
Timothy Spear, MD, PhD
Locations: Main Building, Buerger Center for Advanced Pediatric Care
About Timothy Spear, MD, PhD
Timothy Spear, MD, PhD, is an Instructor in the Division of Oncology with research interests aligned with developing vaccination strategies for pediatric cancers. Dr. Spear's ongoing projects include personalized neoantigen vaccines and vaccine-boost chimeric antigen receptor (CAR)-T cell approaches.
Titles
Attending Physician
Instructor, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Certifications
Pediatrics – American Board of Pediatrics
Awards and Honors
2024, Conquer Cancer Young Investigator Award, American Society of Clinical Oncology (ASCO)
2024, Fellowship Award, St. Baldrick’s Foundation
2024, Young Investigator Award, Alex’s Lemonade Stand Foundation
2024, Young Investigator Grant, Hyundai Hope on Wheels
2023, Early Career Investigator Award, Friends of the American Association of Cancer Research (AACR) Foundation
2018, Cover Images selected from Spear et al. 2018, Journal of Leukocyte Biology [PMID: 29350789]
2016, Departmental Nominee, Dissertation of the Year Award, Loyola University Chicago
2016, Student Travel Award, American Association of Immunologists Annual Meeting, Seattle, WA
2015, Meeting Bursary Award, European Federation of Immunological Societies/European Journal of Immunology, PIVAC-15 Annual Meeting, Tubingen, Germany
2015, Student Travel Award, International Society for the Advancement of Cytometry Annual Meeting, Glasgow, Scotland
2014, Best Oral Presentation, Loyola University Chicago Tumor Immunology Program Annual Retreat, Woodstock, IL
2014-2015, Ruth L. Kirschstein National Research Service Award: F30 Predoctoral Fellowship, National Cancer Institute, National Institutes of Health (see “Funded Grants” section)
2011-2017, Combined MD/PhD Tuition Scholarship & Stipend, Loyola University Chicago SSOM
2011, Departmental Honors for Undergraduate Thesis, Glynn Family Honors Program, University of Notre Dame
2011, Outstanding Senior Biologist, University of Notre Dame
2011, Outstanding Senior Band Member, University Bands, University of Notre Dame
2010, Summer Fellowship, National Science Foundation-Research Experience of Undergraduates, University of Notre Dame
2009, Katz Summer Research Scholarship, Children’s Memorial Research Center
2009, Braco Award for Excellence in Cell Biology Research, University of Notre Dame
2007-2011, Dean’s List, 7/8 semesters, University of Notre Dame
2007, Notre Dame Scholar, University of Notre Dame
Leadership and Memberships
2023-present, American Society of Clinical Oncology
2023-present, Pediatric Immunotherapy Network, NCI, NIH
2023-present, Pediatric Immunotherapy Development and Discovery Network, NCI, NIH
2022-present, American Association of Cancer Research
2021-present, Children's Oncology Group
2021-present, American Society of Hematology
2021-present, American Society of Pediatric Hematology/Oncology
2015-present, American Association for Immunologists
2015-present, International Society for Advancement of Cytometry
2015-present, Society for Leukocyte Biology
2013-present, American Association for Cancer Research
2011-present, American Physician Scientist Association
2011-present, American Medical Association
Editorial and Academic Positions
2025-present, Ad hoc reviewer, Nature Genetics
2025-present, Ad hoc reviewer, Science Advances
2016-present, Ad hoc reviewer, Blood
Education & training
Graduate Degree
PhD in Immunology - Loyola University Chicago, Maywood, IL
Medical Degree
MD - Loyola University Chicago Stritch School of Medicine, Maywood, IL
Residency
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Fellowship
Pediatric Hematology/Oncology - Children’s Hospital of Philadelphia, Philadelphia, PA
Postdoctoral Fellow in Cancer Immunology - Loyola University Chicago, Maywood, IL
Publications
PubMed
Editorials, Reviews, Chapters
2022
Spear TT, Gedminas J. Bone Neoplasms. Book Chapter in Netter’s Pediatrics, 2e. Elsevier. 2022.761-764.
Spear TT. Disorders of Red Blood Cells. Book Chapter in Netter’s Pediatrics, 2e. Elsevier. 2022.462-467.
Spear TT, Londonado, T. Wilm’s Tumor. Book Chapter in Ferri’s Clinical Advisor, 2022 ed. 1588.e10-1588.e12
2015
Nagato K, Spear TT, Nishimura MI. Influence of Antigen Receptor Avidity, Affinity, and Specificity on Genetically Engineered T Cells. Book Chapter in Developments in T Cell Based Cancer Immunotherapies. Springer. 2015. 75-98