Rachana D. Shah, MD, MsTR

female silhouette icon
Rachana D. Shah, MD, MsTR, is an attending physician at Children's Hospital of Philadelphia who specializes in treating children with diabetes, hyperinsulinism and endocrinology disorders.

Areas of Expertise: Polycystic ovarian syndrome (PCOS), Disorders of puberty, Obesity, Insulin resistance, Type 1 and type 2 diabetes in children and adolescents, Thyroid disorders, Adrenal disorders, Growth disorders, Pituitary disorders
Locations: Specialty Care, Market Street; Main Hospital

Phone: 215-590-3630


Dr. Shah is an assistant professor of Pediatrics in the Division of Endocrinology and Diabetes and the Medical Director of the Adolescent PCOS Center. Her clinical expertise is in general endocrinology with an emphasis on disorders of pubertal development and obesity and its related metabolic complications (insulin resistance, PCOS, type 2 diabetes).

Dr. Shah has an active laboratory research program that complements and extends her clinical studies. Dr. Shah has published numerous manuscripts, chapters and reviews. She is a member of numerous professional societies, including the Pediatric Endocrine Society and the Androgen-Excess PCOS Society.

Education and Training

Medical School

MD - Baylor College of Medicine, Houston, TX


Internal Medicine - Baylor College of Medicine, Houston, TX


Pediatrics - Baylor College of Medicine, Houston, TX


Pediatric Endocrinology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Internal Medicine – American Board of Internal Medicine
Pediatric Endocrinology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Graduate Degree

MSc in Translational Research - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests




Cardiometabolic disease




Wu GD, Compher C, Chen EZ, Smith SA, Shah RD, Bittinger K, Chehoud C, Albenberg LG, Nessel L, Gilroy E, Star J, Weljie AM, Flint HJ, Metz DC, Bennett MJ, Li H, Bushman FD, Lewis JD. Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production. Gut. 2016 Jan;65(1):63-72. PMID: 25431456


Shah R, Matthews GJ, Shah RY, McLaughlin C, Chen J, Wolman M, Master SR, Chai B, Xie D, Rader DJ, Raj DS, Mehta NN, Budoff M, Fischer MJ, Go AS, Townsend RR, He J, Kusek JW, Feldman HI, Foulkes AS, Reilly MP; CRIC Study Investigators. Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2015 Aug;66(2):266-73 PMID: 25795074

Ferguson JF, Shah RY, Shah R, Mehta NN, Rickels MR, Reilly MP. Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases. Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):525-34. PMCID:PMC4344396

Shah R, O'Neill SM, Hinkle C, Caughey J, Stephan S, Lynch E, Bermingham K, Lynch G, Ahima RS, Reilly MP. "Metabolic Effects of CX3CR1 Deficiency in Diet-Induced Obese Mice. PLoS One. 2015 Sep 22;10(9):e0138317. PMID: 26393344


Mulvey CK, McNeill AM, Girman CJ, Churchill TW, Terembula K, Ferguson JF, Shah R, Mehta NN, Qasim AN, Rickels MR, Reilly MP. Differential Associations of Oral Glucose Tolerance Test-Derived Measures of Insulin Sensitivity and Pancreatic Beta-Cell Function with Coronary Artery Calcification and Microalbuminuria in Type 2 Diabetes. Diabetes Care. 2014;37(1):124-33 PMID: 23949560

Mehta NN, Matthews GJ, Krishnamoorthy P, Shah R, McLaughlin C, Patel P, Budoff M, Chen J, Wolman M, Go A, He J, Kanetsky PA, Master SR, Rader DJ, Raj D, Gadegbeku CA, Shah R, Schreiber M, Fischer MJ, Townsend RR, Kusek J, Feldman HI, Foulkes AS, Reilly MP; the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study. European Heart Journal. 2014 Aug 14;35(31):2115-22 PMID: 24306482

Ferguson JF, Mulvey CK, Patel PN, Shah RY, Doveikis J, Zhang W, Tabita-Martinez J, Terembula K, Eiden M, Koulman A, Griffin JL, Mehta NN, Shah R, Propert KJ, Song WL, Reilly MP. Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers. Mol Nutr Food Res. 2014 Mar;58(3):601-13. PMID: 24190860



Ferguson JF, Shah R Metabolomics and the Microbiome in Cardiometabolic Health. Keystone Symposia Conference: Gut Microbiota, Metabolic Disorders and Beyond. Newport, RI, April 2016.




Shah R and Kim RJ: Adrenal Disorders. Netter's Pediatrics. Elsevier, 2011.


Shah R and Reilly MP: Inflammation and Adipose Dysfunction. Metabolic Basis of Obesity. Ahima RS (eds.). Springer, 2010.


Shah R and Kelly A: Precocious Puberty. The 5 Minute Pediatric Consult, 5th edition. Schwartz, MW (eds.). Lippincott Williams & Wilkins, 2008.

Posters and Presentations


Midgette Y, Shah R. Omega 3 Fatty Acids Reduce Inflammation and Alter Adipogenesis. ESPR National Meeting, Philadelphia PA. March 2015, platform and PAS/PES National Meeting, San Diego CA April 2015, poster presentation

Shah R. High Rates of Dyslipidemia and Hypertension in Adolescent Girls with Polycystic Ovarian Syndrome. PAS/PES National Meeting. San Diego, CA, April 2015. Poster Presentation.


Shah R. Omega 3 Fatty Acids Suppress Lipid Droplet Formation in Human Adipocytes. Endocrine Society 74th Scientific Sessions, Chicago, IL. June 2014. Poster Presentation.

Editorial and Academic Positions

Academic and institutional committees

2013-present, Evaluation Committee, Division of Endocrinology