Katsuhide Maeda, MD, PhD

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Katsuhide Maeda, MD, PhD, is the Director of Mechanical Circulatory Support and ECMO and the Surgical Director of Cardiac Lymphatics in the Cardiac Center at Children's Hospital of Philadelphia. 

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

PhD - (Dr. of Medical Science) Graduate School of Medicine, University of Tokyo, Tokyo, Japan 

Internship

Dept. of Surgery, University of Tokyo Hospital, Tokyo, Japan

Residency

General Surgery Residency, Dept. of Surgery, Asahi Central Hospital, Chiba, Japan

Cardiothoracic Surgery Residency, Dept. of Cardiothoracic Surgery, University of Tokyo Hospital, Tokyo, Japan

Fellowship

Clinical Fellowship, Fukuoka Children's Hospital, Fukuoka, Japan

Research Fellowship, Division of Pediatric Cardiac Surgery, Dept. of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 

Graduate Degree

MB - School of Medicine, University of Tokyo, Tokyo, Japan 

Titles and Academic Titles

Director of Mechanical Circulatory Support and ECMO

Surgical Director of Cardiac Lymphatics

Associate Professor, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

  1. Pulmonary vascular pathology related to congenital heart disease
  2. Fetal cardiac surgery
  3. Remodeling of cardiac valve structure
  4. Single ventricular VAD model

Publications

Books

Book Chapters

2020

Maeda K, Hanley Frank L. Chapter 12.4 Pediatric Cardiovascular Surgery. Anesthesiologist’s Manual of Surgical Procedures. 6th edition. 2020. Richard A. Jaffe, Clifford A. Schmiesing, Brend Golianu.

Posters and Presentations

2020

Thangappan K, Zafar F, Lorts A, Adachi I, Rossano J, Maeda K, Morales D. Milestone: More than 1,200 children bridges to Transplantation with MCS. 100th Annual Meeting of AATS. (May 2020, New York, web-based))

Ahmed H, Chen S, Yarlagadda V, Almond CS, Murray K, Rosenthal DN, Ma M, Dykes JC, Maeda K. Homograft Degeneration and VAD Support in a Neonate with Single Ventricle Heart Disease. Annual Meeting of American College of Cardiology (ACC) 2020 (March 2020, Chicago)

Maeda K, Nasirov T, Yarlagaddda V, Hollander SA, Navarathnam M, Rosenthal DN, Dykes JC, Kaufman BD, Almond CS, Reinhartz O, Murray J, Chen S. “Surgical strategy and outcome of single ventricular assist devices support for failing Fontan circulation”. 2020 56th STS meeting (Jan 2020, New Orleans)

2019

Maeda K, Ma X, Hanley FL, Riemer KR. Ross Autograft Leaflet Response to Systemic Circulation: Expression Profiling Reveals Divergence From Normal Aortic and Pulmonary Valve Leaflets.2019 AHA annual meeting (Nov 2019, Philadelphia)

Maeda K et al. "Novel Trans-Septal Left Atrial VAD Cannulation Technique for Hypertrophic/Restrictive Cardiomyopathy" 2019 ISHLT meeting (Apr 2019, Florida)

Maeda K, Nasirov T, Yarlagaddda V, Hollander SA, Navarathnam M, Rosenthal DN, Dykes JC, Kaufman BD, Almond CS, Reinhartz O, Murray J, Chen S. “Evolution of Single Ventricular Assist Device Support for Failing Bidirectional Glenn: Lessons learned”. 2019 55th STS meeting (Jan 2019, San Diego)

2018

Maeda K et al. “Modeling Mitral Regurgitation Ex Vivo Using Bioreactor Flow-Culture Demonstrates Markedly Altered Mitral Leaflet Homeostasis by Regurgitive Flow” 2018 AHA meeting (Nov 2018, San Diego)

Maeda K, Riemer KR. "Altered Expression of the Same AR and AS Genes in Proportion to the Decline in Aortic Valve Leaflet Coaptive Strain Implicates Common Leaflet Pathophysiologic Mechanisms" 8th Biennial Heart Valve Biology & Tissue Engineering Meeting (Sep 2018, London)

Maeda K, Ryan K, Conrad C, Yarlagadda V. Alternative Veno-venous ECMO cannulation strategy on children for long-term ambulatory support. 2018 ASAIO 64th Annual conference. (Washington DC, US)

2017

Chen S, Maeda K. American Heart Association Annual Meeting 2017 Bridge to transplant with ventricular assist device support in pediatric patients with single ventricle heart disease: A single center experience.  (senior author)

Maeda K, Ma X, Hanly FL, Riemer RK. American Heart Association Annual Meeting 2017 Ex vivo Flow culture modeling of aortic insufficiencey Reveals additive effects of impaired coaptation and accelerated flow on leaflet gene expression (first author)

Maeda K, Ma X, Green C, Reinhartz O, Rosenthal D, Hanley FL, Riemer RK. “Altered aortic valve leaflet gene expression following continuous flow VAD therapy in pediatric patients” 2017 World Congress of Pediatric Cardiology and Cardiac Surgery Meeting (Barcelloa, Spain)

Maeda K, Hollander S, Navarathnum M, Almond C, Rosenthal D, Chen S, Dykes J, Kaufmann B, Reinhartz O.” Cannulation strategy of ventricular assist device for supporting failing single ventricle: atrium or ventricle? ASAIO meeting 2017 (Chicago)

Maeda K, Ma X, Reinhartz O, Green C, Rosenthal D, Hanley FL, Riemer RK. “Durable Continuous Flow VAD Therapy Induces Pathogenic Changes in AV leaflets: Gene Expression Changes in Common with Calcified Aortic Valve Disease Leaflets. ASAIO meeting 2017 (Chicago)

Maeda K, Murphy DJ, Schnittger I, Tremmel JA, Hanley FL, Mitchell RS, Rogers IS. Surgical unroofing of hemodynamically significant myocardial bridges in a pediatric population. American Association for Thoracic Surgery Centennial 2017 Meeting. (Boston, US)

Maeda K, Reinhartz, Zhang Y, Chen S, Murray JM, Gowan MA, DB McElhinney, Rosenthal DN, Dykes JD, Almond CS. Impact of Left Ventricular Assist Device on End-Organ Function in US Children Awaiting Heart Transplant.  International Society of Heart and Lung Transplant 37th Annual Meeting & Scientific Sessions. (San Diego, US)

Shudo Y, Ha RV, Reinhartz O, Woo J, Boyd J, Almond CS, Rosenthal DN, Chen S, Maeda K. Surgical strategy to support right ventricle with HVAD RVAD: right atrial vs right ventricular diaphragmatic surface cannulation. International Society of Heart and Lung Transplant 37th Annual Meeting & Scientific Sessions. (San Diego, US)

Maeda K, Ma Xiaoyuan, Green CL, Hanley FL, Riemer RK. “Identification of Human Aortic Valve Leaflet Genes Associated with Disruption of Homeostasis in Aortic Regurgitation and Aortic Stenosis Patients. Annual Meeting of American College of Cardiology 2017.

Maeda K, Ma X, Hanley FL, Riemer RK. “Mitral regurgitation from a Leaflet perspective: Ex Vivo Modeling Reveals Early Pathogenesis” Annual Meeting of Heart Valve Society 2017 (Monte Carlo, Monaco)

2016

Maeda K, Ma X, Hanley FL, Riemer RK. “Use of a Novel Flow Culture Bioreactor to Examine Effects of Disrupted Coaptive Strain on Mitral Leaflet Homeostasis. AHA 2016 (New Orleans)

Maeda K, Reinhartz O, Rosenthal DN, Almond C, Kaufman B, Chen S, Bernstein D, Hollander S. “Versatility of Heartware HVAD Support in Pediatric Patients: Indications and Optimal Timing. ASAIO meeting in 2016 (San Francisco, US)

Maeda K, Almond C, Hollander SA, Rosenthal DN, Kaufman B, Yeh J, Gowen MM, Shuttleworth P, Reinhartz O. “Refining of the pump exchange procedure in children supported with the Berlin Heart Excor Ventricular Assist Device: 10 years Experience at at a single Institution. Annual Meeting of ISHLT 2016 (Nice, France)

2015

Stein ML, Yeh J, Rosenthal DN, Maeda K. Heartware HVAD for biventricular support in children and adolescents: The Stanford experience. ASAIO 61st Annual conference (2015, Chicago)

Maeda K, Ma X, Marita K, Bauser-Heaton, H, Hanley H, Riemer K. Valve cycling, Mechanical Forces, and Gene Expression. Inaugural Scientific Meeting of the heart valve Society 2015

Maeda K, Rosenthal DN, Liu E, McDonald N, Kaufmann BG, Jensen K, Barkoff L, Doan LN, Burge ME, Mikula Schneider L, Berstein D, Almond C. United States Trends in Pediatric Heart Transplantation: Are we Busier or does it just feel that way? International Society of Heart and Lung Transplant 35th Annual Meeting & Scientific Sessions.

May LJ, Lo C, Tesoro TM, Zehnder JL, Chen S, Lee J, Desai M, McElhinney DB, Rosenthal DN, Maeda K, Almond CS. Thromboelastography/Platelet Mapping and Aspirin: Is there evidence of a meaningful dose-response relationship in children supported with the Berlin Heart EXCOR ventricular assist device? International Society of Heart and Lung Transplant 35th  Annual Meeting & Scientific Sessions. (2015, Nice)

Maeda K, Almond C, Hollander SA, Rosenthal DN, Kaumann B, Yeh J, Gowen MM, Shuttleworth P, Reinhartz O. “Refining of the pump exchange procedure in children supported with the Berlin Heart EXCOR ventricular assist device: 10 years experience at a single institution. International Society of Heart and Lung Transplant 35th  Annual Meeting & Scientific Sessions. (2015, Nice)

Yarlagadda VV< Shin AY, Reinhartz O, Palmon M, Shuttleworth P, Maeda K, Yeh J, Murray J, Rosenthal DN, McElhinney DB, Almond CS. The current Role of temporary circulatory assist devices in US children awaiting heart transplant. International Society of Heart and Lung Transplant 35th  Annual Meeting & Scientific Sessions. (2015, Nice)

Hollander SA, Tyan DB, Fernandez-Vina M, Bernstein D, McDonald N, Maeda K, Kaufmann BD, May LJ, Rosenthal DN, Almond CS. Center-specific vatiations in donor aitigen frequency: Does the OPTN cPRA calculator apply to your center? International Society of Heart and Lung Transplant 35th  Annual Meeting & Scientific Sessions. (2015, Nice)

Chen S, Lin A, Liu E, May LJ, Doan LN, Maeda K, Reinhartz O, Hollander SA, Almond CS, Rosenthal DN. Discharge outcomes in children supported with continuous flow left ventricular assist device. International Society of Heart and Lung Transplant 35th  Annual Meeting & Scientific Sessions. (2015, Nice)

Leadership and Memberships

Japan Surgical Society The Japanese Association for Thoracic Surgery

The Japanese Society for Cardiovascular Surgery

The Japanese Circulation Society

Japanese Society of Pediatric Cardiology and Cardiac Surgery

International society of Heart and Lung Transplant

American Society of Artificial Internal Organs

The Society of Thoracic Surgeons International Member 

Western Thoracic Surgical Association 

European Society of Cardiothoracic Surgeon

Congenital Heart Surgeon’s Society

American Society of Transplant Surgeons 

American Heart Association