Background

Natalie Rintoul, MD, is an assistant professor at the University of Pennsylvania School of Medicine and attending neonatologist at Children's Hospital of Philadelphia.

After receiving her medical degree at Queen's University in Canada, Dr. Rintoul completed her pediatric residency at Massachusetts General Hospital in Boston and her neonatal fellowship at The Children's Hospital of Philadelphia.

Dr. Rintoul is not only interested in the care of the neonate with congenital anomalies requiring neonatal surgery, but also those neonates requiring heart-lung bypass (ECMO). She is co-director of the Neonatal Surgical Team, and medical director of the Neonatal ECMO Program. She is also a fetal consultant for the Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment (CFDT).

Dr. Rintoul’s research interests include management of myelomeningocele, pulmonary hypoplasia and pulmonary hypertension in congenital diaphragmatic hernia, and perioperative care of the surgical neonate. She is the chair of the Neonatal Perioperative Committee. Dr. Rintoul is also a key member of the Special Delivery Unit, involved in the creation and implementation of delivery room guidelines for infants with congenital anomalies.

Education and Training

Medical School

MD - Queen's University School of Medicine, Kingston, Ontario, Canada

Residency

Pediatrics - Massachusetts General Hospital, Harvard University, Boston, MA

Fellowship

Neonatal-Perinatal Medicine - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Neonatal-Perinatal Medicine
Pediatrics

Titles and Academic Titles

Attending Neonatologist

Co-director, Neonatal Surgical Team

Assistant Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Myelomeningocele
Pulmonary hypertension
Pulmonary hypoplasia
Perioperative care of the surgical neonate
ECMO
Neonatal resuscitation

Publications

Papers

2021

Treatment of pulmonary hypertension during initial hospitalization in a multicenter cohort of infants with congenital diaphragmatic hernia (CDH). Seabrook RB, Grover TR, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Ali N, Chapman R, Daniel J, Harrison HA, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Murthy K; Children’s Hospitals Neonatal Consortium Congenital Diaphragmatic Hernia Focus Group. J Perinatol. 2021 Mar 1. doi: 10.1038/s41372-021-00923-z. Online ahead of print. PMID: 33649432

Central Line Utilization and Complications in Infants with Congenital Diaphragmatic Hernia. Grover TR, Weems MF, Brozanski B, Daniel J, Haberman B, Rintoul N, Walden A, Hedrick H, Mahmood B, Seabrook R, Murthy K, Zaniletti I, Keene S; Children's Hospitals Neonatal Consortium (CHNC) Congenital Diaphragmatic Hernia Focus Group. Am J Perinatol. 2021 Feb 3. doi: 10.1055/s-0041-1722941. Online ahead of print. PMID: 33535242

2020 

Extracorporeal Life Support Organization (ELSO): Guidelines for Neonatal Respiratory Failure. Wild KT, Rintoul N, Kattan J, Gray B.ASAIO J. 2020 May;66(5):463-470. doi: 10.1097/MAT.0000000000001153.PMID: 32282347 No abstract available.

Management of neonatal difficult airway emergencies in the delivery room. Lin EE, Nelson O, Isserman RS, Henderson AA, Rintoul NE, Lioy J, Javia LR, Tran KM, Fiadjoe JE.Paediatr Anaesth. 2020 May;30(5):544-551. doi: 10.1111/pan.13859. Epub 2020 Apr 22.PMID: 32196824

Therapy at 30 days of life predicts lung function at 6 to 12 months in infants with congenital diaphragmatic hernia. Chotzoglou E, Hedrick HL, Herkert LM, Goldshore MA, Rintoul NE, Panitch HB.Pediatr Pulmonol. 2020 Jun;55(6):1456-1467. doi: 10.1002/ppul.24736. Epub 2020 Mar 19.PMID: 3219139

Pediatric neurosurgeons' views regarding prenatal surgery for myelomeningocele and the management of hydrocephalus: a national survey. Riley JS, Antiel RM, Flake AW, Johnson MP, Rintoul NE, Lantos JD, Traynor MD, Adzick NS, Feudtner C, Heuer GG.Neurosurg Focus. 2019 Oct 1;47(4):E8. doi: 10.3171/2019.7.FOCUS19406.PMID: 31574481

Initiating resuscitation before umbilical cord clamping in infants with congenital diaphragmatic hernia: a pilot feasibility trial. Foglia EE, Ades A, Hedrick HL, Rintoul N, Munson DA, Moldenhauer J, Gebb J, Serletti B, Chaudhary A, Weinberg DD, Napolitano N, Fraga MV, Ratcliffe SJ.Arch Dis Child Fetal Neonatal Ed. 2020 May;105(3):322-326. doi: 10.1136/archdischild-2019-317477. Epub 2019 Aug 28.PMID: 31462406 Clinical Trial.

Sedation Practices of Neonates Receiving Extracorporeal Membrane Oxygenation. Franciscovich CD, Monk HM, Brodecki D, Rogers R, Rintoul NE, Hedrick HL, Ely E.ASAIO J. 2020 May;66(5):559-564. doi: 10.1097/MAT.0000000000001043.PMID: 31425254

Rintoul NE, Keller RL, Walsh WF, Burrows PK, Thom EA, Kallan MJ, Howell LJ, Adzick NS, MOMS Investigators. The Management of Myelomeningocele Study: Short-Term Neonatal Outcomes. Fetal Diagn Ther. 2020 Aug 31;1-8. doi: 10.1159/000509245. PMID: 32866951

STEPP IN: Working Together to Keep Infants Warm in the Perioperative Period. Brozanski BS, Piazza AJ, Chuo J, Natarajan G, Grover TR, Smith JR, Mingrone T, McClead RE, Rakesh R, Rintoul N, Guidash J, Bellflower B, Holston M, Richardson T, Pallotto EK. Pediatrics. 2020 Apr;145(4):e20191121. doi: 10.1542/peds.2019-1121.Epub 2020 Mar 19. Read the abstract.

Wild KT, Rintoul N, Kattan J, Gray B, Engle RW, Keene S, Best D, Davis C, DiGeronimo R, Raman L. Extracorporeal Life Support Organization (ELSO): Guidelines for Neonatal Respiratory Failure. ASAIO Journal: May 2020 - Volume 66 - Issue 5 - p 463-470. Read the abstract.

2019

Keene S, Grover TR, Murthy K, Pallotto EK, Brozanski B, Gien J, Zaniletti I, Johnson YR, Seabrook RB, Porta NFM, Haberman B, DiGeronimo R, Rintoul N; Children’s Hospitals Neonatal Consortium’s (CHNC) Congenital Diaphragmatic Hernia Focus Group. Extracorporeal membrane oxygenation and bloodstream infection in congenital diaphragmatic hernia. J Perinatol. 2019 Aug 5. doi: 10.1038/s41372-019-0435-5. [Epub ahead of print}

Fraga MV, Dysart KC, Rintoul N, Chaudhary AS, Ratcliffe SJ, Fedec A, Kren S, Cohen MS, Kirpalani H. Cardiac Output Measurement Using the Ultrasonic Cardiac Output Monitor: A Validation Study in Newborn Infants. Neonatology. 2019 Jul 19:1-9. doi: 10.1159/000501005. [Epub ahead of print]

Extracorporeal membrane oxygenation and bloodstream infection in congenital diaphragmatic hernia. Keene S, Grover TR, Murthy K, Pallotto EK, Brozanski B, Gien J, Zaniletti I, Johnson YR, Seabrook RB, Porta NFM, Haberman B, DiGeronimo R, Rintoul N; Children’s Hospitals Neonatal Consortium’s (CHNC) Congenital Diaphragmatic Hernia Focus Group.J Perinatol. 2019 Oct;39(10):1384-1391. doi: 10.1038/s41372-019-0435-5. Epub 2019 Aug 5.PMID: 31383944

Cardiac Output Measurement Using the Ultrasonic Cardiac Output Monitor: A Validation Study in Newborn Infants. Fraga MV, Dysart KC, Rintoul N, Chaudhary AS, Ratcliffe SJ, Fedec A, Kren S, Cohen MS, Kirpalani H.Neonatology. 2019;116(3):260-268. doi: 10.1159/000501005. Epub 2019 Jul 19.PMID: 31326967

Autism spectrum disorder and neurodevelopmental delays in children with giant omphalocele. Danzer E, Hoffman C, Miller JS, D'Agostino JA, Schindewolf EM, Gerdes M, Bernbaum J, Adams SE, Rintoul NE, Herkert LM, Taylor L, Schreiber J, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2019 Sep;54(9):1771-1777. doi: 10.1016/j.jpedsurg.2019.05.017. Epub 2019 May 28.PMID: 3119666

Use of prostaglandin E1 to treat pulmonary hypertension in congenital diaphragmatic hernia. Lawrence KM, Berger K, Herkert L, Franciscovich C, O'Dea CLH, Waqar LN, Partridge E, Hanna BD, Peranteau WH, Avitabile CM, Hopper RK, Rintoul NE, Hedrick HL.J Pediatr Surg. 2019 Jan;54(1):55-59. doi: 10.1016/j.jpedsurg.2018.10.039. Epub 2018 Oct 5.PMID: 30442461

2018

Predicting Risk of Infection in Infants with Congenital Diaphragmatic Hernia. Murthy K, Porta NFM, Pallotto EK, Rintoul N, Keene S, Chicoine L, Gien J, Brozanski BS, Johnson YR, Haberman B, DiGeronimo R, Zaniletti I, Grover TR; Children's Hospitals Neonatal Consortium (CHNC) Congenital Diaphragmatic Hernia Focus Group.J Pediatr. 2018 Dec;203:101-107.e2. doi: 10.1016/j.jpeds.2018.07.032. Epub 2018 Sep 11.PMID: 30217691

Reduced oxygen concentration for the resuscitation of infants with congenital diaphragmatic hernia. Riley JS, Antiel RM, Rintoul NE, Ades AM, Waqar LN, Lin N, Herkert LM, D'Agostino JA, Hoffman C, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.J Perinatol. 2018 Jul;38(7):834-843. doi: 10.1038/s41372-017-0031-5. Epub 2018 Jun 11.PMID: 29887609

Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia. Lawrence KM, Hedrick HL, Monk HM, Herkert L, Waqar LN, Hanna BD, Peranteau WH, Rintoul NE, Hopper RK.J Pediatr. 2018 Sep;200:44-49. doi: 10.1016/j.jpeds.2018.04.052. Epub 2018 May 18.PMID: 29784517

Short-Term Neurodevelopmental Outcome in Children Born With High-Risk Congenital Lung Lesions. Danzer E, Hoffman C, D'Agostino JA, Boelig MM, Gerdes M, Bernbaum JC, Rosenthal H, Waqar LN, Rintoul NE, Herkert LM, Kallan MJ, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.Ann Thorac Surg. 2018 Jun;105(6):1827-1834. doi: 10.1016/j.athoracsur.2018.01.033. Epub 2018 Feb 10.PMID: 29438655

Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia. Danzer E, Hoffman C, D'Agostino JA, Miller JS, Waqar LN, Gerdes M, Bernbaum JC, Rosenthal H, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.J Autism Dev Disord. 2018 Jun;48(6):2112-2121. doi: 10.1007/s10803-018-3472-6.PMID: 29383650

Extracorporeal membrane oxygenation in infants with congenital diaphragmatic hernia. Grover TR, Rintoul NE, Hedrick HL.Semin Perinatol. 2018 Mar;42(2):96-103. doi: 10.1053/j.semperi.2017.12.005. Epub 2018 Jan 12.PMID: 29338874 Review.

Anticoagulation in neonatal ECMO. Kamdar A, Rintoul N, Raffini L.Semin Perinatol. 2018 Mar;42(2):122-128. doi: 10.1053/j.semperi.2017.12.008. Epub 2018 Jan 12.PMID: 29336832 Review.

Short-Term Neurodevelopmental Outcome in Congenital Diaphragmatic Hernia: The Impact of Extracorporeal Membrane Oxygenation and Timing of Repair. Danzer E, Hoffman C, D'Agostino JA, Connelly JT, Waqar LN, Gerdes M, Bernbaum J, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.Pediatr Crit Care Med. 2018 Jan;19(1):64-74. doi: 10.1097/PCC.0000000000001406.PMID: 29303891

Introduction: Update on neonatal extracorporeal membrane oxygenation. Johnston LC, Rintoul NE, Ades AM. Semin Perinatol. 2018 Mar;42(2):65-67. doi: 10.1053/j.semperi.2017.12.001. Epub 2017 Dec 29.PMID: 29291939 No abstract available.

Acquired Infection and Antimicrobial Utilization During Initial NICU Hospitalization in Infants With Congenital Diaphragmatic Hernia. Keene S, Murthy K, Pallotto E, Brozanski B, Gien J, Zaniletti I, Hulbert C, Seabrook R, Rintoul N, Chicoine L, Porta N, Grover TR.Pediatr Infect Dis J. 2018 May;37(5):469-474. doi: 10.1097/INF.0000000000001835.PMID: 29189614

Danzer E, Hoffman C, D'Agostino J, Ryan M, Gerdes M, Bernbaum J, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Rate and risk factors associated with autism spectrum disorder in congenital diaphragmatic hernia.  Journal of Autism and Developmental Disorders48:2112-2121, 2018. 

Danzer E, Hoffman C, D'Agostino J, Connelly JT, Waqar LN, Gerdes M, Bernbaum J, Rintoul NE, Herkert LM, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Short-term neurodevelopmental outcome in congenital diaphragmatic hernia: The impact of extracorporeal membrane oxygenation and timing of repair. Pediatric Critical Care Medicine 19:64-74, 2018.

Lawrence KM, Berger K, Herkert L, Franciscovich C, O'Dea CLH, Waqar LN, Partridge E, Hanna BD, Peranteau WH, Avitabile CM, Hopper RK, Rintoul NE, Hedrick HL. Use of prostaglandin E1 to treat pulmonary hypertension in congenital diaphragmatic hernia. J Pediatr Surg. 2018 Oct 5;. PMID: 30442461 

Lawrence KM, Hedrick HL, Monk HM, Herkert L, Waqar LN, Hanna BD, Peranteau WH, Rintoul NE, Hopper RK. Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia. J Pediatr. 2018 May 18. [Epub ahead of print] PMID: 29784517

Riley JS, Antiel RM, Rintoul NE, Ades AM, Waqar LN, Lin N, Herkert LM, D'Agostino JA, Hoffman C, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Reduced oxygen concentration for the resuscitation of infants with congenital diaphragmatic hernia. J Perinatol. 2018 Jun 11. [Epub ahead of print]

2017

Weighing the Social and Ethical Considerations of Maternal-Fetal Surgery. Antiel RM, Flake AW, Collura CA, Johnson MP, Rintoul NE, Lantos JD, Curlin FA, Tilburt JC, Brown SD, Feudtner C.Pediatrics. 2017 Dec;140(6):e20170608. doi: 10.1542/peds.2017-0608. Epub 2017 Nov 3.PMID: 29101225 Free article.

Growth trajectory and neurodevelopmental outcome in infants with congenital diaphragmatic hernia. Antiel RM, Lin N, Licht DJ, Hoffman C, Waqar L, Xiao R, Monos S, D'Agostino JA, Bernbaum J, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2017 Dec;52(12):1944-1948. doi: 10.1016/j.jpedsurg.2017.08.063. Epub 2017 Sep 28.PMID: 29079316

Attitudes of paediatric and obstetric specialists towards prenatal surgery for lethal and non-lethal conditions. Antiel RM, Curlin FA, Lantos JD, Collura CA, Flake AW, Johnson MP, Rintoul NE, Brown SD, Feudtner C.J Med Ethics. 2018 Apr;44(4):234-238. doi: 10.1136/medethics-2017-104377. Epub 2017 Oct 10.PMID: 29018178

Physician views regarding the benefits and burdens of prenatal surgery for myelomeningocele. Antiel RM, Collura CA, Flake AW, Johnson MP, Rintoul NE, Lantos JD, Curlin FA, Tilburt JC, Brown SD, Feudtner C.J Perinatol. 2017 Sep;37(9):994-998. doi: 10.1038/jp.2017.75. Epub 2017 Jun 15.PMID: 28617430

Specialty-Based Variation in Applying Maternal-Fetal Surgery Trial Evidence. Antiel RM, Flake AW, Johnson MP, Khalek N, Rintoul NE, Lantos JD, Curlin FA, Tilburt JC, Feudtner C.Fetal Diagn Ther. 2017;42(3):210-217. doi: 10.1159/000455024. Epub 2017 Mar 17.PMID: 28301843

Short-term weight gain velocity in infants with congenital diaphragmatic hernia (CDH). Gien J, Murthy K, Pallotto EK, Brozanski B, Chicoine L, Zaniletti I, Seabrook R, Keene S, Alapati D, Porta N, Rintoul N, Grover TR; Children's Hospitals Neonatal Consortium CDH Study Group.Early Hum Dev. 2017 Mar-Apr;106-107:7-12. doi: 10.1016/j.earlhumdev.2017.01.010. Epub 2017 Feb 6.PMID: 28178582

Electrographic Seizures in Children and Neonates Undergoing Extracorporeal Membrane Oxygenation. Lin JJ, Banwell BL, Berg RA, Dlugos DJ, Ichord RN, Kilbaugh TJ, Kirsch RE, Kirschen MP, Licht DJ, Massey SL, Naim MY, Rintoul NE, Topjian AA, Abend NS.Pediatr Crit Care Med. 2017 Mar;18(3):249-257. doi: 10.1097/PCC.0000000000001067.PMID: 28099234 Free PMC article.

Management and outcomes of scoliosis in children with congenital diaphragmatic hernia. Antiel RM, Riley JS, Cahill PJ, Campbell RM, Waqar L, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2016 Dec;51(12):1921-1925. doi: 10.1016/j.jpedsurg.2016.09.013. Epub 2016 Sep 15.PMID: 28029369

Venoarterial Extracorporeal Life Support for Neonatal Respiratory Failure: Indications and Impact on Mortality. Bamat NA, Tharakan SJ, Connelly JT, Hedrick HL, Lorch SA, Rintoul NE, Williams SB, Dysart KC.ASAIO J. 2017 Jul/Aug;63(4):490-495. doi: 10.1097/MAT.0000000000000495.PMID: 27984316 Free PMC article.

Keene S, Murthy K, Pallotto E, Brozanski B, Gien J, Zaniletti I, Hulbert C, Seabrook R, Rintoul N, Chicoine L, Porta N, Grover TR. Acquired Infection and Antimicrobial Utilization During Initial NICU Hospitalization in Infants with Congenital Diaphragmatic Hernia. Pediatr Infect Dis J. 2017 Nov 16. doi: 10.1097/INF.0000000000001835. [Epub ahead of print]

Danzer E, Hoffman C, D’Agostino JA, Gerdes M, Bernbaum J, Antiel RM, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcomes at 5 years of age in congenital diaphragmatic hernia. J Pediatr Surg. 2017 Mar;52(3):437-443.

Antiel RM, Flake AW, Johnson MP, Khalek N, Rintoul NE, Lantos JD, Curlin FA, Tilburt JC, Feudtner C. Specialty-Based Variation in Applying Maternal-Fetal Surgery Trial Evidence. Fetal Diagn Ther. 2017 Mar 17. Doi:10.1159/000455024 [Epub ahead of print]

Gien J, Murthy K, Pallotto EK, Brozanski B, Chicoine L, Zaniletti I, Seabrook R, Keene S, Alapati D, Porta N, Rintoul N, Grover TR. Children's Hospitals Neonatal Consortium CDH Study Group. Short-term weight gain velocity in infants with congenital diaphragmatic hernia (CDH). Early Hum Dev. 2017 Feb 5;106-107:7-12. [Epub ahead of print]

2016

Neurodevelopmental outcomes at 5years of age in congenital diaphragmatic hernia. Danzer E, Hoffman C, D'Agostino JA, Gerdes M, Bernbaum J, Antiel RM, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2017 Mar;52(3):437-443. doi: 10.1016/j.jpedsurg.2016.08.008. Epub 2016 Aug 30.PMID: 27622588

Right- versus left-sided congenital diaphragmatic hernia: a comparative outcomes analysis. Partridge EA, Peranteau WH, Herkert L, Rendon N, Smith H, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. J Pediatr Surg. 2016 Jun;51(6):900-2. doi: 10.1016/j.jpedsurg.2016.02.049. Epub 2016 Mar 3.PMID: 27342009

Rate of increase of lung-to-head ratio over the course of gestation is predictive of survival in left-sided congenital diaphragmatic hernia. Partridge EA, Peranteau WH, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2016 May;51(5):703-5. doi: 10.1016/j.jpedsurg.2016.02.006. Epub 2016 Feb 11.PMID: 27261559

Predicting death or extended length of stay in infants with congenital diaphragmatic hernia. Murthy K, Pallotto EK, Gien J, Brozanski BS, Porta NF, Zaniletti I, Keene S, Chicoine LG, Rintoul NE, Dykes FD, Asselin JM, Short BL, Padula MA, Durand DJ, Reber KM, Evans JR, Grover TR.J Perinatol. 2016 Aug;36(8):654-9. doi: 10.1038/jp.2016.26. Epub 2016 Mar 10.PMID: 26963428

Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia. Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2016 Jul;51(7):1084-90. doi: 10.1016/j.jpedsurg.2015.12.010. Epub 2016 Jan 5.PMID: 26831532

Bamat NA, Tharakan SJ, Connelly JT, Hedrick HL, Lorch SA, Rintoul NE, Williams SB, Dysart KC. Venoarterial extracorporeal life support for neonatal respiratory failure: indications and impact on mortality. ASAIO J. 2016 Dec 13. Doi:10.1097/MAT.0000000000000495 [Epub ahead of print]

Danzer E, Gerdes M, D’Agostino JA, Bernbaum J, Hoffman C, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia. J Pediatr Surg. 2016 Jul;51(7):1084-90.

Partridge EA, Peranteau WH, Herkert L, Rendon N, Smith H, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Right- versus left-sided congenital diaphragmatic hernia: a comparative outcomes analysis. J Pediatr Surg. 2016 Jun;51(6):900-2.

Partridge EA, Peranteau WH, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Rate of increase of lung-to-head ratio over the course of gestation is predictive of survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2016 May;51(5):703-5.

Peranteau WH, Boelig MM, Khalek N, Moldenhauer JS, Martinez-Poyer J, Hedrick HL, Flake AW, Johnson MP, Adzick NS. Effect of single and multiple courses of maternal betamethasone on prenatal congenital lung lesion growth and fetal survival. J Pediatr Surg. 2016 Jan;51(1):28-32.

Antiel RM, Riley JS, Cahill PJ, Campbell RM, Waqar L, Herkert LM, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Management and outcomes of scoliosis in children with congenital diaphragmatic hernia. J Pediatr Surg. 2016;51(12):1921-1925. 

2015

Hemolysis-Associated Nitric Oxide Dysregulation during Extracorporeal Membrane Oxygenation. Sulkowski JP, Cooper JN, Pearson EG, Connelly JT, Rintoul N, Kilbaugh TJ, Deans KJ, Minneci PC.J Extra Corpor Technol. 2014 Sep;46(3):217-23.PMID: 26357787 Free PMC article.

Short-term outcomes and medical and surgical interventions in infants with congenital diaphragmatic hernia. Grover TR, Murthy K, Brozanski B, Gien J, Rintoul N, Keene S, Najaf T, Chicoine L, Porta N, Zaniletti I, Pallotto EK; Children's Hospitals Neonatal Consortium.Am J Perinatol. 2015 Sep;32(11):1038-44. doi: 10.1055/s-0035-1548729. Epub 2015 Mar 31.PMID: 25825963

Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation. Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert L, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2015 Jun;50(6):898-903. doi: 10.1016/j.jpedsurg.2015.03.040. Epub 2015 Mar 19.PMID: 25818204

Systemic hypertension in giant omphalocele: An underappreciated association. Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2015 Sep;50(9):1477-80. doi: 10.1016/j.jpedsurg.2015.02.051. Epub 2015 Feb 23.PMID: 25783355

Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele. Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL.Early Hum Dev. 2015 Mar;91(3):187-93. doi: 10.1016/j.earlhumdev.2014.12.009. Epub 2015 Feb 9.PMID: 25676186

Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH.J Pediatr Surg. 2015 Feb;50(2):263-6. doi: 10.1016/j.jpedsurg.2014.11.009. Epub 2014 Nov 7.PMID: 25638615

Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2015 Feb;50(2):260-2. doi: 10.1016/j.jpedsurg.2014.11.013. Epub 2014 Nov 7.PMID: 25638614

Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Systemic hypertension in giant omphalocele: An underappreciated association. J Pediatr Surg. 2015 Sep;50(9):1477-80.

Panitch HB, Weiner DJ, Feng R, Perez MR, Healy F, McDonough JM, Rintoul N, Hedrick HL. Lung function over the first 3 years of life in children with congenital diaphragmatic hernia. Pediatr Pulmonol. 2015 Sep;50(9):896-907.

Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS. Fetal Myelomeningocele Repair: The Post-MOMS Experience at the Children's Hospital of Philadelphia. Fetal Diagn Ther. 2015;37(3):235-40. Epub 2014 Aug 15.

Danzer E, Gerdes M, D’Agostino JA, Bernbaum J, Hoffman C, Herkert L, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation. J Pediatr Surg. 2015 Jun;50(6):898-903.

Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). J Pediatr Surg. 2015 Feb;50(2):260-2.

Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. J Pediatr Surg. 2015 Feb;50(2):263-6.

Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele. Early Hum Dev. 2015 Feb 9;91(3):187-193.

Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Systemic hypertension in giant omphalocele: An underappreciated association. J Pediatr Surg. 2015 Feb 23. pii: S0022-3468(15)00131-1. doi: 10.1016. 

2014

Pulmonary hypertension in giant omphalocele infants. Partridge EA, Hanna BD, Panitch HB, Rintoul NE, Peranteau WH, Flake AW, Scott Adzick N, Hedrick HL.J Pediatr Surg. 2014 Dec;49(12):1767-70. doi: 10.1016/j.jpedsurg.2014.09.016. Epub 2014 Nov 14.PMID: 25487480

Fetal myelomeningocele repair: the post-MOMS experience at the Children's Hospital of Philadelphia. Moldenhauer JS, Soni S, Rintoul NE, Spinner SS, Khalek N, Martinez-Poyer J, Flake AW, Hedrick HL, Peranteau WH, Rendon N, Koh J, Howell LJ, Heuer GG, Sutton LN, Johnson MP, Adzick NS.Fetal Diagn Ther. 2015;37(3):235-40. doi: 10.1159/000365353. Epub 2014 Aug 15.PMID: 25138132

Lung function over the first 3 years of life in children with congenital diaphragmatic hernia. Panitch HB, Weiner DJ, Feng R, Perez MR, Healy F, McDonough JM, Rintoul N, Hedrick HL.Pediatr Pulmonol. 2015 Sep;50(9):896-907. doi: 10.1002/ppul.23082. Epub 2014 Jul 10.PMID: 25045135

Safety of epoprostenol and treprostinil in children less than 12 months of age. McIntyre CM, Hanna BD, Rintoul N, Ramsey EZ.Pulm Circ. 2013 Dec;3(4):862-9. doi: 10.1086/674762.PMID: 25006402 Free PMC article.



Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia. Partridge EA, Bridge C, Donaher JG, Herkert LM, Grill E, Danzer E, Gerdes M, Hoffman CH, D'Agostino JA, Bernbaum JC, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2014 Jun;49(6):890-4; discussion 894. doi: 10.1016/j.jpedsurg.2014.01.019. Epub 2014 Jan 31.PMID: 24888829

Partridge EA, Hanna BD, Panitch HB, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Pulmonary hypertension in giant omphalocele infants. J Pediatr Surg. 2014 Dec;49(12):1767-70.

Partridge EA, Bridge C, Donaher JG, Herkert LM, Grill E, Danzer E, Gerdes M, Hoffman CH, D’Agostino JA, Bernbaum JC, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia. J Pediatr Surg. 2014 Jun;49(6):890-4.

2013

Danzer E, Gerdes M, D'Agostino JA, Hoffman C, Bernbaum J, Bebbington MW, Siegle J, Sulkowski J, Rintoul NE, Flake AW, Scott Adzick N, Hedrick HL.J Perinatol. Longitudinal neurodevelopmental and neuromotor outcome in congenital diaphragmatic hernia patients in the first 3 years of life. 2013 Nov;33(11):893-8. doi: 10.1038/jp.2013.47. Epub 2013 May 9.PMID: 23660581

2012

Preschool neurological assessment in congenital diaphragmatic hernia survivors: outcome and perinatal factors associated with neurodevelopmental impairment. Danzer E, Gerdes M, D'Agostino JA, Partridge EA, Hoffman-Craven CH, Bernbaum J, Rintoul NE, Flake AW, Adzick NS, Hedrick HL.Early Hum Dev. 2013 Jun;89(6):393-400. doi: 10.1016/j.earlhumdev.2012.12.009. Epub 2013 Jan 17.PMID: 23333410

Assessment of early pulmonary function abnormalities in giant omphalocele survivors. Danzer E, Hedrick HL, Rintoul NE, Siegle J, Adzick NS, Panitch HB.J Pediatr Surg. 2012 Oct;47(10):1811-20. doi: 10.1016/j.jpedsurg.2012.06.006.PMID: 23084189

Fetal MRI-calculated total lung volumes in the prediction of short-term outcome in giant omphalocele: preliminary findings. Danzer E, Victoria T, Bebbington MW, Siegle J, Rintoul NE, Johnson MP, Flake AW, Adzick NS, Hedrick HL.Fetal Diagn Ther. 2012;31(4):248-53. doi: 10.1159/000334284. Epub 2012 Apr 27.PMID: 22572017 Review.

Early neurodevelopmental outcome of infants with high-risk fetal lung lesions. Danzer E, Siegle J, D'Agostino JA, Gerdes M, Hoffman C, Bernbaum J, Rintoul NE, Flake AW, Adzick NS, Hedrick HL.Fetal Diagn Ther. 2012;31(4):210-5. doi: 10.1159/000336228. Epub 2012 Apr 26.PMID: 22539010 Free article.

2011

Percutaneous sclerotherapy in neonatal and infant head and neck lymphatic malformations: a single center experience. Cahill AM, Nijs E, Ballah D, Rabinowitz D, Thompson L, Rintoul N, Hedrick H, Jacobs I, Low D.J Pediatr Surg. 2011 Nov;46(11):2083-95. doi: 10.1016/j.jpedsurg.2011.07.004.PMID: 22075337

Effects of ozone on species composition in an upland grassland. Wedlich KV, Rintoul N, Peacock S, Cape JN, Coyle M, Toet S, Barnes J, Ashmore M.Oecologia. 2012 Apr;168(4):1137-46. doi: 10.1007/s00442-011-2154-2. Epub 2011 Nov 3.PMID: 22048840

A randomized trial of prenatal versus postnatal repair of myelomeningocele. Adzick NS, Thom EA, Spong CY, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D'Alton ME, Farmer DL; MOMS Investigators.N Engl J Med. 2011 Mar 17;364(11):993-1004. doi: 10.1056/NEJMoa1014379. Epub 2011 Feb 9.PMID: 21306277 Free PMC article. Clinical Trial.

2010

The relationship of seizure activity and chronic epilepsy in early infancy and short-term neurodevelopmental outcome following fetal myelomeningocele closure. Danzer E, Finkel R, Gerdes M, Schwartz EM, Rintoul NN, Adzick NS, Johnson MP.Neuropediatrics. 2010 Jun;41(3):140-3. doi: 10.1055/s-0030-1263164. Epub 2010 Sep 21.PMID: 20859834

Neurodevelopmental outcome of infants with congenital diaphragmatic hernia prospectively enrolled in an interdisciplinary follow-up program. Danzer E, Gerdes M, Bernbaum J, D'Agostino J, Bebbington MW, Siegle J, Hoffman C, Rintoul NE, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2010 Sep;45(9):1759-66. doi: 10.1016/j.jpedsurg.2010.03.011.PMID: 20850617

Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome. Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Siegle J, Hoffman C, Rintoul NE, Liechty KW, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2010 Apr;45(4):718-23. doi: 10.1016/j.jpedsurg.2009.09.004.PMID: 20385277

2009

Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome. Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Siegle J, Hoffman C, Rintoul NE, Liechty KW, Flake AW, Adzick NS, Hedrick HL.J Pediatr Surg. 2010 Apr;45(4):718-23. doi: 10.1016/j.jpedsurg.2009.09.004.PMID: 20385277

2008

Reversal of hindbrain herniation after maternal-fetal surgery for myelomeningocele subsequently impacts on brain stem function. Danzer E, Finkel RS, Rintoul NE, Bebbington MW, Schwartz ES, Zarnow DM, Adzick NS, Johnson MP.Neuropediatrics. 2008 Dec;39(6):359-62. doi: 10.1055/s-0029-1202835. Epub 2009 Jun 30.PMID: 19569004

In utero meconium passage in fetuses and newborns with myelomeningocele. Danzer E, Ernst LM, Rintoul NE, Johnson MP, Adzick NS, Flake AW.J Neurosurg Pediatr. 2009 Feb;3(2):141-6. doi: 10.3171/2008.10.PEDS08199.PMID: 19278315

Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings. Danzer E, Adzick NS, Rintoul NE, Zarnow DM, Schwartz ES, Melchionni J, Ernst LM, Flake AW, Sutton LN, Johnson MP.J Neurosurg Pediatr. 2008 Dec;2(6):406-13. doi: 10.3171/PED.2008.2.12.406.PMID: 19035686

2006

Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of age. Johnson MP, Gerdes M, Rintoul N, Pasquariello P, Melchionni J, Sutton LN, Adzick NS.Am J Obstet Gynecol. 2006 Apr;194(4):1145-50; discussion 1150-2. doi: 10.1016/j.ajog.2006.01.072.PMID: 16580316

2003

Fetal myelomeningocele repair: short-term clinical outcomes. Johnson MP, Sutton LN, Rintoul N, Crombleholme TM, Flake AW, Howell LJ, Hedrick HL, Wilson RD, Adzick NS.Am J Obstet Gynecol. 2003 Aug;189(2):482-7. doi: 10.1067/s0002-9378(03)00295-3.PMID: 14520222

Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep. Bouchard S, Davey MG, Rintoul NE, Walsh DS, Rorke LB, Adzick NS.J Pediatr Surg. 2003 Mar;38(3):451-8; discussion 451-8. doi: 10.1053/jpsu.2003.50078.PMID: 12632366 RESULTS: After MMC creation, significant cerebellar tonsillar herniation was observed in 85% of fetuses that underwent creation of a myelotomy; none of the lambs without a myelotomy (n = 6) had hindbrain herniation. At autopsy, cerebellar tonsillar herniation was present a …

2002

Prenatal diagnosis and treatment of intersex states. Rintoul NE, Crombleholme TM.Adv Exp Med Biol. 2002;511:225-37; discussion 237-8. doi: 10.1007/978-1-4615-0621-8_13.PMID: 12575764 Review. No abstract available.

A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal intervention. Rintoul NE, Sutton LN, Hubbard AM, Cohen B, Melchionni J, Pasquariello PS, Adzick NS.Pediatrics. 2002 Mar;109(3):409-13. doi: 10.1542/peds.109.3.409.PMID: 11875133