Eric Marsh, MD, PhD

Eric Marsh, MD, PhD

Eric Marsh, MD, PhD, is a pediatric neurologist at The Children’s Hospital of Philadelphia.

Areas of Expertise: Developmental Epilepsies, Epilepsy, Infantile Spasms, Malformations of Cortical Development
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

New York University, New York, NY

Internship

Bellevue Hospital/NYU Medical Center, New York, NY

Residency

Bellevue Hospital/NYU Medical Center, New York, NY

Fellowship

Children's Hospital of Philadelphia, Philadelphia, Pa.

Board Certification

American Board of Psychiatry and Neurology/Child Neurology and Clinical Neurophysiology
American Board of Radiology/Diagnostic Radiology

Graduate Degree

New York University, New York, NY

Titles and Academic Titles

Attending physician

Pediatric neurologist, Perelman School of Medicine at the University of Pennsylvania.

Departments and Services

Research Interests

My primary research interest is in understanding the relationship between interneuronal development and altered excitability that leads to epilepsy. This pattern is primarily seen in children with malformations of cortical development but also a number of emerging set of diseases called interneuronopathies. We are studying how loss of a gene important for interneuronal development, the gene ARX, can lead to changes in excitability and development of epilepsy. I am also interested in analyzing intracranial EEG recordings to learn how to better localized the epileptic zone and network. These studies will improve how patients are cared for during epilepsy surgery and improve the understanding of how abnormal brain generates seizures.

Publications

Papers

2014

Pierson Tyler Mark, Yuan Hongjie, Marsh Eric D, Fuentes-Fajardo Karin, Adams David R, Markello Thomas, Golas Gretchen, Simeonov Dimitre R, Holloman Conisha, Tankovic Anel, Karamchandani Manish M, Schreiber John M, Mullikin James C, Tifft Cynthia J, Toro Camilo, Boerkoel Cornelius F, Traynelis Stephen F, Gahl William A: GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine. Annals of clinical and translational neurology 1(3): 190-198, 2014. 

Simonet Jacqueline C, Sunnen C Nicole, Wu Jue, Golden Jeffrey A, Marsh Eric D: Conditional Loss of Arx From the Developing Dorsal Telencephalon Results in Behavioral Phenotypes Resembling Mild Human ARX Mutations. Cerebral cortex (New York, N.Y. : 1991) 2014. 

Matalon Dena, Goldberg Ethan, Medne Livija, Marsh Eric D: Confirming an expanded spectrum of SCN2A mutations: a case series. Epileptic disorders : international epilepsy journal with videotape 16(1): 13-8, 2014. 

Sunnen C Nicole, Simonet Jacqueline C, Marsh Eric D, Golden Jeffrey A: Arx is required for specification of the zona incerta and reticular nucleus of the thalamus. Journal of neuropathology and experimental neurology 73(3): 253-61, 2014. 

Falk Marni J, Li Dong, Gai Xiaowu, McCormick Elizabeth, Place Emily, Lasorsa Francesco M, Otieno Frederick G, Hou Cuiping, Kim Cecilia E, Abdel-Magid Nada, Vazquez Lyam, Mentch Frank D, Chiavacci Rosetta, Liang Jinlong, Liu Xuanzhu, Jiang Hui, Giannuzzi Giulia, Marsh Eric D, Yiran Guo, Tian Lifeng, Palmieri Ferdinando, Hakonarson Hakon: AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate. JIMD reports 2014.