Eric Marsh, MD, PhD

Eric Marsh, MD, PhD

Eric Marsh, MD, PhD, is a pediatric neurologist at Children’s Hospital of Philadelphia.

Areas of Expertise: Developmental Epilepsies, Epilepsy, Infantile Spasms, Malformations of Cortical Development
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

New York University, New York, NY

Internship

Bellevue Hospital/NYU Medical Center, New York, NY

Residency

Bellevue Hospital/NYU Medical Center, New York, NY

Fellowship

Children's Hospital of Philadelphia, Philadelphia, Pa.

Board Certification

American Board of Psychiatry and Neurology/Child Neurology and Clinical Neurophysiology
American Board of Radiology/Diagnostic Radiology

Graduate Degree

New York University, New York, NY

Titles and Academic Titles

Attending physician

Pediatric neurologist, Perelman School of Medicine at the University of Pennsylvania.

Departments and Services

Research Interests

My primary research interest is in understanding the relationship between interneuronal development and altered excitability that leads to epilepsy. This pattern is primarily seen in children with malformations of cortical development but also a number of emerging set of diseases called interneuronopathies. We are studying how loss of a gene important for interneuronal development, the gene ARX, can lead to changes in excitability and development of epilepsy. I am also interested in analyzing intracranial EEG recordings to learn how to better localized the epileptic zone and network. These studies will improve how patients are cared for during epilepsy surgery and improve the understanding of how abnormal brain generates seizures.

Publications

Papers

2018

Rogers SL, Rankin-Gee E, Risbud RM, Porter BE, Marsh ED. Normal Development of the Perineuronal Net in Humans; In Patients with and without Epilepsy. Neuroscience. 2018 Aug 1;384:350-360. doi: 10.1016/j.neuroscience.2018.05.039. Epub 2018 Jun 7.

Tomlinson SB, Khambhati AN, Bermudez C, Kamens RM, Heuer GG, Porter BE, Marsh ED. Alterations of network synchrony after epileptic seizures: An analysis of post-ictal intracranial recordings in pediatric epilepsy patients. Epilepsy Res. 2018 Jul;143:41-49. doi: 10.1016/j.eplepsyres.2018.04.003. Epub 2018 Apr 5.

Thiele EA, Marsh ED, French JA, Mazurkiewicz-Beldzinska M, Benbadis SR, Joshi C, Lyons PD, Taylor A, Roberts C, Sommerville K; GWPCARE4 Study Group. Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2018 Mar 17;391(10125):1085-1096. doi: 10.1016/S0140-6736(18)30136-3. Epub 2018 Jan 26.

Lee BH, Reijnders MRF, Abubakare O, Tuttle E, Lape B, Minks KQ, Stodgell C, Bennetto L, Kwon J, Fong CT, Gripp KW, Marsh ED, Smith WE, Huq AM, Coury SA, Tan WH, Solis O, Mehta RI, Leventer RJ, Baralle D, Hunt D, Paciorkowski AR. Expanding the neurodevelopmental phenotype of PURA syndrome. Am J Med Genet A. 2018 Jan;176(1):56-67. doi: 10.1002/ajmg.a.38521. Epub 2017 Nov 17.

2017

Helbig I, von Deimling M, Marsh ED. Epileptic Encephalopathies as Neurodegenerative Disorders. Adv Neurobiol. 2017;15:295-315. doi: 10.1007/978-3-319-57193-5_11.

von Deimling M, Helbig I, Marsh ED. Epileptic Encephalopathies-Clinical Syndromes and Pathophysiological Concepts. Curr Neurol Neurosci Rep. 2017 Feb;17(2):10. doi: 10.1007/s11910-017-0720-7. Review.

Ahrens-Nicklas RC, Umanah GK, Sondheimer N, Deardorff MA, Wilkens AB, Conlin LK, Santani AB, Nesbitt A, Juulsola J, Ma E, Dawson TM, Dawson VL, Marsh ED. Precision therapy for a new disorder of AMPA receptor recycling due to mutations in ATAD1. Neurol Genet. 2017 Feb 1;3(1):e130. doi: 10.1212/NXG.0000000000000130. eCollection 2017 Feb.

Tomlinson SB, Porter BE, Marsh ED. Interictal network synchrony and local heterogeneity predict epilepsy surgery outcome among pediatric patients. Epilepsia. 2017 Mar;58(3):402-411. doi: 10.1111/epi.13657. Epub 2017 Feb 6.

Olson HE, Kelly M, LaCoursiere CM, Pinsky R, Tambunan D, Shain C, Ramgopal S, Takeoka M, Libenson MH, Julich K, Loddenkemper T, Marsh ED, Segal D, Koh S, Salman MS, Paciorkowski AR, Yang E, Bergin AM, Sheidley BR, Poduri A. Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017 Mar;81(3):419-429. doi: 10.1002/ana.24883. Epub 2017 Feb 14.

Shen D, Hernandez CC, Shen W, Hu N, Poduri A, Shiedley B, Rotenberg A, Datta AN, Leiz S, Patzer S, Boor R, Ramsey K, Goldberg E, Helbig I, Ortiz-Gonzalez XR, Lemke JR, Marsh ED, Macdonald RL. De novo GABRG2 mutations associated with epileptic encephalopathies. Brain. 2017 Jan;140(1):49-67. doi: 10.1093/brain/aww272. Epub 2016 Nov 17.

Gofshteyn JS, Wilfong A, Devinsky O, Bluvstein J, Charuta J, Ciliberto MA, Laux L, Marsh ED. Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases. J Child Neurol. 2017 Jan;32(1):35-40. doi: 10.1177/0883073816669450. Epub 2016 Sep 29.

2016

Tomlinson SB, Bermudez C, Conley C, Brown MW, Porter BE, Marsh ED. Spatiotemporal Mapping of Interictal Spike Propagation: A Novel Methodology Applied to Pediatric Intracranial EEG Recordings. Front Neurol. 2016 Dec 19;7:229. doi: 10.3389/fneur.2016.00229. eCollection 2016.

Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W, Schulien AJ, Chiavacci R, Tankovic A, Naase C, Brueckner F, von Stülpnagel-Steinbeis C, Hu C, Kusumoto H, Hedrich UB, Elsen G, Hörtnagel K, Aizenman E, Lemke JR, Hakonarson H, Traynelis SF, Falk MJ. GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers. Am J Hum Genet. 2016 Oct 6;99(4):802-816. doi: 10.1016/j.ajhg.2016.07.013. Epub 2016 Sep 8.

Hazra A, Corbett BF, You JC, Aschmies S, Zhao L, Li K, Lepore AC, Marsh ED, Chin J. Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer's disease. Neurobiol Aging. 2016 Aug;44:96-107. doi: 10.1016/j.neurobiolaging.2016.04.016. Epub 2016 Apr 29.

Marsh ED, Nasrallah MP, Walsh C, Murray KA, Nicole Sunnen C, McCoy A, Golden JA. Developmental interneuron subtype deficits after targeted loss of Arx. BMC Neurosci. 2016 Jun 10;17(1):35. doi: 10.1186/s12868-016-0265-8.

2015

Ng JM, Martinez D, Marsh ED, Zhang Z, Rappaport E, Santi M, Curran T. Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53. Cancer Res. 2015 Nov 1;75(21):4629-39. doi: 10.1158/0008-5472.CAN-15-0874. Epub 2015 Sep 11.

Skjei KL, Church EW, Harding BN, Santi M, Holland-Bouley KD, Clancy RR, Porter BE, Heuer GG, Marsh ED. Clinical and histopathological outcomes in patients with SCN1A mutations undergoing surgery for epilepsy. J Neurosurg Pediatr. 2015 Dec;16(6):668-74. doi: 10.3171/2015.5.PEDS14551. Epub 2015 Sep 4. 

2014

Bourgeois EB, Johnson BN, McCoy AJ, Trippa L, Cohen AS, Marsh ED. A toolbox for spatiotemporal analysis of voltage-sensitive dye imaging data in brain slices. PLoS One. 2014 Sep 26;9(9):e108686. doi: 10.1371/journal.pone.0108686. eCollection 2014.

Falk MJ, Li D, Gai X, McCormick E, Place E, Lasorsa FM, Otieno FG, Hou C, Kim CE, Abdel-Magid N, Vazquez L, Mentch FD, Chiavacci R, Liang J, Liu X, Jiang H, Giannuzzi G, Marsh ED, Guo Y, Tian L, Palmieri F, Hakonarson H. Erratum to: AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate. JIMD Rep. 2014;14:119. doi: 10.1007/8904_2014_314. Epub 2014 Jun 29. No abstract available.

Pierson Tyler Mark, Yuan Hongjie, Marsh Eric D, Fuentes-Fajardo Karin, Adams David R, Markello Thomas, Golas Gretchen, Simeonov Dimitre R, Holloman Conisha, Tankovic Anel, Karamchandani Manish M, Schreiber John M, Mullikin James C, Tifft Cynthia J, Toro Camilo, Boerkoel Cornelius F, Traynelis Stephen F, Gahl William A: GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine. Annals of clinical and translational neurology 1(3): 190-198, 2014. 

Simonet Jacqueline C, Sunnen C Nicole, Wu Jue, Golden Jeffrey A, Marsh Eric D: Conditional Loss of Arx From the Developing Dorsal Telencephalon Results in Behavioral Phenotypes Resembling Mild Human ARX Mutations. Cerebral cortex (New York, N.Y. : 1991) 2014. 

Matalon Dena, Goldberg Ethan, Medne Livija, Marsh Eric D: Confirming an expanded spectrum of SCN2A mutations: a case series. Epileptic disorders : international epilepsy journal with videotape 16(1): 13-8, 2014. 

Sunnen C Nicole, Simonet Jacqueline C, Marsh Eric D, Golden Jeffrey A: Arx is required for specification of the zona incerta and reticular nucleus of the thalamus. Journal of neuropathology and experimental neurology 73(3): 253-61, 2014. 

Falk Marni J, Li Dong, Gai Xiaowu, McCormick Elizabeth, Place Emily, Lasorsa Francesco M, Otieno Frederick G, Hou Cuiping, Kim Cecilia E, Abdel-Magid Nada, Vazquez Lyam, Mentch Frank D, Chiavacci Rosetta, Liang Jinlong, Liu Xuanzhu, Jiang Hui, Giannuzzi Giulia, Marsh Eric D, Yiran Guo, Tian Lifeng, Palmieri Ferdinando, Hakonarson Hakon: AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate. JIMD reports 2014.