Jonathan Spergel, MD, PhD

Jonathan Spergel, MD, PhD

Jonathan Spergel, MD, PhD, is chief of the Allergy Section at Children's Hospital of Philadelphia. He holds the Stuart E Starr Chair of Pediatrics.

Areas of Expertise: Allergies and Asthma, Atopic dermatitis, Eosinophilic esophagitis, Food allergy
Locations: Buerger Center for Advanced Pediatric Care; Specialty Care, Princeton at Plainsboro
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Mount Sinai School of Medicine, New York, NY


Pediatrics - Yale-New Haven Hospital, New Haven, CT


Pediatrics - Yale-New Haven Hospital, New Haven, CT


Allergy and Immunology - Children's Hospital, Boston, MA

Board Certification

Allergy and Immunology

Graduate Degree

PhD in Biomedical Sciences - Mount Sinai School of Medicine, New York, NY

Titles and Academic Titles

Chief, Allergy Section

Stuart E. Starr Chair of Pediatrics

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests



Spergel JM. New genetic links in eosinophilic esophagitis. Genome Med. 2010 Sep 7;2(9):60. [Epub ahead of print] Read abstract.

 Brown-Whitehorn TF, Spergel JM. The link between allergies and eosinophilic esophagitis: implications for management strategies. Expert Rev Clin Immunol. 2010 Jan;6(1):101-9. Review. Read abstract.

Sleiman PM, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SA, Wang K, Rafaels NM, Michel S, Bonnelykke K, Zhang H, Kim CE, Frackelton EC, Glessner JT, Hou C, Otieno FG, Santa E, Thomas K, Smith RM, Glaberson WR, Garris M, Chiavacci RM, Beaty TH, Ruczinski I, Orange JM, Allen J, Spergel JM, Grundmeier R, Mathias RA, Christie JD, von Mutius E, Cookson WO, Kabesch M, Moffatt MF, Grunstein MM, Barnes KC, Devoto M, Magnusson M, Li H, Grant SF, Bisgaard H, Hakonarson H. Variants of DENND1B associated with asthma in children. N Engl J Med. 2010 Jan 7;362(1):36-44. Epub 2009 Dec 23. Erratum in: N Engl J Med. 2010 Sep 2;363(10):994. Read abstract.

Cianferoni A, Spergel JM. Food allergy: review, classification and diagnosis. Allergol Int. 2009 Dec;58(4):457-66. Epub 2009 Oct 25. Review. Read abstract.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91. Epub 2010 Mar 7. Read abstract.

Franciosi JP, Fiorino K, Ruchelli E, Shults J, Spergel J, Liacouras CA, Leonard M. Changing Indications for Upper Endoscopy in Children During a 20-year Period. J Pediatr Gastroenterol Nutr. 2010 Jun 16. [Epub ahead of print] Read abstract.


Spergel JM, Beausoleil JA, Mascarenhas MR, Liacouras CA. The use of prick skin tests and patch tests to identify causative foods in eosinophilic esophagitis [abstract]. American Association of Allergy, Asthma & Immunology Annual Meeting; 2002; New York, NY.

Perez E, Spergel, JM. Rice-protein induced enterocolitis [abstract]. American College of Asthma Immunology and Asthma Annual Meeting, San Antonio, Texas, 2002.

Andrews T, Fielder J, Spergel JM. “New” soy allergy in 12-year-old boy [abstract]. American College of Asthma Immunology and Asthma Annual Meeting, San Antonio, Texas, 2002.

Comparison of self-management plans in asthma and atopic dermatitis [abstract]. International Symposium on Atopic Dermatitis; 2003; Rome, Italy. J Invest Dermatol, 121 (5): 1259-1259 Nov 2003

Spergel JM, Nurse N, Taylor P, ParneixSpake A. Effect of topical pimecrolimus on epicutaneous skin testing [abstract]. European Academy of Dermatology and Venerology Annual Meeting; 2004; Florence, Italy.

Fogg MI, Spergel, JM. 2005. Atopy patch testing in food-protein induced enterocolitis [abstract]. American Association of Allergy, Asthma & Immunology Annual Meeting; 2005; San Antonio, TX. J. Allergy Clin. Immunol. 2005; 115 (2) 55.


Spergel JM, Schnieder LC. Atopic dermatitis [review]. Internet J. of Allergy and Immunol. 1997; 1(1) 1-8.

Spergel JM, Pawlowski NA.  Food allergy.  In:  Mascarenhas M, Piccoli  D, editors. Gastrointestinal disease. Ped. Clinic of North America. 2001; 49(1): 73-96.

Spergel JM, Fiedler JM. Natural history of peanut allergy. Curr Opin in Pediatr. 2001; (6): 517-22.

Spergel JM, Clayton R. Pediatric asthma: a review. Biomedicina. 2002; 5 (3): 117-24.

Sullivan KE, Spergel JM,  editors. Genetics of allergic and immunoregulatory disorders. Immunology and Allergy Clinics of North America. 2002; 22 (2).

Spergel JM. Allergen-Induced Model of Murine Atopic Dermatitis” in Animal Models of Human Inflammatory Diseases, CRC publishers, 2003. Chapter 28: 423-32.

Spergel, JM, Chapter 3, 7 and 10 “Allergies and Asthma; Asthma Day to Day and Asthma Medication” in “Guide to Asthma, The Children Hospital of Philadelphia, 2003

Spergel, JM. Atopic march: link to upper airways. Curr Opin Allergy Clin Immunol. 2005; 5(1): 17-21.

Spergel, JM and T Brown-Whitehorn. The Use of Patch Testing in the Diagnosis of Food Allergies. Current Allergy and Asthma Reports 2005; 5: 86-90.

Spergel, JM and JF Fiedler. “Foods/Food Additives” in Asthma Triggers. Immunol Allergy Clin North Am. 2005; 25(1): 149-67.

Spergel, J, ME Rothenberg, and M. Fogg. Eliminating Eosinophilic Esophagitis. Clin. Immunol. 2005; 115(2) 131-2.

Fonacier, L, JM Spergel, EN Charlesworth, E Wheldon, V Beltani, J Bernhisel-Broadbent, M Boguniewicz, and DY Leung. Report of the Topical Calcineurin Inhibitor Task Force of the ACAAI and AAAAI.  April 1, 2005. 

J. Allergy Clin. Immunol. 2005; 115: 1249-53.

Spergel, JM and MI Fogg. Pediatric Asthma. In Conn’s Current Therapy, 2005 872-880.  Editors RE Rakel and ET Bope. Elsevier Saunders, Philadelphia, PA

Spergel, JM   Eosinophilic oesophagitis and pollen. Clin Exp Allergy. 2005; 35(11):1421-2.

Spergel, JM, T Brown-Whitehorn, J Beausoleil, and CA Liacouras.   Author’s Response to Editorial on Atopy Patch Testing in Eosinophilic Esophagitis, Ann Allergy Asthma Immunol 2006; 96 (2): 376-8.

Yan, AC, Lauren, C, Honig, PJ and JM Spergel. “Atopic Dermatitis” in Comprehensive Pediatric Hospital Medicine. Editors,  LA Zaoutis, VW Chaing. Elsevier Publishers, Philadelphia, PA2007. Chapter 155: 981-990.

Heltzer, M and JM Spergel. “Asthma” in Comprehensive Pediatric Hospital Medicine. Editors,  LA Zaoutis, VW Chaing. Elsevier Publishers, Philadelphia, PA2007. Chapter 75: 463-481.

Consultation and referral guidelines citing the evidence: How the allergist-immunologist can help, J Allergy Clin Immunol 2006: 117: S495-523

Akdis, CA, M Akdis, T,Bieber, C Bindslev-Jensen, M Boguniewicz, P Eigenmann, Q Hamid, A Kapp, DYM Leung, J Lipozencic, TA  Luger, A   Muraro, N Novak,   TA E Platts-Mills,   L Rosenwasser, A Scheynius, FER Simons, J Spergel, K Turjanmaa,   U Wahn, S Weidinger, T Werfel, and T Zuberbier. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergy and Clinical Immunology/American Academy of Allergy Asthma and Immunology/Practall Consensus Report, J. Allergy Clin Immunol 2006 118 (1): 152-169 and Allergy. 2006 61(8):969-87.

Spergel, JM and MI. Fogg, Pediatric Asthma. in Conn’s Current Therapy, 2006 Editors RE Rakel and ET Bope. Elsevier Saunders, Philadelphia, PA (in press)

Leung, DY and Spergel, JM, Safety of TIM (Topical Calcineurin Immune Modulators) in Atopic Dermatitis: Evaluation of the Evidence/Should we be Concerned?, Curr Allergy Asthma Rep. 2006 6(4):270-4.

Fonancier, L, E, Charlesworth, JM Spergel and DY Leung. The Black Box Warning for Topical Calcineurin Inhibitors: Looking outside the Box. Ann Allergy Asthma Immunol 2006; 97(1):117-20.

Spergel, J.M. Non-prescription Treatment in Atopic Dermatitis.  US Pharmacy Review 2006:

Spergel, J.M. Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients, Current Opin in Allergy Clin Immunol, 2007 Jun;7(3):274-278.

Furuta, GT, Liacouras, CA, Collins, MH, Gupta, SK, Justinich, C, Putnam, PE, Bonis, P, Hassall, E, Straumann, A, Rothenberg, ME, First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees.  Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007 Oct;133(4):1342-63. Epub 2007 Aug 8.

Spergel, JM and Shuker, M. Nutritional management of eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008 Jan;18(1):179-94.

Editorial and Academic Positions

Editorial positions
Clinical and Diagnostic Laboratory Immunology (Editorial board)
Journal of Allergy and Clinical Immunology (Reviewer board)
Nature-Clinical Practice  (Ad hoc reviewer)
Annuals of Allergy Asthma and Immunology  (Ad hoc reviewer)
Clin Exp Allergy (Ad hoc reviewer)
Allergy (Ad hoc reviewer)
Clinical and Diagnostic Laboratory Immunology (Ad hoc reviewer)
Experimental Dermatology (Ad hoc reviewer)
Expert Review Dermatology (Ad hoc reviewer)
Journal of American Medical Association (Ad hoc reviewer)
Journal of Allergy and Clinical Immunology (Ad hoc reviewer)
Pediatric Emergency Care (Ad hoc reviewer)
Canadian Medical Association Journal (Ad hoc reviewer)
International Archives of Allergy and Immunology (Ad hoc reviewer)
Journal of American Acad. of Dermatology (Ad hoc reviewer)
Journal of Investigative Dermatology (Ad hoc reviewer)
Environmental Health Perspectives, Journal of Nat. Inst. Of Environ Health Sciences (Ad hoc reviewer)
Digestive and Liver Disease (Ad hoc reviewer)
Pediatric Dermatology (Ad hoc reviewer)
NIH Study section RFA AI-05-002 “Units for HIV/AIDS Clinical Trials Networks” (Ad hoc reviewer)

Academic Committees
Executive Committee of Medical Staff
Pediatric Residency Committee (Interviewer)
Medical Admission Committee (Interviewer)
Adverse Drug Reaction Committee
GCRC Advisory Committee
Clinical Space Programming Work Groups
Clinical Affairs Committee
Asthma Clinical and Research Committee