Judith R. Kelsen, MD

Judith R. Kelsen, MD

Judith R Kelsen, MD, is Program Director of the Very Early Onset Inflammatory Bowel Disease (VEO-IBD) Clinic and an Attending Physician in the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia.

Areas of Expertise: Very Early-onset inflammatory bowel disease, Inflammatory bowel disease
Locations: Main Campus
Phone: 215-590-3630

Education and Training

Medical School

MD - The Weill Medical School of Cornell University, New York, NY

Internship

Pediatrics - Albert Einstein Medical Center, Philadelphia, PA

Residency

Pediatrics - Mount Sinai Medical Center, New York, NY

Fellowship

Pediatric Gastroenterology, Hepatology and Nutrition - The Children's Hospital of Philadelphia, Philadelphia, PA
IBD Clinical Research Fellowship - Center for Pediatric Inflammatory Bowel Disease, The Children's Hospital of Philadelphia, Philadelphia, PA
Master of Translational Research - The University of Pennsylvania, Philadelphia, PA

Additional Training

Certificate in Epidemiology and Biostatistics - University of Pennsylvania, Philadelphia, PA

Board Certification

Gastroenterology
Pediatrics

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2017

Maxwell E, Dawany N, Baldassano RN, _ Mamula P, Mattei P, Albenberg L, Kelsen JR: Diverting Ileostomy for the Treatment of Severe, Refractory, Pediatric Inflammatory Bowel Disease. JPGN January  2017.

2016

Zhe Zhang, Ph.D.; Lihua Shi, Ph.D.; Noor Dawany; Judith Kelsen; Michelle A Petri, MD MPH; Kathleen E Sullivan, MD PHD: H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus. Clinical Epigenetics 2016.

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM: Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition. J. Allergy Clin Immunol. November 2016.

Conrad MA1, Stein RE, Maxwell EC, Albenberg L, Baldassano RN, Dawany N, Grossman AB, Mamula P, Piccoli DA, Kelsen JR.: Vedolizumab Therapy in Severe Pediatric Inflammatory Bowel Disease. Inflamm Bowel Dis October 2016.

Rosenbaum DG, Conrad MA, Biko DM, Ruchelli ED, Kelsen JR, Anupindi SA: Ultrasound and MRI predictors of surgical bowel resection in pediatric Crohn disease. Pediatr Radiol September 2016.

Rona Yaeger, Manish A. Shah, Vincent A. Miller, Judith R. Kelsen, Kai Wang, Zachary J. Heins, Jeffrey S. Ross, Yuting He, Eric Sanford, Rhonda K. Yantiss, Sohail Balasubramanian, Philip J. Stephens, Nikolaus Schultz, Moshe Oren, Laura Tang, David Kelsen: Genomic Alterations Observed in Colitis-associated Cancers are Distinct from Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease. Gastroenterology April 2016.

David R. Withers*, Matthew R. Hepworth, Xinxin Wang, Emma C. Mackley, Emily E. Halford, Emma E. Dutton, Clare L. Marriott, Verena rucklacher-Waldert, Marc Veldhoen, Judith Kelsen, Robert N. Baldassano, Gregory F. Sonnenberg  : Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving ILC3  Nature Medicine January 2016.

2015

Sahn B, Chen-Lim ML, Ciavardone D, Farace L, Jannelli F, Nieberle M, Ely E, Zhang X, Kelsen J, Puma A, Mamula P.: Safety of a 1-Day Polyethylene Glycol 3350 Bowel Preparation for Colonoscopy in Children. JPGN 2015.

Kelsen J, Bittinger K, Pauly-Hubabrd H, Posivak L, Grunberg S, Baldassano R, Lewis J, Wu G, Bushman F: Alterations of the Subgingival microbiota in pediatric Crohn's Disease Studied longitudinally in Discovery and Validation cohorts. Inflammatory Bowel Disease 21(12), December 2015.

Judith R. Kelsen, Noor Dawany, Christopher J. Moran, Mahdi Sarmady,  Ariella Sasson, Helen Pauly-Hubbard, Alejuandro Martinez, Kelly Maurer, Joanne Soong Eric Rappaport, Harland S. Winter, Petar Mamula, David A. Piccoli, Mark Daly,  David Artis, Gregory F. Sonnenberg, Kathleen E. Sullivan, Robert N. Baldassano, Marcella Devoto: Exome Sequencing Analysis Reveals variants in Primary Immunodeficiency Genes in Very Early Onset Inflammatory Bowel Disease. Gastroenterology 149(6): 1415-24, Nov 2015.

Judith R. Kelsen, MD1, Noor Dawany, PhD,2 Alejuandro Martinez,1 Christopher M. Grochowski,3 Kelly Maurer, 4 Eric Rappaport, PhD5,  David A. Piccoli, MD1 Robert N. Baldassano, MD1, Petar Mamula, MD1, Kathleen E. Sullivan, MD, PhD4, Marcella Devoto, PhD6: A de novo whole gene deletion of XIAP Detected by Exome Sequencing Analysis in Very Early Onset Inflammatory Bowel Disease. BMC Gastroenterol 15, November 2015.

Hepworth, Mauser, Kelsen, Baldassano, Sonnenberg: Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD+4 T cells."  Science April 2015.

Sahn B, Anupindi SA, Dadhania NJ, Kelsen JR, Nancy ML, Mamula P: Duodenal Hematoma Following EGD: Comparison with Blunt Abdominal Trauma-Induced Duodenal Hematoma. JPGN 60(1), Jan 2015.

2013

Gupta K, Noble A, Kachelries KE, Albenberg L, Kelsen JR, Grossman AB, Baldassano RN: A novel enteral nutrition protocol for the treatment of pediatric Crohn's disease. Inflamm Bowel Dis 19(7): 1374-8, June 2013.

Christopher J. Cardinale, Judith R. Kelsen, Robert N. Baldassano, and Hakon Hakonarson: The Impact of Exome Sequencing in Inflammatory Bowel Disease. World Journal of Gastroenterology In press 2013.

2012

Judith Kelsen, Gary Wu: The gut microbiota, environment and diseases of modern society Gut Microbes. Landes Bioscience, 3(4), July 2012 Notes: Epub ahead of print.

Lindsey Albenberg, Petar Mamula, Judith Kelsen: Biologics for the treatment of moderate-severe ulcerative colitis in pediatric patients. Pediatric Health, Medicine and Therapeutics. Dove Press, In print, 2012.

2011

Dige A, Hvas CL, Deleuran B, Kelsen J, Bendix-Stuve M, Dahlerup JF, et al. Adalimumab treatment in Crohn's disease does not induce early changes in regulatory T cells. Scand J Gastroenterol. 2011 Oct;46(10):1206-14. Epub 2011 July 27. Cited in PubMed; PMID 21793633. Read the abstract

Kelsen J, Dige A, Schwindt H, D'Amore F, Pedersen FS, Agnholt J, et al. Infliximab induces clonal expansion of yδ-T cells in Crohn's disease: a predictor of lymphoma risk: PLoS One. 2011 Mar 31;6(3):e17890. Cited in PubMed; PMID 21483853. Read the article

Kelsen JR, Kim J, Latta D, Smathers S, McGowan KL, Zaoutis T, et al. Recurrence rate of clostridium difficile infection in hospitalized pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2011 Jan;17(1):50-5. Doi: 10.1002/ibd.21421. Epub 2010 Aug 18. Cited in PubMed; PMID 20722068.  Read the article

Jørgensen SP, Agnholt J, Glerup H, Lyhne S, Villadsen GE, Hvas CL, et al. Clinical trial: vitamin D3 treatment in Crohn's disease - a randomized double-blind placebo-controlled study. Aliment Pharmacol Ther. 2010 Aug;32(3):377-83. Epub 2010 may 11. Cited in PubMed; PMID 20491740. Read the abstract

2010

Kelsen JR, Rosh J, Heyman M, Winter HS, Ferry G, Cohen S, et al. Phase I trial of sargramostim in pediatric Crohn's disease. Inflamm Bowel Dis. 2010 Jul;16(7):1203-8. Epub 2010 Jan 5. Cited in PubMed; PMID 20052780. Read the article

Abstracts

2016

Conrad MA, Dawany N, Bittinger K, Baldassano RN, Piccoli D, Bushman FD, Devoto M, Kelsen JR  : Characterization of the Intestinal Microbiome in Very Early Onset Inflammatory Bowel Disease  Digestive Disease Week Annual Meeting, San Diego, CA May 2016.

Kelsen JR, Dawany N, Conrad, MA, Martinez A, Artis D, Sonnenberg GF, Mamula P, Piccoli DA, Baldassano RN, Sullivan KE, Devoto M: SU1851 Transcriptome Analysis Elucidates the Relevance of WES-Identified Variants in Patients with VEO-IBD. Gastroenterology 150(4): S570, April 2016.

Kelsen J, Dawany N, Conrad M, Martinez A, Mamula P, Piccoli D, Artis D, Sonnenberg G, Baldassano R, Sullivan K, Devoto M: 0-003 Understanding the Relevance of Whole Exome Sequencing Identified Variants in Patients with Very Early-Onset-IBD. Inflamm Bowel Dise 22 Suppl 1: S1-2, Mar 2016.

2015

Yaeger R, Miller V, Kelsen JR, Wang K, Tang L, Kelsen D: Clinically relevant genomic alterations are frequent in Colitis Associated Cancers. ASCO 2015.

Kelsen J, Albenberg L, Bailey A,  Bittinger K,  Schall1 J,  Mascarenhas M, Bushman FD, and Stallings G  : 16S Gene Sequencing Reveals a Unique Bacterial Signature in the Gut Microbiota of Pediatric Patients with Cystic Fibrosis. Digestive Disease week 2015.

Conrad M, Stein R, Maxwell E, Grossman A, Albenberg L, Baldassano R, Piccoli D, Kelsen J: Vedolizumab for Treatment of Severe Pediatric Inflammatory Disease. Digestive Disease Week 2015 2015 Notes: Oral presentation by collaborator Stein R.

2013

Moran C, Kelsen J, Kaplan J, Baril-Dore1 M; Schindelar L; Kirschner B,  Baldassano R,Xavier R, Winter H, Daly M, PhD5: Whole Exome Sequencing in Very Early Onset Inflammatory Bowel Disease. North American Society for Pediatric Gastroenterology Hepatology and Nutrition Annual Meeting, Chicago, IL October  2013.

Fish S, Wei Z, Bradfield J, Hakonarson H, Baldassano R, Kelsen J: SLC11A1 Polymorphism Increases the Risk of Early Surgery in Pediatric Patients With Inflammatory Bowel Disease. Oral Abstract, North American Society for Pediatric Gastroenterology Hepatology and Nutrition Annual Meeting, Chicago, IL October 2013 2013.

Jump C, Loomes KM, Piccoli DA, Blinman TA, Rosh J, Anupindi S, Smith-Whitley K, and Kelsen JR: "Role of Colectomy to Treat Life-Threatening Thrombotic Storm in Pediatric IBD"  North American Society for Pediatric Gastroenterology Hepatology and Nutrition Annual Meeting, Chicago, IL October 2013.

2012

Sahn B, Kelsen J, Maltman S, Stanley N, Mamula: A prospective randomized comparison of air and carbon dioxide insufflation in pediatric colonoscopy. J Pediatr Gastroenterol Nutr 55(Suppl 1 E 18), 2012.

J Kelsen1, L Posivak1, S Grunberg2, A Bailey2, R Baldassano1, JD Lewis4, FD Bushman2  GD Wu4  : "The Oral Microbiome in Pediatric Crohn's Disease," Advances in IBD, CCFA annual conference, Fort Lauderdale, Fl. Inflammatory Bowel Disease December 2012.

Books

Chapters

2012

Menard C, Kelsen J: Perianal Abscess in Children. The 5-Minute Pediatric Consult. LWW, 6, 2012.

Kelsen J, Markowitz J: Ulcerative Colitis in Children. The 5-Minute Pediatric Consult. LWW, 6, 2012.

Judith Kelsen, Maria Mascarenhas: Upper Gastrointestinal Bleeding. Five Minute Pediatric Consult. Schwartz, Bell, Bingham, Friedman, Loomes, Mamula, Mascarenhas, Tanel (eds.). LWW, 6: 886-887, 2012.

Judith Kelsen, Gary Wu: The Gut Microbiota and IBD. Pediatric Inflammatory Bowel Disease. Mamula, Baldassano, Markowitz (eds.). Springer, 2, In print 2012.

Judith Kelsen, Andrew Mulberg: Imperforate Anus. Five Minute Pediatric Consult. Schwartz, Bell, Bingham, Friedman, Loomes, Mamula, Mascarenhas, Tanel (eds.). LWW, 6, 2012.

Albenberg L, Mamula P, Kelsen J: Biologics for the treatment of moderate to severe ulcerative colitis in pediatric patients. Pediatric Health, Medicine and Therapeutics 3: 51-8, 2012.

Albenberg L, Kelsen J, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with ulcerative colitis, The Complete Guide to Medical Management. Medical Therapy of ulcerative colitis. Gary Lichenstein (eds.). Springer, 2, In print 2012.

2011

Lindsey Albenberg, Judith Kelsen, Robert Baldassano: Pediatric Considerations in Medical Therapy in Patients with Crohn's Disease, The Complete Guide to Medical Management. Medical therapy for Crohn's Disease. Lichenstein (eds.). Springer, 3, 2011.

Kelsen J, Hunter A, Baldessano RN: Pediatric therapies in inflammatory bowel disease. Advanced Therapy in Inflammatory Bowel Disease. Theodore M. Bayless and Stephen B. Hanauer (eds.). People's Medical Publishing House, 1, 2011.

Kelsen J,  Baldassano RN, : Pediatric Considerations in Medical Therapy in Patients with Ulcerative Colitis. Medical Therapy in Patients with Ulcerative Colitis, The Complete Guide to Medical Management. Gary Lichenstein (eds.). 2, 2011.

Anna Hunter, Judith Kelsen, Robert Baldassano: Crohn's disease therapy in Children and Adolescent. Advanced Therapies In Inflammatory Bowel Disease. Theodore M. Bayless (eds.). 3, 2011.

Kelsen J, Mamula P: Ulcerative Colitis in Children. eMedicine from WebMD March 2011.

2010

Anupindi S, Ayyala R, Kelsen J, Mamula P, Applegate K: Imaging of inflammatory bowel disease in children. Evidence-Based Imaging in Pediatrics. Medine, Appelgate, Blackmore (eds.). Springer  Page: 487-505, 2010.

2008

Kelsen J, Mascarenhas M. Upper gastrointestinal bleeding, In: Schwartz MW, editor. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008. p. 886-887.

Kelsen J, Mulberg A. Imperforate anus. In: Schwartz MW, editor. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008. p. 444-445.

Kelsen J, Mulberg A. C1 esterase inhibitor. In: Schwartz MW, editor. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008.

Kelsen J, Mascarenhas M, Short bowel syndrome. In: Schwartz MW, editor. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008. p. 774-775.

Posters and Presentations

2016

Kelsen JR, Dawany N, Conrad M, Giraudo C, Behrens E, Devoto M, Sullivan KE,: "A Diagnostic Approach of Immune Dysregulation in Very Early-Onset IBD" Oral abstract, Advances in IBD, Orlando Florida. IBD 2016.

2015

Kelsen J Dawany, N, Moran C, Winter D, Daly M, Rappaport E, Mamula P, Piccoli P, Artis D, Sonnenberg G, Baldassano R, Sullivan K, Devoto, M: Autosomal recessive model of transmission in VEO-IBD using WES. Oral Abstract DDW 2015.

Invited Lectures

2017

"Novel Molecular Defects Associated with Very Early Onset Inflammatory Bowel Disease." American Academy of Allergy and Immunology Annual Conference, Atlanta GA, March 2017.

2016

Very Early-onset IBD, It is the Genes!, Gastroenterology Grand Rounds, Columbia University, NY NY, September 2016.

The Ethics of Genetic Studies in IBD, DDW 2016, San Diego, Ca, May 2016.

The Genomic architecture of VEO-IBD, Visiting Young Investigator, Division of Pediatric GI, Baylor College of Medicine, Texas Children's Hospital, May 2016.

Genes, gut microbiome and diet in pediatrics IBD, Grand Rounds, Lancaster Medical Center, Lancaster, PA, April 2016.

2015

The Role of Genetics, Diet and the Gut Microbiome in Pediatric Inflammatory Bowel Disease, The Italian Pediatric Society Annual Conference, Rome Italy, June 2015.

"Genomics and IBD, what have we learned from very early-onset IBD," Great debates in IBD, San Francisco, CA, March 2015., March 2015.

Awards and Honors

2014, Young Faculty Investigator Award, The North American Society for Gastroenterology, Hepatology and Nutrition

2009, Komarov Research Competition, Clinical Sciences, 3rd place

2009, We Care Digestive Disease Week Travel Grant

2008, North American Society for Pediatric Gastroenterology Hepatology, and Nutrition Travel Grant

Editorial and Academic Positions

Editorial positions

2013-present, JPGN, Ad Hoc reviewer

2012-present, PLOS ONE, Ad Hoc reviewer

2009-present, American Journal of Gastroenterology, Ad Hoc Reviewer

2008-present, Inflammatory Bowel Diseases, Ad Hoc Reviewer

Academic and institutional committees

2016-present, CHOP Antibiotics DUE subcommittee

2016-present, Clinic Trials Workgroup

2014-present, CHOP Therapeutics and Standards Committee

Leadership and Memberships

Memberships in professional organizations

International

2006-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

 - 2015, IBD Committee

 - 2012, Professional Education Committee

National

2010-present, The Crohn's and Colitis Foundation of America

2006-present, American Gastroenterological Association (AGA)

2006-present, American Association for the Study of Liver Diseases (AASLD)

2001-present, American Academy of Pediatrics (AAP)