Division of Infectious Diseases Clinical Studies

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Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM)

The PRISM study is looking to understand what happens to children and young adults who get infected with SARS-CoV-2 and how their immune system responds. To do this, we are examining blood, urine, stool, saliva, and nasal swab samples, as well as information related to SARS-CoV-2 infection and MIS-C, collected from subjects. We will also study subjects' results on breathing tests, echocardiograms, electrocardiograms, and a chest CT scan. Participation lasts for up to 1 year and includes in-person, telephone, and video study visits.

Breath Biomarkers of Mitochondrial Dysfunction

This prospective cohort study will compare breath biomarkers from subjects with mitochondrial disease to healthy controls. The age range for the study is 4-80 years and all subjects will be recruited at CHOP. Participation would consist of a one time visit, up to 2 hours maximum, to collect identifiable information and breath sample. The goal is to identify VOC biomarkers that characterize mitochondrial disease compared to healthy controls, which could lead to a non-invasive breath test for mitochondrial function. Subjects will be compensated as a form of appreciation for participating in the study.