Eric Marsh, MD, PhD

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Eric Marsh, MD, PhD, is a pediatric neurologist in the Division of Neurology at Children’s Hospital of Philadelphia.

Areas of Expertise: Developmental Epilepsies, Epilepsy, Infantile Spasms, Malformations of Cortical Development
Locations: Buerger Center for Advanced Pediatric Care

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Eric Marsh, MD, PhD, is an attending pediatric neurologist in the Division of Neurology at Children’s Hospital of Philadelphia (CHOP). He specializes in diagnosing and treating children with developmental epilepsies, epilepsy, infantile spasm and malformations of cortical development.

Dr. Marsh’s philosophy of care centers around helping families feel heard and informed.

“It’s important that families are listened to, their concerns are taken seriously and the issues and conditions they face are explained to them to the best of our abilities,” he says.

In addition to his role at CHOP, Dr. Marsh is an associate professor of neurology at the Perelman School of Medicine at the University of Pennsylvania.

Dr. Marsh has long been fascinated by the workings of the brain and how its billions of neurons can lead to neurological diseases when not functioning properly. This interest has driven his research into genetic epilepsies and genetic neurodevelopmental disorders.

“Understanding these disorders can lead to a better grasp of how the brain works and can lead to novel treatments and cures for these conditions,” he says.

Much of Dr. Marsh’s research focuses on mutations in the ARX gene, which cause epilepsy and other diseases. He is also studying the clinical presentations of Rett syndrome, Dravet syndrome and Lennox-Gastaut syndrome, CDKL5 syndrome and related disorders, and is involved in a number of clinical trials for novel therapeutics.

“There is an emergence of cell-, RNA- and DNA-based therapies as well as pathway-directed pharmaceutical approaches to treating these difficult to treat conditions,” he says. “I feel that a better clinical understanding of these conditions using new technologies to track and monitor neurological function will allow for novel therapies to improve patients’ lives.”

Education and Training

Medical School

MD - New York University, New York, NY

Internship

Pediatrics - Bellevue Hospital/NYU Medical Center, New York, NY

Residency

Pediatrics - Bellevue Hospital/NYU Medical Center, New York, NY
Child Neurology - Children's Hospital of Philadelphia/Hospital of the University of Pennsylvania, Philadelphia, PA

Fellowship

Clinical Neurophysiology - Children's Hospital of Philadelphia, Philadelphia, PA
Post Doctoral Fellow - Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Clinical Neurophsyiology
Child Neurology
Pediatrics

Graduate Degree

MS in Physiology and Neuroscience - New York University- Sackler School of Biomedical Sciences, New York, NY
PhD in Physiology and Neuroscience - New York University- Sackler School of Biomedical Sciences, New York, NY

Titles and Academic Titles

Attending Physician

Head, Neurogenetics Program

Associate Professor of Neurology, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

My primary research interest is in understanding the relationship between interneuronal development and altered excitability that leads to epilepsy. This pattern is primarily seen in children with malformations of cortical development but also a number of emerging set of diseases called interneuronopathies. We are studying how loss of a gene important for interneuronal development, the gene ARX, can lead to changes in excitability and development of epilepsy. I am also interested in analyzing intracranial EEG recordings to learn how to better localized the epileptic zone and network. These studies will improve how patients are cared for during epilepsy surgery and improve the understanding of how abnormal brain generates seizures.

Publications

Papers

2018

Rogers SL, Rankin-Gee E, Risbud RM, Porter BE, Marsh ED. Normal Development of the Perineuronal Net in Humans; In Patients with and without Epilepsy. Neuroscience. 2018 Aug 1;384:350-360. doi: 10.1016/j.neuroscience.2018.05.039. Epub 2018 Jun 7.

Tomlinson SB, Khambhati AN, Bermudez C, Kamens RM, Heuer GG, Porter BE, Marsh ED. Alterations of network synchrony after epileptic seizures: An analysis of post-ictal intracranial recordings in pediatric epilepsy patients. Epilepsy Res. 2018 Jul;143:41-49. doi: 10.1016/j.eplepsyres.2018.04.003. Epub 2018 Apr 5.

Thiele EA, Marsh ED, French JA, Mazurkiewicz-Beldzinska M, Benbadis SR, Joshi C, Lyons PD, Taylor A, Roberts C, Sommerville K; GWPCARE4 Study Group. Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2018 Mar 17;391(10125):1085-1096. doi: 10.1016/S0140-6736(18)30136-3. Epub 2018 Jan 26.

Lee BH, Reijnders MRF, Abubakare O, Tuttle E, Lape B, Minks KQ, Stodgell C, Bennetto L, Kwon J, Fong CT, Gripp KW, Marsh ED, Smith WE, Huq AM, Coury SA, Tan WH, Solis O, Mehta RI, Leventer RJ, Baralle D, Hunt D, Paciorkowski AR. Expanding the neurodevelopmental phenotype of PURA syndrome. Am J Med Genet A. 2018 Jan;176(1):56-67. doi: 10.1002/ajmg.a.38521. Epub 2017 Nov 17.

2017

Helbig I, von Deimling M, Marsh ED. Epileptic Encephalopathies as Neurodegenerative Disorders. Adv Neurobiol. 2017;15:295-315. doi: 10.1007/978-3-319-57193-5_11.

von Deimling M, Helbig I, Marsh ED. Epileptic Encephalopathies-Clinical Syndromes and Pathophysiological Concepts. Curr Neurol Neurosci Rep. 2017 Feb;17(2):10. doi: 10.1007/s11910-017-0720-7. Review.

Ahrens-Nicklas RC, Umanah GK, Sondheimer N, Deardorff MA, Wilkens AB, Conlin LK, Santani AB, Nesbitt A, Juulsola J, Ma E, Dawson TM, Dawson VL, Marsh ED. Precision therapy for a new disorder of AMPA receptor recycling due to mutations in ATAD1. Neurol Genet. 2017 Feb 1;3(1):e130. doi: 10.1212/NXG.0000000000000130. eCollection 2017 Feb.

Tomlinson SB, Porter BE, Marsh ED. Interictal network synchrony and local heterogeneity predict epilepsy surgery outcome among pediatric patients. Epilepsia. 2017 Mar;58(3):402-411. doi: 10.1111/epi.13657. Epub 2017 Feb 6.

Olson HE, Kelly M, LaCoursiere CM, Pinsky R, Tambunan D, Shain C, Ramgopal S, Takeoka M, Libenson MH, Julich K, Loddenkemper T, Marsh ED, Segal D, Koh S, Salman MS, Paciorkowski AR, Yang E, Bergin AM, Sheidley BR, Poduri A. Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017 Mar;81(3):419-429. doi: 10.1002/ana.24883. Epub 2017 Feb 14.

Shen D, Hernandez CC, Shen W, Hu N, Poduri A, Shiedley B, Rotenberg A, Datta AN, Leiz S, Patzer S, Boor R, Ramsey K, Goldberg E, Helbig I, Ortiz-Gonzalez XR, Lemke JR, Marsh ED, Macdonald RL. De novo GABRG2 mutations associated with epileptic encephalopathies. Brain. 2017 Jan;140(1):49-67. doi: 10.1093/brain/aww272. Epub 2016 Nov 17.

Gofshteyn JS, Wilfong A, Devinsky O, Bluvstein J, Charuta J, Ciliberto MA, Laux L, Marsh ED. Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases. J Child Neurol. 2017 Jan;32(1):35-40. doi: 10.1177/0883073816669450. Epub 2016 Sep 29.

2016

Tomlinson SB, Bermudez C, Conley C, Brown MW, Porter BE, Marsh ED. Spatiotemporal Mapping of Interictal Spike Propagation: A Novel Methodology Applied to Pediatric Intracranial EEG Recordings. Front Neurol. 2016 Dec 19;7:229. doi: 10.3389/fneur.2016.00229. eCollection 2016.

Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W, Schulien AJ, Chiavacci R, Tankovic A, Naase C, Brueckner F, von Stülpnagel-Steinbeis C, Hu C, Kusumoto H, Hedrich UB, Elsen G, Hörtnagel K, Aizenman E, Lemke JR, Hakonarson H, Traynelis SF, Falk MJ. GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers. Am J Hum Genet. 2016 Oct 6;99(4):802-816. doi: 10.1016/j.ajhg.2016.07.013. Epub 2016 Sep 8.

Hazra A, Corbett BF, You JC, Aschmies S, Zhao L, Li K, Lepore AC, Marsh ED, Chin J. Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer's disease. Neurobiol Aging. 2016 Aug;44:96-107. doi: 10.1016/j.neurobiolaging.2016.04.016. Epub 2016 Apr 29.

Marsh ED, Nasrallah MP, Walsh C, Murray KA, Nicole Sunnen C, McCoy A, Golden JA. Developmental interneuron subtype deficits after targeted loss of Arx. BMC Neurosci. 2016 Jun 10;17(1):35. doi: 10.1186/s12868-016-0265-8.

2015

Ng JM, Martinez D, Marsh ED, Zhang Z, Rappaport E, Santi M, Curran T. Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53. Cancer Res. 2015 Nov 1;75(21):4629-39. doi: 10.1158/0008-5472.CAN-15-0874. Epub 2015 Sep 11.

Skjei KL, Church EW, Harding BN, Santi M, Holland-Bouley KD, Clancy RR, Porter BE, Heuer GG, Marsh ED. Clinical and histopathological outcomes in patients with SCN1A mutations undergoing surgery for epilepsy. J Neurosurg Pediatr. 2015 Dec;16(6):668-74. doi: 10.3171/2015.5.PEDS14551. Epub 2015 Sep 4. 

2014

Bourgeois EB, Johnson BN, McCoy AJ, Trippa L, Cohen AS, Marsh ED. A toolbox for spatiotemporal analysis of voltage-sensitive dye imaging data in brain slices. PLoS One. 2014 Sep 26;9(9):e108686. doi: 10.1371/journal.pone.0108686. eCollection 2014.

Falk MJ, Li D, Gai X, McCormick E, Place E, Lasorsa FM, Otieno FG, Hou C, Kim CE, Abdel-Magid N, Vazquez L, Mentch FD, Chiavacci R, Liang J, Liu X, Jiang H, Giannuzzi G, Marsh ED, Guo Y, Tian L, Palmieri F, Hakonarson H. Erratum to: AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate. JIMD Rep. 2014;14:119. doi: 10.1007/8904_2014_314. Epub 2014 Jun 29. No abstract available.

Pierson Tyler Mark, Yuan Hongjie, Marsh Eric D, Fuentes-Fajardo Karin, Adams David R, Markello Thomas, Golas Gretchen, Simeonov Dimitre R, Holloman Conisha, Tankovic Anel, Karamchandani Manish M, Schreiber John M, Mullikin James C, Tifft Cynthia J, Toro Camilo, Boerkoel Cornelius F, Traynelis Stephen F, Gahl William A: GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine. Annals of clinical and translational neurology 1(3): 190-198, 2014. 

Simonet Jacqueline C, Sunnen C Nicole, Wu Jue, Golden Jeffrey A, Marsh Eric D: Conditional Loss of Arx From the Developing Dorsal Telencephalon Results in Behavioral Phenotypes Resembling Mild Human ARX Mutations. Cerebral cortex (New York, N.Y. : 1991) 2014. 

Matalon Dena, Goldberg Ethan, Medne Livija, Marsh Eric D: Confirming an expanded spectrum of SCN2A mutations: a case series. Epileptic disorders : international epilepsy journal with videotape 16(1): 13-8, 2014. 

Sunnen C Nicole, Simonet Jacqueline C, Marsh Eric D, Golden Jeffrey A: Arx is required for specification of the zona incerta and reticular nucleus of the thalamus. Journal of neuropathology and experimental neurology 73(3): 253-61, 2014. 

Falk Marni J, Li Dong, Gai Xiaowu, McCormick Elizabeth, Place Emily, Lasorsa Francesco M, Otieno Frederick G, Hou Cuiping, Kim Cecilia E, Abdel-Magid Nada, Vazquez Lyam, Mentch Frank D, Chiavacci Rosetta, Liang Jinlong, Liu Xuanzhu, Jiang Hui, Giannuzzi Giulia, Marsh Eric D, Yiran Guo, Tian Lifeng, Palmieri Ferdinando, Hakonarson Hakon: AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate. JIMD reports 2014. 

Books

Devinsky O, Conway E, Glick S: Epilepsy in Children: What Every Parent Needs to Know. Demos Medical Books. Demos Health, Page: 320 pages, Dec 2015 Notes: Edited and reviewed multiple chapters and acknowledged in booksISBN-10: 1936303787.

Chapters

2017

Helbig I, von Deimling M, and Marsh ED: Epileptic encephalopathies as neurodegenerative disorders Neurodegenerative Diseases: Pathology, Mechanisms, and Potential Therapeutic Targets: Advances in Neurobiology. Philip Beart, Michael Robinson, Marcus Rattray, Nicholas Maragakis  (eds.). Springer, 15: 295-315, 2017.

von Deimling M, Helbig I, and Marsh ED,: Epileptic Encephalopathies-Clinical Syndromes and Pathophysiological Concepts. Current Neurology and Neuroscience Reports. Drs. Fahn, Brust, and Kaufman (eds.). Springer, 2(10), Feb 2017.

2013

Abend NS, Marsh E, Dlugos DJ.: Status Epilepticus  Requisites in Pediatrics (Critical Care Edition). Mark Helfer and Danielle Davis (eds.). Elsevier, 2013.

2012

Marsh, E. D. and Golden, J. A.:  Aristaless-related homeobox mutations  Jasper's Basic Mechanisms of the Epilepsies. Jeffrey L Noebels, Massimo Avoli, Michael A Rogawski, Richard W Olsen, and Antonio V Delgado-Escueta (eds.). Oxford University Press, 4: Chapter 63, June 2012.

2008

Marsh, E., and Brooks-Kayal, A.: Partial and Generalized Seizures. The 5-Minute Pediatric Clinical Consult. M. William Schwartz (eds.). Lippincott Williams & Wilkens, 5th Edition : 762-63, 2008.

Marsh, E. and Brooks-Kayal, A: Status Epilepticus. The 5-Minute Pediatric Clinical Consult. M. William Schwartz (eds.). Lippincott Williams & Wilkens, 5th Edition: 800-01, 2008.

Marsh, E. and Brooks-Kayal, A: Coma  The 5-Minute Pediatric Clinical Consult. M. William Schwartz (eds.). Lippincott Williams & Wilkens, 5th Edition: 20-21, 2008.

Marsh, E. and Brooks-Kayal, A: Febrile Seizures  The 5-Minute Pediatric Clinical Consult. M. William Schwartz (eds.). Lippincott Williams & Wilkens, 5th Edition: 760-61, 2008.

Marsh, E. and Brooks-Kayal, A: Infantile Spasms. The 5-Minute Pediatric Clinical Consult. M. William Schwartz (eds.). Lippincott Williams & Wilkens, 5th Edition: 484-85, 2008.

Marsh E.D. and Brooks-Kayal A.R.: Cellular, molecular, andbehavioural consequences of early life-seizures. Encyclopedia of Basic Epilepsy Research. Schwartzkroin P (eds.). Elsevier Ltd, Page: Chapter 36, 2008.

Posters and Presentations

Invited Lectures

2018

Marsh E. "The emerging data for Cannabinoids in Epilepsy", George Washington University, Washington DC. Jun 2018.

Marsh E. "Cannabinoids in Epilepsy", International Conference on the Science of Botanicals, Oxford Miss. Apr 2018.

Marsh E. "Understanding the epileptic encephalopathies: Arx as a model disorder", SickKids Hospital, Toronto Canada. Apr 2018.

2017

Marsh E. "Electrophysiological Biomakers Session: Introduction and Moderator", Neurodevelopmental disabilities Biomarkers Symposium- NICHD, Bethesda MD. Dec 2017.

Marsh E. "Medical Marijuana- Benefits, Side Effects, and the Law", Richmond University Medical Center, New York, NY. May 2017.

Awards and Honors

  • 2014, Leonard Berwick Teaching Award/Perelman School of Medicine
  • 2007, Young Investigator Award of the MRDDC center at the Children's Hospital of Philadelphia
  • 2005, American Epilepsy Society/Milken Family Foundation- Early Career Investigator Award
  • 2004, Merritt Putnam Award of the Epilepsy Foundation Research and Clinical Training Grant
  • 2004, Abass-Alavi Postdoctoral Fellow Award in Mental Retardation and Developmental Disabilities
  • 2002, Child Neurology Society- TOPs Scholar
  • 2000, Resident of year award, NYU Department of Pediatrics
  • 1996, Graduate student award, Annual Neural Control of Movement Meeting

Editorial and Academic Positions

Editorial Positions

2017-present, Ad hoc Reviewer, Annals of Neurology
2017-present, Ad Hoc Reviewer, Neurology
2016-present, Ad Hoc Reviewer, Science Translational Medicine
2016-present, Ad Hoc Reviewer, Human Molecular Genetics
2015-present, Ad hoc Reviewer, Neurobiology of Stress
2014-present, Ad hoc reviewer, American Journal of Human Genetics
2013-present, Ad Hoc Reviewer; Epilepsy Research
2013-present, Ad Hoc Reviewer, Journal of Neuroscience
2011-present, Ad hoc reviewer, Neurochemistry International
2008-present, AdHoc Reviewer/Epilepsy and Behavior
2008-present, AdHoc Reviewer; Journal of Neuroscience Research
2007-present, AdHoc Reviewer/European Journal of Neuroscience
2007-present, AdHoc Reviewer/Pediatric Emergency Care
2007-present, AdHoc Reviewer/Epilepsia
2006-present, AdHoc Reviewer/Clinical Neurophysiology

Leadership and Memberships

Memberships in Professional Organizations

  • 2016-present, Jefferson Medical College Center for Medicinal Cannabis Education and Research
    • 2016-present, Advisory Board Member
  • 2015-present, National Institutes of Neurological Disease and Stroke
  • 2015-present, Lennox Gastaut Syndrome Foundation
    • 2015-present, Member scientific advisory board
  • 2015-present, Citizens United for Research in Epilepsy (C.U.R.E)
  • 2007-present, Society for Neuroscience
  • 2003-present, American Epilepsy Society
  • 2000-present, Child Neurology Society
  • 2000-present, American Academy of Neurology