Education and Training

Medical School

MD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Residency

Neurological Surgery - Hospital of the University of Pennsylvania, Philadelphia, PA

Fellowship

Neurosurgical Oncology and Skull Base Surgery - Wellington Regional Hospital, Wellington, New Zealand
Neurosurgery - Children's Hospital of Philadelphia, Philadelphia, PA

Graduate Degree

Masters of Bioethics - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Neurosurgeon

Departments and Services

Publications

Papers

2020

Madsen PJ, Taylor JA, Heuer GG. Commentary: Craniopagus separation, a model for innovation in surgery. Surgery. 2020; epub ahead of print.

Piazza M, Zadnik-Sullivan P, Madsen PJ, Branche M, McShane B, Saylany A, Sharma N, Arlet V, Ozturk A. Proximal junctional kyphosis following Tl 0-pelvis fusion presenting with neurologic compromise: case presentations and review of the literature. Br J Neurosurg. 2020; epub ahead of print.

Proximal junctional kyphosis following Tl 0-pelvis fusion presenting with neurologic compromise: case presentations and review of the literature. Br J Neurosurg. 2020; epub ahead of print.

Flanders TM, Madsen PJ, Pisapia JM, Hudgins ED, Mackell CM, Alexander EE, Moldenhauer JS, Zarnow DM, Flake AW, Adzick NS, Heuer GG. Improved post-operative metrics with modified myofascial closure in fetal myelomeningocele repair. Oper. Neurosurg. 2020; 18(2): 158-65.

Flanders TM, Heuer GG, Madsen PJ, Buch VP, Mackell CM, Alexander E, Moldenhauer JS, Zarnow DM, Flake AW, Adzick NS. Detailed analysis of hydrocephalus and hindbrain herniation after prenatal and postnatal myelomeningocele closure: Report from a single institution. Neurosurg. 2020; 86(5):637-45.

2019

Heuer GG, Madsen PJ, Flanders TM, Kennedy BC, Storm PB, Taylor JA. A multidisciplinary separation of craniopagus twins. NEJM 2019; 380:358-64.

Ramayya AG, Carrasquilla A, Hitti FL, Madsen PJ, Thawani JP, Sinha S, Kvint S, Kung DK, Schuster J. Non­-traumatic Rupture of the Ligamentum Flavum with Symptomatic Spontaneous Lumbar Epidural Hematoma: A case report. Interdiscip. Neurosurg. 2019; 16:51-3.Foster JB*, Madsen P J*, Hegde M, Ahmed NM, Cole KA, Maris JM, Resnick AC, Storm PB, Waanders AJ. lmmunotherapy for Pediatric Brain Tumors: Past and Present. Neuro Onco. 2019; 21(10):1226-38.

Goldstein HE, Shao B, Madsen PJ, Hartnett SM, Blount JP, Brockmeyer DL, Campbell RM, Conklin M, Hankinson TC, Heuer GG, Jea AH, Kennedy BC, Tuite GF, Rodriguez L, Feldstein NA, Vitale MG, Anderson RCE. Increased complications without neurological benefit are associated with prophylactic spinal cord untethering prior to scoliosis surgery in children with myelomeningocele. Childs Nerv Syst. 2019; 35(11):2187-94.

Madsen PJ, Buch VP, Douglas JE, Parasher AK, Lerner DK; Alexander E, Workman AD, Palmer JN, Lang SS, Kennedy BC, Vossough A, Adappa ND, Storm PB. Endoscopic Endonasal Resection of Pediatric Craniopharyngioma: Comparison to Open Resection with a Focus on Cerebrovascular and Related Complications. J. Neurosurg. Pediatr. 2019; 24(3):236-45. 2019 JNS Editor's Choice - Tumor.

2018

Madsen PJ, Mallela AN, Hudgins ED, Storm PB, Heuer GG, Stein SC. The Effect and Evolution of Patient Selection on Outcomes in Endoscopic Third Ventriculostomy for Hydrocephalus: A Large-Scale Review of the Literature. J. Neural. Sci. 2018; 385: 185-91.

Stewart L, Sinha S, Madsen PJ, Glaser L, Chen I, Culyba MJ. Spinal epidural abscess caused by Gardnerella vagina/is andPrevotella amnii. Infec. Dis. Clin. Pract. 2018; 26(4):237-9.

2017

Buch VP, Madsen PJ, Vaughan KA, Koch PF, Kung DK, Ozturk AK Rotational vertebrobasilar insufficiency due to compression of a persistent first intersegmental artery: A case report. J. Neurosurg. Spine. 2017; 26(2): 199-202.

2016

Thawani JP, Ramayya AG, Abdullah KG, Hudgins E, Vaughan K, Piazza M, Madsen PJ, Buch V, Grady MS. Resident simulation training in endoscopic endonasal surgery utilizing haptic feedback technology. J. ofClin. Neurosci. 2016; 34:112-16.

2013

Madsen PJ, Lang, SS, Pisapia JM, Storm PB, Hurst RW, Heuer GG. An Institutional Series and Literature Review of Pial Arteriovenous Fistulas in the Pediatric Population. J. Neurosurg. Pediatr. 2013; 12( 4):344-50.

Sievert AJ, Lang SS, Boucher KL, Madsen PJ, Slaunwhite EM, Brewington D, Storm PB, Resnick AC. Paradoxical Activation and RAF Inhibitor Resistance of BRAF Fusions Characterizing Pediatric Astrocytomas. PNAS. 2013; 110(15):5957-62.

2012

Stephen JH, Sievert AJ, Madsen PJ, Judkins AR, Resnick AC, Storm PB, Rushing EJ, and Santi M.: Spinal Cord Ependymomas and Myxopapillary Ependymomas in the First Two Decades of Life: A Clinicopathological and Immunohistochemical Characterization of 19 Cases. J. Neurosurg. Pediatr. 2012; 9(6):646-53.

2010

Popescu DL, Vrabel M, Brausam A, Madsen PJ, Lente G, Fabian I, Ryabov AD, van Eldik R, Collins TJ. Thermodynamic, Electrochemical, High-Pressure Kinetic, and Mechanistic Studies of the Formation of Oxo Fe1v-TAML Species in Water. 2010; Inorg. Chem. 49(24):11439-48.

2008

Shappell NW, Vrabel MA, Madsen PJ, Harrington GE, Billey LO, Hakk H, Larsen GL, Beach ES, Horwitz CP, Ro KS, Hunt PG, Collins TJ. Destruction of Estrogens Using Fe-TAML/Peroxide Catalysis. Environ. Sci. Technol. 2008; 42(2): 1296-300.

Books

Chapters

2020

Madsen PJ, Kennedy BC. "Initial Evaluation and Management of Patients with Neurosurgical Devices." Management of the Hi-Tech Patient in Emergency, Acute and Critical Care: A Practical Guide to Managing Patients with Hi-Tech Hardware. 2020; In production.

Madsen PJ, Taylor JA, Heuer GG. "Craniopagus Twins." Youmans and Winn Neurological Surgery. 2020; In preparation.

2018

Madsen PJ, Chen HCI, Chen SS. "Neurosurgical Approaches to the Treatment of Muscle Hyperactivity." Muscle Over-activity in Upper Motor Neuron Syndrome: Assessment and Problem Solving.for Complex Cases. Philadelphia: Elsevier, 2018.

Posters and Presentations

2019

Buch VP, Park BJ, Mensah-Brown K, Genni J, Madsen PJ, Quattrone F, Morley C, Choudhry 0, Schuster JM, Chen HI. Intraoperative Mixed Reality Holographic Visualization during Spinal Fixation: Early Insights. 2019 Meeting of the American Association of Neurological Surgeons. Oral presentation.

2018

Taylor JA, Madsen PJ, Kennedy BC, Storm PB, Heuer GG. A Multidisciplinary and Innovative Separation of Craniopagus Twins. 2018 Biennial Congress of the European Society of Pediatric Neurosurge1y. Oral presentation.

Taylor J, Madsen PJ, Kennedy BC, Storm PB, Heuer G: A Multidisciplinary and Innovative Separation of Craniopagus Twins. 2018 European Society for Pediatric Neurosurgery. Oral presentation.

Madsen PJ, Han HJ, Liu G, Sonawane P, Menschik AI, Raman P, Waanders AJ, Storm PB, Resnick AC. ACVRI-mutant DIPGs are characterized by aberrant activin-mediated BMP signaling but may lack cytotoxic response to targeted A CVR I -receptor inhibition. 2018 Meeting of the American Association of Neurological Surgeons. Poster presentation.

Madsen PJ, Zhang B, Wang K, Waanders AJ, Storm PB, Resnick AC. In silico identification of neo-antigens in a high-grade pediatric brain tumor cohort utilizing next-generation sequencing: pilot study of a discovery pipeline for immunotherapy targets. 2018 Meeting of the American Association of Neurological Surgeons. Oral presentation. AANS/CNS Tumor Section, Columbia Softball Charity Award.

Heuer GG, Flanders TM, Madsen PJ, Kennedy BC, Storm PB, Taylor JA. A novel multidisciplinary approach to craniopagus twin separation. 2018 Neurosurgical Society of America Annual Meeting. Oral presentation.

Flanders TM, Heuer GG, Madsen P, Mackell C, Alexander E, Moldenhauer J, Zarnow D, Flake A, Adzick NS. Analysis of hydrocephalus and Chiari malformation after prenatal and postnatal myelomeningocele closure: report from a single institution. 2018 Meeting of the American Association of Neurological Surgeons. Oral presentation.

Flanders TM, Heuer GG, Madsen P, Mackell C, Alexander E, Moldenhauer J, Zarnow D, Flake A, Adzick NS. Modified myofascial technique for open fetal myelomeningocele repair results in improved outcomes. 2018 Meeting of the American Association of Neurological Surgeons. Poster presentation.

Awards and Honors

2020, Penn Health Tech Pilot Award
2018, AANS/CNS Tumor Section, Columbia Softball Charity Award
2012-2013, Class of 1949 Medical Student Scholarship
2009-2013, Samuel Bellet Scholarship, University of Pennsylvania, Center for Bioethics
2008-2012, Schlesinger Medical Student Scholarship
2008, University Honors, Carnegie Mellon University
2008, Sigma Xi, Research honor society
2008, Senior Leadership Award, Carnegie Mellon University
2007, HHMI Undergraduate Student Research Travel Award

Leadership and Memberships

Memberships in Professional Organizations

American Academy of Neurological Surgery
 - 2019-present, Communications Subcommittee, Social Media Contributor
Congress of Neurological Surgeons