Daniel Thomas Malleske, MD, MS

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Daniel Thomas Malleske, MD, MS, is an an attending neonatologist with the Division of Neonatology at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Northeastern Ohio Medical University, Rootstown, OH


Internal Medicine and Pediatrics - The Ohio State University Medical Center and Columbus (Nationwide) Children’s Hospital, Columbus, OH


Pediatric Pulmonary Medicine - Nationwide Children’s Hospital, Columbus, OH
Neonatal and Perinatal Medicine - The Ohio State University Medical Center and Children’s Hospital, Columbus, Ohio
Pulmonary and Critical Care, Allergy and Clinical Immunology - Medical University of South Carolina, Charleston, SC

Board Certification

Internal Medicine – American Board of Internal Medicine
Neonatal-Perinatal Medicine – American Board of Pediatrics
Pediatrics – American Board of Pediatrics
Pulmonary Disease – American Board of Internal Medicine

Graduate Degree

MS in Immunology - Youngstown State University, The Graduate School, Youngstown, OH

Titles and Academic Titles

Attending Neonatologist

Associate Professor of Clinical Pediatrics

Departments and Services




Duncan AF, Malleske DT, Maitre NL. Use of Antenatal Corticosteroids for Risk of Preterm Birth-Is Timing Everything? JAMA Pediatr. 2022 Apr 11:e220480. doi: 10.1001/jamapediatrics.2022.0480. Epub ahead of print. PMID: 35404440.61.


Bauer SE, Schneider L, Lynch SK, Malleske DT, Shepherd EG, Nelin LD. Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia. 2020, Jan 8. EPUB. PMID: 31926665


Panesso-Gomez S, Shimamura M, Conces M, Talavera MM, Moallam M, Sanchez PJ, Malleske DT. Detection of Cytomegalovirus in Intestinal Tissue of Infants with Necrotizing Enterocolitis or Spontaneous Intestinal Perforation . J. Peds. 2019 Nov; 214: 34-40. PMID: 31493911


Malleske DT, Hayes D Jr, Lallier SW, Hill CL, Reynolds SD. Regulation of human airway epithelial tissue stem cell differentiation by β-catenin, P300, and CBP. Stem Cells. 2018 Dec; 36(12):1905-. PMID: 30171668

Shepherd EG, Clouse BJ, Hasenstab KA, Sitaram S, Malleske DT, Nelin LD, Jadcherla SR. Infant Pulmonary Function Testing and Phenotypes in Severe Bronchopulmonary Dysplasia. Pediatrics. 2018 May;141(5). PMID: 29622720

Malleske DT, Chorna O, Maitre NL. Pulmonary Sequelae and Functional Limitations in Children and Adults with Bronchopulmonary Dysplasia. Paediatric Respiratory Reviews, Paediatr Respir Rev. 2018 Mar; 26:55-59. PMID: 29031795


ChristensenRD, Malleske DT, Lambert DK, Baer VL, Prchal JT, Denson LE, Gerday E, Weaver Lewis KA, Shepherd JG. Measuring End-Tidal Carbon Monoxide of Jaundiced Neonates in the Birth Hospital to Identify Those with Hemolysis. Neonatology. 2015 Sep 23; 109(1): 1-5. PMID: 26394287

Schober ME, Requena DF, Abdullah OM, Casper TC, Beachy J, Malleske D, Pauly JR. Dietary Docosahexaenoic Acid Improves Cognitive Function, Tissue Sparing and Magnetic Resonance Imaging Indices of Edema and White Matter Injury in the Immature Rat after Traumatic Brain Injury. J Neurotrauma. 2015 Aug 6. PMID: 26247583.

Malleske DT and BA Yoder. Congenital chylothorax treated with oral sildenafil: a case report and review of the literature. J Perinatol, May 2015 May; 35(5): 384-6. PMID: 25917021


Zinkhan EK, Lang BY, Yu B, Wang Y, Jiang C, Fitzhugh M, Dahl M, Campbell MS, Fung C, Malleske D, Albertine KH, Joss-Moore L, Lane RH. Maternal Tobacco Smoke Increased Visceral Adiposity and Serum Corticosterone Levels in Adult Male Rat Offspring. Pediatr Res, 2014 Jul;76(1): 17-23. PMID: 24727947.


Dull RO, Cluff M, Kingston J, Hill D, Chen H, Hoehne S, Malleske DT, Kaur R. Lung heparan sulfates modulate filtration coefficient (Kfc) during increased vascular pressure; evidence for glyocalyx mediated mechano-transduction. Am J Physiol Lung Cell Mol Physiol, 2012 May 1;302(9): L816-282011. PMID: 22160307


Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics, 2011; 127(3):427-35. PMID: 21339274.


Nelin LD, Stenger MR, Malleske DT and Chicoine LG. Vascular arginase and hypertension. Current Hypertension Reviews, 2007; 3(4): 242-9. DOI: 10.2174/157340207782403881.


Malleske DT, Rogers LK, Velluci SM, Young TL, Park MS, Long DW, Welty SE, Smith CV, Nelin LD. Hyperoxia increases hepatic arginase expression and ornithine production in mice. Toxicology and Applied Pharmacology, 2006 Aug 15; 215(1): 109-17. PMID: 16554078.




Shepherd EG, Lynch SK, Malleske DT, Nelin LD. “Mechanical Ventilation of the Infant with Severe Bronchopulmonary Dysplasia.” Respiratory Management of Newborns. Ed. Hany Aly, Ed. Hesham Abdel-Hady. Rijeka, Croatia: In Tech, 2016. 83-94. www.intechopen.com/books. Web. 31 Aug. 2016.

Posters and Presentations


Daniel Thomas Malleske. Effect of protocolized inhaled prostacyclin therapy on the need for ECMO in CDH patients unresponsive to iNO. ECMO and the Advanced Therapies for Cardiovascular Failure conference, 2019.

Daniel Thomas Malleske. Molecular Testing for Common Gastrointestinal Pathogens in Intestinal Tissue of Infants with Necrotizing Enterocolitis and Spontaneous Intestinal Perforation. Pediatric Academic Societies meeting, 2019.

Invited Lectures


Pulmonary Fellows Forum. Nationwide Children’s Hospital, Columbus, OH, May 4, 2018. Neonatal Fellowship Academic Series, Nationwide Children’s Hospital, Columbus, OH, July 2016 to 2020

Awards and Honors

2014, Intermountain Medical Center NICU “Most Valuable Physician Award”, Nominee
2013, Intermountain Medical Center NICU “Most Valuable Physician Award”, Nominee
2012, Intermountain Medical Center NICU “Most Valuable Physician Award”, Nominee
2012, Primary Children’s Medical Center Physician of the Year, Nominee
2009, March of Dimes Neonatologist of the Year, Finalist
2003, Young Investigators Travel Awards Program, Pediatric Academic Society and Society for Pediatric Research, poster presentation, Seattle, Washington
2000, Dean’s Letter of Recognition for completing graduate school with a 4.0 g.p.a.
1996, Nomination to Phi Kappa Phi () national academic honor society, Youngstown State University, Youngstown, Ohio
1992, Certificate of Appreciation for Outstanding Service and Contributions to the Field Of Emergency Medical Services, Gold Cross Ambulance, Youngstown, Ohio

Military Awards

Army Commendation Medal with 1 OLC
Army Achievement Medal
Air Force Achievement Medal
Global War on Terrorism Expeditionary Medal
Global War on Terrorism Service Medal
National Defense Service Medal
Army Reserve Component Achievement Medal with 1 OLC
Armed Forces Reserve Medal with “M” device
Army Service Ribbon
Army Reserve Components Overseas Training Ribbon, 2nd award
Ohio Faithful Service Award (state award)
Serbian Remembrance Medal (foreign service award)

Editorial and Academic Positions

Editorial Positions


Sleep Medicine
Journal of Perinatology
The Anatomical Record
Journal of Applied Physiology

Leadership and Memberships

Memberships in Professional Organizations

2018-present, American Thoracic Society
2001-present, American Academy of Pediatrics, Fellow
 - 2018-present, Section on Neonatal-Perinatal Medicine MidCaN representative
2001-present, American College of Physicians
1996-present, Honor Society of Phi Kappa Phi