children. Clin Gastroenterol Hepatol April 2019.

Zhou L, Chu C, Teng F, Bessman NJ, Goc J, Santosa EK, Putzel GG, Kabata H, Kelsen JR, Baldassano RN, Shah MA, Sockolow RE, Vivier E, Eberl G, Smith KA, Sonnenberg GF.: Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature April 2019.

Kelsen JR, Conrad MA, Dawany N, Patel T, Shraim R, Merz A, Maurer K, Sullivan KE, Devoto M.: The Unique Disease Course of Children with Very Early onset-Inflammatory Bowel Disease. Inflammatory Bowel Disease September  2019.

2018

O'Connell AE, Zhou F, Shah MS, Murphy Q, Rickner H, Kelsen J, Boyle J, Doyle JJ, Gangwani B, Thiagarajah JR, Kamin DS, Goldsmith JD, Richmond C, Breault DT, Agrawal PB.: Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 103(1): 131-137, July 2018.

Clarke EL, Connell AJ, Six E, Kadry NA, Abbas AA, Hwang Y, Everett JK, Hofstaedter CE, Marsh R, Armant M, Kelsen J, Notarangelo LD, Collman RG, Hacein-Bey-Abina S, Kohn DB, Cavazzana M, Fischer A, Williams DA, Pai SY, Bushman FD.: T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency. Genome Medicine 10, September  2018.

Dunn K, Pasternak B, Kelsen JR, Sullivan KE, Dawany N, Wright BL.: Mevalonate kinase deficiency presenting as recurrent rectal abscesses and perianal fistulae. Ann Allergy Asthma Immunol 2018.

Mao L, Kitani A, Similuk M ,Oler AJ, Albenberg L , Kelsen J, Aktay A, Quezado M, Yao M, Montgomery-Recht K, Fuss IJ, Strober W: Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease. J Clin Invest 2018.

2017

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM: Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition. J. Allergy Clin Immunol. 139(5): 1698-1701, May 2017.

Schwerd T, Bryant RV, Pandey S, Capitani M, Meran L, Cazier JB, Jung J, Mondal K, Parkes M, Mathew CG, Fiedler K, McCarthy DJ; WGS500 Consortium; Oxford IBD cohort study investigators; COLORS in IBD group investigators; UK IBD Genetics Consortium, Sullivan PB, Rodrigues A, Travis SPL, Moore C, Sambrook J, Ouwehand WH, Roberts DJ, Danesh J; INTERVAL Study, Russell RK, Wilson DC, Kelsen JR, Cornall R, Denson LA, Kugathasan S, Knaus UG, Serra EG, Anderson CA, Duerr RH, McGovern DP, Cho J, Powrie F, Li VS, Muise AM, Uhlig HH.: NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease. Mucosal Immunology Page: doi: 10.1038, November 2017 Notes: Epub ahead of print.

Máire A. Conrad MD, MS1,2*, Noor Dawany PhD3, Kathleen E. Sullivan MD, PhD2,4, Marcella Devoto PhD2,5,6,7, Judith R. Kelsen MD1,2 : Novel ZBTB24 mutation associated with immunodeficiency, centromere instability, and facial anomalies type 2 syndrome identified in a patient with very early onset inflammatory bowel disease. Inflammatory Bowel Disease 23(12): 2252-2255, December 2017.

Maxwell E, Dawany N, Baldassano RN, _ Mamula P, Mattei P, Albenberg L, Kelsen JR: Diverting Ileostomy for the Treatment of Severe, Refractory, Pediatric Inflammatory Bowel Disease. JPGN January 2017.

2016

Zhe Zhang, Ph.D.; Lihua Shi, Ph.D.; Noor Dawany; Judith Kelsen; Michelle A Petri, MD MPH; Kathleen E Sullivan, MD PHD: H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus. Clinical Epigenetics 2016.

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM: Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition. J. Allergy Clin Immunol. November 2016.

Conrad MA1, Stein RE, Maxwell EC, Albenberg L, Baldassano RN, Dawany N, Grossman AB, Mamula P, Piccoli DA, Kelsen JR.: Vedolizumab Therapy in Severe Pediatric Inflammatory Bowel Disease. Inflamm Bowel Dis October 2016.

Rosenbaum DG, Conrad MA, Biko DM, Ruchelli ED, Kelsen JR, Anupindi SA: Ultrasound and MRI predictors of surgical bowel resection in pediatric Crohn disease. Pediatr Radiol September 2016.

Rona Yaeger, Manish A. Shah, Vincent A. Miller, Judith R. Kelsen, Kai Wang, Zachary J. Heins, Jeffrey S. Ross, Yuting He, Eric Sanford, Rhonda K. Yantiss, Sohail Balasubramanian, Philip J. Stephens, Nikolaus Schultz, Moshe Oren, Laura Tang, David Kelsen: Genomic Alterations Observed in Colitis-associated Cancers are Distinct from Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease. Gastroenterology April 2016.

David R. Withers*, Matthew R. Hepworth, Xinxin Wang, Emma C. Mackley, Emily E. Halford, Emma E. Dutton, Clare L. Marriott, Verena Brucklacher-Waldert, Marc Veldhoen, Judith Kelsen, Robert N. Baldassano, Gregory F. Sonnenberg  : Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving ILC3  Nature Medicine January 2016.

2015

Sahn B, Chen-Lim ML, Ciavardone D, Farace L, Jannelli F, Nieberle M, Ely E, Zhang X, Kelsen J, Puma A, Mamula P.: Safety of a 1-Day Polyethylene Glycol 3350 Bowel Preparation for Colonoscopy in Children. JPGN 2015.

Kelsen J, Bittinger K, Pauly-Hubabrd H, Posivak L, Grunberg S, Baldassano R, Lewis J, Wu G, Bushman F: Alterations of the Subgingival microbiota in pediatric Crohn's Disease Studied longitudinally in Discovery and Validation cohorts. Inflammatory Bowel Disease 21(12), December 2015.

Judith R. Kelsen, Noor Dawany, Christopher J. Moran, Mahdi Sarmady,  Ariella Sasson, Helen Pauly-Hubbard, Alejuandro Martinez, Kelly Maurer, Joanne Soong Eric Rappaport, Harland S. Winter, Petar Mamula, David A. Piccoli, Mark Daly,  David Artis, Gregory F. Sonnenberg, Kathleen E. Sullivan, Robert N. Baldassano, Marcella Devoto: Exome Sequencing Analysis Reveals variants in Primary Immunodeficiency Genes in Very Early Onset Inflammatory Bowel Disease. Gastroenterology 149(6): 1415-24, Nov 2015.

Judith R. Kelsen, MD1, Noor Dawany, PhD,2 Alejuandro Martinez,1 Christopher M. Grochowski,3 Kelly Maurer, 4 Eric Rappaport, PhD5,  David A. Piccoli, MD1 Robert N. Baldassano, MD1, Petar Mamula, MD1, Kathleen E. Sullivan, MD, PhD4, Marcella Devoto, PhD6: A de novo whole gene deletion of XIAP Detected by Exome Sequencing Analysis in Very Early Onset Inflammatory Bowel Disease. BMC Gastroenterol 15, November 2015.

Hepworth, Mauser, Kelsen, Baldassano, Sonnenberg: Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD+4 T cells."  Science April 2015.

Sahn B, Anupindi SA, Dadhania NJ, Kelsen JR, Nancy ML, Mamula P: Duodenal Hematoma Following EGD: Comparison with Blunt Abdominal Trauma-Induced Duodenal Hematoma. JPGN 60(1), Jan 2015.

2013

Gupta K, Noble A, Kachelries KE, Albenberg L, Kelsen JR, Grossman AB, Baldassano RN: A novel enteral nutrition protocol for the treatment of pediatric Crohn's disease. Inflamm Bowel Dis 19(7): 1374-8, June 2013.

Christopher J. Cardinale, Judith R. Kelsen, Robert N. Baldassano, and Hakon Hakonarson: The Impact of Exome Sequencing in Inflammatory Bowel Disease. World Journal of Gastroenterology In press 2013.

2012

Judith Kelsen, Gary Wu: The gut microbiota, environment and diseases of modern society Gut Microbes. Landes Bioscience, 3(4), July 2012 Notes: Epub ahead of print.

Lindsey Albenberg, Petar Mamula, Judith Kelsen: Biologics for the treatment of moderate-severe ulcerative colitis in pediatric patients. Pediatric Health, Medicine and Therapeutics. Dove Press, In print, 2012.

2011

Dige A, Hvas CL, Deleuran B, Kelsen J, Bendix-Stuve M, Dahlerup JF, et al. Adalimumab treatment in Crohn's disease does not induce early changes in regulatory T cells. Scand J Gastroenterol. 2011 Oct;46(10):1206-14. Epub 2011 July 27. Cited in PubMed; PMID 21793633.

Kelsen J, Dige A, Schwindt H, D'Amore F, Pedersen FS, Agnholt J, et al. Infliximab induces clonal expansion of yδ-T cells in Crohn's disease: a predictor of lymphoma risk: PLoS One. 2011 Mar 31;6(3):e17890. Cited in PubMed; PMID 21483853.

Kelsen JR, Kim J, Latta D, Smathers S, McGowan KL, Zaoutis T, et al. Recurrence rate of clostridium difficile infection in hospitalized pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2011 Jan;17(1):50-5. Doi: 10.1002/ibd.21421. Epub 2010 Aug 18. Cited in PubMed; PMID 20722068. 

Jørgensen SP, Agnholt J, Glerup H, Lyhne S, Villadsen GE, Hvas CL, et al. Clinical trial: vitamin D3 treatment in Crohn's disease - a randomized double-blind placebo-controlled study. Aliment Pharmacol Ther. 2010 Aug;32(3):377-83. Epub 2010 may 11. Cited in PubMed; PMID 20491740.

2010

Kelsen JR, Rosh J, Heyman M, Winter HS, Ferry G, Cohen S, et al. Phase I trial of sargramostim in pediatric Crohn's disease. Inflamm Bowel Dis. 2010 Jul;16(7):1203-8. Epub 2010 Jan 5. Cited in PubMed; PMID 20052780.

Abstracts

2016

Conrad MA, Dawany N, Bittinger K, Baldassano RN, Piccoli D, Bushman FD, Devoto M, Kelsen JR  : Characterization of the Intestinal Microbiome in Very Early Onset Inflammatory Bowel Disease  Digestive Disease Week Annual Meeting, San Diego, CA May 2016.

Kelsen JR, Dawany N, Conrad, MA, Martinez A, Artis D, Sonnenberg GF, Mamula P, Piccoli DA, Baldassano RN, Sullivan KE, Devoto M: SU1851 Transcriptome Analysis Elucidates the Relevance of WES-Identified Variants in Patients with VEO-IBD. Gastroenterology 150(4): S570, April 2016.

Kelsen J, Dawany N, Conrad M, Martinez A, Mamula P, Piccoli D, Artis D, Sonnenberg G, Baldassano R, Sullivan K, Devoto M: 0-003 Understanding the Relevance of Whole Exome Sequencing Identified Variants in Patients with Very Early-Onset-IBD. Inflamm Bowel Dise 22 Suppl 1: S1-2, Mar 2016.

2015

Yaeger R, Miller V, Kelsen JR, Wang K, Tang L, Kelsen D: Clinically relevant genomic alterations are frequent in Colitis Associated Cancers. ASCO 2015.

Kelsen J, Albenberg L, Bailey A,  Bittinger K,  Schall1 J,  Mascarenhas M, Bushman FD, and Stallings G  : 16S Gene Sequencing Reveals a Unique Bacterial Signature in the Gut Microbiota of Pediatric Patients with Cystic Fibrosis. Digestive Disease week 2015.

Conrad M, Stein R, Maxwell E, Grossman A, Albenberg L, Baldassano R, Piccoli D, Kelsen J: Vedolizumab for Treatment of Severe Pediatric Inflammatory Disease. Digestive Disease Week 2015 2015 Notes: Oral presentation by collaborator Stein R.

2013

Moran C, Kelsen J, Kaplan J, Baril-Dore1 M; Schindelar L; Kirschner B,  Baldassano R,Xavier R, Winter H, Daly M, PhD5: Whole Exome Sequencing in Very Early Onset Inflammatory Bowel Disease. North American Society for Pediatric Gastroenterology Hepatology and Nutrition Annual Meeting, Chicago, IL October  2013.

Fish S, Wei Z, Bradfield J, Hakonarson H, Baldassano R, Kelsen J: SLC11A1 Polymorphism Increases the Risk of Early Surgery in Pediatric Patients With Inflammatory Bowel Disease. Oral Abstract, North American Society for Pediatric Gastroenterology Hepatology and Nutrition Annual Meeting, Chicago, IL October 2013 2013.

Jump C, Loomes KM, Piccoli DA, Blinman TA, Rosh J, Anupindi S, Smith-Whitley K, and Kelsen JR: "Role of Colectomy to Treat Life-Threatening Thrombotic Storm in Pediatric IBD"  North American Society for Pediatric Gastroenterology Hepatology and Nutrition Annual Meeting, Chicago, IL October 2013.

2012

Sahn B, Kelsen J, Maltman S, Stanley N, Mamula: A prospective randomized comparison of air and carbon dioxide insufflation in pediatric colonoscopy. J Pediatr Gastroenterol Nutr 55(Suppl 1 E 18), 2012.

J Kelsen1, L Posivak1, S Grunberg2, A Bailey2, R Baldassano1, JD Lewis4, FD Bushman2  GD Wu4  : "The Oral Microbiome in Pediatric Crohn's Disease," Advances in IBD, CCFA annual conference, Fort Lauderdale, Fl. Inflammatory Bowel Disease December 2012.

Books

Chapters

2017

Mamula, Grossman, Baldassano, Kelsen, Markowitz: Pediatric Inflammatory Bowel Disease, Volume 3. Springer. Mamula, Grossman, Baldassano, Kelsen, Markowitz (eds.). 3, June 2017.

2012

Menard C, Kelsen J: Perianal Abscess in Children. The 5-Minute Pediatric Consult. LWW, 6, 2012.

Kelsen J, Markowitz J: Ulcerative Colitis in Children. The 5-Minute Pediatric Consult. LWW, 6, 2012.

Judith Kelsen, Maria Mascarenhas: Upper Gastrointestinal Bleeding. Five Minute Pediatric Consult. Schwartz, Bell, Bingham, Friedman, Loomes, Mamula, Mascarenhas, Tanel (eds.). LWW, 6: 886-887, 2012.

Judith Kelsen, Gary Wu: The Gut Microbiota and IBD. Pediatric Inflammatory Bowel Disease. Mamula, Baldassano, Markowitz (eds.). Springer, 2, In print 2012.

Judith Kelsen, Andrew Mulberg: Imperforate Anus. Five Minute Pediatric Consult. Schwartz, Bell, Bingham, Friedman, Loomes, Mamula, Mascarenhas, Tanel (eds.). LWW, 6, 2012.

Albenberg L, Mamula P, Kelsen J: Biologics for the treatment of moderate to severe ulcerative colitis in pediatric patients. Pediatric Health, Medicine and Therapeutics 3: 51-8, 2012.

Albenberg L, Kelsen J, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with ulcerative colitis, The Complete Guide to Medical Management. Medical Therapy of ulcerative colitis. Gary Lichenstein (eds.). Springer, 2, In print 2012.

2011

Lindsey Albenberg, Judith Kelsen, Robert Baldassano: Pediatric Considerations in Medical Therapy in Patients with Crohn's Disease, The Complete Guide to Medical Management. Medical therapy for Crohn's Disease. Lichenstein (eds.). Springer, 3, 2011.

Kelsen J, Hunter A, Baldessano RN: Pediatric therapies in inflammatory bowel disease. Advanced Therapy in Inflammatory Bowel Disease. Theodore M. Bayless and Stephen B. Hanauer (eds.). People's Medical Publishing House, 1, 2011.

Kelsen J,  Baldassano RN, : Pediatric Considerations in Medical Therapy in Patients with Ulcerative Colitis. Medical Therapy in Patients with Ulcerative Colitis, The Complete Guide to Medical Management. Gary Lichenstein (eds.). 2, 2011.

Anna Hunter, Judith Kelsen, Robert Baldassano: Crohn's disease therapy in Children and Adolescent. Advanced Therapies In Inflammatory Bowel Disease. Theodore M. Bayless (eds.). 3, 2011.

Kelsen J, Mamula P: Ulcerative Colitis in Children. eMedicine from WebMD March 2011.

2010

Anupindi S, Ayyala R, Kelsen J, Mamula P, Applegate K: Imaging of inflammatory bowel disease in children. Evidence-Based Imaging in Pediatrics. Medine, Appelgate, Blackmore (eds.). Springer  Page: 487-505, 2010.

2008

Kelsen J, Mascarenhas M. Upper gastrointestinal bleeding, In: Schwartz MW, editor. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008. p. 886-887.

Kelsen J, Mulberg A. Imperforate anus. In: Schwartz MW, editor. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008. p. 444-445.

Kelsen J, Mulberg A. C1 esterase inhibitor. In: Schwartz MW, editor. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008.

Kelsen J, Mascarenhas M, Short bowel syndrome. In: Schwartz MW, editor. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008. p. 774-775.

Posters and Presentations

2016

Kelsen JR, Dawany N, Conrad M, Giraudo C, Behrens E, Devoto M, Sullivan KE,: "A Diagnostic Approach of Immune Dysregulation in Very Early-Onset IBD" Oral abstract, Advances in IBD, Orlando Florida. IBD 2016.

2015

Kelsen J Dawany, N, Moran C, Winter D, Daly M, Rappaport E, Mamula P, Piccoli P, Artis D, Sonnenberg G, Baldassano R, Sullivan K, Devoto, M: Autosomal recessive model of transmission in VEO-IBD using WES. Oral Abstract DDW 2015.

Invited Lectures

2017

"Novel Molecular Defects Associated with Very Early Onset Inflammatory Bowel Disease." American Academy of Allergy and Immunology Annual Conference, Atlanta GA, March 2017.

2016

Very Early-onset IBD, It is the Genes!, Gastroenterology Grand Rounds, Columbia University, NY NY, September 2016.

The Ethics of Genetic Studies in IBD, DDW 2016, San Diego, Ca, May 2016.

The Genomic architecture of VEO-IBD, Visiting Young Investigator, Division of Pediatric GI, Baylor College of Medicine, Texas Children's Hospital, May 2016.

Genes, gut microbiome and diet in pediatrics IBD, Grand Rounds, Lancaster Medical Center, Lancaster, PA, April 2016.

2015

The Role of Genetics, Diet and the Gut Microbiome in Pediatric Inflammatory Bowel Disease, The Italian Pediatric Society Annual Conference, Rome Italy, June 2015.

"Genomics and IBD, what have we learned from very early-onset IBD," Great debates in IBD, San Francisco, CA, March 2015., March 2015.