Research News from CHOP

CHOP Researchers Identify Protein that Restricts Herpes Simplex Virus Infection
Using a novel proteomics approach, CHOP researchers have identified a host protein that restricts herpes simplex virus 1 (HSV-1) infection.
Long-Term Study Finds Dozens of New Genetic Markers Associated with Lifetime Bone Growth
Findings suggest that risk of fractures occurring in later life could be identified in childhood and may lead to tailored interventions.
CHOP Researchers Identify Knowledge Gaps in Evaluating Cath Lab Quality
CHOP researchers have identified knowledge gaps in the metrics currently used to measure quality in pediatric/congenital cardiac catheterization laboratories.
New Cell Models Help Researchers Study Disease Development and Growth Issues in Beckwith-Wiedemann Syndrome
New Cell Models Help Researchers Study Disease Development and Growth Issues in Beckwith-Wiedemann Syndrome
Nearly Half of Young Drivers Are Resuming Driving Just Weeks After Sustaining a Concussion
Adolescent drivers were more likely to get behind the wheel post-concussion than return to exercise or organized sports, suggesting the need for evidence-based guidelines
Friedreich’s Ataxia Center of Excellence at CHOP Awarded $1.275 Million to Advance Medical Research
The Friedreich’s Ataxia Center of Excellence at CHOP was awarded $1.275 million by the Friedreich’s Ataxia Research Alliance, Hamilton and Finneran families and the CureFA Foundation

CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity
CHOP researchers found the elevated biomarker in all children who tested positive for SARS-CoV-2, whether they were symptomatic for COVID-19 or not.
Researchers Develop Sequencing Method to Detect RNA Modifications on Viral RNAs
CHOP researchers have developed a sequencing method to detect RNA modifications that regulate RNA splicing during adenovirus infection.

CHOP Researchers Find Mitochondrial Dysregulation Driving Spaceflight Health Risks
As part of a landmark package NASA papers, CHOP researchers have described significant mitochondrial changes due to spaceflight.
Study Involving Seven Major Children’s Hospitals Shows COVID-19 is Typically Mild in Children
Large, national study on COVID-19 in children led by CHOP found 4% of children tested were positive, but there were disparities in positivity rates and disease severity.