Dr. Lindell is a graduate of the University of Georgia and Vanderbilt University School of Medicine. He completed his pediatrics residency training and pediatric critical care fellowship at Children’s Hospital of Philadelphia, where he also served as a Chief Resident in Pediatrics. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at Children’s Hospital of Philadelphia.
The broad goal of Dr. Lindell’s clinical and translational research program is to provide high-quality precision care for children with critical illness, particularly in cohorts of children with immune dysfunction. His current research is focused on clinical and translational studies of pediatric septic shock and the development of multiple organ dysfunction syndrome (MODS) in critically-ill children.
Since joining the University of Pennsylvania faculty, Dr. Lindell has developed a pipeline for prospective immunophenotyping of blood samples from children with multiple organ dysfunction syndrome (MODS). The development of this longitudinal bedside-to-bench pipeline is supported by an Early Career Award from the Thrasher Research Fund and NIH LRP funding from NICHD. The combination of high-dimensional spectral flow and mass cytometry and comprehensive plasma proteomics represents a modern, multi-omics approach to sepsis immunobiology in children with the potential to advance our mechanistic understanding of pediatric sepsis and MODS.
MD - Vanderbilt University School of Medicine, Nashville, TN
General Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA (Chief Resident)
Pediatric Critical Care Medicine - Children’s Hospital of Philadelphia, Philadelphia, PA
Pediatrics – American Board of Pediatrics
Attending Physician, Pediatric Critical Care Medicine
Assistant Professor of Anesthesiology, Critical Care, and Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Tsukahara K, Lindell RB, Newman H, Lerman BJ, Kersun LS, Piccione J: Successful whole lung lavage in a child with pulmonary alveolar proteinosis secondary to hematologic malignancy. Pediatr Pulmonol. 2022 Jan, 57 (1).
Lindell RB, Wolf MS, Alcamo AM, Silverman MA, Dulek DE, Otto WR, Olson TS, Kitko CL, Paueksakon P, Chiotos K: Case Report: Immune dysregulation due to Toxoplasma gondii reactivation after allogeneic hematopoietic cell transplant. Front. Pediatr. 9(719679), Aug 2021.
Lindell RB, Nishisaki A, Weiss SL, Traynor DM, Fitzgerald JC. Risk of mortality in immunocompromised children with severe sepsis and septic shock. Crit Care Med. 2020 Jul;48(7):1026-1033. [PMID: 32301846] [PMCID: PMC7311286] [DOI: 10.1097/CCM.0000000000004329]
Dziorny AC, Lindell RB, Bennett TD, Bailey LC. Joining Datasets without Identifiers: Probabilistic Linkage of Virtual Pediatric Systems and PEDSnet. Pediatr Crit Care Med 21(9): e628-e634, Sept 2020.Elliott EM, Weintraub AY, Francis CR, Lindell RB. E-cigarette and vaping associated lung injury: What’s lurking inside! Anesthesiology. 2020 Aug;133(2):427-428. [PMID: 32501958] [DOI: 10.1097/aln.0000000000003397]
Lindell RB, Fitzgerald JC. Anthracycline Exposure and Subsequent Critical Illness: Getting to the Heart of the Problem. Pediatr Crit Care Med. 2019 Jul;20(7):672-673. PMID: 31274791.
Dziorny AC, Orenstein E, Lindell RB, Hames NA, Washington N, Desai B. Automatic detection of front-line clinician hospital shifts: a novel use of EHR timestamp data. Appl Clin Inform. 2019 Jan 9. [Epub ahead of print.] PMID: 30625502.
Dewan M, Herrmann LE, Tchou MJ, Parsons A, Muthu N, Tenney-Soeiro R, Fieldston E, Lindell RB, Dziorny A, Gosdin C. Development and evaluation of high-value pediatrics: a high-value care pediatric resident curriculum. Hosp Pediatr. 2018 Dec;8(12):785-792. PMID: 30425056.
Lindell RB, Nishisaki A, Weiss SL, Balamuth F, Traynor DM, Chilutti MR, Grundmeier RW, Fitzgerald JC. Comparison of methods for identification of pediatric severe sepsis and septic shock in the Virtual Pediatric Systems database. Crit Care Med. 2018 Oct 31. [Epub ahead of print.] PMID: 30394917.
Schultz CL, Alderfer MA, Lindell RB, McClain Z, Zelley K, Nichols KE, Ford CA. The influence of adolescence on parents' perspectives of testing and discussing inherited cancer predisposition. J Genet Couns. 2018 Dec;27(6):1395-1404. PMID: 29909594.
Morgan RW, Stinson HR, Wolfe H, Lindell RB, Topjian AA, Nadkarni VM, Sutton RM, Berg RA, Kilbaugh TJ. Pediatric in-hospital cardiac arrest secondary to acute pulmonary embolism. Crit Care Med. 2018 Mar;46(3):e229-e234. PMCID: PMC5825246
Lindell RB, Gertz SJ, Rowan CM, McArthur J, Beske F, Plunkett A, Weiss SL, Thomas NJ, Nadkarni VM, Fitzgerald JC. High levels of morbidity and mortality among pediatric hematopoietic cell transplant recipients with severe sepsis: insights from the SPROUT international point prevalence study. Pediatr Crit Care Med. 2017 Dec;18(12):1114-1125. PMID: 28926489
Alderfer MA, Lindell RB, Viadro CI, Zelley K, Valdez J, Mandrell B, Ford CA, Nichols KE. Should genetic testing be offered for children? The perspectives of adolescents and emerging adults in families offered testing for Li-Fraumeni Syndrome. J Genet Couns. 2017 Oct;26(5):1106-1115. PMID: 28303452
Lindell RB, Esbenshade AJ, Alvarez JM, Koyama T, Campbell K, Simmons JH, Friedman DL. Knowledge of diagnosis, treatment history, and risk of late effects among childhood cancer survivors and parents: the impact of a survivorship clinic. Pediatr Blood Cancer. 2015 Aug;62(8):1444-51. PMID: 25894324
Anupindi SA, Bedoya M, Lindell RB, Rambhatla S, Zelley K, Nichols KE, Chauvin NA. Diagnostic performance of whole body MRI (WBMRI) as a tool for cancer screening in children with genetic cancer predisposing conditions. AJR Am J Roentgenol. 2015 Aug;205(2):400-8. PMID: 26204294
Alderfer MA, Zelley K, Lindell RB, Novokmet A, Mai PL, Garber J, Nathan D, Scollon S, Chun N, Patenaude A, Ford J, Plon SE, Schiffman JD, Diller LR, Savage S, Malkin D, Ford CA, Nichols KE. Parent decision making around genetic testing of children for germline TP53 mutations. Cancer. 2015 Jan;121(2):286-93. PMID: 25223899
Esbenshade AJ, Di Pentima C, Zhao Z, Shintani A, Esbenshade JC, Simpson ME, Montgomery KC, Lindell RB, Lee H, Wallace A, Garcia KL, Moons KGM, Friedman DL. Development and validation of a prediction model for diagnosing blood stream infections in febrile, non-neutropenic children with cancer. Pediatr Blood Cancer. 2015 Jan;62(2):262–268. PMCID: PMC4402108
Esbenshade AJ, Simmons JH, Koyama T, Lindell RB, Friedman DL. Obesity and insulin resistance in pediatric acute lymphoblastic leukemia worsens during maintenance therapy. Pediatr Blood Cancer. 2013 Aug;60(8):1287-91. PMCID: PMC3881979
Zelley K, Lindell RB, Schiffman JD, Nichols KE. "Genetic Predisposition to Cancer." In: Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux S, editors. Nathan and Oski's Hematology and Oncology of Infancy and Childhood, 8th edition. Philadelphia: Saunders, 2014. 1270-93.
Lindell RB, Fitzgerald JC, Rowan CW, Flori HR, Di Nardo M, Napolitano N, Traynor DM, Lenz KB, Emeriaud G, Jeyapalan A, Nishisaki A: Duration of pre-intubation respiratory support is associated with increased mortality in immunocompromised children with respiratory failure. Critical Care Medicine January 2022 Notes: Research Snapshot Presentation at 51st Critical Care Congress, February 2022, San Juan, Puerto Rico (Virtual).
Brennan MM, Lindell RB, Nishisaki A, Fitzgerald JC, Dziorny AC: Application of Machine Learning in a Linked Multi-Center Dataset: Classifying MODS in Severe Sepsis. Critical Care Medicine January 2022 Notes: Research Snapshot Presentation at 51st Critical Care Congress, February 2022, San Juan, Puerto Rico (Virtual).
Lindell RB, Wherry EJ, Weiss SL, Henrickson SE. : Preferential loss of peripheral non-naïve CD4+ Lymphocytes in Pediatric Sepsis. American Academy of Allergy, Asthma and Immunology February 2021 Notes: Oral Presentation at the American Academy of Allergy, Asthma and Immunology Annual Meeting, 2021 February 26-March 1 (Virtual).
Watts SL, Bruins BB, Blowey BL, Lindell RB: Amlodipine and benazepril toxicity successfully treated with maximal medical therapie Critical Care Medicine 49(1): 652, January 2021 Notes: Research Snapshot Poster Presentation at 50th Critical Care Congress, February, 2021, (Virtual).
Reddy AR, Jenssen B, Chidambaram A, Yehya N, Lindell RB: Characterizing E-cigarette vaping associated lung injury in the pediatric intensive care unit. Critical Care Medicine 49(1): 483, January 2021 Notes: Research Snapshot Poster Presentation at 50th Critical Care Congress, February, 2021 (Virtual).
Lenz K, Nishisaki A, Lindell RB, Yehya N, Bruins BB, Napolitano N, Craig N, Traynor D, Fitzgerald J: Stem cell transplant status is not associated with adverse eventsduring tracheal intubation. Critical Care Medicine 49(1): 462, January 2021 Notes: Research Snapshot Presentation at 50th Critical Care Congress, February 2021, (Virtual).
Dziorny AC, Lindell RB, Moore J, Nishisaki A, Fitzgerald JC. Classification of MODS beyond day 1 of illness in pediatric severe sepsis and septic shock. Society of Critical Care Medicine Annual Congress, Orlando, FL. February 16, 2020.
Lindell RB, Fitzgerald JC, Nishisaki A, Traynor DM, Weiss SL. Predictive Validity of Mortality Prediction Scores in Pediatric Severe Sepsis and Septic Shock. Society of Critical Care Medicine Annual Congress, San Diego, CA. February 18, 2019.
Lindell RB, Nishisaki A, Weiss SL, Traynor DM, Fitzgerald JC. Risk of mortality in immunocompromised children with severe sepsis and septic shock. Society of Critical Care Medicine Annual Congress, San Diego, CA. February 18, 2019.
Lindell RB. "Functional changes in the T cell repertoire in pediatric sepsis", lecture at at athe Pediatric Acute Lung Injury & Sepsis Investigators Annual Spring Meeting, March 11, 2021 (virtual due to Covid)
Lindell RB. "Early vs. late tracheal intubation in immunocompromised and HCT patients with respiratory failure" lecture at Pediatric Acute Lung Injury & Sepsis Investigators Annual Spring Meeting, March 10, 2021 (virtual due to Covid)
Lindell RB. "Preferential Loss of Peripheral Non-Naïve CD4+ Lymphocytes in Pediatric Sepsis", lecture at American Academy of Allergy, Asthma, and Immunology Annual Meeting February 27, 2021 (virtual due to Covid)
Lindell RB. "Amlodipine and Benazepril Toxicity Successfully Treated with Maximal Medical Therapies", lecture at Society of Critical Care Medicine Annual Congress February 9, 2021 (virtual due to Covid)
Lindell RB. "Characterizing E-Cigarette Vaping Associated Lung Injury (EVALI) in the Pediatric Intensive Care Unit", lecture at Society of Critical Care Medicine Annual Congress February 9, 2021 (virtual due to Covid)
Lindell RB. "Stem cell transplant status is not associated with adverse events during tracheal intubation", lecture at Society of Critical Care Medicine Annual Congress, February 9, 2021 (virtual due to Covid)
Lindell RB. "Variations among Electronic Health Record and Physiologic Streaming Vital Signs for Use in Predictive Algorithms in Pediatric Severe Sepsis", November 16, 2020, lecture at American Medical Informatics Association Annual Symposium, Chicago, IL (virtual due to Covid)
Lindell RB. EVALI in Children: What Anesthesiologists Need to Know about Vaping. Anesthesiology Grand Rounds, Children’s Hospital of Philadelphia, Philadelphia, PA.
Lindell RB. Classification of MODS beyond day 1 of illness in pediatric severe sepsis and septic shock. Society of Critical Care Medicine Annual Congress, Orlando, FL.
Lindell RB. Literature Update: New Insights into Fluid Balance in HCT Patients with Critical Illness. Pediatric Acute Lung Injury & Sepsis Investigators Annual Spring Meeting. New Orleans, LA.
Lindell RB. Manuscript writing: figures and graphs. Lecture for CHOP-GWCMC Joint Academic Pediatrician Training Program. Guangzhou, China.
Lindell RB. Risk of mortality in immunocompromised children with severe sepsis and septic shock. Society of Critical Care Medicine Annual Congress, San Diego, CA.
Lindell RB. Predictive validity of mortality prediction scores in pediatric severe sepsis and septic shock. Society of Critical Care Medicine Annual Congress, San Diego, CA.
Lindell RB. VPS + PEDSnet: implications for comparative effectiveness research in HCT. Pediatric Acute Lung Injury & Sepsis Investigators Annual Fall Meeting. Vancouver, BC.
Lindell RB. Disease state overview: Clinical and economic impacts of sepsis. American Society of Microbiology Webinar Series, Washington, DC.
Lindell RB. What critical care clinicians need to know about vaping: Addressing real-life cases with a CDC overview. Society of Critical Care Medicine Webinar Series, Mount Prospect, IL.
Lindell RB. Evolving cases that surprised us all. Annual Pediatric Surgical and Trauma Nursing Conference, Children’s Hospital of Philadelphia, Philadelphia, PA.
2021, Selected for Young Investigator Showcase at the Pediatric Acute Lung Injury & Sepsis Investigators Annual Spring Meeting
2020, NIH Loan Repayment Program Awardee, NICHD
2019, Travel Grant Recipient, St. Jude Pediatric Oncology / Critical Care Symposium
2019, Early Career Award, Thrasher Research Fund
2019, Silver Snapshot Award, Society of Critical Care Medicine Annual Meeting
2018, Distinguished Poster Award, American Medical Informatics Association Annual Meeting
2016, Resident Boot Camp Award Recipient, American Thoracic Society
2014, CHOP Alumni Organization Research Award
2012, Volunteer of the Year Award, Shade Tree Clinic, Nashville, TN
2011, Best Poster Award, Tennessee Cancer Coalition, Nashville, TN
2007, Dean’s Scholarship, Vanderbilt University School of Medicine
2007, Best Paper Award, Center for Undergraduate Research, University of Georgia
2007, Phi Beta Kappa, University of Georgia
2007, Graduation summa cum laude with highest honors, University of Georgia
2003, Foundation Fellowship, University of Georgia
2021-present, Pediatric Transplantation
2021-present, Clinical Therapeutics
2020-present, Journal of Pediatric Intensive Care
2019-present, Pediatrics
2018, Critical Care Medicine
2018, Pediatric Critical Care Medicine
2020-present, Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania
2020-present, Member, Institute for Immunology, University of Pennsylvania School of Medicine
2018-present, Pediatric Sepsis Program
2017-present, PICU/PCU Sepsis QI Committee
2017-present, Pediatric Acute Lung Injury and Sepsis Investigators, HCT-Cancer Immunotherapy Subgroup
2016-present, Pediatric Acute Lung Injury and Sepsis Investigators
2016-present, Society of Critical Care Medicine
2012-present, American Academy of Pediatrics