Blood and Marrow Transplant Program Clinical Studies

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(16BT052; Unrelated And Partially Matched Related Donor PSCT w/ TCR αβ depletion for patients with BMF

The purpose of this research study is to test a new method of cell processing for stem cell transplants with an unrelated donor or partially matched related donor for patients with BMF who do not have a well matched related donor. The new method is called alpha/beta T cell and B cell depletion using a device called CliniMACs.  We want to see if this method can reduce some of the complications of the transplant and decrease the time it takes for the new stem cells to establish a new immune system.

BMT CTN 1503 (STRIDE2): BMT for SCD

The purpose of this research study is to compare transplant (HCT/BMT) to standard of care treatment in young adults with SCD who have experienced complications. Once consented we would assess to see if you have a matched donor. Subjects who have a closely matched donor will undergo a bone marrow transplant. This is called the Donor Arm. Subjects who do not have a closely matched donor will receive the current standard of care for their disease. This is called the No Donor Arm. We will follow subjects in both arms for two years to evaluate outcomes over that time period.
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