CHOP Open-access Medical Education: Hematology and Oncology Course Presentations

This seminar focuses on pediatric hematology and oncology; it was delivered in Salzburg, Austria, from April 23 – 29, 2017. Topics include acute lymphoblastic leukemia, lymphoma in children, anemia, splenectomy, palliative care, and cancer survivorship.

Acute Lymphoblastic Leukemia

At the end of this session, learners will be able to understand what acute lymphoblastic leukemia is, origins of ALL, risk factors that affect prognosis, clinical presentation of symptoms, lab evaluation to detect ALL, various principles of treatment, survival after relapsing, and relapse therapy.

Acute and Chronic Myeloid Leukemia in Children

At the end of this session, learners will be able to understand acute myeloid leukemia (AML) basics; epidemiology: constitutional predispositions and environmental exposures, diagnosis, classification, numerous therapy methods; and one hospital’s standard of care for AML. Additionally, learners will be able to understand what chronic myeloid leukemia (CML) is, the clinical features, natural history, cytogenetics, biology of pediatric CML, and therapy methods.

Lymphoma in Children and Young Adults

At the end of this session, learners will be able to provide an overview of Hodgkin and non-Hodgkin lymphoma, including understanding the clinical presentation and prognosis, the biologic factors, current approaches to therapy, some relapsed diseases and newer agents, and future directions for lymphoma.

Hematopoietic Stem Cell Transplantation

At the end of this session, learners will be able to understand bone marrow and transplant basics, differences and indications for autologous and allogeneic transplantation, HLA matching, advantages and disadvantages of donor selection, conditioning for transplant process, risk and complications of the transplant process, and the future of transplantation.

Pediatric Brain Tumors: Diagnosis and Treatment

At the end of this session, learners will be able to understand the epidemiology, pathogenesis, clinical presentation, red flags, symptoms and treatment methods of pediatric brain tumors. In addition, the learner will be able to understand the diagnosis and treatment of many types of brain tumors along with the challenge of treating them, improving radiation outcomes, and new directions of treatment.

Precision Medicine in Pediatric Oncology

At the end of this session, learners will be able to understand what precision medicine entails, how to bring modern science to patients, first success of precision medicine in CML patients, how precision medicine has evolved, and how precision medicine is used in pediatric oncology today.

Approach to Anemia

At the end of this session, learners will be able to understand how to effectively diagnose anemia in children and describe the four questions of anemia and their answers.

Survivorship

At the end of this session, learners will be able to understand the survivorship of various types of childhood cancer, landmarks in pediatric oncology, neuro-cognitive outcomes and late effects. In addition, the learner will be able to understand the Childhood Cancer Survivor Study, and the late complications of childhood cancer therapy.

Splenectomy for Blood Disorders

At the end of this session, learners will be able to understand the functions of the spleen, indications for splenectomy in various disorders, types of splenectomy, complications of surgery, and the prevention of post-splenectomy sepsis.

Hemoglobinopathies, Transfusion and Iron Overload

At the end of this session, learners will be able to understand the role of transfusion in hemoglobinopathies and other pediatric blood disorders, iron overload as a complication of transfusion, methods of monitoring iron overload, organ iron loading and dysfunction, iron chelators, disease prevention, and new therapies in practice.

Pediatric Soft Tissue Sarcomas

At the end of this session, learners will be able to understand different cases of soft tissue sarcoma (STS), the spectrum of STS histology by age, and non-rhabdo STS most common histologies. In addition, learners will be able to understand what rhabdomyosarcoma is, the baseline evaluation to identifying it, the biology, tumor location and prognosis, and future opportunities for research.

Bleeding Disorders and Thrombosis

At the end of this session, learners will be able to understand how a blood clot forms, the mechanisms of abnormal bleeding, how to test for abnormal bleeding, and coagulation testing. In addition, learners will understand the clinical signs and symptoms, diagnosis and treatment for both hemophilia and types of von Willebrand factor (VWD), along with therapy methods.

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