Hayat Mousa, MD

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Dr. Hayat Mousa is the director of the Suzi and Scott Lustgarten GI Motility Center and a pediatric gastroenterologist in the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia. She holds the Suzi and Scott Lustgarten Endowed Chair for Clinical Care of GI Motility Disorders.

Locations: Buerger Center for Advanced Pediatric Care

Phone: 215-590-1678


Hayat Mousa, MD, is Director of the Suzi and Scott Lustgarten GI Motility Center, Director of the Frontier Program for Precision Diagnosis and Therapy for Pediatric Motility Disorders, and Program Director of the Advanced GI Motility Fellowship – all at Children’s Hospital of Philadelphia (CHOP). She is also the Suzi and Scott Lustgarten Endowed Chair for Clinical Care of GI Motility Disorders and a pediatric gastroenterologist with the Division of Gastroenterology, Hepatology and Nutrition at CHOP, and Endowed Chair and Professor at the Perelman School of Medicine at the University of Pennsylvania.

Dr. Mousa joined CHOP on Sept. 1, 2020, from her previous role as Clinical Director of Pediatric Gastroenterology and Director of the Neurogastroenterology and Motility Center at Rady Children's Hospital-San Diego, CA.

Dr. Mousa is a national leader and world-renowned expert in pediatric gastrointestinal (GI) motility disorders. She was trained at Children's Hospital of Pittsburgh, with broad exposure to all GI disorders including liver disease, small bowel transplantation and GI motility disorders. Subsequently, she joined the GI group at Nationwide Children's Hospital in Columbus, OH, where she developed its Motility Center, served as Medical Director for Motility for 15 years, and served as Fellowship Director of a GME-approved training program in pediatric motility disorders for 10 years.

Dr. Mousa’s key interests include gastroparesis, gastric electric stimulation (GES), chronic intestinal pseudo-obstruction, swallowing disorders, constipation, cecostomy, sacral nerve stimulation, rumination, gastroesophageal reflux, Hirschsprung's disease, GI motility diseases and other functional disorders. She has special clinical expertise in managing patients in multidisciplinary settings and had an active role in developing both aerodigestive and colorectal multidisciplinary teams.

Since Dr. Mousa’s pediatric GI fellowship training at Children’s Hospital of Pittsburgh, her clinical and research activities have been focused on motility and functional GI disorders. In her prospective clinical trials, she evaluated GI physiology, as well as investigated the pathophysiology of functional GI disorders, specifically the changes in gastric accommodation and compliance after fundoplication, and clinical outcomes after gastric electric stimulation and sacral nerve stimulation. She pioneered the use of gastric electric stimulation in pediatrics at Nationwide Children’s Hospital in collaboration with the pediatric surgeon and motility team. She and the team recently reported their 10-year experience in pediatric gastric electric stimulation. Most recently, Dr. Mousa has begun applying body surface gastric mapping (BSGM) to pediatric clinical research at CHOP.

Dr. Mousa’s contributions to science include innovation in the following areas:

  • High-resolution electrogastrography: In collaboration with biomedical engineering, Dr. Mousa has helped validate non-invasive, high-resolution electrogastrography (EGG) by simultaneously performing antroduodenal manometry studies and HR-EGG using a wearable multi-channel system and artifact removal signal processing methods. Dr. Mousa’s team also evaluated the benefits of using cutaneous, high-resolution electrogastrography (HR-EGG) in subjects with active foregut symptoms and found that abnormal spatial parameters – detected by cutaneous HR-EGG – correlated with a severity of upper GI symptoms, regardless of gastric emptying. This non-invasive diagnostic study has the potential to lead therapeutic intervention in patients with foregut functional symptoms. Dr. Mousa hopes to soon offer this technique to patients at CHOP with functional GI disorders and implement interventions based on their personal gastric rhythm.
  • EndoFLIP technique: Understanding the pathophysiology of dysphagia and offering a cure were the drivers to master EndoFLIP technique in patients with dysphagia. Dr. Mousa collaborated with biomedical engineering and created a program for an automated analysis of the dynamic changes and dispensability findings. In this prospective study, the team aimed to investigate whether esophageal compliance is a more sensitive measure than esophageal dispensability in detecting epithelial remodeling on regional and global esophageal levels in children with eosinophilic esophagitis (EoE) compared to controls. Dr. Mousa and her research team hypothesized that compliance was a stronger indicator of remodeling than distensibility. She helped standardize the protocol for the FLIP catheter position and collaborated with biomedical engineering to develop an automated analysis protocol.
  • Neuromodulation of the gastrointestinal tract: Dr. Mousa has also examined gastric pacing in the management of patients with gastroparesis and evaluated the benefits of gastric electric stimulation on children with gastroparesis and functional dyspepsia. In addition, she and the team have evaluated the use of sacral nerve stimulation in patient with defecation disorders, and the value of colonic motility in predicting the outcome of cecostomy placement in patients with severe constipation.
  • Non-invasive assessments of gastrointestinal transit time. Dr. Mousa has also investigated the sensitivity and validity of the Wireless Motility Capsule Test in diagnostic capsule endoscopy in children.

Dr. Mousa is very passionate about organizational leadership and process improvement. She has held several leadership positions and received certificates in leadership from CHOP and Rady Children’s Hospital. Dr. Mousa has published extensively on topic including chronic intestinal pseudo-obstruction; pre- and post-transplantation; gastric accomodation and compliance after fundoplication; gastroesophageal reflux and its association with apnea and respiratory symptoms; and how gastric pacing impacts gastric function and quality of life.

She is an active member of several professional societies including the American Neurogastrointestinal Motility Society (ANMS), North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), and the American Gastroenterology Association (AGA). She currently chairs NASPGHAN’s Aerodigestive Special Interest Group (SIG). She organized the 2021 NASPGHAN Single Topic Symposium and led the publication of its proceedings with the Aerodigestive team.

Dr. Mousa has been awarded the NASPGHAN Motility Prize, Nationwide Children’s Hospital’s IMPACT Business Process Improvement Program Award, and the Award of Excellence at Rady Children’s Hospital, San Diego, CA.

“I am grateful for the opportunity to partner with my colleagues and parents on the care of those special patients,” Dr. Mousa says. “I am a physician dedicated to my patients, my team and my institution. I am committed to the field and honored to be at CHOP.”

Education and Training

Medical School

MD - Damascus University, Damascus, Syria


Henry Ford Hospital, Detroit, MI


Pediatric GI, Hepatology and Nutrition - Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA

Additional Training

Faculty Leadership Institute, Ohio State University, Columbus, OH
Faculty Mentor Training Program (FMTP), University of California San Diego, San Diego, CA
Physician Leadership, The Physician Leadership Academy, Rady Children's Hospital, University of California, San Diego, CA
PHIS Clinical Effectiveness, Public Health Information System, San Diego, CA

Titles and Academic Titles

Attending Physician

Clinical Director and Endowed Chair, Suzi and Scott Lustgarten Center for GI Motility

Clinical Director, Frontier Program for Precision Diagnosis and Therapy for Pediatric Motility Disorders

Director, Advanced GI Motility Fellowship Program

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services




Killian HJ, Bakula DM, Wallisch A, Swinburne Romine R, Fleming K, Edwards S, Bruce AS, Chang CN, Mousa H & Davis AM. (2023). Pediatric Tube Weaning: A Meta-analysis of Factors Contributing to Success. Journal of Clinical Psychology in Medical Settings. (In Press)


Williamson P, Proudfoot J, Gharibans A, Dohil L, Newbury R, Barsamian J, Hassan M, Rawson R, Katzka D, Kurten R, Dohil R, Mousa H, Aceves S. Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2022 Jan;20(1):57-64.e3. doi: 10.1016/j.cgh.2020.09.040. Epub 2020 Sep 30. PMID: 33007513; PMCID: PMC8007666.


Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Sep;33(9):e14199. doi: 10.1111/nmo.14199. Epub 2021 Jun 15. PMID: 34132458.

Bhat S, Varghese C, Carson DA, Hayes TCL, Andrews CN, Mousa H, O'Grady G, Gharibans AA. Electrogastrography Abnormalities in Pediatric Gastroduodenal Disorders: A Systematic Review and Meta-analysis. J Pediatr Gastroenterol Nutr. 2021 Jul 1;73(1):9-16. doi: 10.1097/MPG.0000000000003140. PMID: 33797449.

Edwards S, Hyman PE, Mousa H, Bruce A, Cocjin J, Dean K, Fleming K, Romine RS, Davis AM. iKanEat: Protocol for a Randomized Controlled Trial of Megestrol as a Component of a Pediatric Tube Weaning Protocol. Trials. 2021 Feb 27;22(1):169. doi: 10.1186/s13063-021-05131-w. PMID: 33640012; PMCID: PMC7913389.

O'Donnell JEM, Purcell M, Mousa H, Dall'Oglio L, Rosen R, Faure C, Gottrand F, Krishnan U. Clinician Knowledge of Societal Guidelines on Management of Gastrointestinal Complications in Esophageal Atresia. J Pediatr Gastroenterol Nutr. 2021 Feb 1;72(2):232-238. doi: 10.1097/MPG.0000000000002945. PMID: 32932384.

Khlevner J, Rosen R, Ambartsumyan L, Lusman SS, Rosen JM, Yacob D, Mousa H, Nurko S, Di Lorenzo C, Boruta M, Ratcliffe EM, Feinstein L, Snyder J, Wood RJ, Graham K, Saps M, Gyawali CP, Rodriguez L, Belkind-Gerson J. Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 Jan 1;72(1):168-180. doi: 10.1097/MPG.0000000000002965. PMID: 33075010.


Hirsch S, Friedlander JA, Mousa H, Cohran V, Garza JM, Sanghavi R, Ambartsumyan L, Mitchell PD, Rosen R; NASPGHAN Aerodigestive Interest Group. Comparison of Aerodigestive and Nonaerodigestive Provider Responses to Clinical Case Vignettes. J Pediatr. 2021 May;232:166-175.e2. doi: 10.1016/j.jpeds.2020.12.067. Epub 2020 Dec 30. PMID: 33387591.

Rawson R, Yang T, Newbury RO, Aquino M, Doshi A, Bell B, Broide DH, Dohil R, Kurten R, Aceves SS. TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2016 Sep;138(3):791-800.e4. doi: 10.1016/j.jaci.2016.02.028. Epub 2016 Apr 8. PMID: 27212082; PMCID: PMC5014565.


Woodley FW, Machado RS, Hayes D Jr, Di Lorenzo C, Kaul A, Skaggs B, McCoy K, Patel A, Mousa H. Children with Cystic Fibrosis Have Prolonged Chemical Clearance of Acid Reflux Compared to Symptomatic Children Without Cystic Fibrosis. Dig Dis Sci. 2014 Mar;59(3):623-30. doi: 10.1007/s10620-013-2950-0. Epub 2013 Nov 28. PMID: 24287640.

Woodley FW, Hayes D Jr, Kopp BT, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla S, Di Lorenzo C, Kaul A, Mousa H. Gastroesophageal Reflux in Cystic Fibrosis Across the Age Spectrum. Transl Gastroenterol Hepatol. 2019 Sep 16;4:69. doi: 10.21037/tgh.2019.08.11. PMID: 31620651; PMCID: PMC6789305.

Gharibans AA, Coleman TP, Mousa H, Kunkel DC. Spatial Patterns From High-Resolution Electrogastrography Correlate With Severity of Symptoms in Patients With Functional Dyspepsia and Gastroparesis. Clin Gastroenterol Hepatol. 2019 Dec;17(13):2668-2677. doi: 10.1016/j.cgh.2019.04.039. Epub 2019 Apr 19. PMID: 31009794.

Hassan M, Aceves S, Dohil R, Gharibans A, Newbury R, Proudfoot J, Mousa H. Esophageal Compliance Quantifies Epithelial Remodeling in Pediatric Patients With Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr. 2019 Apr;68(4):559-565. doi: 10.1097/MPG.0000000000002202. PMID: 30418408; PMCID: PMC6453699.


Lu PL, Mousa HM. Constipation: Beyond the Old Paradigms. Gastroenterol Clin North Am. 2018 Dec;47(4):845-862. doi: 10.1016/j.gtc.2018.07.009. Epub 2018 Sep 28. PMID: 30337036.

Gharibans AA, Smarr BL, Kunkel DC, Kriegsfeld LJ, Mousa HM, Coleman TP. Artifact Rejection Methodology Enables Continuous, Noninvasive Measurement of Gastric Myoelectric Activity in Ambulatory Subjects. Sci Rep. 2018 Mar 22;8(1):5019. doi: 10.1038/s41598-018-23302-9. PMID: 29568042; PMCID: PMC5864836.

Rosen RL, Krishnan U, Mousa H, Dall'oglio L, Faure C, Gottrand F. The Case for Thoughtful Prescribing of Proton Pump Inhibitors in Infants. J Pediatr Gastroenterol Nutr. 2018 Jan;66(1):e26-e27. doi: 10.1097/MPG.0000000000001794. PMID: 29045354; PMCID: PMC5765768.


Mousa H, Krishnan U, Hassan M, Dall'Oglio L, Rosen R, Gottrand F, Faure C. How to Care for Patients with EA-TEF: The Known and the Unknown. Curr Gastroenterol Rep. 2017 Nov 25;19(12):65. doi: 10.1007/s11894-017-0605-6. PMID: 29177550; PMCID: PMC6450800.

Hassan M, Mousa H: Impedance Testing in Esophageal Atresia Patients. Frontiers in Pediatrics 5(1): 85, April 2017.

Lu PL, Asti L, Lodwick DL, Nacion KM, Deans KJ, Minneci PC, Teich S, Alpert SA, Yacob D, DiLorenzo C, Mousa H: Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation. Journal of Pediatric Surgery, 52(4): 558-562, Apr 2017.

Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D, Kopp BT, Kaul A, Di Lorenzo C, Mousa H: Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux. Pediatric Gastroenterology, Hepatology and Nutrition, 20(3): 153-159, Sep 2017.


Machado R, Woodley F, Skaggs B, DiLorenzo C, Eneli I, Splaingard M, Mousa H: Gastroesophageal Reflux Affects Sleep Quality in Obese Children Without Obstructive Sleep Apnea Pediatric Gastroenterology Hepatology Nutrition, 19(1): 12-19, March 2016.

Machado RS, Woodley FW, Skaggs B, Di Lorenzo C, Eneli I, Splaingard M, Mousa H: Gastroesophageal Reflux Affects Sleep Quality in Snoring Obese Children. Pediatric Gastroenterology, Hepatology and Nutrition, 19(1): 12-9, Mar 2016.

Davis AM, Dean K, Mousa H, Edwards S, Cocjin J, Almadhoun O, He J, Bruce A, Hyman P: A Randomized Controlled Trial of an Outpatient Protocol for Moving Children from Tube to Oral Feeding: The Role of Amitriptyline. The Journal of Pediatrics, 172: 136-141, May 2016.

Lu PL, Moore-Clingenpeel M, DiLorenzo C, Yacob D, Mousa M: The Rising Cost of Hospital Care for Children with Gastroparesis: 2004-2013. Neurogastroenterology and Motility, 28(11): 1698-1704, May 2016.


Mugie SM, Bates DG, Punati JB, Benninga MA, Di Lorenzo C, Mousa H: The value of fluoroscopic defecography in the diagnostic and therapeutic management of defecation disorders in children. Pediatric Radiology, 45(2): 173-80, Feb 2015.

Woodley FW, Machado R, Di Lorenzo C, Mousa H: Chemical clearance in infants and children with acid reflux in the physiologic range. Journal of Pediatric Gastroenterology and Nutrition, 60(6): 783-6, Jun 2015.

Sulkowski JP, Nacion KM, Deans KJ, Minneci PC, Levitt MA, Mousa M, Alpert SA, Teich S: Sacral Nerve Stimulation: A Promising Therapy for Fecal and Urinary Incontinence and Constipation in Children. Journal of Pediatric Surgery, 50(10): 1644-1647, October 2015.

Edwards S, McGrath Davis A, Ernst L, Sitzmann B, Bruce A, Keeler D, Almadhoun O, Mousa H, Hyman P: Interdisciplinary Strategies for Treating Oral Aversions in Children, Journal of Parenteral and Enteral Nutrition, 39(8): 899-909, November 2015.



Lu PL, Ryan K, Orsagh-Yentis DK, Diefenbach KA, Teich S, Hayat M, Bali N, Vaz K, Desale Y, Di Lorenzo C, poster presentation: Gastric Electrical Stimulation for Children with Severe Nausea and Vomiting: Long-term Outcomes and Patient Satisfaction Based on a 10-year Experience, poster presentation. NASPGHAN Annual Meeting, Chicago, IL October 2019.

Williamson P, Dohil R, Hassan M, Gharibans A, Barsamian J, Newbury R, Mousa H, and Aceves S: PAI-1 as an Epithelial Marker of Disease Severity in Pediatric Eosinophilic Esophagitis, poster presentation. NASPGHAN Annual Meeting, Chicago, IL, October 2019.

Rosen R, Giefer M, Friedlander J, Ryan M, Mousa M, Acra S, Gold B: Differences in Practice Patterns between Multidisciplinary Aerodigestive Gastroenterologists Compared to General Gastroenterologists, poster presentation. NASPGHAN Annual Meeting, Chicago, IL, October 2019.

Williamson P, Gharibans A, Barsamian J, Dohil R, Newbury R, Aceves S, and Mousa H: Esophageal Compliance Can Reflect the Severity of Fibrosis and Epithelial Remodeling in Pediatric Eosinophilic Esophagitis, poster presentation. NASPGHAN Annual Meeting 2019, Chicago, IL October 2019.


Agrusa AA, Gharibans A, Allegra A, Kunkel DC, Coleman TP, Mousa H: A Deep Learning Approach to Classify Gastrointestinal Abnormalities, poster presentation. UC San Diego Bioengineering Day, San Diego, CA, April 2018.

Hassan M, Brigger M, Quizon A, Rao A, Mazzeo A, Bundogji N, Mousa H: The Increasing Utility of Flexible Endoscopic Evaluation of Swallowing to Improve Outcomes, poster presentation. 9th Annual Pediatric Research Symposium, Rady Children's Hospital, San Diego, CA, May 2018.


Gharibans AA, Beltran A, Kunkel DC, Coleman TP, Mousa H: Improving the Clinical Utility of Electrogastrography by Conducting Simultaneous High-Resolution Electrogastrogram and Androduodenal Manometry in Children, poster presentation. UC San Diego Pediatrics Symposium, San Diego, CA, January 2017.

Gharibans AA, Coleman TP, Mousa HM: Can the High-Resolution Electrogastrogram Separate Antral and Pyloric Activity in Children? poster presentation. North American Society for Gastroenterology, Hepatology and Nutrition Annual Meeting, Las Vegas, NV, May 2017.

Hassan M, Aceves S, Newbury R, Mousa H: Esophageal Distensibility as a Predictor of Clinical Phenotype in Pediatric Patients with Eosinophilic Esophagitis, poster presentation. Digestive Disease Week (DDW), Chicago, IL, May 2017.

Ibarra AA, Gharibans AA, Allegra DC, Coleman TP, Smarr L, Mousa H, Kunkel DC: Mathematical Modeling of Gastric Electrophysiology, Poster presentation. UC San Diego Frontiers of Innovation Scholars Symposium, San Diego, CA, October 2017.

Mousa H, Hassan M, Parker J, Weber R: Quality Improvement: Improving Adherence to Clinical Care Guidelines in Children with Esophageal Atresia With or Without Trachea-Esophageal Fistula (EA-TEF), poster presentation. Pay for Performance Quality Summit, Rady Children's Hospital, San Diego, CA October 2017.

Hassan M, Aceves S, Dohil R, Newbury R, Proudfoot J, Mousa H: Esophageal Compliance is a Superior Measure to Quantify Esophageal Remodeling in Pediatric Patients with Eosinophilic Esophagitis, poster presentation. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), Las Vegas, NV, November 2017.

Hassan M, Pierce H, Mousa H: Quality Improvement: Improving the Standardization and Interpretation of Breath Testing by GI Providers at Rady Children's Hospital, poster presentation. Rady Children's Health Center Interprofessional Innovations Symposium, San Diego, CA, November 2017.

Awards and Honors

2018, The Leading Physicians of the World, Doctor of Excellence
2018, Physician Excellence in CARES Values, Rady Children's Hospital, San Diego
2017-2018, Excellence Award, Rady Children's Specialists of San Diego
2017, Top Pediatrician in San Diego
2017, FDA expert in Gastric Electric Stimulation (GES) panel recognized to be the Pediatric Gastroenterologist in the Network of Experts
2016, Faculty Development Award, Rady Children's Hospital 2017 CARES Award, Rady Children's Hospital
2014-2015, Faculty Advancement, Mentoring and Engagement (FAME) Scholarship, Faculty Leadership Institute, Ohio State University

Leadership and Memberships


2023-present, Chair Pediatric Body Surface Gastric Mapping (BSGM) Consortium, member of BSGM International Working Group

2022, International examiner for Sharman Pei Yi Tan Tanny, MBBS, for the degree of Doctor of Philosophy. The University of Melbourne, Department of pediatrics faculty of medicine. Thesis title: Utilizing high-resolution impedance manometry to diagnose and manage esophageal dysfunction in children with esophageal atresia.

2020-present, Chair, Aerodigestive Special Interest Group (SIG) of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

2021-present; Gastroparesis Special Interest Group (GIG) of The American Neurogastroenterology and Motility Society (ANMS)

2016-present, Federal Drug Administration (FDA), Center for Devices and Radiological Health (External Expert, Gastroparesis and Gastric Electric Stimulation)

2016-present, National Institutes of Health (Expert in pediatric neuromodulation and end organ effect)

2010-present, American Gastroenterology Association (AGA)

2009-present, Society of Pediatric Research (SPR) Pediatric Academic Societies (Member, Abstract Review Committee for Pediatric Academic Societies)

2007-present, American Neurogastroenterology and Motility Society (ANMS)

  • 2007-present, Clinical Training Program
  • 2007-present, Task Force on Training in Gastrointestinal Motility and Functional Disorders
  • 2007-present, Slide Preparation Committee for the Training in Gastrointestinal Motility and Functional Disorders
  • 2007-present, Director, Clinical Training Program
  • 2010-present, Education Committee

2016-present, Physician Advisory Council Charter, Southwest Pediatric Practice Transformation Network (SPPTN)

2012-2015, Bureau for Children with Medical Handicaps (BCMH)

2009-present, Bureau for Children with Medical Handicaps (BCMH) (Member, Medical Advisory Council Board Member)