Timothy S. Olson, MD, PhD

Medical School

MD - University of Virginia School of Medicine, Charlottesville, VA

Internship

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Hematology-Oncology
Pediatrics

Graduate Degree

PhD in Molecular Physiology - University of Virginia, Charlottesville, VA

Papers

2016

Kamio, T., Gu B-W., Olson T.S., Zhang Y., Mason P.J., and Bessler, M. (2016) Mice with a mutation in the Mdm2 gene that interferes with MDM2/ribosomal protein binding develop a defect in erythropoiesis. PLoS One. 2016 Apr 4;11(4):e0152263. doi: 10.1371/journal.pone.0152263. eCollection 2016.

Betensky M., Babushok D., Roth J.J., Mason P.J., Biegel J.A., Busse T.M., Li Y., Lind C., Papazoglou A., Monos D., Podsakoff G., Bessler M., and Olson T.S. (2016) Clonal Evolution and Clinical Significance of Copy Number Neutral Loss of Heterozygosity of Chromosome Arm 6p in Acquired Aplastic Anemia. Cancer Genet. 209(1-2):1-10. PMCID PMC4738084.

Babushok D.V., Grignon A.L., Li Y., Atienza J., Xie H.M., Lam H-S., Hartung H., Bessler M., and Olson T.S. (2016) Disrupted lymphocyte homeostasis in hepatitis-associated acquired aplastic anemia is associated with short telomeres. Am J Hematol 91(2) 243-7. PMCID PMC4724330.

Babushok, D.V., Stanley N., Xie H.M., Huang H., Bagg A., Olson T.S., and Bessler M. (2016) Clonal Replacement Underlies Spontaneous Remission in Paroxysmal Nocturnal Haemoglobinuria. Br J Haematol 2016 Feb 23 [Epub ahead of Print] PMID: 26913981.

Babushok, D.V., Bessler M., and Olson T.S. (2016) Genetic predisposition to myelodysplastic syndrome and acute myeloid leukemia in children and young adults.  Leuk Lymphoma. 57(3): 520-36. PMCID: PMC4798888. 

2015

Babushok D.V., Perdigones N., Perin J.C., Olson T.S., Ye W., Roth J.J., Lind C., Cattier C., Li Y., Hartung H., Paessler M.E., Frank D.M., Xie H.M., Cross S., Cockroft J.D., Podsakoff G.M., Monos D., Biegel J.A., Mason P.J., and Bessler M. : Emergence of Clonal Hematopoiesis in the Majority of Patients with Acquired Aplastic Anemia. Cancer Genet 208(4): 115-28, Apr 2015.

Otsuru S., Hofmann T.J., Raman P., Olson T.S., Guess A.J., Dominici M., and Horwitz E.M. : Genomic and Functional Comparison of Mesenchymal Stromal Cells Prepared Using Two Isolation Methods. Cytotherapy 17(3): 262-70, Mar 2015.

2014

Olson T.S., Chan E.S., Paessler M.E., Sullivan K.E., Frantz, C.N., Russo, P. and Bessler, M. (2014). Liver Failure Due to Hepatic Angiosarcoma in an Adolescent with Dyskeratosis Congenita.  J Pediatr Hematol Oncol May; 36(4):312-15. PMCID: PMC3714320

Oshrine B.R., Olson T.S., and Bunin N.  (2014) Mixed chimerism and graft loss in pediatric recipients of an alemtuzumab-based reduced-intensity conditioning regimen for nonmalignant disease. Ped Blood Cancer 2014 Jun 17 [Epub ahead of print] PMID24939325

Olson T.S., Reiss U.M., Rogers Z.R., Sieff C., Vlachos A., Walkovich K., Wang W., and Shimamura A. (2014). Diagnosis and Treatment of Pediatric Acquired Aplastic Anemia (AAA): An Initial Survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC).  Pediatr Blood Cancer. 2014 May;61(5):869-74. doi: 10.1002/pbc.24875. Epub 2013 Nov 27.

Babushok D.V., Xie H.M., Roth J.J., Perdigones N., Olson T.S., Cockroft J.D., Gai X., Perin J.C., Li Y., Paessler M.E., Hakonarson H., Podsakoff G.M., Mason P.J., Biegel J.A., and Bessler M. (2014). Single Nucleotide Polymorphism Array Analysis of Bone Marrow Failure Patients Reveals Characteristic Patters of Genetic Changes.  Br. J. Hematol. Jan; 164(1):73-82. 

Oshrine B.R., Olson T.S., and Bunin N.  (2014) Mixed chimerism and graft loss in pediatric recipients of an alemtuzumab-based reduced-intensity conditioning regimen for nonmalignant disease. Pediatr Blood Cancer. Oct; 61 (1): 1852-9. PMID: 24939325.

Olson T.S., Chan E.S., Paessler M.E., Sullivan K.E., Frantz, C.N., Russo, P. and Bessler, M. (2014). Liver Failure Due to Hepatic Angiosarcoma in an Adolescent with Dyskeratosis Congenita.  J Pediatr Hematol Oncol May; 36(4):312-15. PMCID: PMC3714320.

Williams D.A., Bennett C.A., Bertuch A., Bessler M., Coates T., Corey S., Dror Y., Huang J.,  Lipton J., Olson T.S., Reiss U.M., Rogers Z.R., Sieff C., Vlachos A., Walkovich K., Wang W., and Shimamura A. (2014). Diagnosis and Treatment of Pediatric Acquired Aplastic Anemia (AAA): An Initial Survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC).  Ped Blood Cancer. May; 61(5):869-74. PMCID: PMC4280184.

Abstracts

2014

Hartung H., Babushok D., Perdigones N., Perin J.C., Roth J., Olson T.S., Biegel J.A., Paessler M.E., Mason, P.J., and Bessler, M. : Towards Precision Medicine in Acquired and Inherited Bone Marrow Failure Syndromes. American Academy of Pediatrics National Conference, San Diego, CA 2014.

Posters and Presentations

2015

Betensky M., Babushok D., Roth J.J., Mason P.J., Biegel J.A., Lind C., Monos D., Bessler M., and Olson T.S. : Copy Number Neutral Loss of Heterozygosity of Chromosome Arm 6p in Acquired Aplastic Anemia: Frequency, Clonal Evolution and Clinical Significance. Annual Meeting of the American Society of Pediatric Hematology/Oncology , Phoenix, AZ (Oral Presentation) May 2015.

2014

Roth J.J., Babushok D.V., Perdigones, N., Olson T.S., Hartung, H.D., Cockroft, J.D., Pamu, S., Paessler M.E., Mason P.J., Bessler M., Wilmoth, D.M., Biegel J.A.: Utility of single nucleotide polymorphism arrays for patients with bone marrow failure. Presentation at The American Cytogenetics Conference, Asheville, NC 2014.

Olson T.S., Otsuru S., Hofmann T.J., Dominici M., and Horwitz E.M.: Expansion of the Endosteal Hematopoietic Stem Cell Niche Following Myeloablative and Reduced Intensity Conditioning Is Triggered By Hematopoietic Cell Loss. Annual Meeting of the American Society of Hematology, San Francisco, CA (Poster Presentation) Dec 2014.

Betensky M., Babushok D., Roth J.J., Mason P.J., Biegel J.A., Lind C., Monos D., Bessler M., and Olson T.S. : Clonal Evolution and Clinical Significance of Copy Number Neutral Loss of Heterozygosity of Chromosome Arm 6p in Acquired Aplastic Anemia Annual Meeting of the American Society of Hematology, San Francisco, CA (Poster Presentation) Dec 2014.

Oshrine, B., Olson T.S., and Bunin, N.: Mixed Chimerism and Graft Loss in Pediatric Recipients of an Alemtuzumab-Based Reduced-Intensity Conditioning Regimen for Nonmalignant Disease. Annual Meeting of the American Society of Bone Marrow Transplantation, Grapevine, TX. (Oral Presentation) Feb 2014.

Invited Lectures

2015

"Bone Marrow Failure and Transplant" - 2015 Regional Conference of the Association of Pediatric Hematology/ Oncology Nurses, Villanova, PA.

2014

"Pediatric-Adult Transition for Patients with Dyskeratosis Congenita" - DC Outreach Camp and Educational Meeting for Patients with Dyskeratosis Congenita and their Families, Camp Sunshine, Portland, ME.

"Pediatric-Adult Transition for Patients with Telomeropathies" - Inaugural Meeting of the Clinical Care Consortium of Telomere-Associated Ailments, Chicago, IL.