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Researchers at Children’s Hospital of Philadelphia Highlight Role of Alternative Splicing in Chemotherapy Resistance

Researchers at Children’s Hospital of Philadelphia (CHOP) have elucidated the significant role that alternative splicing – a process whereby a single gene produces multiple proteins by rearranging its messenger RNA segments in different combinations – plays in resistance to chemotherapy in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). The study published today in the journal Cancer Research.

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Researchers at Children’s Hospital of Philadelphia Highlight Benefits of Proton Therapy for Pediatric Hodgkin Lymphoma Patients

A new study from Children’s Hospital of Philadelphia (CHOP) showed promising results for Pediatric Hodgkin Lymphoma (pHL) patients who underwent proton therapy to treat their disease in rare regions located below the diaphragm, such as the abdomen and pelvis. The study highlights the advantages of proton therapy over conventional photon radiotherapy, demonstrating fewer side effects and better protection for critical organs. It was published recently in the journal Pediatric Blood and Cancer.

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